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Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (ARISTOTLE)

5. června 2018 aktualizováno: Bristol-Myers Squibb

A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

Přehled studie

Postavení

Dokončeno

Podmínky

Intervence / Léčba

Typ studie

Intervenční

Zápis (Aktuální)

20976

Fáze

  • Fáze 3

Kontakty a umístění

Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.

Studijní místa

  • Argentina
      • Buenos Aires, Argentina, 1119
        • Local Institution
      • Buenos Aires, Argentina, C1280AEB
        • Local Institution
      • Buenos Aires, Argentina, 1181
        • Local Institution
      • Buenos Aires, Argentina, C1426ANZ
        • Local Institution
      • Buenos Aires, Argentina, 1280
        • Local Institution
      • Cordoba, Argentina, 5000
        • Local Institution
      • Cordoba, Argentina, X5000EPU
        • Local Institution
      • Cordoba, Argentina, X5008KKF
        • Local Institution
      • Cordoba, Argentina, X5003DCE
        • Local Institution
      • Salta, Argentina, 4400
        • Local Institution
      • Santa Fe, Argentina, 3000
        • Local Institution
      • Tucuman, Argentina, T4000NIL
        • Local Institution
    • Buenos Aires
      • Adrogue, Buenos Aires, Argentina, 1846
        • Local Institution
      • Bahia Blanca, Buenos Aires, Argentina, B8000FTD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, CP1425A WC
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1128AAD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1128
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, C1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, CP1425AWC
        • Local Institution
      • Ciudad Autonoma De, Buenos Aires, Argentina, 1180
        • Local Institution
      • Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina, CI094AAD
        • Local Institution
      • Coronel Suarez, Buenos Aires, Argentina, B7540GHD
        • Local Institution
      • Haedo, Buenos Aires, Argentina, B1706AJU
        • Local Institution
      • Junin, Buenos Aires, Argentina, 6000
        • Local Institution
      • La Plata, Buenos Aires, Argentina, 1900
        • Local Institution
      • La Plata, Buenos Aires, Argentina, B1900AXI
        • Local Institution
      • La Plata, Buenos Aires, Argentina, 1902
        • Local Institution
      • Mar Del Plata, Buenos Aires, Argentina, 7600
        • Local Institution
      • Merlo, Buenos Aires, Argentina, B1722COV
        • Local Institution
      • Merlo, Buenos Aires, Argentina, 1722
        • Local Institution
      • Olivos, Buenos Aires, Argentina, 1602
        • Local Institution
      • Quilmes, Buenos Aires, Argentina, 1878
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, B1704ESN
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, B1704ETD
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, 1706
        • Local Institution
      • San Justo, Buenos Aires, Argentina, 1754
        • Local Institution
      • San Martin, Buenos Aires, Argentina, 1650
        • Local Institution
      • San Nicolas, Buenos Aires, Argentina, 2900
        • Local Institution
      • Zarate, Buenos Aires, Argentina, 2800
        • Local Institution
      • Zarate, Buenos Aires, Argentina, B2800DGH
        • Local Institution
    • Provincia DE Cordoba
      • Cordoba, Provincia DE Cordoba, Argentina, 5000
        • Local Institution
    • RIO Negro
      • Cipolletti, RIO Negro, Argentina, 8324
        • Local Institution
    • Santa FE
      • Rosario, Santa FE, Argentina, 2000
        • Local Institution
      • Rosario, Santa FE, Argentina, S2000CVB
        • Local Institution
      • Rosario, Santa FE, Argentina, S2001ODA
        • Local Institution
    • Santa Fe
      • Rosario, Santa Fe, Argentina, S2000CVD
        • Local Institution
      • Rosario, Santa Fe, Argentina, S2000 CVD
        • Local Institution
    • Tucuman
      • San Miquel De Tucuman, Tucuman, Argentina, 4000
        • Local Institution
  • Austrálie
    • New South Wales
      • Coffs Harbour, New South Wales, Austrálie, 2450
        • Local Institution
      • Concord, New South Wales, Austrálie, 2139
        • Local Institution
      • Gosford, New South Wales, Austrálie, 2250
        • Local Institution
      • Kogarah, New South Wales, Austrálie, 2217
        • Local Institution
      • Miranda, New South Wales, Austrálie, 2228
        • Local Institution
    • Queensland
      • Auchenflower, Queensland, Austrálie, 4066
        • Local Institution
      • Brisbane, Queensland, Austrálie, 4032
        • Local Institution
      • Caboolture, Queensland, Austrálie, 4510
        • Local Institution
      • Herston, Queensland, Austrálie, 4029
        • Local Institution
      • Kippa Ring, Queensland, Austrálie, 4021
        • Local Institution
      • Nambour, Queensland, Austrálie, 4560
        • Local Institution
      • Sherwood, Queensland, Austrálie, 4075
        • Local Institution
    • South Australia
      • Adelaide, South Australia, Austrálie, SA 5000
        • Local Institution
      • Ashford, South Australia, Austrálie, 5035
        • Local Institution
      • Bedford Park, South Australia, Austrálie, 5042
        • Local Institution
      • Woodville, South Australia, Austrálie, 5011
        • Local Institution
    • Victoria
      • Box Hill, Victoria, Austrálie, 3128
        • Local Institution
      • Dandenong, Victoria, Austrálie, 3175
        • Local Institution
      • Geelong, Victoria, Austrálie, 3220
        • Local Institution
    • Western Australia
      • Fremantle, Western Australia, Austrálie, 6160
        • Local Institution
      • Joondalup, Western Australia, Austrálie, 6027
        • Local Institution
  • Belgie
      • Aalst, Belgie, 9300
        • Local Institution
      • Antwerpen, Belgie, 2020
        • Local Institution
      • Antwerpen, Belgie, 2060
        • Local Institution
      • Arlon, Belgie, 6700
        • Local Institution
      • Brugge, Belgie, 8000
        • Local Institution
      • Brussels, Belgie, 1090
        • Local Institution
      • Dillingen, Belgie, 66763
        • Local Institution
      • Genk, Belgie, 3600
        • Local Institution
      • Gent, Belgie, 9000
        • Local Institution
      • Gilly, Belgie, 6060
        • Local Institution
      • Hasselt, Belgie, 3500
        • Local Institution
      • Huy, Belgie, 4500
        • Local Institution
      • Kortrijk, Belgie, 8500
        • Local Institution
      • Menen, Belgie, 8930
        • Local Institution
      • Mol, Belgie, 2400
        • Local Institution
      • Montegnee, Belgie, 4420
        • Local Institution
      • Verviers, Belgie, 4800
        • Local Institution
      • Woluwe- Saint Lambert, Belgie, 1200
        • Local Institution
      • Yvoir, Belgie, 5530
        • Local Institution
  • Brazílie
      • Rio De Janeiro, Brazílie, 20551
        • Local Institution
      • Rio De Janeiro, Brazílie, 20551-030
        • Local Institution
      • Rio De Janeiro, Brazílie, 22251-030
        • Local Institution
      • Rio De Janeiro, Brazílie, 22251
        • Local Institution
      • Sao Paulo, Brazílie, 01323-010
        • Local Institution
      • Sao Paulo, Brazílie, 01323
        • Local Institution
      • Sao Paulo, Brazílie, 04012
        • Local Institution
      • Sao Paulo, Brazílie, 04024-002
        • Local Institution
      • Sao Paulo, Brazílie, 04038
        • Local Institution
      • Sao Paulo, Brazílie, 01221-900
        • Local Institution
      • Sao Paulo, Brazílie, 01221
        • Local Institution
      • Sao Paulo, Brazílie, 01322-001
        • Local Institution
      • Sao Paulo, Brazílie, 01322
        • Local Institution
      • Sao Paulo, Brazílie, 01323-001
        • Local Institution
      • Sao Paulo, Brazílie, 04012-180
        • Local Institution
      • Sao Paulo, Brazílie, 04024
        • Local Institution
      • Sao Paulo, Brazílie, 04038-031
        • Local Institution
      • Sao Paulo, Brazílie, 08270-070
        • Local Institution
      • Sao Paulo, Brazílie, 08270
        • Local Institution
    • Bahia
      • Salvador, Bahia, Brazílie, 40144
        • Local Institution
      • Salvador, Bahia, Brazílie, 41810
        • Local Institution
      • Salvador, Bahia, Brazílie, 40144-900
        • Local Institution
      • Salvador, Bahia, Brazílie, 41810-010
        • Local Institution
    • Minas Gerais
      • Belo Horzonte, Minas Gerais, Brazílie, 30150-221
        • Local Institution
      • Belo Horzonte, Minas Gerais, Brazílie, 30150
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brazílie, 36021-630
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brazílie, 36021
        • Local Institution
      • Uberaba, Minas Gerais, Brazílie, 38056 055
        • Local Institution
      • Uberlandia, Minas Gerais, Brazílie, 38400-299
        • Local Institution
      • Uberlandia, Minas Gerais, Brazílie, 38400
        • Local Institution
    • Para
      • Belem, Para, Brazílie, 66087-660
        • Local Institution
      • Belem, Para, Brazílie, 66087
        • Local Institution
    • Parana
      • Campina Grande Do Sul, Parana, Brazílie, 83430-000
        • Local Institution
      • Campina Grande Do Sul, Parana, Brazílie, 83430
        • Local Institution
      • Curitiba, Parana, Brazílie, 80010
        • Local Institution
      • Curitiba, Parana, Brazílie, 80730
        • Local Institution
      • Curitiba, Parana, Brazílie, 80010-030
        • Local Institution
      • Curitiba, Parana, Brazílie, 80730-150
        • Local Institution
      • Londrina, Parana, Brazílie, 86010-450
        • Local Institution
      • Londrina, Parana, Brazílie, 86010
        • Local Institution
    • RIO Grande DO Norte
      • Natal, RIO Grande DO Norte, Brazílie, 59020-100
        • Local Institution
    • RIO Grande DO SUL
      • Porte Alegre, RIO Grande DO SUL, Brazílie, 90610-000
        • Local Institution
      • Porte Alegre, RIO Grande DO SUL, Brazílie, 90880-480
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazílie, 90035-903
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazílie, 90020-090
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazílie, 90620-001
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazílie, 91350-280
        • Local Institution
    • Rio Grande Do Norte
      • Natal, Rio Grande Do Norte, Brazílie, 59020
        • Local Institution
    • Rio Grande Do Sul
      • Porte Alegre, Rio Grande Do Sul, Brazílie, 90610
        • Local Institution
      • Porte Alegre, Rio Grande Do Sul, Brazílie, 90880480
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazílie, 90035
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazílie, 90020
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazílie, 90620
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazílie, 91350
        • Local Institution
    • SAO Paulo
      • Botucatu, SAO Paulo, Brazílie, 18618-000
        • Local Institution
      • Campinas, SAO Paulo, Brazílie, 13059-740
        • Local Institution
      • Marilia, SAO Paulo, Brazílie, 17515-000
        • Local Institution
      • Marilia, SAO Paulo, Brazílie, 17515-460
        • Local Institution
      • Marilia, SAO Paulo, Brazílie, 17519-000
        • Local Institution
      • San Jose Do Rio Preto, SAO Paulo, Brazílie, 15090-000
        • Local Institution
      • Santo Andre, SAO Paulo, Brazílie, 09190-610
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brazílie, 15015-750
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brazílie, 15015-210
        • Local Institution
    • Santa Catarina
      • Blumenau, Santa Catarina, Brazílie, 89010
        • Local Institution
      • Blumenau, Santa Catarina, Brazílie, 89010-500
        • Local Institution
      • Sao Jose, Santa Catarina, Brazílie, 88103
        • Local Institution
      • Sao Jose, Santa Catarina, Brazílie, 88103-450
        • Local Institution
    • Sao Paulo
      • Botucatu, Sao Paulo, Brazílie, 18618
        • Local Institution
      • Campinas, Sao Paulo, Brazílie, 13059
        • Local Institution
      • Marilia, Sao Paulo, Brazílie, 17519
        • Local Institution
      • Marilia, Sao Paulo, Brazílie, 17515
        • Local Institution
