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Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (ARISTOTLE)

5. juni 2018 opdateret af: Bristol-Myers Squibb

A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

20976

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Argentina
      • Buenos Aires, Argentina, 1119
        • Local Institution
      • Buenos Aires, Argentina, C1280AEB
        • Local Institution
      • Buenos Aires, Argentina, 1181
        • Local Institution
      • Buenos Aires, Argentina, C1426ANZ
        • Local Institution
      • Buenos Aires, Argentina, 1280
        • Local Institution
      • Cordoba, Argentina, 5000
        • Local Institution
      • Cordoba, Argentina, X5000EPU
        • Local Institution
      • Cordoba, Argentina, X5008KKF
        • Local Institution
      • Cordoba, Argentina, X5003DCE
        • Local Institution
      • Salta, Argentina, 4400
        • Local Institution
      • Santa Fe, Argentina, 3000
        • Local Institution
      • Tucuman, Argentina, T4000NIL
        • Local Institution
    • Buenos Aires
      • Adrogue, Buenos Aires, Argentina, 1846
        • Local Institution
      • Bahia Blanca, Buenos Aires, Argentina, B8000FTD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, CP1425A WC
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1128AAD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1128
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, C1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, CP1425AWC
        • Local Institution
      • Ciudad Autonoma De, Buenos Aires, Argentina, 1180
        • Local Institution
      • Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina, CI094AAD
        • Local Institution
      • Coronel Suarez, Buenos Aires, Argentina, B7540GHD
        • Local Institution
      • Haedo, Buenos Aires, Argentina, B1706AJU
        • Local Institution
      • Junin, Buenos Aires, Argentina, 6000
        • Local Institution
      • La Plata, Buenos Aires, Argentina, 1900
        • Local Institution
      • La Plata, Buenos Aires, Argentina, B1900AXI
        • Local Institution
      • La Plata, Buenos Aires, Argentina, 1902
        • Local Institution
      • Mar Del Plata, Buenos Aires, Argentina, 7600
        • Local Institution
      • Merlo, Buenos Aires, Argentina, B1722COV
        • Local Institution
      • Merlo, Buenos Aires, Argentina, 1722
        • Local Institution
      • Olivos, Buenos Aires, Argentina, 1602
        • Local Institution
      • Quilmes, Buenos Aires, Argentina, 1878
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, B1704ESN
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, B1704ETD
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, 1706
        • Local Institution
      • San Justo, Buenos Aires, Argentina, 1754
        • Local Institution
      • San Martin, Buenos Aires, Argentina, 1650
        • Local Institution
      • San Nicolas, Buenos Aires, Argentina, 2900
        • Local Institution
      • Zarate, Buenos Aires, Argentina, 2800
        • Local Institution
      • Zarate, Buenos Aires, Argentina, B2800DGH
        • Local Institution
    • Provincia DE Cordoba
      • Cordoba, Provincia DE Cordoba, Argentina, 5000
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    • RIO Negro
      • Cipolletti, RIO Negro, Argentina, 8324
        • Local Institution
    • Santa FE
      • Rosario, Santa FE, Argentina, 2000
        • Local Institution
      • Rosario, Santa FE, Argentina, S2000CVB
        • Local Institution
      • Rosario, Santa FE, Argentina, S2001ODA
        • Local Institution
    • Santa Fe
      • Rosario, Santa Fe, Argentina, S2000CVD
        • Local Institution
      • Rosario, Santa Fe, Argentina, S2000 CVD
        • Local Institution
    • Tucuman
      • San Miquel De Tucuman, Tucuman, Argentina, 4000
        • Local Institution
  • Australien
    • New South Wales
      • Coffs Harbour, New South Wales, Australien, 2450
        • Local Institution
      • Concord, New South Wales, Australien, 2139
        • Local Institution
      • Gosford, New South Wales, Australien, 2250
        • Local Institution
      • Kogarah, New South Wales, Australien, 2217
        • Local Institution
      • Miranda, New South Wales, Australien, 2228
        • Local Institution
    • Queensland
      • Auchenflower, Queensland, Australien, 4066
        • Local Institution
      • Brisbane, Queensland, Australien, 4032
        • Local Institution
      • Caboolture, Queensland, Australien, 4510
        • Local Institution
      • Herston, Queensland, Australien, 4029
        • Local Institution
      • Kippa Ring, Queensland, Australien, 4021
        • Local Institution
      • Nambour, Queensland, Australien, 4560
        • Local Institution
      • Sherwood, Queensland, Australien, 4075
        • Local Institution
    • South Australia
      • Adelaide, South Australia, Australien, SA 5000
        • Local Institution
      • Ashford, South Australia, Australien, 5035
        • Local Institution
      • Bedford Park, South Australia, Australien, 5042
