Search clinical trials for: the TKI dose reduction

Total 231246 results

xuna

Recruiting

A Study on the Withdrawal of Second-generation Tyrosine Kinase Inhibitors After Dose Reduction in Patients With CML

MMR on 12 Month

China
National Research Center for Hematology, Russia

Active, not recruiting

A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib) (READIT)

Chronic Myeloid Leukemia | Chronic Myeloid Leukemia in Remission | BCR-ABL Positive Chronic Myelogenous Leukemia

Russian Federation
Cambridge University Hospitals NHS Foundation Trust

Not yet recruiting

Low-Dose IL-2 For The Reduction Of Vascular Inflammation In ACS -Clinical Outcomes & Follow-up Study (IVORY-FINALE)

Acute Coronary Syndromes

United Kingdom
Brazilian Clinical Research Institute
Alliança Diagnostic

Not yet recruiting

Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low Dose Rivaroxaban for Major Adverse Cardiovascular Events Reduction in Ischemic Stroke (ARCHIMEDES)

Ischemic Stroke
National Cancer Institute (NCI)

Not yet recruiting

Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

Breast Carcinoma | Breast Ductal Carcinoma In Situ | Breast Lobular Carcinoma In Situ | Estrogen Receptor-Positive Breast Carcinoma

United States
YourChoice Therapeutics, Inc.

Recruiting

First in Human Study Evaluating Single Ascending Oral Doses of YCT-529 in Healthy Males

Male Contraception

United Kingdom
Universitaire Ziekenhuizen KU Leuven
Fonds voor Wetenschappelijk Reumaonderzoek (FWRO)

Not yet recruiting

Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-guided Dose Reduction in Patients With Rheumatoid Arthritis (RITUXERA)

Rheumatoid Arthritis

Belgium
Silvia Gomez Ordonez

Recruiting

Evaluation of Pain Level Reduction After Low-dose Radiation in Symptomatic Facet Joint Arthritis (LORAFA)

Osteoarthritis, Spine | Lower Back Pain Chronic | Facet Joint Arthrosis

Switzerland
Xiangya Hospital of Central South University
Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Recruiting

Apatinib Mesylate Versus Standard Second-line TKI in the Treatment of Advanced GIST

Gastrointestinal Stromal Tumors

China
Emory University
National Cancer Institute (NCI)

Recruiting

Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer

Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Oropharyngeal HPV-Positive Squamous Cell Carcinoma

United States
Novartis Pharmaceuticals

Recruiting

Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia (ASC2ESCALATE)

Chronic Myelogenous Leukemia - Chronic Phase

United States
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

A Study of the Efficacy and Safety of Flumatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.

CML, Chronic Phase

China
dafna yahav

Not yet recruiting

Booster Dose of COVID-19 Vaccine for Kidney Transplant Recipients Without Adequate Humoral Response (WHO)

Immunosuppression | COVID-19 Acute Respiratory Distress Syndrome
Lutris Pharma Ltd.

Recruiting

LUT014 for the Reduction of Dose-Limiting Acneiform Lesions Associated With EGFRI Treatment of mCRC

EGFRI Induced Acneiform Lesions

United States, Israel
Memorial Sloan Kettering Cancer Center
National Institutes of Health (NIH)

Recruiting

Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs

Soft Tissue Sarcoma

United States
Cambridge University Hospitals NHS Foundation Trust

Recruiting

Low-dose Interleukin-2 for the Reduction of Vascular Inflammation in Acute Coronary Syndromes - IVORY (IVORY)

Acute Coronary Syndromes

United Kingdom
Reade Rheumatology Research Institute
ZonMw: The Netherlands Organisation for Health Research and Development; Sint...