      • San Jose Do Rio Preto, Sao Paulo, Brazílie, 15090
        • Local Institution
      • Santo Andre, Sao Paulo, Brazílie, 09190
        • Local Institution
      • Sao Jose Do Rio Preto, Sao Paulo, Brazílie, 15015
        • Local Institution
  • Chile
    • LOS Lagos
      • Osorno, LOS Lagos, Chile, 5311089
        • Local Institution
      • Osorno, LOS Lagos, Chile, 5311523
        • Local Institution
    • Metropolitana
      • Santiago, Metropolitana, Chile, 7500520
        • Local Institution
      • Santiago, Metropolitana, Chile, 7500922
        • Local Institution
      • Santiago, Metropolitana, Chile, 8330074
        • Local Institution
    • Region DE LA Araucania
      • Temuco, Region DE LA Araucania, Chile, 4781176
        • Local Institution
    • Region De La Araucania
      • Temuco, Region De La Araucania, Chile, 4781156
        • Local Institution
    • Valparaiso
      • Temuco, Valparaiso, Chile, 4781173
        • Local Institution
      • Vina Del Mar, Valparaiso, Chile, 2570017
        • Local Institution
  • Dánsko
      • Arhus C, Dánsko, 8000
        • Local Institution
      • Esbjerg, Dánsko, 6700
        • Local Institution
      • Frederiksberg, Dánsko, 2000
        • Local Institution
      • Frederikssund, Dánsko, 3600
        • Local Institution
      • Gentofte, Dánsko, 2900
        • Local Institution
      • Haderslev, Dánsko, 6100
        • Local Institution
      • Hellerup, Dánsko, 2900
        • Local Institution
      • Herlev, Dánsko, 2730
        • Local Institution
      • Herning, Dánsko, 7400
        • Local Institution
      • Hillerod, Dánsko, 3400
        • Local Institution
      • Hvidovre, Dánsko, 2650
        • Local Institution
      • Kobenhavn, Dánsko, 2100
        • Local Institution
      • Kolding, Dánsko, 6000
        • Local Institution
      • Odense, Dánsko, 5000
        • Local Institution
      • Silkeborg, Dánsko, 8600
        • Local Institution
      • Slagelse, Dánsko, 4200
        • Local Institution
      • Svendborg, Dánsko, 5700
        • Local Institution
  • Filipíny
      • Manila, Filipíny, 1000
        • Local Institution
      • Manila, Filipíny, 1008
        • Local Institution
      • Naga City, Filipíny, 4400
        • Local Institution
      • Pasig City, Filipíny, 1600
        • Local Institution
      • Quezon, Filipíny, 1100
        • Local Institution
      • Quezon City, Filipíny, 1102
        • Local Institution
      • San Juan, Filipíny, 1100
        • Local Institution
    • Ilocos Norte
      • Laoag City, Ilocos Norte, Filipíny, 2900
        • Local Institution
  • Finsko
      • Helsinki, Finsko, 00280
        • Local Institution
      • Helsinki, Finsko, FI-00280
        • Local Institution
      • Hus, Finsko, 00029
        • Local Institution
      • Jyvaskyla, Finsko, 40100
        • Local Institution
      • Kemi, Finsko, 94100
        • Local Institution
      • Oulu, Finsko, 90100
        • Local Institution
      • Pori, Finsko, 28120
        • Local Institution
      • Tampere, Finsko, 33100
        • Local Institution
  • Francie
      • Amiens Cedex 1, Francie, 80054
        • Local Institution
      • Bordeaux Cedex, Francie, 33075
        • Local Institution
      • Brest, Francie, 29609
        • Local Institution
      • Grenoble Cedex 09, Francie, 38043
        • Local Institution
      • La Seyne Sur Mer, Francie, 83500
        • Local Institution
      • Paris Cedex 18, Francie, 75018
        • Local Institution
      • Six Fours Les Plages, Francie, 83140
        • Local Institution
  • Holandsko
      • Breda, Holandsko, 4818 CK
        • Local Institution
      • Deventer, Holandsko, 7416 SE
        • Local Institution
      • Eindhoven, Holandsko, 5623 EJ
        • Local Institution
      • Eindhoven, Holandsko, 5623EJ
        • Local Institution
      • Enschede, Holandsko, 7513 ER
        • Local Institution
      • Hardenberg, Holandsko, 7772 SE
        • Local Institution
      • Hilversum, Holandsko, 1213 XZ
        • Local Institution
      • Nijmegen, Holandsko, 6525 GA
        • Local Institution
      • Oss, Holandsko, 5342 BT
        • Local Institution
      • Rotterdam, Holandsko, 3045 PM
        • Local Institution
      • S-Hertogenbosch, Holandsko, 5211 NL
        • Local Institution
      • Tiel, Holandsko, 4002 WP
        • Local Institution
      • Utrecht, Holandsko, 3582 KE
        • Local Institution
      • Velp, Holandsko, 6883 AZ
        • Local Institution
  • Hongkong
      • Hong Kong, Hongkong
        • Local Institution
      • Shatin, Hongkong
        • Local Institution
  • Indie
      • Ahmedabad, Indie, 380014
        • Local Institution
      • Annamalainagar, Indie, 608002
        • Local Institution
      • Bangalore, Indie, 560052
        • Local Institution
      • Chennai, Indie, 600006
        • Local Institution
      • Hyderabad, Indie, 500001
        • Local Institution
      • Hyderabad, Indie, 500044
        • Local Institution
      • Indore, Indie, 452014
        • Local Institution
      • Indore, Indie, 452001
        • Local Institution
      • Kolkata, Indie, 700054
        • Local Institution
      • Kottayam, Indie, 686016
        • Local Institution
      • Lucknow, Indie, 226003
        • Local Institution
      • Mumbai Naka, Indie, 422005
        • Local Institution
      • Nashik, Indie, 422002
        • Local Institution
      • New Delhi, Indie, 110025
        • Local Institution
      • New Delhi, Indie, 110060
        • Local Institution
      • New Delhi, Indie, 116025
        • Local Institution
      • Pune, Indie, 411001
        • Local Institution
      • Pune, Indie, 411004
        • Local Institution
      • Thrissur, Indie, 680002
        • Local Institution
      • Vijayawada, Indie, 520008
        • Local Institution
    • Andhra Pradesh
      • Visakhapatnam, Andhra Pradesh, Indie, 530003
        • Local Institution
    • Andhrapradesh
      • Visakhapatnam, Andhrapradesh, Indie, 530002
        • Local Institution
    • Andra Pradesh
      • Hyderabad, Andra Pradesh, Indie, 500004
        • Local Institution
    • Gujarat
      • Ahmedabad, Gujarat, Indie, 380060
        • Local Institution
      • Vadodara, Gujarat, Indie, 390007
        • Local Institution
    • Karnataka
      • Bangalore, Karnataka, Indie, 560054
        • Local Institution
      • Bangalore, Karnataka, Indie, 5600034
        • Local Institution
      • Bangalore, Karnataka, Indie, 560094
        • Local Institution
      • Mysore, Karnataka, Indie, 570004
        • Local Institution
    • Kerela
      • Calicut, Kerela, Indie, 673 004
        • Local Institution
    • Maharashta
      • Pune, Maharashta, Indie, 411011
        • Local Institution
    • Maharashtra
      • Nagpur, Maharashtra, Indie, 440010
        • Local Institution
      • Nagpur, Maharashtra, Indie, 440012
        • Local Institution
      • Pune, Maharashtra, Indie, 411001
        • Local Institution
      • Pune, Maharashtra, Indie, 421006
        • Local Institution
    • Punjab
      • Jalandhar, Punjab, Indie, 144008
        • Local Institution
    • Rajasthan
      • Bikaner, Rajasthan, Indie, 334001
        • Local Institution
      • Bikaner, Rajasthan, Indie, 334003
        • Local Institution
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, Indie, 226003
        • Local Institution
  • Itálie
      • Ascoli Piceno, Itálie, 63100
        • Local Institution
      • Campobasso, Itálie, 86100
        • Local Institution
      • Chieti, Itálie, 66013
        • Local Institution
      • Cremona, Itálie, 26100
        • Local Institution
      • Fidenza (Pr), Itálie, 43036
        • Local Institution
      • Genova, Itálie, 16132
        • Local Institution
      • Isernia, Itálie, 86170
        • Local Institution
      • Livorno, Itálie, 57100
        • Local Institution
      • Milano, Itálie, 20132
        • Local Institution
      • Napoli, Itálie, 80131
        • Local Institution
      • Palermo, Itálie, 90127
        • Local Institution
      • Reggio Emilia, Itálie, 42100
        • Local Institution
      • Roma, Itálie, 00168
        • Local Institution
      • San Daniele De Friuli, Itálie, 33038
        • Local Institution
      • Torino, Itálie, 10153
        • Local Institution
      • Vittorio Veneto (Tv), Itálie, 31029
        • Local Institution
    • Lucca
      • Lido Di Camaiore, Lucca, Itálie, 55043
        • Local Institution
  • Izrael
      • Afula, Izrael, 18101
        • Local Institution
      • Ashkelon, Izrael, 78306
        • Local Institution
      • Givatayim, Izrael, 53583
        • Local Institution
      • Hadera, Izrael, 38100
        • Local Institution
      • Haifa, Izrael, 31096
        • Local Institution
      • Haifa, Izrael, 34362
        • Local Institution
      • Holon, Izrael, 58100
        • Local Institution
      • Jerusalem, Izrael, 91120
        • Local Institution
      • Jerusalem, Izrael, 91240
        • Local Institution
      • Kfar-Saba, Izrael, 44281
        • Local Institution
      • Nazareth, Izrael, 16100
        • Local Institution
      • Nazareth, Izrael, 16000
        • Local Institution
      • Petach-Tikva, Izrael, 49100
        • Local Institution
      • Safed, Izrael, 13100
        • Local Institution
      • Tel Aviv, Izrael, 64239
        • Local Institution
  • Japonsko
      • Fukui, Japonsko, 9100067
        • Local Institution
      • Kagoshima, Japonsko, 8920822
        • Local Institution
      • Kyoto, Japonsko, 6168152
        • Local Institution
      • Nagasaki, Japonsko, 852-8102
        • Local Institution
      • Oita, Japonsko, 8700033
        • Local Institution
      • Osaka, Japonsko, 558-8558
        • Local Institution
      • Osaka, Japonsko, 551-0032
        • Local Institution
      • Osaka, Japonsko, 5510032
        • Local Institution
      • Saga, Japonsko, 8490917
        • Local Institution
    • Fukuoka
      • Itoshima City, Fukuoka, Japonsko, 819-1104
        • Local Institution
      • Kurume, Fukuoka, Japonsko, 8390863
        • Local Institution
      • Ohkawa-City, Fukuoka, Japonsko, 8310016
        • Local Institution
    • Fukushima
      • Shirakawa City, Fukushima, Japonsko, 961-0005
        • Local Institution
    • Gunma
      • Takasaki City, Gunma, Japonsko, 3700829
        • Local Institution
    • Hokkaido
      • Asahikawa-Shi, Hokkaido, Japonsko, 0788214
        • Local Institution
      • Katou-Gun, Hokkaido, Japonsko, 0800111
        • Local Institution
      • Katou-gun, Hokkaido, Japonsko, 080111
        • Local Institution
      • Sapporo-Shi, Hokkaido, Japonsko, 0028043
        • Local Institution
      • Tomakomai-Shi, Hokkaido, Japonsko, 002-8043
        • Local Institution
      • Tomakomai-shi, Hokkaido, Japonsko, 0028043
        • Local Institution
      • Yubari, Hokkaido, Japonsko, 0680402
        • Local Institution
    • Hyogo
      • Kobe, Hyogo, Japonsko, 6540026
        • Local Institution
    • Kagoshima Prefecture
      • Izumi City, Kagoshima Prefecture, Japonsko, 8990131
        • Local Institution
    • Kanagawa
      • Isehara, Kanagawa, Japonsko, 2591193
        • Local Institution
      • Yokohama, Kanagawa, Japonsko, 2458575
        • Local Institution
      • Yokohama City, Kanagawa, Japonsko, 2278501
        • Local Institution
      • Yokosuka, Kanagawa, Japonsko, 2388567
        • Local Institution
    • Miyagi
      • Sendai City, Miyagi, Japonsko, 983-8520
        • Local Institution
    • Nara
      • Nara City, Nara, Japonsko, 630-8305
        • Local Institution
    • Osaka
      • Izumi City, Osaka, Japonsko, 594-0071
        • Local Institution
      • Osaka City, Osaka, Japonsko, 5330022
        • Local Institution
      • Osaka-Shi, Osaka, Japonsko, 540-0006
        • Local Institution
      • Osaka-shi, Osaka, Japonsko, 5400006
        • Local Institution
      • Suita-City, Osaka, Japonsko, 5658565
        • Local Institution
      • Takatsuki City, Osaka, Japonsko, 5690852
        • Local Institution
      • Yao, Osaka, Japonsko, 5810036
        • Local Institution
    • Saga
      • Saga City, Saga, Japonsko, 840-8571
        • Local Institution
      • Saga City, Saga, Japonsko, 849-8501
        • Local Institution
    • Saitama
      • Kasukabe-Shi, Saitama, Japonsko, 344-0035
        • Local Institution