        • Local Institution
      • Woodville, South Australia, Australien, 5011
        • Local Institution
    • Victoria
      • Box Hill, Victoria, Australien, 3128
        • Local Institution
      • Dandenong, Victoria, Australien, 3175
        • Local Institution
      • Geelong, Victoria, Australien, 3220
        • Local Institution
    • Western Australia
      • Fremantle, Western Australia, Australien, 6160
        • Local Institution
      • Joondalup, Western Australia, Australien, 6027
        • Local Institution
  • Belgien
      • Aalst, Belgien, 9300
        • Local Institution
      • Antwerpen, Belgien, 2020
        • Local Institution
      • Antwerpen, Belgien, 2060
        • Local Institution
      • Arlon, Belgien, 6700
        • Local Institution
      • Brugge, Belgien, 8000
        • Local Institution
      • Brussels, Belgien, 1090
        • Local Institution
      • Dillingen, Belgien, 66763
        • Local Institution
      • Genk, Belgien, 3600
        • Local Institution
      • Gent, Belgien, 9000
        • Local Institution
      • Gilly, Belgien, 6060
        • Local Institution
      • Hasselt, Belgien, 3500
        • Local Institution
      • Huy, Belgien, 4500
        • Local Institution
      • Kortrijk, Belgien, 8500
        • Local Institution
      • Menen, Belgien, 8930
        • Local Institution
      • Mol, Belgien, 2400
        • Local Institution
      • Montegnee, Belgien, 4420
        • Local Institution
      • Verviers, Belgien, 4800
        • Local Institution
      • Woluwe- Saint Lambert, Belgien, 1200
        • Local Institution
      • Yvoir, Belgien, 5530
        • Local Institution
  • Brasilien
      • Rio De Janeiro, Brasilien, 20551
        • Local Institution
      • Rio De Janeiro, Brasilien, 20551-030
        • Local Institution
      • Rio De Janeiro, Brasilien, 22251-030
        • Local Institution
      • Rio De Janeiro, Brasilien, 22251
        • Local Institution
      • Sao Paulo, Brasilien, 01323-010
        • Local Institution
      • Sao Paulo, Brasilien, 01323
        • Local Institution
      • Sao Paulo, Brasilien, 04012
        • Local Institution
      • Sao Paulo, Brasilien, 04024-002
        • Local Institution
      • Sao Paulo, Brasilien, 04038
        • Local Institution
      • Sao Paulo, Brasilien, 01221-900
        • Local Institution
      • Sao Paulo, Brasilien, 01221
        • Local Institution
      • Sao Paulo, Brasilien, 01322-001
        • Local Institution
      • Sao Paulo, Brasilien, 01322
        • Local Institution
      • Sao Paulo, Brasilien, 01323-001
        • Local Institution
      • Sao Paulo, Brasilien, 04012-180
        • Local Institution
      • Sao Paulo, Brasilien, 04024
        • Local Institution
      • Sao Paulo, Brasilien, 04038-031
        • Local Institution
      • Sao Paulo, Brasilien, 08270-070
        • Local Institution
      • Sao Paulo, Brasilien, 08270
        • Local Institution
    • Bahia
      • Salvador, Bahia, Brasilien, 40144
        • Local Institution
      • Salvador, Bahia, Brasilien, 41810
        • Local Institution
      • Salvador, Bahia, Brasilien, 40144-900
        • Local Institution
      • Salvador, Bahia, Brasilien, 41810-010
        • Local Institution
    • Minas Gerais
      • Belo Horzonte, Minas Gerais, Brasilien, 30150-221
        • Local Institution
      • Belo Horzonte, Minas Gerais, Brasilien, 30150
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brasilien, 36021-630
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brasilien, 36021
        • Local Institution
      • Uberaba, Minas Gerais, Brasilien, 38056 055
        • Local Institution
      • Uberlandia, Minas Gerais, Brasilien, 38400-299
        • Local Institution
      • Uberlandia, Minas Gerais, Brasilien, 38400
        • Local Institution
    • Para
      • Belem, Para, Brasilien, 66087-660
        • Local Institution
      • Belem, Para, Brasilien, 66087
        • Local Institution
    • Parana
      • Campina Grande Do Sul, Parana, Brasilien, 83430-000
        • Local Institution
      • Campina Grande Do Sul, Parana, Brasilien, 83430
        • Local Institution
      • Curitiba, Parana, Brasilien, 80010
        • Local Institution
      • Curitiba, Parana, Brasilien, 80730
        • Local Institution
      • Curitiba, Parana, Brasilien, 80010-030
        • Local Institution
      • Curitiba, Parana, Brasilien, 80730-150
        • Local Institution
      • Londrina, Parana, Brasilien, 86010-450
        • Local Institution
      • Londrina, Parana, Brasilien, 86010
        • Local Institution
    • RIO Grande DO Norte
      • Natal, RIO Grande DO Norte, Brasilien, 59020-100
        • Local Institution
    • RIO Grande DO SUL
      • Porte Alegre, RIO Grande DO SUL, Brasilien, 90610-000
        • Local Institution
      • Porte Alegre, RIO Grande DO SUL, Brasilien, 90880-480
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasilien, 90035-903
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasilien, 90020-090
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasilien, 90620-001