Recruiting

Adalimumab Drug Optimisation in Rheumatoid Arthritis Using Therapeutic Drug Monitoring (ADDORA)

Rheumatoid Arthritis

Netherlands
Assistance Publique - Hôpitaux de Paris

Recruiting

BETAmethasone Dose Reduction: Non-Inferiority on the Neurocognitive Outcomes of Children Born Before 32 Weeks of Gestation (BETANINO)

Premature Childbirth

France
Eyenovia Inc.

Recruiting

Microdosed Atropine 0.1% and 0.01% Ophthalmic Solutions for Reduction of Pediatric Myopia Progression

Myopia

United States
Reade Rheumatology Research Institute
ZonMw: The Netherlands Organisation for Health Research and Development

Recruiting

Use of Tocilizumab Drug Levels to Optimize Treatment in RA (TODORA)

Rheumatoid Arthritis

Netherlands
Medical University of Vienna
M.D. Anderson Cancer Center; Odense University Hospital; Radboud University Medical... and other collaborators

Recruiting

Image Guided IMRT, Radiochemotherapy and MRI-based IGABT in Locally Advanced Cervical Cancer (EMBRACEII)

Uterine Cervical Neoplasms

Austria
McMaster University
Canadian Institutes of Health Research (CIHR); David Braley and Nancy Gordon... and other collaborators

Recruiting

Team Approach to Polypharmacy Evaluation and Reduction (Pharmacy)

Polypharmacy | Multi-morbidity | Medication Therapy Management

Canada
University of Alabama at Birmingham
National Heart, Lung, and Blood Institute (NHLBI); University of Pittsburgh; Brigham... and other collaborators

Recruiting

Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis (STRIVE-IPF)

Idiopathic Pulmonary Fibrosis, Acute Fatal Form

United States
McMaster University
Canadian Institutes of Health Research (CIHR); David Braley and Nancy Gordon... and other collaborators

Recruiting

Team Approach to Polypharmacy Evaluation and Reduction (TAPER-RCT)

Polypharmacy | Multi-morbidity | Medication Therapy Management

Canada
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients With Primary or Metastatic Brain Tumors

Metastatic Malignant Neoplasm in the Brain | Malignant Brain Neoplasm | Recurrent Malignant Brain Neoplasm

United States
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

B Acute Lymphoblastic Leukemia | Central Nervous System Leukemia | Testicular Leukemia | B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

United States, Canada, Puerto Rico, Australia, New Zealand, Switzerland, Ireland
VA Office of Research and Development

Active, not recruiting

Reducing Use of Sleep Medications Assisted by a Digital Insomnia Intervention (SEDATIVE)

Insomnia

United States
Janssen Research & Development, LLC

Completed

Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicide

Depressive Disorder, Major

United States, France, Italy, Spain, Hungary, Belgium, Brazil, Bulgaria, Poland
Indiana University

Completed

Radiosurgery Dose Reduction for Brain Metastases on Immunotherapy (RADREMI): A Prospective Pilot Study (RADREMI)

Brain Cancer | Brain Tumor | Brain Metastases

United States
Radboud University Medical Center
UMC Utrecht; Amsterdam UMC, location VUmc; Maastro Clinic, The Netherlands; Rad...

Completed

Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity (UPGRADE-RT)

Head and Neck Neoplasms | Carcinoma, Squamous Cell

Netherlands
University of Alabama at Birmingham
Bracco Corporate

Active, not recruiting

Evaluating the Performance of AI in Evaluating Breast MRI Performed With Dose Reduction

Breast Malignant Tumor | Breast Benign Tumor

United States
M.D. Anderson Cancer Center

Active, not recruiting

Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques

Liver Metastases | Colorectal Carcinoma | Colon Carcinoma | Diseases of Liver

United States
Spruce Biosciences

Active, not recruiting

A Ph2b to Evaluate Tildacerfont in the Reduction of Glucocorticoid Steroid Doses in Adult CAH