      • Kasukabe-shi, Saitama, Japonsko, 3440035
        • Local Institution
    • Tokyo
      • Itabashi-Ku, Tokyo, Japonsko, 173-0015
        • Local Institution
      • Itabashi-ku, Tokyo, Japonsko, 1730015
        • Local Institution
      • Meguro-Ku, Tokyo, Japonsko, 153-8515
        • Local Institution
      • Meguro-ku, Tokyo, Japonsko, 1538515
        • Local Institution
      • Shinagawa-Ku, Tokyo, Japonsko, 1428666
        • Local Institution
    • Toyama
      • Toyama City, Toyama, Japonsko, 9308550
        • Local Institution
    • Yamaguchi
      • Iwakuni, Yamaguchi, Japonsko, 7400021
        • Local Institution
  • Jižní Afrika
    • Bloemfontein
      • Westdene, Bloemfontein, Jižní Afrika, 9301
        • Local Institution
    • Cape Town
      • Observatory, Cape Town, Jižní Afrika, 7925
        • Local Institution
    • Gauteng
      • Pretoria, Gauteng, Jižní Afrika, 0084
        • Local Institution
      • Pretoria, Gauteng, Jižní Afrika, 0132
        • Local Institution
    • KWA ZULU Natal
      • Richards Bay, KWA ZULU Natal, Jižní Afrika, 3900
        • Local Institution
    • Western CAPE
      • Bellville Cape Town, Western CAPE, Jižní Afrika, 7530
        • Local Institution
      • George, Western CAPE, Jižní Afrika, 6529
        • Local Institution
      • Parow, Western CAPE, Jižní Afrika, 7505
        • Local Institution
      • Somerset West, Western CAPE, Jižní Afrika, 7130
        • Local Institution
      • Worcester, Western CAPE, Jižní Afrika, 6850
        • Local Institution
  • Kanada
      • Quebec, Kanada, G1J 1Z6
        • Local Institution
    • Alberta
      • Calgary, Alberta, Kanada, T2E 7C5
        • Local Institution
      • Edmonton, Alberta, Kanada, T6G 2B7
        • Local Institution
      • Edmonton, Alberta, Kanada, T5X 3N5
        • Local Institution
      • Edmonton, Alberta, Kanada, TSA 4L8
        • Local Institution
      • Edmonton, Alberta, Kanada, T56-3NJ
        • Local Institution
    • British Columbia
      • Burnaby, British Columbia, Kanada, V5G 1T4
        • Local Institution
      • Nanaimo, British Columbia, Kanada, V9R 3G9
        • Local Institution
      • New Westminster, British Columbia, Kanada, V3L 3W4
        • Local Institution
      • North Vancouver, British Columbia, Kanada, V7N 4M2
        • Local Institution
      • Victoria, British Columbia, Kanada, V8R 4R2
        • Local Institution
    • Manitoba
      • Winnipeg, Manitoba, Kanada, R2V 4W3
        • Local Institution
    • New Brunswick
      • Bathurst, New Brunswick, Kanada, E2A 4X7
        • Local Institution
    • Newfoundland and Labrador
      • Mount Pearl, Newfoundland and Labrador, Kanada, A1N 1W7
        • Local Institution
      • St Johns, Newfoundland and Labrador, Kanada, A1B 3V6
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Kanada, A1A 3R5
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Kanada, A1E 2C2
        • Local Institution
    • Ontario
      • Brampton, Ontario, Kanada, L6Z 4N5
        • Local Institution
      • Burlington, Ontario, Kanada, L7M 4Y1
        • Local Institution
      • Cambridge, Ontario, Kanada, N1R 7R1
        • Local Institution
      • Cambridge, Ontario, Kanada, N1R 6V6
        • Local Institution
      • Hamilton, Ontario, Kanada, L8L 2X2
        • Local Institution
      • London, Ontario, Kanada, N6G 2V2
        • Local Institution
      • Mississauga, Ontario, Kanada, L5B 4A2
        • Local Institution
      • Newmarket, Ontario, Kanada, L3Y 5G8
        • Local Institution
      • Newmarket, Ontario, Kanada, L3Y 8C3
        • Local Institution
      • Niagara Falls, Ontario, Kanada, L2E 7H1
        • Local Institution
      • Niagara Falls, Ontario, Kanada, L2E7H1
        • Local Institution
      • North Bay, Ontario, Kanada, P1B 2H3
        • Local Institution
      • Oshawa, Ontario, Kanada, L1J 2J9
        • Local Institution
      • Oshawa, Ontario, Kanada, L1J 2K1
        • Local Institution
      • Ottawa, Ontario, Kanada, K1Y 4E9
        • Local Institution
      • Ottawa, Ontario, Kanada, K1Y 4W7
        • Local Institution
      • Sarnia, Ontario, Kanada, N7T 4X3
        • Local Institution
      • Scarborough, Ontario, Kanada, M1B 5N1
        • Local Institution
      • Sudbury, Ontario, Kanada, P3E 3B8
        • Local Institution
      • Sudbury, Ontario, Kanada, P3C 5K7
        • Local Institution
      • Sudbury, Ontario, Kanada, P3E 2N8
        • Local Institution
      • Sudbury, Ontario, Kanada, P3C5K7
        • Local Institution
      • Toronto, Ontario, Kanada, M9W 4L6
        • Local Institution
      • Toronto, Ontario, Kanada, M5B 1W8
        • Local Institution
      • Weston, Ontario, Kanada, M9N 1W4
        • Local Institution
    • Prince Edward Island
      • Charlottetown, Prince Edward Island, Kanada, C1A 5Y9
        • Local Institution
    • Quebec
      • Drummondville, Quebec, Kanada, J2B 7T1
        • Local Institution
      • Greenfield Park, Quebec, Kanada, J4V 2G8
        • Local Institution
      • Lachine, Quebec, Kanada, H8S 2E4
        • Local Institution
      • Levis, Quebec, Kanada, G6V 4Z5
        • Local Institution
      • Longueuil, Quebec, Kanada, J4K 1C8
        • Local Institution
      • Longueuil, Quebec, Kanada, J4N 0C9
        • Local Institution
      • Longueuil, Quebec, Kanada, J4N 1C2
        • Local Institution
      • Montreal, Quebec, Kanada, H3T 1E2
        • Local Institution
      • Montreal, Quebec, Kanada, H3A 1A1
        • Local Institution
      • Montreal, Quebec, Kanada, H1T 1C8
        • Local Institution
      • Montreal, Quebec, Kanada, H2W 1T8
        • Local Institution
      • Montreal, Quebec, Kanada, W3R-153
        • Local Institution
      • Pointe- Claire, Quebec, Kanada, H9R 3J1
        • Local Institution
      • St-Lambert, Quebec, Kanada, J4P 2H4
        • Local Institution
      • Ste-Foy, Quebec, Kanada, G1W 4R4
        • Local Institution
    • Saskatchewan
      • Saskatoon, Saskatchewan, Kanada, S7L OY7
        • Local Institution
  • Kolumbie
      • Barranquilla, Kolumbie
        • Local Institution
      • Barranquilla, Kolumbie, XXXXX
        • Local Institution
      • Bogota, Kolumbie
        • Local Institution
      • Bogota, Kolumbie, 000
        • Local Institution
      • Cali, Kolumbie
        • Local Institution
      • Medellin, Kolumbie
        • Local Institution
    • Antioquia
      • Medellin, Antioquia, Kolumbie
        • Local Institution
  • Korejská republika
      • Busan, Korejská republika, 602-702
        • Local Institution
      • Daegu, Korejská republika, 700-712
        • Local Institution
      • Daegu, Korejská republika, 705-717
        • Local Institution
      • Daejon, Korejská republika, 302-718
        • Local Institution
      • Goyang, Korejská republika, 411-706
        • Local Institution
      • Gwang Ju, Korejská republika, 501-757
        • Local Institution
      • Gyeonggi, Korejská republika, 463-707
        • Local Institution
      • Pusan, Korejská republika, 602-739
        • Local Institution
      • Scongnam-Si, Korejská republika, 463-712
        • Local Institution
      • Seoul, Korejská republika, 110-744
        • Local Institution
      • Seoul, Korejská republika, 143-729
        • Local Institution
      • Seoul, Korejská republika, 130-709
        • Local Institution
      • Suwon, Korejská republika, 443-721
        • Local Institution
    • Gyeonggi-Do
      • Anyang-Si, Gyeonggi-Do, Korejská republika, 431-070
        • Local Institution
    • Korea
      • Incheon, Korea, Korejská republika, 400-711
        • Local Institution
  • Krocan
      • Ankara, Krocan, 06100
        • Local Institution
      • Eskisehir, Krocan, 26480
        • Local Institution
      • Izmir, Krocan, 35100
        • Local Institution
  • Malajsie
      • Kuala Lumpur, Malajsie, 56000
        • Local Institution
      • Kuala Lumpur, Malajsie, 59100
        • Local Institution
    • Kelantan
      • Kubang Kerian, Kelantan, Malajsie, 16150
        • Local Institution
    • Sarawak
      • Kota Samarahan, Sarawak, Malajsie, 94300
        • Local Institution
    • Selangor
      • Batu Caves, Selangor, Malajsie, 68100
        • Local Institution
  • Maďarsko
      • Budapest, Maďarsko, 1125
        • Local Institution
      • Budapest, Maďarsko, 1023
        • Local Institution
      • Budapest, Maďarsko, 1032
        • Local Institution
      • Budapest, Maďarsko, 1096
        • Local Institution
      • Budapest, Maďarsko, 1085
        • Local Institution
      • Debrecen, Maďarsko, 4032
        • Local Institution
      • Dunaujvaros, Maďarsko, 2400
        • Local Institution
      • Gyor, Maďarsko, 9023
        • Local Institution
      • Gyula, Maďarsko, 5700
        • Local Institution
      • Hodmezovasarhely, Maďarsko, 6800
        • Local Institution
      • Komarom, Maďarsko, 2921
        • Local Institution
      • Mosonmagyarovar, Maďarsko, 9200
        • Local Institution
      • Oroshaza, Maďarsko, 5900
        • Local Institution
      • Pecs, Maďarsko, 7624
        • Local Institution
      • Siofok, Maďarsko, 8600
        • Local Institution
      • Siofok, Maďarsko, 8601
        • Local Institution
      • Sopron, Maďarsko, 9400
        • Local Institution
      • Szentes, Maďarsko, 6600
        • Local Institution
      • Zalaegerszeg, Maďarsko, 8900
        • Local Institution
  • Mexiko
      • Puebla, Mexiko, 11490
        • Local Institution
      • Queretaro, Mexiko, 76000
        • Local Institution
    • BAJA California
      • Tijuana, BAJA California, Mexiko, 22500
        • Local Institution
    • Distrito Federal
      • Col. Toriello Guerra, Distrito Federal, Mexiko, CP 14050
        • Local Institution
      • Mexico City, Distrito Federal, Mexiko, 06726
        • Local Institution
      • Mexico City, Distrito Federal, Mexiko, 14080
        • Local Institution
      • Mexico City, Distrito Federal, Mexiko, 07760
        • Local Institution
      • Mexico City, Distrito Federal, Mexiko, 06070
        • Local Institution
      • Mexico City, Distrito Federal, Mexiko, 10700
        • Local Institution
    • Jalisco
      • Guadalajara, Jalisco, Mexiko, 44200
        • Local Institution
      • Guadalajara, Jalisco, Mexiko, 44600
        • Local Institution
      • Guadalajara, Jalisco, Mexiko, 44656
        • Local Institution
    • Michoacan
      • Morelia, Michoacan, Mexiko, 58000
        • Local Institution
    • Nuevo LEON
      • Monterrey, Nuevo LEON, Mexiko, 64710
        • Local Institution
      • Monterrey, Nuevo LEON, Mexiko, 64000
        • Local Institution
      • Monterrey, Nuevo LEON, Mexiko, 64700
        • Local Institution
    • Sinaloa
      • Culiacan, Sinaloa, Mexiko, 80020
        • Local Institution
    • Veracruz
      • Jalapa, Veracruz, Mexiko, 91020
        • Local Institution
  • Norsko
      • Alesund, Norsko, 6003
        • Local Institution
      • Bergen, Norsko, 5021
        • Local Institution
      • Bergen, Norsko, N-5021
        • Local Institution
      • Elverum, Norsko, 2408
        • Local Institution
      • Flekkefjord, Norsko, 4400
        • Local Institution
      • Nesttun, Norsko, 5221
        • Local Institution
      • Oslo, Norsko, 0407
        • Local Institution
      • Skien, Norsko, 3710
        • Local Institution
      • Stavanger, Norsko, 4064
        • Local Institution
      • Straume, Norsko, 5353
        • Local Institution
      • Tonsberg, Norsko, 3116
        • Local Institution
      • Tromso, Norsko, 9038
        • Local Institution
  • Německo
      • Aachen, Německo, 52074
        • Local Institution
      • Bad Krozingen, Německo, 79189
        • Local Institution
      • Bad Neustadt/ Salle, Německo, 97616
        • Local Institution
      • Bad Oeynhausen, Německo, 32545
        • Local Institution
      • Berlin, Německo, 13353
        • Local Institution
      • Berlin, Německo, 14050
        • Local Institution
      • Berlin, Německo, 10787
        • Local Institution
      • Berlin, Německo, 10789
        • Local Institution
      • Berlin, Německo, 12043
        • Local Institution
      • Berlin-Kopenick, Německo, 12559
        • Local Institution
      • Betzdorf, Německo, 57518
        • Local Institution
      • Bochum, Německo, 44791
        • Local Institution