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasilien, 91350-280
        • Local Institution
    • Rio Grande Do Norte
      • Natal, Rio Grande Do Norte, Brasilien, 59020
        • Local Institution
    • Rio Grande Do Sul
      • Porte Alegre, Rio Grande Do Sul, Brasilien, 90610
        • Local Institution
      • Porte Alegre, Rio Grande Do Sul, Brasilien, 90880480
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasilien, 90035
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasilien, 90020
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasilien, 90620
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasilien, 91350
        • Local Institution
    • SAO Paulo
      • Botucatu, SAO Paulo, Brasilien, 18618-000
        • Local Institution
      • Campinas, SAO Paulo, Brasilien, 13059-740
        • Local Institution
      • Marilia, SAO Paulo, Brasilien, 17515-000
        • Local Institution
      • Marilia, SAO Paulo, Brasilien, 17515-460
        • Local Institution
      • Marilia, SAO Paulo, Brasilien, 17519-000
        • Local Institution
      • San Jose Do Rio Preto, SAO Paulo, Brasilien, 15090-000
        • Local Institution
      • Santo Andre, SAO Paulo, Brasilien, 09190-610
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brasilien, 15015-750
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brasilien, 15015-210
        • Local Institution
    • Santa Catarina
      • Blumenau, Santa Catarina, Brasilien, 89010
        • Local Institution
      • Blumenau, Santa Catarina, Brasilien, 89010-500
        • Local Institution
      • Sao Jose, Santa Catarina, Brasilien, 88103
        • Local Institution
      • Sao Jose, Santa Catarina, Brasilien, 88103-450
        • Local Institution
    • Sao Paulo
      • Botucatu, Sao Paulo, Brasilien, 18618
        • Local Institution
      • Campinas, Sao Paulo, Brasilien, 13059
        • Local Institution
      • Marilia, Sao Paulo, Brasilien, 17519
        • Local Institution
      • Marilia, Sao Paulo, Brasilien, 17515
        • Local Institution
      • San Jose Do Rio Preto, Sao Paulo, Brasilien, 15090
        • Local Institution
      • Santo Andre, Sao Paulo, Brasilien, 09190
        • Local Institution
      • Sao Jose Do Rio Preto, Sao Paulo, Brasilien, 15015
        • Local Institution
  • Canada
      • Quebec, Canada, G1J 1Z6
        • Local Institution
    • Alberta
      • Calgary, Alberta, Canada, T2E 7C5
        • Local Institution
      • Edmonton, Alberta, Canada, T6G 2B7
        • Local Institution
      • Edmonton, Alberta, Canada, T5X 3N5
        • Local Institution
      • Edmonton, Alberta, Canada, TSA 4L8
        • Local Institution
      • Edmonton, Alberta, Canada, T56-3NJ
        • Local Institution
    • British Columbia
      • Burnaby, British Columbia, Canada, V5G 1T4
        • Local Institution
      • Nanaimo, British Columbia, Canada, V9R 3G9
        • Local Institution
      • New Westminster, British Columbia, Canada, V3L 3W4
        • Local Institution
      • North Vancouver, British Columbia, Canada, V7N 4M2
        • Local Institution
      • Victoria, British Columbia, Canada, V8R 4R2
        • Local Institution
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2V 4W3
        • Local Institution
    • New Brunswick
      • Bathurst, New Brunswick, Canada, E2A 4X7
        • Local Institution
    • Newfoundland and Labrador
      • Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
        • Local Institution
      • St Johns, Newfoundland and Labrador, Canada, A1B 3V6
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Canada, A1A 3R5
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Canada, A1E 2C2
        • Local Institution
    • Ontario
      • Brampton, Ontario, Canada, L6Z 4N5
        • Local Institution
      • Burlington, Ontario, Canada, L7M 4Y1
        • Local Institution
      • Cambridge, Ontario, Canada, N1R 7R1
        • Local Institution
      • Cambridge, Ontario, Canada, N1R 6V6
        • Local Institution
      • Hamilton, Ontario, Canada, L8L 2X2
        • Local Institution
      • London, Ontario, Canada, N6G 2V2
        • Local Institution
      • Mississauga, Ontario, Canada, L5B 4A2
        • Local Institution
      • Newmarket, Ontario, Canada, L3Y 5G8
        • Local Institution
      • Newmarket, Ontario, Canada, L3Y 8C3
        • Local Institution
      • Niagara Falls, Ontario, Canada, L2E 7H1
        • Local Institution
      • Niagara Falls, Ontario, Canada, L2E7H1
        • Local Institution
      • North Bay, Ontario, Canada, P1B 2H3
        • Local Institution
      • Oshawa, Ontario, Canada, L1J 2J9
        • Local Institution
      • Oshawa, Ontario, Canada, L1J 2K1
        • Local Institution
      • Ottawa, Ontario, Canada, K1Y 4E9
        • Local Institution
      • Ottawa, Ontario, Canada, K1Y 4W7
        • Local Institution
      • Sarnia, Ontario, Canada, N7T 4X3
        • Local Institution
      • Scarborough, Ontario, Canada, M1B 5N1
        • Local Institution
      • Sudbury, Ontario, Canada, P3E 3B8
        • Local Institution