Congenital Adrenal Hyperplasia

United States, Australia, Brazil, Estonia, Germany, Korea, Republic of, Latvia, Lithuania, Poland, Romania, Spain, Sweden, Turkey, Canada, Italy, United Kingdom
Radboud University Medical Center
University Hospital, Ghent; ZonMw: The Netherlands Organisation for Health... and other collaborators

Active, not recruiting

Dose Reduction of IL17 and IL23 Inhibitors in Psoriasis (BeNeBio)

Psoriasis | Psoriasis Vulgaris

Netherlands, Belgium
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine

Monkeypox

United States
Abramson Cancer Center at Penn Medicine

Active, not recruiting

TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck

Oropharyngeal Cancer | Human Papilloma Virus | Squamous Cell Carcinoma

United States
Reade Rheumatology Research Institute
ZonMw: The Netherlands Organisation for Health Research and Development; Sint...

Completed

Adalimumab Dose Reduction Aiming Low Serum Concentration With Control of Disease Activity (ADDORA-low)

Rheumatoid Arthritis

Netherlands
Amgen

Completed

Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study

Cardiovascular Disease

United States, Australia, Netherlands, Canada, Denmark, Iceland, Japan
AMIpharm Co., Ltd.

Completed

Determine the Dosing Interval and Optimal Dose of AYP-101 for the Reduction of Submental Fat in Chin Area

Moderate or Severe Submental Fullness

Korea, Republic of
Masaryk University

Active, not recruiting

Efficacy and Safety of TKIs' Withdrawal After a Two-step Dose Reduction in Patients With Chronic Myeloid Leukemia (HALF)

Chronic Myeloid Leukemia, Chronic Phase | Withdrawal;Drug

Czechia
Fondazione EMN Italy Onlus

Active, not recruiting

STUDY TO DETERMINE THE EFFICACY AND SAFETY OF STANDARD SCHEDULE VERSUS A NEW ALGORITHM OF DOSE REDUCTIONS IN ELDERLY AND UNFIT NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS RECEIVING LENALIDOMIDE PLUS STEROIDS

Multiple Myeloma

Italy
Basilea Pharmaceutica
ArQule, Inc. (a wholly owned subsidiary of Merck Sharp and Dohme, a subsidiary...

Completed

Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations

Solid Tumor

United States, Italy
University of Washington
National Institute on Drug Abuse (NIDA); Kaiser Permanente

Completed

Strategies to Improve Pain and Enjoy Life (STRIPE)

Chronic Pain

United States
Nektar Therapeutics
Bristol-Myers Squibb

Completed

A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors (PIVOT-02)

Melanoma | Renal Cell Carcinoma | Gastric Cancer | Non Small Cell Lung Cancer | Triple Negative Breast Cancer | Urothelial Carcinoma | HR+/HER2- Breast Cancer

United States, Spain, Canada, France, Italy, Belgium, Poland, United Kingdom
Medical University of South Carolina

Completed

A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.

Surgery

United States
Universitaire Ziekenhuizen KU Leuven

Completed

Patient Tailored Contrast Volume for Preoperative CT Angiography of the Aorta

Aortic Aneurysm
Assistance Publique - Hôpitaux de Paris

Completed

Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth (BETADOSE)

Neonatal Complications

France
Novartis Pharmaceuticals
Molecular Partners AG

Terminated

A Dose Finding, Efficacy and Safety Study of Ensovibep (MP0420) in Ambulatory Adult Patients With Symptomatic COVID-19 (EMPATHY)

COVID-19

United States, India, Hungary, Netherlands, South Africa
University Hospital, Ghent
KU Leuven; University Ghent

Terminated

Dose Tapering Study of Adalimumab in Psoriasis

Psoriasis Vulgaris

Belgium
Pfizer

Completed

To Examine the Effects of Axitinib Dose Reduction and Interruption for Adverse Event Management Among Patients Receiving Axitinib in for the Treatment of Advanced Renal Cell Carcinoma

Renal Cell Carcinoma

United States

Search clinical trials for: the TKI dose reduction

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