      • Bochum, Německo, 44789
        • Local Institution
      • Bonn, Německo, 53127
        • Local Institution
      • Coburg, Německo, 96450
        • Local Institution
      • Dillingen, Německo, 66763
        • Local Institution
      • Dresden, Německo, 01099
        • Local Institution
      • Duisburg, Německo, 47139
        • Local Institution
      • Essen, Německo, 45122
        • Local Institution
      • Frankfurt Am Main, Německo, 60594
        • Local Institution
      • Gottingen, Německo, 37075
        • Local Institution
      • Halle/Saale, Německo, 06120
        • Local Institution
      • Hannover, Německo, 30625
        • Local Institution
      • Heidelberg, Německo, 69120
        • Local Institution
      • Heidelberg, Německo, 69115
        • Local Institution
      • Kassel, Německo, 34121
        • Local Institution
      • Lahr, Německo, 77933
        • Local Institution
      • Ludwigshafen, Německo, 67063
        • Local Institution
      • Ludwigshafen, Německo, 67073
        • Local Institution
      • Mannheim, Německo, 68167
        • Local Institution
      • Marburg, Německo, 35043
        • Local Institution
      • Munchen, Německo, 81675
        • Local Institution
      • Munchen, Německo, 80636
        • Local Institution
      • Munchen, Německo, 81545
        • Local Institution
      • Osnabruck, Německo, 49076
        • Local Institution
      • Regensburg, Německo, 93053
        • Local Institution
      • Riesa, Německo, D-01587
        • Local Institution
      • Rostiock, Německo, 18057
        • Local Institution
      • Trier, Německo, 54292
        • Local Institution
      • Waren, Německo, 17192
        • Local Institution
      • Witten, Německo, 58455
        • Local Institution
      • Wolmirstedt, Německo, 39326
        • Local Institution
      • Worms, Německo, 67550
        • Local Institution
  • Peru
      • Lima, Peru, LIMA 33
        • Local Institution
      • Lima, Peru, LIMA 01
        • Local Institution
      • Lima, Peru, LIMA 1
        • Local Institution
    • Callao
      • Bellavista, Callao, Peru, 2176
        • Local Institution
      • Bellavista, Callao, Peru, CALLAO 2
        • Local Institution
    • Lambayeque
      • Chiclayo, Lambayeque, Peru, CIX
        • Local Institution
    • Lima
      • Jesus Maria, Lima, Peru, 11
        • Local Institution
      • Jesus Maria, Lima, Peru, LIMA 11
        • Local Institution
      • Miraflores, Lima, Peru, LIMA 18
        • Local Institution
      • San Borja, Lima, Peru, LIMA 41
        • Local Institution
      • San Martin De Porres, Lima, Peru, LIMA 31
        • Local Institution
  • Polsko
      • Gdynia, Polsko, 81-423
        • Local Institution
      • Gdynia, Polsko, 81-472
        • Local Institution
      • Gdynia, Polsko, 81-519
        • Local Institution
      • Grodzisk Mazowiecki, Polsko, 05-825
        • Local Institution
      • Inowroclaw, Polsko, 88-100
        • Local Institution
      • Kielce, Polsko, 25-736
        • Local Institution
      • Kielce, Polsko, 25-763
        • Local Institution
      • Krakow, Polsko, 31-202
        • Local Institution
      • Krakow, Polsko, 30-092
        • Local Institution
      • Krakow, Polsko, 31-135
        • Local Institution
      • Lodz, Polsko, 91-347
        • Local Institution
      • Lodz, Polsko, 91347
        • Local Institution
      • Piotrkow Trybunalski, Polsko, 97-300
        • Local Institution
      • Plock, Polsko, 09-402
        • Local Institution
      • Plock, Polsko, 09-400
        • Local Institution
      • Plonsk, Polsko, 09-100
        • Local Institution
      • Poznan, Polsko, 60-531
        • Local Institution
      • Poznan, Polsko, 60479
        • Local Institution
      • Ruda Slaska, Polsko, 41-703
        • Local Institution
      • Skierniewice, Polsko, 96-100
        • Local Institution
      • Slupsk, Polsko, 76-200
        • Local Institution
      • Torun, Polsko, 87100
        • Local Institution
      • Warszawa, Polsko, 01-138
        • Local Institution
      • Warszawa, Polsko, 04-073
        • Local Institution
      • Warszawa, Polsko, 04-628
        • Local Institution
      • Warszawa, Polsko, 04-749
        • Local Institution
      • Wegrow, Polsko, 07100
        • Local Institution
  • Portoriko
      • Cayey, Portoriko, 00736
        • Local Institution
      • Cidra, Portoriko, 00739
        • Local Institution
      • Ponce, Portoriko, 00717
        • Local Institution
  • Rakousko
      • Graz, Rakousko, 8036
        • Local Institution
      • Oberpullendorf, Rakousko, 7350
        • Local Institution
      • Vienna, Rakousko, 1160
        • Local Institution
  • Rumunsko
      • Baia Mare, Rumunsko, 430031
        • Local Institution
      • Bucharest, Rumunsko, 011192
        • Local Institution
      • Bucharest, Rumunsko, 020125
        • Local Institution
      • Bucharest, Rumunsko, 050098
        • Local Institution
      • Bucharest, Rumunsko, 021659
        • Local Institution
      • Bucharest, Rumunsko, 030572
        • Local Institution
      • Cluj Napoca, Rumunsko, 400001
        • Local Institution
      • Cluj Napoca, Rumunsko, 400347
        • Local Institution
      • Iasi, Rumunsko, 700503
        • Local Institution
      • Oradea, Rumunsko, 410169
        • Local Institution
      • Sibiu, Rumunsko, 550245
        • Local Institution
      • Targu-Mures, Rumunsko, 540103
        • Local Institution
      • Timisoara, Rumunsko, 300024
        • Local Institution
      • Timisoara, Rumunsko, 300320
        • Local Institution
      • Tirgu Mures, Rumunsko, 540136
        • Local Institution
  • Ruská Federace
      • Chelyabinsk, Ruská Federace, 454136
        • Local Institution
      • Chita, Ruská Federace, 672090
        • Local Institution
      • Dzerzhinskiy, Ruská Federace, 140091
        • Local Institution
      • Kazan, Ruská Federace, 420012
        • Local Institution
      • Kemerovo, Ruská Federace, 650002
        • Local Institution
      • Kirovsk, Ruská Federace, 187342
        • Local Institution
      • Krasnodar, Ruská Federace, 350042
        • Local Institution
      • Moscow, Ruská Federace, 119992
        • Local Institution
      • Moscow, Ruská Federace, 125367
        • Local Institution
      • Moscow, Ruská Federace, 109240
        • Local Institution
      • Moscow, Ruská Federace, 105229
        • Local Institution
      • Moscow, Ruská Federace, 111539
        • Local Institution
      • Moscow, Ruská Federace, 115487
        • Local Institution
      • Moscow, Ruská Federace, 115093
        • Local Institution
      • Moscow, Ruská Federace, 121552
        • Local Institution
      • Moscow, Ruská Federace, 117593
        • Local Institution
      • Moscow, Ruská Federace, 127018
        • Local Institution
      • Moscow, Ruská Federace, 125284
        • Local Institution
      • Moscow, Ruská Federace, 111020
        • Local Institution
      • Moscow, Ruská Federace, 119121
        • Local Institution
      • Moscow, Ruská Federace, 121356
        • Local Institution
      • Moscow, Ruská Federace, 117556
        • Local Institution
      • Moscow, Ruská Federace, 119048
        • Local Institution
      • Moscow, Ruská Federace, 123182
        • Local Institution
      • Moscow, Ruská Federace, 125206
        • Local Institution
      • Moscow, Ruská Federace, 125424
        • Local Institution
      • Moscow, Ruská Federace, 129090
        • Local Institution
      • Nizhni Novgorod, Ruská Federace, 603003
        • Local Institution
      • Nizhni Novgorod, Ruská Federace, 603005
        • Local Institution
      • Novosibirsk, Ruská Federace, 630008
        • Local Institution
      • Novosibirsk, Ruská Federace, 630054
        • Local Institution
      • Odintsovo, Ruská Federace, 143000
        • Local Institution
      • Penza, Ruská Federace, 440026
        • Local Institution
      • Perm, Ruská Federace, 614097
        • Local Institution
      • Rostov-On-Don, Ruská Federace, 344022
        • Local Institution
      • Ryazan, Ruská Federace, 390026
        • Local Institution
      • Saint Petersburg, Ruská Federace, 193312
        • Local Institution
      • Saint Petersburg, Ruská Federace, 193144
        • Local Institution
      • Saint-Petersburg, Ruská Federace, 190103
        • Local Institution
      • Saint-Petersburg, Ruská Federace, 191025
        • Local Institution
      • Saint-Petersburg, Ruská Federace, 193163
        • Local Institution
      • Saint-Petersburg, Ruská Federace, 196601
        • Local Institution
      • Saint-Petersburg, Ruská Federace, 198013
        • Local Institution
      • Samara, Ruská Federace, 443070
        • Local Institution
      • Saratov, Ruská Federace, 410002
        • Local Institution
      • St Petersburg, Ruská Federace, 198013
        • Local Institution
      • St Petersburg, Ruská Federace, 192288
        • Local Institution
      • St-Petersburg, Ruská Federace, 194354
        • Local Institution
      • St-Petersburg, Ruská Federace, 195271
        • Local Institution
      • St. Petersburg, Ruská Federace, 197341
        • Local Institution
      • St. Petersburg, Ruská Federace, 197110
        • Local Institution
      • St.-Petersburg, Ruská Federace, 197341
        • Local Institution
      • St.Petersburg, Ruská Federace, 199106
        • Local Institution
      • Tomsk, Ruská Federace, 634012
        • Local Institution
      • Tumen, Ruská Federace, 625023
        • Local Institution
      • Tver, Ruská Federace, 170036
        • Local Institution
      • Voronezh, Ruská Federace, 394066
        • Local Institution
      • Voronezh, Ruská Federace, 394065
        • Local Institution
      • Yaroslavl, Ruská Federace, 150030
        • Local Institution
      • Yaroslavl, Ruská Federace, 150003
        • Local Institution
      • Yaroslavl, Ruská Federace, 150002
        • Local Institution
      • Zheleznodorozhniy, Ruská Federace, 143920
        • Local Institution
      • Zhukovsky, Ruská Federace, 140160
        • Local Institution
      • Zhukovsky, Ruská Federace, 140180
        • Local Institution
  • Singapur
      • Singapore, Singapur, 168752
        • Local Institution
  • Spojené království
      • Antrim, Spojené království, BT41 2RL
        • Local Institution
      • Blackpool, Spojené království, FY3 8NR
        • Local Institution
      • Glasgow, Spojené království, G21 3UW
        • Local Institution
    • Aberdeenshire
      • Aberdeen, Aberdeenshire, Spojené království, AB25 2ZN
        • Local Institution
      • Glasgow, Aberdeenshire, Spojené království, G11 6NT
        • Local Institution
    • Antrim
      • Belfast, Antrim, Spojené království, BT14 6AB
        • Local Institution
    • Armagh
      • Craigavon, Armagh, Spojené království, BT63 5QQ
        • Local Institution
    • Cambridgeshire
      • Cambridge, Cambridgeshire, Spojené království, CB2 2QQ
        • Local Institution
      • Peterborough, Cambridgeshire, Spojené království, PE2 5GP
        • Local Institution
    • Derbyshire
      • Chesterfield, Derbyshire, Spojené království, S44 5BL
        • Local Institution
      • Chesterfield, Derbyshire, Spojené království, S40 4TF
        • Local Institution
    • Dorset
      • Bournemouth, Dorset, Spojené království, BH7 7DW
        • Local Institution
    • Dumbartonshire
      • Glasgow, Dumbartonshire, Spojené království, G11 6NT
        • Local Institution
    • EAST Sussex
      • Chichester, EAST Sussex, Spojené království, PO19 6SE
        • Local Institution
    • Essex
      • Colchester, Essex, Spojené království, C03 4LN
        • Local Institution
      • Romford, Essex, Spojené království, RH7 0AG
        • Local Institution
    • Greater London
      • Denmark Hill, Greater London, Spojené království, SE5 9RS
        • Local Institution
      • London, Greater London, Spojené království, SW17 0RE
        • Local Institution
    • Gwent
      • Newport, Gwent, Spojené království, NP20 2UB
        • Local Institution
    • Hertfordshire
      • Barnet, Hertfordshire, Spojené království, EN5 3DJ
        • Local Institution
    • MID Glamorgan
      • Cardiff, MID Glamorgan, Spojené království, CF14 4XW
        • Local Institution
      • Llandough, MID Glamorgan, Spojené království, CF64 2XX