      • Sudbury, Ontario, Canada, P3C 5K7
        • Local Institution
      • Sudbury, Ontario, Canada, P3E 2N8
        • Local Institution
      • Sudbury, Ontario, Canada, P3C5K7
        • Local Institution
      • Toronto, Ontario, Canada, M9W 4L6
        • Local Institution
      • Toronto, Ontario, Canada, M5B 1W8
        • Local Institution
      • Weston, Ontario, Canada, M9N 1W4
        • Local Institution
    • Prince Edward Island
      • Charlottetown, Prince Edward Island, Canada, C1A 5Y9
        • Local Institution
    • Quebec
      • Drummondville, Quebec, Canada, J2B 7T1
        • Local Institution
      • Greenfield Park, Quebec, Canada, J4V 2G8
        • Local Institution
      • Lachine, Quebec, Canada, H8S 2E4
        • Local Institution
      • Levis, Quebec, Canada, G6V 4Z5
        • Local Institution
      • Longueuil, Quebec, Canada, J4K 1C8
        • Local Institution
      • Longueuil, Quebec, Canada, J4N 0C9
        • Local Institution
      • Longueuil, Quebec, Canada, J4N 1C2
        • Local Institution
      • Montreal, Quebec, Canada, H3T 1E2
        • Local Institution
      • Montreal, Quebec, Canada, H3A 1A1
        • Local Institution
      • Montreal, Quebec, Canada, H1T 1C8
        • Local Institution
      • Montreal, Quebec, Canada, H2W 1T8
        • Local Institution
      • Montreal, Quebec, Canada, W3R-153
        • Local Institution
      • Pointe- Claire, Quebec, Canada, H9R 3J1
        • Local Institution
      • St-Lambert, Quebec, Canada, J4P 2H4
        • Local Institution
      • Ste-Foy, Quebec, Canada, G1W 4R4
        • Local Institution
    • Saskatchewan
      • Saskatoon, Saskatchewan, Canada, S7L OY7
        • Local Institution
  • Chile
    • LOS Lagos
      • Osorno, LOS Lagos, Chile, 5311089
        • Local Institution
      • Osorno, LOS Lagos, Chile, 5311523
        • Local Institution
    • Metropolitana
      • Santiago, Metropolitana, Chile, 7500520
        • Local Institution
      • Santiago, Metropolitana, Chile, 7500922
        • Local Institution
      • Santiago, Metropolitana, Chile, 8330074
        • Local Institution
    • Region DE LA Araucania
      • Temuco, Region DE LA Araucania, Chile, 4781176
        • Local Institution
    • Region De La Araucania
      • Temuco, Region De La Araucania, Chile, 4781156
        • Local Institution
    • Valparaiso
      • Temuco, Valparaiso, Chile, 4781173
        • Local Institution
      • Vina Del Mar, Valparaiso, Chile, 2570017
        • Local Institution
  • Colombia
      • Barranquilla, Colombia
        • Local Institution
      • Barranquilla, Colombia, XXXXX
        • Local Institution
      • Bogota, Colombia
        • Local Institution
      • Bogota, Colombia, 000
        • Local Institution
      • Cali, Colombia
        • Local Institution
      • Medellin, Colombia
        • Local Institution
    • Antioquia
      • Medellin, Antioquia, Colombia
        • Local Institution
  • Danmark
      • Arhus C, Danmark, 8000
        • Local Institution
      • Esbjerg, Danmark, 6700
        • Local Institution
      • Frederiksberg, Danmark, 2000
        • Local Institution
      • Frederikssund, Danmark, 3600
        • Local Institution
      • Gentofte, Danmark, 2900
        • Local Institution
      • Haderslev, Danmark, 6100
        • Local Institution
      • Hellerup, Danmark, 2900
        • Local Institution
      • Herlev, Danmark, 2730
        • Local Institution
      • Herning, Danmark, 7400
        • Local Institution
      • Hillerod, Danmark, 3400
        • Local Institution
      • Hvidovre, Danmark, 2650
        • Local Institution
      • Kobenhavn, Danmark, 2100
        • Local Institution
      • Kolding, Danmark, 6000
        • Local Institution
      • Odense, Danmark, 5000
        • Local Institution
      • Silkeborg, Danmark, 8600
        • Local Institution
      • Slagelse, Danmark, 4200
        • Local Institution
      • Svendborg, Danmark, 5700
        • Local Institution
  • Den Russiske Føderation
      • Chelyabinsk, Den Russiske Føderation, 454136
        • Local Institution
      • Chita, Den Russiske Føderation, 672090
        • Local Institution
      • Dzerzhinskiy, Den Russiske Føderation, 140091
        • Local Institution
      • Kazan, Den Russiske Føderation, 420012
        • Local Institution
      • Kemerovo, Den Russiske Føderation, 650002
        • Local Institution
      • Kirovsk, Den Russiske Føderation, 187342
        • Local Institution
      • Krasnodar, Den Russiske Føderation, 350042
        • Local Institution
      • Moscow, Den Russiske Føderation, 119992
        • Local Institution
      • Moscow, Den Russiske Føderation, 125367
        • Local Institution
      • Moscow, Den Russiske Føderation, 109240
        • Local Institution
      • Moscow, Den Russiske Føderation, 105229
        • Local Institution
      • Moscow, Den Russiske Føderation, 111539
        • Local Institution
      • Moscow, Den Russiske Føderation, 115487
        • Local Institution
      • Moscow, Den Russiske Føderation, 115093
        • Local Institution