        • Local Institution
    • Middlesex
      • Harrow, Middlesex, Spojené království, HA1 3UJ
        • Local Institution
    • Nottinghamshire
      • Nottingham, Nottinghamshire, Spojené království, NG5 1PB
        • Local Institution
      • Worksop, Nottinghamshire, Spojené království, S81 OBD
        • Local Institution
    • Renfrewshire
      • Paisley, Renfrewshire, Spojené království, PA2 9PN
        • Local Institution
    • South Yorkshire
      • Barnsley, South Yorkshire, Spojené království, S75 2EP
        • Local Institution
      • Doncaster, South Yorkshire, Spojené království, DN2 5LT
        • Local Institution
    • Stirlingshire
      • Stirling, Stirlingshire, Spojené království, FK8 2AU
        • Local Institution
    • Strathclyde
      • Glasgow, Strathclyde, Spojené království, G51 4TF
        • Local Institution
    • Suffolk
      • Bury St Edmunds, Suffolk, Spojené království, IP31 2HD
        • Local Institution
      • Bury St Edmunds, Suffolk, Spojené království, IP33 2QZ
        • Local Institution
      • Bury St. Edmunds, Suffolk, Spojené království, IP30 9QU
        • Local Institution
      • Ipswich, Suffolk, Spojené království, IP14 2PU
        • Local Institution
      • Ipswich, Suffolk, Spojené království, IP7 5DN
        • Local Institution
    • Tyne and Wear
      • Newcastle Upon Tyne, Tyne and Wear, Spojené království, NE1 4LP
        • Local Institution
    • WEST Glamorgan
      • Swansea, WEST Glamorgan, Spojené království, SA6 6NL
        • Local Institution
    • WEST Lothian
      • Livingston, WEST Lothian, Spojené království, EH54 6PP
        • Local Institution
    • WEST Midlands
      • Birmingham, WEST Midlands, Spojené království, B18 7QH
        • Local Institution
    • Wiltshire
      • Westbury, Wiltshire, Spojené království, BA 13 3JD
        • Local Institution
      • Westbury, Wiltshire, Spojené království, BA13 3JD
        • Local Institution
    • Yorkshire
      • York, Yorkshire, Spojené království, YO31 8HE
        • Local Institution
      • York, Yorkshire, Spojené království, YO31 HE
        • Local Institution
  • Spojené státy
    • Alabama
      • Birmingham, Alabama, Spojené státy, 35209
        • Cardiovascular Associates, Pc
      • Birmingham, Alabama, Spojené státy, 35235
        • Alabama Internal Medicine Pc
      • Birmingham, Alabama, Spojené státy, 35235
        • Birmingham Heart Clinic P.C.
      • Huntsville, Alabama, Spojené státy, 35801
        • Heart Center, Inc.
      • Mobile, Alabama, Spojené státy, 36608
        • Mobile Heart Specialists, PC
      • Mobile, Alabama, Spojené státy, 36617
        • Clara V. Massey, Md
    • Alaska
      • Anchorage, Alaska, Spojené státy, 99508
        • Alaska Heart Institute
    • Arizona
      • Phoenix, Arizona, Spojené státy, 85006
        • Internal Medicine Physicians Associates, P.C.
      • Tucson, Arizona, Spojené státy, 85723
        • Southern Arizona VA Health Care System
      • Tucson, Arizona, Spojené státy, 85710
        • Southwest Heart
      • Tucson, Arizona, Spojené státy, 85745
        • Pima Research Foundation
    • Arkansas
      • Hot Springs, Arkansas, Spojené státy, 71913
        • Dr. Rajesh Shroff
      • Little Rock, Arkansas, Spojené státy, 72204
        • Mary K. Richards, Md Pa
    • California
      • Anaheim, California, Spojené státy, 92801
        • Advanced Clinical Reserach Institute
      • Beverly Hills, California, Spojené státy, 90210
        • Act/Cardiovascular Research Institute
      • Carmichael, California, Spojené státy, 95608
        • Capitol Interventional Cardiology
      • Escondido, California, Spojené státy, 92025
        • Escondido Cardiology Associates, Inc.
      • Healdsburg, California, Spojené státy, 95448
        • William D. Bowden, D.O.
      • La Mesa, California, Spojené státy, 91942
        • La Mesa Cardiac Center, A Medical Group
      • Los Angeles, California, Spojené státy, 90073
        • VA Greater Los Angeles Healthcare System
      • Mission Viejo, California, Spojené státy, 92691
        • Coastal Cardiology
      • Oceanside, California, Spojené státy, 92056
        • Kenneth W. Carr Md
      • Palm Springs, California, Spojené státy, 92262
        • Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
      • Rancho Mirage, California, Spojené státy, 92270
        • Desert Cardiology Consultants Medical Group, Inc
      • Sacramento, California, Spojené státy, 95821
        • Northern California Research
      • Sacramento, California, Spojené státy, 95825
        • Sacramento Heart And Vascular Medical Associates
      • Sacramento, California, Spojené státy, 95819
        • Regional Cardiolody Associates
      • Santa Barbara, California, Spojené státy, 93105
        • Arrhythmia Consultants Of The Central Coast Medical Group
      • Santa Rosa, California, Spojené státy, 95403
        • Northern California Medical Associates
      • Vista, California, Spojené státy, 92083
        • Progressive Clinical Research
      • Walnut Creek, California, Spojené státy, 94598
        • Cardivasclular Consultants Medical Group
      • Wildomar, California, Spojené státy, 92595
        • Shiva Heart Center Medical Group
    • Colorado
      • Colorado Springs, Colorado, Spojené státy, 80910
        • Electrophysiology Associates, Pc
      • Denver, Colorado, Spojené státy, 80220
        • Denver VA Medical Center
      • Denver, Colorado, Spojené státy, 80218
        • Aurora Denver Cardiology Associates, P.C.
      • Golden, Colorado, Spojené státy, 80401
        • New West Physicians Clinical Research
      • Littleton, Colorado, Spojené státy, 80120
        • South Denver Cardiology Associates PC
    • Connecticut
      • Bridgeport, Connecticut, Spojené státy, 06610
        • Bridgeport Hospital
      • Bridgeport, Connecticut, Spojené státy, 06606
        • Connecticut Clinical Research, Llc
      • Guilford, Connecticut, Spojené státy, 06437
        • Cardiology Associates Of New Haven,Pc
      • Norwich, Connecticut, Spojené státy, 06360
        • William W Backus Hospital
      • Norwich, Connecticut, Spojené státy, 06360
        • The William W. Backus Hospital
      • Stamford, Connecticut, Spojené státy, 06905
        • Stamford Therapeutics Consortium
      • Waterbury, Connecticut, Spojené státy, 06708
        • Chase Medical Research, LLC
    • Delaware
      • Newark, Delaware, Spojené státy, 19713
        • Alfieri Cardiology
    • District of Columbia
      • Washington, District of Columbia, Spojené státy, 20422
        • Washington VA Medical Center
      • Washington, District of Columbia, Spojené státy, 20037
        • George Washington University Medical Faculty Associates
    • Florida
      • Atlantis, Florida, Spojené státy, 33462
        • Medical Specialist Of The Palm Beach
      • Aventura, Florida, Spojené státy, 33180
        • Miami International Cardiology Consultants
      • Boca Raton, Florida, Spojené státy, 33431
        • David Charles Mishkel, Md, Pa
      • Clearwater, Florida, Spojené státy, 33756
        • The Heart & Vascular Institute Of Florida
      • Clearwater, Florida, Spojené státy, 33756
        • The Heart And Vascular Institute Of Florida
      • Davie, Florida, Spojené státy, 33324
        • Cardiovascular Specialist Of South Florida
      • Daytona Beach, Florida, Spojené státy, 32114
        • Daytona Heart Group
      • Fort Lauderdale, Florida, Spojené státy, 33316
        • Broward General Medical Center
      • Fort Lauderdale, Florida, Spojené státy, 33308
        • Cardiology Associates Of Fort Lauderdale, P.A.
      • Fort Myers, Florida, Spojené státy, 33907
        • Florida Heart Associates
      • Gainesville, Florida, Spojené státy, 32605
        • Florida Research Network, LLC
      • Hollywood, Florida, Spojené státy, 33021
        • Healthworx
      • Hollywood, Florida, Spojené státy, 33021
        • Luis Tami, Md
      • Inverness, Florida, Spojené státy, 34452
        • Nature Coast Clinical Research
      • Jacksonville, Florida, Spojené státy, 32216
        • Jacksonville Center for Clinical Research
      • Jacksonville, Florida, Spojené státy, 32216
        • Jacksonville Cardiovascular Center
      • Jacksonville, Florida, Spojené státy, 32258
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Spojené státy, 32204
        • St. Vincent'S Ambulatory Care, Inc
      • Jacksonville, Florida, Spojené státy, 32207
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Spojené státy, 32216
        • St. Luke'S Cardiology
      • Jacksonville Beach, Florida, Spojené státy, 32250
        • Jacksonville Heart Center, P.A.
      • Jupiter, Florida, Spojené státy, 33458
        • Cvms Research Institute, Llc
      • Jupiter, Florida, Spojené státy, 33458
        • Ricardo Bedoya, M.D.
      • Melbourne, Florida, Spojené státy, 32901
        • Melbourne Internal Medicine Associates
      • Miami, Florida, Spojené státy, 33137
        • Miami International Cardiology Consultants
      • Miami, Florida, Spojené státy, 33137-3732
        • Miami International Cardiology Consultants
      • Naples, Florida, Spojené státy, 34119
        • Physicians Regional Medical Group
      • Orlando, Florida, Spojené státy, 32803
        • Florida Heart Group
      • Oviedo, Florida, Spojené státy, 32765
        • Alpha Medical Research
      • Pensacola, Florida, Spojené státy, 32501
        • Cardiology Consultants
      • Saint Petersburg, Florida, Spojené státy, 33709
        • The Heart And Vascular Institute Of Florida
      • Sarasota, Florida, Spojené státy, 34239
        • Heart & Vascular Center Research, Inc.
      • Sarasota, Florida, Spojené státy, 34232
        • Niranjan Seshadri, Md
      • Vero Beach, Florida, Spojené státy, 32960
        • Research, Inc.
    • Georgia
      • Atlanta, Georgia, Spojené státy, 30342
        • Cardiovascular Specialits, Pc
      • Augusta, Georgia, Spojené státy, 30901
        • Augusta Cardiology Clinic, P.C.
      • Columbus, Georgia, Spojené státy, 31909
        • Columbus Cardiology Associates Pc
      • Columbus, Georgia, Spojené státy, 31909
        • Columbus Cardiology Associates,Pc
      • Covington, Georgia, Spojené státy, 30014
        • Georgia Heart Specialists, L.L.C.
      • Decatur, Georgia, Spojené státy, 30030
        • Atlanta Institute For Medical Research, Inc
      • Gainesville, Georgia, Spojené státy, 30501
        • Northeast Georgia Heart Center, PC
      • Marietta, Georgia, Spojené státy, 30060
        • Wellstar Cardiovascular Medicine, Pc
    • Illinois
      • Aurora, Illinois, Spojené státy, 60504
        • Fox Valley Clinical Research Center, LLC
      • Chicago, Illinois, Spojené státy, 60611
        • Nmff
      • Gurnee, Illinois, Spojené státy, 60031
        • Clinical Investigation Specialists, Inc
      • Maywood, Illinois, Spojené státy, 60153
        • Loyola University Medical Center
      • Normal, Illinois, Spojené státy, 61761
        • Illinois Heart & Lung Research Center, Sc
      • North Chicago, Illinois, Spojené státy, 60064
        • Cpt. James A Lovell Federal Health Care Center
    • Indiana
      • Anderson, Indiana, Spojené státy, 46011
        • Community Clinical Research Center
      • Bloomington, Indiana, Spojené státy, 47403
        • Premier Healthcare, Llc
      • Elkhart, Indiana, Spojené státy, 46514
        • Elkhart Clinic, LLC
      • Fort Wayne, Indiana, Spojené státy, 46804
        • Lutheran Medical Group, Llc
      • Fort Wayne, Indiana, Spojené státy, 46805
        • Fort Wayne Cardiology
      • Indianapolis, Indiana, Spojené státy, 46290
        • The Care Group, Llc
      • Indianapolis, Indiana, Spojené státy, 46290
        • The Care Group, Llc.
      • Indianapolis, Indiana, Spojené státy, 46237
        • St Francis Medical Group - Indiana Heart Physicians
      • Michigan City, Indiana, Spojené státy, 46360
        • Dali, Sammi
      • South Bend, Indiana, Spojené státy, 46601
        • Cardiology Associates, Inc.
    • Iowa
      • Ames, Iowa, Spojené státy, 50010
        • McFarland Clinic PC
    • Kansas
      • Overland Park, Kansas, Spojené státy, 66209
        • Midwest Cardiology Associates , P.C.
    • Kentucky
      • Elizabethtown, Kentucky, Spojené státy, 42701