      • Moscow, Den Russiske Føderation, 121552
        • Local Institution
      • Moscow, Den Russiske Føderation, 117593
        • Local Institution
      • Moscow, Den Russiske Føderation, 127018
        • Local Institution
      • Moscow, Den Russiske Føderation, 125284
        • Local Institution
      • Moscow, Den Russiske Føderation, 111020
        • Local Institution
      • Moscow, Den Russiske Føderation, 119121
        • Local Institution
      • Moscow, Den Russiske Føderation, 121356
        • Local Institution
      • Moscow, Den Russiske Føderation, 117556
        • Local Institution
      • Moscow, Den Russiske Føderation, 119048
        • Local Institution
      • Moscow, Den Russiske Føderation, 123182
        • Local Institution
      • Moscow, Den Russiske Føderation, 125206
        • Local Institution
      • Moscow, Den Russiske Føderation, 125424
        • Local Institution
      • Moscow, Den Russiske Føderation, 129090
        • Local Institution
      • Nizhni Novgorod, Den Russiske Føderation, 603003
        • Local Institution
      • Nizhni Novgorod, Den Russiske Føderation, 603005
        • Local Institution
      • Novosibirsk, Den Russiske Føderation, 630008
        • Local Institution
      • Novosibirsk, Den Russiske Føderation, 630054
        • Local Institution
      • Odintsovo, Den Russiske Føderation, 143000
        • Local Institution
      • Penza, Den Russiske Føderation, 440026
        • Local Institution
      • Perm, Den Russiske Føderation, 614097
        • Local Institution
      • Rostov-On-Don, Den Russiske Føderation, 344022
        • Local Institution
      • Ryazan, Den Russiske Føderation, 390026
        • Local Institution
      • Saint Petersburg, Den Russiske Føderation, 193312
        • Local Institution
      • Saint Petersburg, Den Russiske Føderation, 193144
        • Local Institution
      • Saint-Petersburg, Den Russiske Føderation, 190103
        • Local Institution
      • Saint-Petersburg, Den Russiske Føderation, 191025
        • Local Institution
      • Saint-Petersburg, Den Russiske Føderation, 193163
        • Local Institution
      • Saint-Petersburg, Den Russiske Føderation, 196601
        • Local Institution
      • Saint-Petersburg, Den Russiske Føderation, 198013
        • Local Institution
      • Samara, Den Russiske Føderation, 443070
        • Local Institution
      • Saratov, Den Russiske Føderation, 410002
        • Local Institution
      • St Petersburg, Den Russiske Føderation, 198013
        • Local Institution
      • St Petersburg, Den Russiske Føderation, 192288
        • Local Institution
      • St-Petersburg, Den Russiske Føderation, 194354
        • Local Institution
      • St-Petersburg, Den Russiske Føderation, 195271
        • Local Institution
      • St. Petersburg, Den Russiske Føderation, 197341
        • Local Institution
      • St. Petersburg, Den Russiske Føderation, 197110
        • Local Institution
      • St.-Petersburg, Den Russiske Føderation, 197341
        • Local Institution
      • St.Petersburg, Den Russiske Føderation, 199106
        • Local Institution
      • Tomsk, Den Russiske Føderation, 634012
        • Local Institution
      • Tumen, Den Russiske Føderation, 625023
        • Local Institution
      • Tver, Den Russiske Føderation, 170036
        • Local Institution
      • Voronezh, Den Russiske Føderation, 394066
        • Local Institution
      • Voronezh, Den Russiske Føderation, 394065
        • Local Institution
      • Yaroslavl, Den Russiske Føderation, 150030
        • Local Institution
      • Yaroslavl, Den Russiske Føderation, 150003
        • Local Institution
      • Yaroslavl, Den Russiske Føderation, 150002
        • Local Institution
      • Zheleznodorozhniy, Den Russiske Føderation, 143920
        • Local Institution
      • Zhukovsky, Den Russiske Føderation, 140160
        • Local Institution
      • Zhukovsky, Den Russiske Føderation, 140180
        • Local Institution
  • Det Forenede Kongerige
      • Antrim, Det Forenede Kongerige, BT41 2RL
        • Local Institution
      • Blackpool, Det Forenede Kongerige, FY3 8NR
        • Local Institution
      • Glasgow, Det Forenede Kongerige, G21 3UW
        • Local Institution
    • Aberdeenshire
      • Aberdeen, Aberdeenshire, Det Forenede Kongerige, AB25 2ZN
        • Local Institution
      • Glasgow, Aberdeenshire, Det Forenede Kongerige, G11 6NT
        • Local Institution
    • Antrim
      • Belfast, Antrim, Det Forenede Kongerige, BT14 6AB
        • Local Institution
    • Armagh
      • Craigavon, Armagh, Det Forenede Kongerige, BT63 5QQ
        • Local Institution
    • Cambridgeshire
      • Cambridge, Cambridgeshire, Det Forenede Kongerige, CB2 2QQ
        • Local Institution
      • Peterborough, Cambridgeshire, Det Forenede Kongerige, PE2 5GP
        • Local Institution
    • Derbyshire
      • Chesterfield, Derbyshire, Det Forenede Kongerige, S44 5BL
        • Local Institution
      • Chesterfield, Derbyshire, Det Forenede Kongerige, S40 4TF
        • Local Institution
    • Dorset