        • Central Cardiology Assoc.
      • Lexington, Kentucky, Spojené státy, 40504
        • New Lexington Clinic, P.S.C.
      • Louisville, Kentucky, Spojené státy, 40205
        • Norton Cardiovascular Associates
      • Louisville, Kentucky, Spojené státy, 40202
        • VA Medical Center
      • Owensboro, Kentucky, Spojené státy, 42303
        • Owensboro Heart & Vascular
    • Louisiana
      • Alexandria, Louisiana, Spojené státy, 71301
        • Alexandria Cardiology Clinic
      • Houma, Louisiana, Spojené státy, 70360
        • Cardiovascular Institute of the South
      • Lacombe, Louisiana, Spojené státy, 70445
        • Smith, Patel & Amkieh, Llc
      • Lake Charles, Louisiana, Spojené státy, 70601
        • Imperial Calcasieu Medical Group, Llp
      • Marrero, Louisiana, Spojené státy, 70072
        • Cardiology Center, Llc
      • Shreveport, Louisiana, Spojené státy, 71105
        • Cardiology Associates
      • Slidell, Louisiana, Spojené státy, 70458
        • Louisiana Heart Center
      • Slidell, Louisiana, Spojené státy, 70458
        • Medical Research Inst, Inc
      • Slidell, Louisiana, Spojené státy, 70458
        • Medical Research Institute, Inc
      • Ventura, Louisiana, Spojené státy, 93003
        • Ventura Cardio. Cond. Med. Group, Inc.
    • Maine
      • Lewiston, Maine, Spojené státy, 04240
        • Central Maine Heart & Vascular Institute
    • Maryland
      • Baltimore, Maryland, Spojené státy, 21224
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Spojené státy, 21237
        • Franklin Square Hospital
      • Baltimore, Maryland, Spojené státy, 21208
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Spojené státy, 21237
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Spojené státy, 21204
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Spojené státy, 21218
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Spojené státy, 21224-2735
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Spojené státy, 21237
        • Midatlantic Cardiovascular Associates, P.A.
      • Bel Air, Maryland, Spojené státy, 21014
        • Midatlantic Cardiovascular Associates, Pa
      • Columbia, Maryland, Spojené státy, 21044
        • Cardiovascular Specialists Of Central Maryland, P.A.
      • Reisterstown, Maryland, Spojené státy, 21136
        • Clinical Associates Research
      • Westminster, Maryland, Spojené státy, 21157
        • Midatlantic Cardiovascular Associates, Pa
    • Massachusetts
      • Billerica, Massachusetts, Spojené státy, 01821
        • Burlington Medical Associates
      • Boston, Massachusetts, Spojené státy, 02135
        • Caritas St. Elizabeth's Medical Center
      • Burlington, Massachusetts, Spojené státy, 01805
        • Lahey Clinic Medical Center
      • Fall River, Massachusetts, Spojené státy, 02720
        • Neccr Internal Medicine & Cardiology Associates,Llc
      • Haverhill, Massachusetts, Spojené státy, 01830
        • Pentucket Medical Associates
      • Haverhill, Massachusetts, Spojené státy, 01830-6278
        • Pentucket Medical Associates
      • Natick, Massachusetts, Spojené státy, 01760
        • Charles River Medical Associates
    • Michigan
      • Alpena, Michigan, Spojené státy, 49707
        • Great Lakes Heart Center Of Alpena
      • Detroit, Michigan, Spojené státy, 48202
        • Henry Ford Hospital
      • Lansing, Michigan, Spojené státy, 48910
        • Thoracic And Cardiovascular Healthcare Foundation
      • Livonia, Michigan, Spojené státy, 48154
        • Advanced Cardiovascular Health Specialists, Pc
      • Petoskey, Michigan, Spojené státy, 49770
        • Michigan Heart And Vascular Specialists
      • Royal Oak, Michigan, Spojené státy, 48073
        • William Beaumont Hospital
      • Ypsilanti, Michigan, Spojené státy, 48197
        • Michigan Heart, P.C.
    • Minnesota
      • Minneapolis, Minnesota, Spojené státy, 55455
        • University of Minnesota
      • Minneapolis, Minnesota, Spojené státy, 55417
        • Minneapolis VA Medical Center
      • Robbinsdale, Minnesota, Spojené státy, 55422
        • North Memorial Health Care
    • Mississippi
      • Olive Branch, Mississippi, Spojené státy, 38654
        • Olive Branch Family Medical Center
      • Tupelo, Mississippi, Spojené státy, 38801
        • Tupelo Neurology Clinic, Pa
    • Missouri
      • Columbia, Missouri, Spojené státy, 65212
        • University of Missouri
      • Kansas City, Missouri, Spojené státy, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Spojené státy, 64111
        • Saint Luke's Lipid and Diabetes Research Center
    • Nebraska
      • Grand Island, Nebraska, Spojené státy, 68803
        • Internal Medical Associates Of Grand Island, P.C
      • Grand Island, Nebraska, Spojené státy, 68803-4311
        • Internal Medical Associates Of Grand Island, P.C
      • Hastings, Nebraska, Spojené státy, 68901
        • Nebraska Heart Institute
    • Nevada
      • Las Vegas, Nevada, Spojené státy, 89106
        • VA Southern Nevada Healthcare System
    • New Jersey
      • Berlin, New Jersey, Spojené státy, 08009
        • Comprehensive Clinical Research
      • Elmer, New Jersey, Spojené státy, 08318
        • Cardiovascular Associates Of The Delware Valley, P.A.
      • Haddon Heights, New Jersey, Spojené státy, 08035
        • Cardiovascular Associates Of The Delaware Valley, P.A.
      • Princeton, New Jersey, Spojené státy, 08540
        • Princeton Medical Institute
      • Sewell, New Jersey, Spojené státy, 08080
        • Cardio Assoc Of Del Val, P.A.
      • South Plainfield, New Jersey, Spojené státy, 07080
        • Central New Jersey Cardiology
    • New Mexico
      • Albuquerque, New Mexico, Spojené státy, 87012
        • Abq Health Partners, Llc
      • Albuquerque, New Mexico, Spojené státy, 87131-0001
        • University Of New Mexico/University Hospital
      • Albuquerque, New Mexico, Spojené státy, 87131
        • University Of New Mexico/University Hospital
    • New York
      • Albany, New York, Spojené státy, 12205
        • Albany Associates In Cardiology
      • Albany, New York, Spojené státy, 12205
        • Albany Assoc. In Cardiology
      • Binghamton, New York, Spojené státy, 13905
        • Cardiology Associates, Pc
      • Buffalo, New York, Spojené státy, 14215
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Spojené státy, 14215-1145
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Spojené státy, 14215
        • Bruce L. Platt Md, Pc
      • Buffalo, New York, Spojené státy, 14215
        • Bruce L. Platt, Md
      • East Syracuse, New York, Spojené státy, 13057
        • Heart Care Center, P.C.
      • Huntington, New York, Spojené státy, 11743
        • Huntington Hospital
      • Liverpool, New York, Spojené státy, 13088
        • SJH Cardiology Associates
      • Mineola, New York, Spojené státy, 11501
        • Long Island Heart Associates
      • Saratoga Springs, New York, Spojené státy, 12866
        • Saratoga Cardiology Associates, Pc
      • Williamsville, New York, Spojené státy, 14221
        • Office Of Dr. Kozinn
      • Williamsville, New York, Spojené státy, 14221
        • Suburban Cardiology
    • North Carolina
      • Asheville, North Carolina, Spojené státy, 28803
        • Asheville Cardiology Associates
      • Burlington, North Carolina, Spojené státy, 27215
        • Kernodle Clinic, Inc.
      • High Point, North Carolina, Spojené státy, 27262
        • Carolina Cardiology Associates, Pa
      • Pinehurst, North Carolina, Spojené státy, 28374
        • Pinehurst Medical Center, Inc
    • North Dakota
      • Fargo, North Dakota, Spojené státy, 58103
        • Lillestol Research LLC
    • Ohio
      • Akron, Ohio, Spojené státy, 44304
        • Akron Cardiology Consultants
      • Bucyrus, Ohio, Spojené státy, 44820
        • Christopher M. Johnson, D.O.
      • Bucyrus, Ohio, Spojené státy, OHIO
        • Christopher M. Johnson, D.O.
      • Canal Fulton, Ohio, Spojené státy, 44614
        • Community Health Care, Inc.
      • Canton, Ohio, Spojené státy, 44710
        • Cardiology Associates
      • Cincinnati, Ohio, Spojené státy, 45219
        • The Carl & Edyth Lindner Center For R&E At The Christ Hosp
      • Toledo, Ohio, Spojené státy, 43608
        • Toledo Cardiology Consultants
      • Wadsworth, Ohio, Spojené státy, 44281
        • Family Practice Center of Wadsworth, Inc.
    • Oklahoma
      • Muskogee, Oklahoma, Spojené státy, 74401
        • Jack C. Va Medical Center
      • Oklahoma City, Oklahoma, Spojené státy, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Spojené státy, 73112
        • Plaza Medical Group, Pc
      • Oklahoma City, Oklahoma, Spojené státy, 73103
        • COR Clinical Research, LLC
      • Oklahoma City, Oklahoma, Spojené státy, 73135
        • South Oklahoma Heart Research
      • Oklahoma City, Oklahoma, Spojené státy, 73120
        • Oklahoma Heart Hospital Physicians
      • Oklahoma City, Oklahoma, Spojené státy, 73139
        • Eminence Research, LLC
      • Tulsa, Oklahoma, Spojené státy, 74136
        • Castlerock Clinical Research Consultants, Llc
    • Oregon
      • Bend, Oregon, Spojené státy, 97701
        • St. Charles Health System, Inc.
      • Bend, Oregon, Spojené státy, 97701
        • St. Charles Health System, Inc
      • Eugene, Oregon, Spojené státy, 97401
        • Oregon Medical Group - Clinical Research
      • Hillsboro, Oregon, Spojené státy, 97123
        • Hillsboro Cardiology Pc
      • Medford, Oregon, Spojené státy, 97504
        • Rogue Valley Physicians - Clinical Research Group
    • Pennsylvania
      • Abington, Pennsylvania, Spojené státy, 19001
        • Abington Medical Specialists
      • Altoona, Pennsylvania, Spojené státy, 16602
        • Blair Medical Associates, Inc.
      • Camp Hill, Pennsylvania, Spojené státy, 17011
        • Heritage Cardiology Assoc.
      • Doylestown, Pennsylvania, Spojené státy, 18901
        • Central Bucks Cardiology
      • Erie, Pennsylvania, Spojené státy, 16509
        • Internal Medicine And Lipid Mgmt.
      • Harrisburg, Pennsylvania, Spojené státy, 17112
        • Kandra, Fierer, Kuskin Associates
      • Hatfield, Pennsylvania, Spojené státy, 19440
        • Pivotal Clinical Research, Llc
      • Jersey Shore, Pennsylvania, Spojené státy, 17740
        • Lycoming Internal Medicine Inc.
      • Sayre, Pennsylvania, Spojené státy, 18840
        • Guthrie Medical Group, P.C.
      • Sayre, Pennsylvania, Spojené státy, 18840
        • Guthrie Clinic Ltd.
      • Uniontown, Pennsylvania, Spojené státy, 15401
        • Preferred Primary Care Physicians
      • West Chester, Pennsylvania, Spojené státy, 19380
        • West Chester Cardiology, Pc
      • Yardley, Pennsylvania, Spojené státy, 19067
        • Cardiology Consultants of Philadelphia
    • Rhode Island
      • Providence, Rhode Island, Spojené státy, 02903
        • Rhode Island Hospital
    • South Carolina
      • Anderson, South Carolina, Spojené státy, 29621
        • Southeastern Research Associates, Inc
      • Beaufort, South Carolina, Spojené státy, 29906
        • Lowcountry Medical Group, Llc
      • Beaufort, South Carolina, Spojené státy, 29906
        • Lowcountry Medical Group
      • Charleston, South Carolina, Spojené státy, 29425
        • Medical University of South Carolina
      • Columbia, South Carolina, Spojené státy, 29203
        • Columbia Heart Clinic
      • Greenville, South Carolina, Spojené státy, 29607
        • Upstate Cardiology
      • Greer, South Carolina, Spojené státy, 29650
        • Internal Medicine Of Greer
      • Orangeburg, South Carolina, Spojené státy, 29118
        • Palmetto Nephrology Pa
      • Spartanburg, South Carolina, Spojené státy, 29303
        • S. Carolina Pharmaceutical Research
    • South Dakota
      • Pierre, South Dakota, Spojené státy, 57501
        • Avera Medical Associates Clinic
    • Tennessee
      • Bristol, Tennessee, Spojené státy, 37620
        • Holston Medical Group
      • Kingsport, Tennessee, Spojené státy, 37660
        • Holston Medical Group
      • Knoxville, Tennessee, Spojené státy, 37920
        • Volunteer Research Group
      • Knoxville, Tennessee, Spojené státy, 37916
        • Knoxville Heart Group
      • Knoxville, Tennessee, Spojené státy, 37920-1502