      • Bournemouth, Dorset, Det Forenede Kongerige, BH7 7DW
        • Local Institution
    • Dumbartonshire
      • Glasgow, Dumbartonshire, Det Forenede Kongerige, G11 6NT
        • Local Institution
    • EAST Sussex
      • Chichester, EAST Sussex, Det Forenede Kongerige, PO19 6SE
        • Local Institution
    • Essex
      • Colchester, Essex, Det Forenede Kongerige, C03 4LN
        • Local Institution
      • Romford, Essex, Det Forenede Kongerige, RH7 0AG
        • Local Institution
    • Greater London
      • Denmark Hill, Greater London, Det Forenede Kongerige, SE5 9RS
        • Local Institution
      • London, Greater London, Det Forenede Kongerige, SW17 0RE
        • Local Institution
    • Gwent
      • Newport, Gwent, Det Forenede Kongerige, NP20 2UB
        • Local Institution
    • Hertfordshire
      • Barnet, Hertfordshire, Det Forenede Kongerige, EN5 3DJ
        • Local Institution
    • MID Glamorgan
      • Cardiff, MID Glamorgan, Det Forenede Kongerige, CF14 4XW
        • Local Institution
      • Llandough, MID Glamorgan, Det Forenede Kongerige, CF64 2XX
        • Local Institution
    • Middlesex
      • Harrow, Middlesex, Det Forenede Kongerige, HA1 3UJ
        • Local Institution
    • Nottinghamshire
      • Nottingham, Nottinghamshire, Det Forenede Kongerige, NG5 1PB
        • Local Institution
      • Worksop, Nottinghamshire, Det Forenede Kongerige, S81 OBD
        • Local Institution
    • Renfrewshire
      • Paisley, Renfrewshire, Det Forenede Kongerige, PA2 9PN
        • Local Institution
    • South Yorkshire
      • Barnsley, South Yorkshire, Det Forenede Kongerige, S75 2EP
        • Local Institution
      • Doncaster, South Yorkshire, Det Forenede Kongerige, DN2 5LT
        • Local Institution
    • Stirlingshire
      • Stirling, Stirlingshire, Det Forenede Kongerige, FK8 2AU
        • Local Institution
    • Strathclyde
      • Glasgow, Strathclyde, Det Forenede Kongerige, G51 4TF
        • Local Institution
    • Suffolk
      • Bury St Edmunds, Suffolk, Det Forenede Kongerige, IP31 2HD
        • Local Institution
      • Bury St Edmunds, Suffolk, Det Forenede Kongerige, IP33 2QZ
        • Local Institution
      • Bury St. Edmunds, Suffolk, Det Forenede Kongerige, IP30 9QU
        • Local Institution
      • Ipswich, Suffolk, Det Forenede Kongerige, IP14 2PU
        • Local Institution
      • Ipswich, Suffolk, Det Forenede Kongerige, IP7 5DN
        • Local Institution
    • Tyne and Wear
      • Newcastle Upon Tyne, Tyne and Wear, Det Forenede Kongerige, NE1 4LP
        • Local Institution
    • WEST Glamorgan
      • Swansea, WEST Glamorgan, Det Forenede Kongerige, SA6 6NL
        • Local Institution
    • WEST Lothian
      • Livingston, WEST Lothian, Det Forenede Kongerige, EH54 6PP
        • Local Institution
    • WEST Midlands
      • Birmingham, WEST Midlands, Det Forenede Kongerige, B18 7QH
        • Local Institution
    • Wiltshire
      • Westbury, Wiltshire, Det Forenede Kongerige, BA 13 3JD
        • Local Institution
      • Westbury, Wiltshire, Det Forenede Kongerige, BA13 3JD
        • Local Institution
    • Yorkshire
      • York, Yorkshire, Det Forenede Kongerige, YO31 8HE
        • Local Institution
      • York, Yorkshire, Det Forenede Kongerige, YO31 HE
        • Local Institution
  • Filippinerne
      • Manila, Filippinerne, 1000
        • Local Institution
      • Manila, Filippinerne, 1008
        • Local Institution
      • Naga City, Filippinerne, 4400
        • Local Institution
      • Pasig City, Filippinerne, 1600
        • Local Institution
      • Quezon, Filippinerne, 1100
        • Local Institution
      • Quezon City, Filippinerne, 1102
        • Local Institution
      • San Juan, Filippinerne, 1100
        • Local Institution
    • Ilocos Norte
      • Laoag City, Ilocos Norte, Filippinerne, 2900
        • Local Institution
  • Finland
      • Helsinki, Finland, 00280
        • Local Institution
      • Helsinki, Finland, FI-00280
        • Local Institution
      • Hus, Finland, 00029
        • Local Institution
      • Jyvaskyla, Finland, 40100
        • Local Institution
      • Kemi, Finland, 94100
        • Local Institution
      • Oulu, Finland, 90100
        • Local Institution
      • Pori, Finland, 28120
        • Local Institution
      • Tampere, Finland, 33100
        • Local Institution
  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35209
        • Cardiovascular Associates, Pc
      • Birmingham, Alabama, Forenede Stater, 35235
        • Alabama Internal Medicine Pc
      • Birmingham, Alabama, Forenede Stater, 35235
        • Birmingham Heart Clinic P.C.
      • Huntsville, Alabama, Forenede Stater, 35801
        • Heart Center, Inc.
      • Mobile, Alabama, Forenede Stater, 36608
        • Mobile Heart Specialists, PC
      • Mobile, Alabama, Forenede Stater, 36617
        • Clara V. Massey, Md
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 99508
        • Alaska Heart Institute
    • Arizona
      • Phoenix, Arizona, Forenede Stater, 85006
        • Internal Medicine Physicians Associates, P.C.
      • Tucson, Arizona, Forenede Stater, 85723
        • Southern Arizona VA Health Care System
      • Tucson, Arizona, Forenede Stater, 85710
        • Southwest Heart
      • Tucson, Arizona, Forenede Stater, 85745
        • Pima Research Foundation
    • Arkansas
      • Hot Springs, Arkansas, Forenede Stater, 71913
        • Dr. Rajesh Shroff
      • Little Rock, Arkansas, Forenede Stater, 72204
        • Mary K. Richards, Md Pa
    • California
      • Anaheim, California, Forenede Stater, 92801
        • Advanced Clinical Reserach Institute
      • Beverly Hills, California, Forenede Stater, 90210
        • Act/Cardiovascular Research Institute
      • Carmichael, California, Forenede Stater, 95608
        • Capitol Interventional Cardiology
      • Escondido, California, Forenede Stater, 92025
        • Escondido Cardiology Associates, Inc.
      • Healdsburg, California, Forenede Stater, 95448
        • William D. Bowden, D.O.
      • La Mesa, California, Forenede Stater, 91942
        • La Mesa Cardiac Center, A Medical Group
      • Los Angeles, California, Forenede Stater, 90073
        • VA Greater Los Angeles Healthcare System
      • Mission Viejo, California, Forenede Stater, 92691
        • Coastal Cardiology
      • Oceanside, California, Forenede Stater, 92056
        • Kenneth W. Carr Md
      • Palm Springs, California, Forenede Stater, 92262
        • Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
      • Rancho Mirage, California, Forenede Stater, 92270
        • Desert Cardiology Consultants Medical Group, Inc
      • Sacramento, California, Forenede Stater, 95821
        • Northern California Research
      • Sacramento, California, Forenede Stater, 95825
        • Sacramento Heart And Vascular Medical Associates
      • Sacramento, California, Forenede Stater, 95819
        • Regional Cardiolody Associates
      • Santa Barbara, California, Forenede Stater, 93105
        • Arrhythmia Consultants Of The Central Coast Medical Group
      • Santa Rosa, California, Forenede Stater, 95403
        • Northern California Medical Associates
      • Vista, California, Forenede Stater, 92083
        • Progressive Clinical Research
      • Walnut Creek, California, Forenede Stater, 94598
        • Cardivasclular Consultants Medical Group
      • Wildomar, California, Forenede Stater, 92595
        • Shiva Heart Center Medical Group
    • Colorado
      • Colorado Springs, Colorado, Forenede Stater, 80910
        • Electrophysiology Associates, Pc
      • Denver, Colorado, Forenede Stater, 80220
        • Denver VA Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Aurora Denver Cardiology Associates, P.C.
      • Golden, Colorado, Forenede Stater, 80401
        • New West Physicians Clinical Research
      • Littleton, Colorado, Forenede Stater, 80120
        • South Denver Cardiology Associates PC
    • Connecticut
      • Bridgeport, Connecticut, Forenede Stater, 06610
        • Bridgeport Hospital
      • Bridgeport, Connecticut, Forenede Stater, 06606
        • Connecticut Clinical Research, Llc
      • Guilford, Connecticut, Forenede Stater, 06437
        • Cardiology Associates Of New Haven,Pc
      • Norwich, Connecticut, Forenede Stater, 06360
        • William W Backus Hospital
      • Norwich, Connecticut, Forenede Stater, 06360
        • The William W. Backus Hospital
      • Stamford, Connecticut, Forenede Stater, 06905
        • Stamford Therapeutics Consortium
      • Waterbury, Connecticut, Forenede Stater, 06708
        • Chase Medical Research, LLC
    • Delaware
      • Newark, Delaware, Forenede Stater, 19713
        • Alfieri Cardiology
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20422
        • Washington VA Medical Center
      • Washington, District of Columbia, Forenede Stater, 20037
        • George Washington University Medical Faculty Associates
    • Florida
      • Atlantis, Florida, Forenede Stater, 33462
        • Medical Specialist Of The Palm Beach
      • Aventura, Florida, Forenede Stater, 33180
        • Miami International Cardiology Consultants
      • Boca Raton, Florida, Forenede Stater, 33431
        • David Charles Mishkel, Md, Pa
      • Clearwater, Florida, Forenede Stater, 33756
        • The Heart & Vascular Institute Of Florida
      • Clearwater, Florida, Forenede Stater, 33756
        • The Heart And Vascular Institute Of Florida
      • Davie, Florida, Forenede Stater, 33324
        • Cardiovascular Specialist Of South Florida
      • Daytona Beach, Florida, Forenede Stater, 32114
        • Daytona Heart Group
      • Fort Lauderdale, Florida, Forenede Stater, 33316
        • Broward General Medical Center
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Cardiology Associates Of Fort Lauderdale, P.A.
      • Fort Myers, Florida, Forenede Stater, 33907
        • Florida Heart Associates
      • Gainesville, Florida, Forenede Stater, 32605
        • Florida Research Network, LLC
      • Hollywood, Florida, Forenede Stater, 33021
        • Healthworx
      • Hollywood, Florida, Forenede Stater, 33021
        • Luis Tami, Md
      • Inverness, Florida, Forenede Stater, 34452
        • Nature Coast Clinical Research
      • Jacksonville, Florida, Forenede Stater, 32216
        • Jacksonville Center for Clinical Research
      • Jacksonville, Florida, Forenede Stater, 32216
        • Jacksonville Cardiovascular Center
      • Jacksonville, Florida, Forenede Stater, 32258
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Forenede Stater, 32204
        • St. Vincent'S Ambulatory Care, Inc
      • Jacksonville, Florida, Forenede Stater, 32207
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Forenede Stater, 32216
        • St. Luke'S Cardiology
      • Jacksonville Beach, Florida, Forenede Stater, 32250
        • Jacksonville Heart Center, P.A.