        • Volunteer Research Group
      • Tullahoma, Tennessee, Spojené státy, 37388
        • Tennessee Center For Clinical Trials
    • Texas
      • Amarillo, Texas, Spojené státy, 79106
        • Amarillo Heart Clinical Research Institute Inc.
      • Corsicana, Texas, Spojené státy, 75110
        • Corsicana Medical Research, PLLC
      • Dallas, Texas, Spojené státy, 75226
        • Soltero Cardiovascular Research Center
      • Dallas, Texas, Spojené státy, 75230
        • HeartPlace
      • Fort Worth, Texas, Spojené státy, 76104
        • Heart Center of North Texas
      • Houston, Texas, Spojené státy, 77030
        • The Methodist Hospital
      • Houston, Texas, Spojené státy, 77030
        • The University of Texas MD Anderson Cancer Center
      • Houston, Texas, Spojené státy, 77030
        • Center For Atrial Fibrillation
      • Houston, Texas, Spojené státy, 77030
        • The Methodist Hospital Neurology Institute
      • Houston, Texas, Spojené státy, 77065
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Spojené státy, 77070
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Spojené státy, 77074
        • Francisco R. Maislos
      • Houston, Texas, Spojené státy, 77090
        • Woodlands North Houston Heart Center
      • Humble, Texas, Spojené státy, 77338
        • Regional Medical Center And Diagnostic Clinics
      • Lackland Air Force Base, Texas, Spojené státy, 78236
        • Wilford Hall Medical Center
      • Lackland Air Force Base, Texas, Spojené státy, 78236-9908
        • Wilford Hall Medical Center
      • Longview, Texas, Spojené státy, 75605
        • DCOL Center for Clinical Research
      • McKinney, Texas, Spojené státy, 75069
        • North Dallas Research Associates
      • Plano, Texas, Spojené státy, 75093
        • North Texas Medical Research
      • Plano, Texas, Spojené státy, 75024
        • Legacy Heart Center
      • San Antonio, Texas, Spojené státy, 78229
        • Covenant Clinical Research, Pa
      • San Antonio, Texas, Spojené státy, 78217
        • Bhs Specialty Network, Inc
      • San Antonio, Texas, Spojené státy, 78229
        • Star Clinical Trails
      • Seguin, Texas, Spojené státy, 78155
        • Edward Balli, Md, Pa
      • Tomball, Texas, Spojené státy, 77375
        • Northwest Heart Center
      • Tyler, Texas, Spojené státy, 75701
        • Tyler Cardiovascular Consultants
      • Tyler, Texas, Spojené státy, 75708
        • University of Texas Health Science Center at Tyler
      • Tyler, Texas, Spojené státy, 75708
        • The Univ. Of Texas Health Science Ctr. At Tyler
    • Utah
      • Layton, Utah, Spojené státy, 84041
        • Utah Cardiology P.C
    • Virginia
      • Norfolk, Virginia, Spojené státy, 23510
        • Sentara York Clinical Research
      • Richmond, Virginia, Spojené státy, 23220
        • Medical Research Initiatives
      • Roanoke, Virginia, Spojené státy, 24014
        • Roanoke Heart Institute, Plc
      • Virginia Beach, Virginia, Spojené státy, 23454
        • Cardiovascular Associates
    • Washington
      • Burien, Washington, Spojené státy, 98166
        • Daniel W. Gottlieb, Md, Ps
      • Burien, Washington, Spojené státy, 98166
        • Daniel William Gottlieb, Md
      • Spokane, Washington, Spojené státy, 99202
        • Rockwood Clinic Research Cent.
      • Walla Walla, Washington, Spojené státy, 99362
        • Walla Walla Clinic
    • West Virginia
      • Lewisburg, West Virginia, Spojené státy, 24901
        • Lynn N. Smith, Md
    • Wisconsin
      • Green Bay, Wisconsin, Spojené státy, 54301
        • Cardiology Associates Of Green Bay Ltd-Bellin Hospital
      • Madison, Wisconsin, Spojené státy, 53715
        • St. Mary's Hospital
      • Madison, Wisconsin, Spojené státy, 53715
        • St.Mary's Hospital
      • Milwaukee, Wisconsin, Spojené státy, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Spojené státy, 53215
        • Aurora Health Care
      • Waukesha, Wisconsin, Spojené státy, 53188
        • Cardiology Assc. Of Waukesha
  • Tchaj-wan
      • Taipei, Tchaj-wan, 100
        • Local Institution
      • Taipei, Tchaj-wan, 112
        • Local Institution
      • Taipei, Tchaj-wan, 111
        • Local Institution
      • Taipei, Tchaj-wan, 220
        • Local Institution
      • Taipei, Tchaj-wan, 10449
        • Local Institution
      • Taipei, Tchaj-wan, 104
        • Local Institution
  • Ukrajina
      • Chernivtsy, Ukrajina, 58013
        • Local Institution
      • Dnipropetrovsk, Ukrajina, 49006
        • Local Institution
      • Dnipropetrovsk, Ukrajina, 49060
        • Local Institution
      • Donetsk, Ukrajina, 83045
        • Local Institution
      • Donetsk, Ukrajina, 83003
        • Local Institution
      • Donetsk, Ukrajina, 83114
        • Local Institution
      • Ivano-Frankivsk, Ukrajina, 76025
        • Local Institution
      • Kharkiv, Ukrajina, 61018
        • Local Institution
      • Kharkiv, Ukrajina, 61115
        • Local Institution
      • Kharkov, Ukrajina, 61039
        • Local Institution
      • Kharkov, Ukrajina, 61002
        • Local Institution
      • Kharkov, Ukrajina, 61178
        • Local Institution
      • Kiev, Ukrajina, 01032
        • Local Institution
      • Kyiv, Ukrajina, 03680
        • Local Institution
      • Kyiv, Ukrajina, 02091
        • Local Institution
      • Kyiv, Ukrajina, 03049
        • Local Institution
      • Kyiv, Ukrajina, 03115
        • Local Institution
      • Kyiv, Ukrajina, 04050
        • Local Institution
      • Kyiv, Ukrajina, 04107
        • Local Institution
      • Kyiv, Ukrajina, 01023
        • Local Institution
      • Kyiv, Ukrajina, 02660
        • Local Institution
      • Kyiv, Ukrajina, 01103
        • Local Institution
      • Lugansk, Ukrajina, 91011
        • Local Institution
      • Lugansk, Ukrajina, 91016
        • Local Institution
      • Lutsk, Ukrajina, 43024
        • Local Institution
      • Lviv, Ukrajina, 79013
        • Local Institution
      • Lviv, Ukrajina, 79015
        • Local Institution
      • Mykolayiv, Ukrajina, 54003
        • Local Institution
      • Odessa, Ukrajina, 65009
        • Local Institution
      • Odessa, Ukrajina, 65039
        • Local Institution
      • Odessa, Ukrajina, 65114
        • Local Institution
      • Odessa, Ukrajina, 65025
        • Local Institution
      • Uzhgorod, Ukrajina, 88000
        • Local Institution
      • Vinnitsa, Ukrajina, 21029
        • Local Institution
      • Zaporozhye, Ukrajina, 69035
        • Local Institution
      • Zhytomyr, Ukrajina, 10002
        • Local Institution
  • Česko
      • Boskovice, Česko, 680 21
        • Local Institution
      • Brno, Česko, 625 00
        • Local Institution
      • Brno-Malomerice, Česko, 614 00
        • Local Institution
      • Ivancice, Česko, 664 91
        • Local Institution
      • Kladno, Česko, 272 59
        • Local Institution
      • Litomysl, Česko, 570 14
        • Local Institution
      • Mestec Kralove, Česko, 289 03
        • Local Institution
      • Ostrava, Česko, 70852
        • Local Institution
      • Prague 13, Česko, 158 00
        • Local Institution
      • Prague 2, Česko, 128 08
        • Local Institution
      • Pribram, Česko, 261 01
        • Local Institution
      • Usti Nad Orlici, Česko, 562 18
        • Local Institution
  • Čína
    • Beijing
      • Beijing, Beijing, Čína, 100050
        • Local Institution
      • Beijing, Beijing, Čína, 100001
        • Local Institution
      • Beijing, Beijing, Čína, 100853
        • Local Institution
      • Beijing, Beijing, Čína, 100020
        • Local Institution
      • Beijing, Beijing, Čína, 100088
        • Local Institution
      • Beijing, Beijing, Čína, 100101
        • Local Institution
    • Gansu
      • Lanzhou, Gansu, Čína, 730000
        • Local Institution
      • Lanzhou, Gansu, Čína, 730030
        • Local Institution
    • Guangdong
      • Guangzhou, Guangdong, Čína, 510080
        • Local Institution
      • Guangzhou, Guangdong, Čína, 510120
        • Local Institution
    • Hebei
      • Shijiazhuang, Hebei, Čína, 050000
        • Local Institution
    • Heilongjiang
      • Daqing, Heilongjiang, Čína, 163001
        • Local Institution
      • Haerbin, Heilongjiang, Čína, 150086
        • Local Institution
      • Haerbin, Heilongjiang, Čína, 150001
        • Local Institution
    • Hubei
      • Wuhan, Hubei, Čína, 430060
        • Local Institution
    • Hunan
      • Changsha, Hunan, Čína, 410000
        • Local Institution
    • Jiangsu
      • Hangzhou, Jiangsu, Čína, 310009
        • Local Institution
      • Nanjing, Jiangsu, Čína, 210029
        • Local Institution
    • Liaoning
      • Dalian, Liaoning, Čína, 116011
        • Local Institution
      • Dalian, Liaoning, Čína, 116021
        • Local Institution
      • Dalian, Liaoning, Čína, 116027
        • Local Institution
      • Shenyang, Liaoning, Čína, 110016
        • Local Institution
      • Shenyang, Liaoning, Čína, 110003
        • Local Institution
    • Shandong
      • Jinan, Shandong, Čína, 250012
        • Local Institution
      • Jinan, Shandong, Čína, 250033
        • Local Institution
      • Qingdao, Shandong, Čína, 266011
        • Local Institution
    • Shanghai
      • Shanghai, Shanghai, Čína, 200080
        • Local Institution
      • Shanghai, Shanghai, Čína, 200025
        • Local Institution
      • Shanghai, Shanghai, Čína, 200433
        • Local Institution
      • Shanghai, Shanghai, Čína, 200011
        • Local Institution
      • Shanghai, Shanghai, Čína, 200233
        • Local Institution
      • Shanghai, Shanghai, Čína, 200003
        • Local Institution
      • Shanghai, Shanghai, Čína, 100037
        • Local Institution
      • Shanghai, Shanghai, Čína, 200031
        • Local Institution
    • Sichuan
      • Chengdu, Sichuan, Čína, 610041
        • Local Institution
      • Chongqing, Sichuan, Čína, 400010
        • Local Institution
    • Zhejiang
      • Hangzhou, Zhejiang, Čína, 310009
        • Local Institution
  • Španělsko
      • Albacete, Španělsko, 02006
        • Local Institution
      • Barcelona, Španělsko, 08035
        • Local Institution
      • Barcelona, Španělsko, 08003
        • Local Institution
      • Elda, Španělsko, 03600
        • Local Institution
      • Figueres, Španělsko, 17600
        • Local Institution
      • Gerona, Španělsko, 17007
        • Local Institution
      • Las Palmas, Španělsko, 35010
        • Local Institution
      • Madrid, Španělsko, 28006
        • Local Institution
      • Madrid, Španělsko, 28046
        • Local Institution
      • Madrid, Španělsko, 28040
        • Local Institution
      • Palma De Mallorca, Španělsko, 07010
        • Local Institution
      • San Sebastian De Los Reyes, Španělsko, 28703
        • Local Institution
      • Tarragona, Španělsko, 43007
        • Local Institution
      • Viladecans, Španělsko, 08840
        • Local Institution
    • Alicante
      • San Juan, Alicante, Španělsko, 03550
        • Local Institution
      • Torrevieja, Alicante, Španělsko, 03186
        • Local Institution
    • Almeria
      • La Canada, Almeria, Španělsko, 04120
        • Local Institution
    • Galicia
      • Lugo, Galicia, Španělsko, 27003
        • Local Institution
  • Švédsko
      • Goteberg, Švédsko, 413 45
        • Local Institution
      • Helsingborg, Švédsko, 251 87
        • Local Institution
      • Linkoping, Švédsko, 581 85
        • Local Institution
      • Lund, Švédsko, 222 21
        • Local Institution
      • Orebro, Švédsko, 70185
        • Local Institution
      • Orebro, Švédsko, 701 85
        • Local Institution
      • Skelleftea, Švédsko, 931 86
        • Local Institution
      • Stockholm, Švédsko, 141 86
        • Local Institution
      • Stockholm, Švédsko, 171 76
        • Local Institution
      • Stockholm, Švédsko, 111 57
        • Local Institution
      • Stockholm, Švédsko, 118 83
        • Local Institution
      • Stockholm, Švédsko, 111 35
        • Local Institution
      • Uppsala, Švédsko, 751 85
        • Local Institution
      • Vaxjo, Švédsko, 351 85
        • Local Institution
  • Švýcarsko
      • Baden, Švýcarsko, 5404
        • Local Institution
      • Bern, Švýcarsko, 3010
        • Local Institution

Kritéria účasti

Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.

Kritéria způsobilosti

Věk způsobilý ke studiu

  • Dítě
  • Dospělý
  • Starší dospělý

Přijímá zdravé dobrovolníky

Ne

Pohlaví způsobilá ke studiu

Všechno

Popis

Inclusion Criteria:

  • Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
  • Age ≥ 75, previous stroke
  • transient ischemic attack (TIA) or Systemic Embolism (SE)
  • Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
  • Diabetes mellitus or hypertension requiring pharmacological treatment

Studijní plán

Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.

Jak je studie koncipována?

Detaily designu

  • Primární účel: Prevence
  • Přidělení: Randomizované
  • Intervenční model: Paralelní přiřazení
  • Maskování: Dvojnásobek

Zbraně a zásahy

Skupina účastníků / Arm
Intervence / Léčba
Experimentální: 2
Lék: apixaban
Oral tablets, 5.0 mg or 2.5 mg, twice daily
Ostatní jména:
  • BMS-562247
Aktivní komparátor: 1
Lék: warfarin
Oral tablets, 2.0 mg, adjusted to an INR of 2.5 (range 2.0 to 3.0)
Ostatní jména:
  • Coumadin
  • BMS-565793

Co je měření studie?

Primární výstupní opatření

Měření výsledku
Popis opatření
Časové okno
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period
Časové okno: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period
Časové okno: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

Sekundární výstupní opatření

Měření výsledku
Popis opatření
Časové okno
Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period
Časové okno: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated All-Cause Death During the Intended Treatment Period
Časové okno: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period
Časové okno: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period
Časové okno: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period
Časové okno: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period
Časové okno: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With All Bleeding Events During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of All Bleeding Events During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Další výstupní opatření

Měření výsledku
Popis opatření
Časové okno
Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
AE: all SAEs or AEs with onset from first dose through 2 days (AEs) or 30 days (SAEs) after the last dose of blinded study drug (BSD). SAE: all SAEs with onset from first dose through 30 days after the last dose of BSD. Bleeding AE: all serious or non-serious bleeding-related AEs with onset from first dose through 2 days after the last dose of BSD. Discontinuations due to AE: all SAEs or AEs with onset from first dose of BSD and with action taken=drug discontinued. Deaths: all deaths occurring from first dose through 30 days after the last dose of BSD.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated GUSTO bleeding events per 100 patient years. GUSTO Bleeding Criteria: GUSTO severe (or life-threatening) bleeding: either intracranial hemorrhage or bleeding that causes hemodynamic compromise and requires intervention. GUSTO moderate bleeding: bleeding that requires blood transfusion but does not result in hemodynamic compromise.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated TIMI bleeding events per 100 patient years. TIMI Bleeding Criteria: Major bleeding=Intracranial bleeding and/or clinically overt bleeding associated with ≥5 gm/dL fall in Hgb or 15% fall in hematocrit (Hct) from baseline, accounting for transfusions. Minor bleeding=Clinically overt bleeding associated with ≥3 gm/dL fall in Hgb or a ≥10% fall in Hct from baseline, accounting for transfusions.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Net-Clinical Benefit During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Net-Clinical Benefit During Treatment Period
Časové okno: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of events of net-clinical benefit per 100 patient years. Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Spolupracovníci a vyšetřovatelé

Zde najdete lidi a organizace zapojené do této studie.

Sponzor

Bristol-Myers Squibb

Publikace a užitečné odkazy

Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.

Obecné publikace

Užitečné odkazy

Termíny studijních záznamů

Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.

Hlavní termíny studia

Začátek studia (Aktuální)

31. prosince 2006

Primární dokončení (Aktuální)

25. května 2011

Dokončení studie (Aktuální)

25. května 2011

Termíny zápisu do studia

První předloženo

18. prosince 2006

První předloženo, které splnilo kritéria kontroly kvality

18. prosince 2006

První zveřejněno (Odhad)

19. prosince 2006

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

3. července 2018

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

5. června 2018

Naposledy ověřeno

1. května 2018

Více informací

Termíny související s touto studií

Další relevantní podmínky MeSH

Další identifikační čísla studie

  • CV185-030

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