      • Jupiter, Florida, Forenede Stater, 33458
        • Cvms Research Institute, Llc
      • Jupiter, Florida, Forenede Stater, 33458
        • Ricardo Bedoya, M.D.
      • Melbourne, Florida, Forenede Stater, 32901
        • Melbourne Internal Medicine Associates
      • Miami, Florida, Forenede Stater, 33137
        • Miami International Cardiology Consultants
      • Miami, Florida, Forenede Stater, 33137-3732
        • Miami International Cardiology Consultants
      • Naples, Florida, Forenede Stater, 34119
        • Physicians Regional Medical Group
      • Orlando, Florida, Forenede Stater, 32803
        • Florida Heart Group
      • Oviedo, Florida, Forenede Stater, 32765
        • Alpha Medical Research
      • Pensacola, Florida, Forenede Stater, 32501
        • Cardiology Consultants
      • Saint Petersburg, Florida, Forenede Stater, 33709
        • The Heart And Vascular Institute Of Florida
      • Sarasota, Florida, Forenede Stater, 34239
        • Heart & Vascular Center Research, Inc.
      • Sarasota, Florida, Forenede Stater, 34232
        • Niranjan Seshadri, Md
      • Vero Beach, Florida, Forenede Stater, 32960
        • Research, Inc.
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30342
        • Cardiovascular Specialits, Pc
      • Augusta, Georgia, Forenede Stater, 30901
        • Augusta Cardiology Clinic, P.C.
      • Columbus, Georgia, Forenede Stater, 31909
        • Columbus Cardiology Associates Pc
      • Columbus, Georgia, Forenede Stater, 31909
        • Columbus Cardiology Associates,Pc
      • Covington, Georgia, Forenede Stater, 30014
        • Georgia Heart Specialists, L.L.C.
      • Decatur, Georgia, Forenede Stater, 30030
        • Atlanta Institute For Medical Research, Inc
      • Gainesville, Georgia, Forenede Stater, 30501
        • Northeast Georgia Heart Center, PC
      • Marietta, Georgia, Forenede Stater, 30060
        • Wellstar Cardiovascular Medicine, Pc
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Fox Valley Clinical Research Center, LLC
      • Chicago, Illinois, Forenede Stater, 60611
        • Nmff
      • Gurnee, Illinois, Forenede Stater, 60031
        • Clinical Investigation Specialists, Inc
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Normal, Illinois, Forenede Stater, 61761
        • Illinois Heart & Lung Research Center, Sc
      • North Chicago, Illinois, Forenede Stater, 60064
        • Cpt. James A Lovell Federal Health Care Center
    • Indiana
      • Anderson, Indiana, Forenede Stater, 46011
        • Community Clinical Research Center
      • Bloomington, Indiana, Forenede Stater, 47403
        • Premier Healthcare, Llc
      • Elkhart, Indiana, Forenede Stater, 46514
        • Elkhart Clinic, LLC
      • Fort Wayne, Indiana, Forenede Stater, 46804
        • Lutheran Medical Group, Llc
      • Fort Wayne, Indiana, Forenede Stater, 46805
        • Fort Wayne Cardiology
      • Indianapolis, Indiana, Forenede Stater, 46290
        • The Care Group, Llc
      • Indianapolis, Indiana, Forenede Stater, 46290
        • The Care Group, Llc.
      • Indianapolis, Indiana, Forenede Stater, 46237
        • St Francis Medical Group - Indiana Heart Physicians
      • Michigan City, Indiana, Forenede Stater, 46360
        • Dali, Sammi
      • South Bend, Indiana, Forenede Stater, 46601
        • Cardiology Associates, Inc.
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC
    • Kansas
      • Overland Park, Kansas, Forenede Stater, 66209
        • Midwest Cardiology Associates , P.C.
    • Kentucky
      • Elizabethtown, Kentucky, Forenede Stater, 42701
        • Central Cardiology Assoc.
      • Lexington, Kentucky, Forenede Stater, 40504
        • New Lexington Clinic, P.S.C.
      • Louisville, Kentucky, Forenede Stater, 40205
        • Norton Cardiovascular Associates
      • Louisville, Kentucky, Forenede Stater, 40202
        • VA Medical Center
      • Owensboro, Kentucky, Forenede Stater, 42303
        • Owensboro Heart & Vascular
    • Louisiana
      • Alexandria, Louisiana, Forenede Stater, 71301
        • Alexandria Cardiology Clinic
      • Houma, Louisiana, Forenede Stater, 70360
        • Cardiovascular Institute of the South
      • Lacombe, Louisiana, Forenede Stater, 70445
        • Smith, Patel & Amkieh, Llc
      • Lake Charles, Louisiana, Forenede Stater, 70601
        • Imperial Calcasieu Medical Group, Llp
      • Marrero, Louisiana, Forenede Stater, 70072
        • Cardiology Center, Llc
      • Shreveport, Louisiana, Forenede Stater, 71105
        • Cardiology Associates
      • Slidell, Louisiana, Forenede Stater, 70458
        • Louisiana Heart Center
      • Slidell, Louisiana, Forenede Stater, 70458
        • Medical Research Inst, Inc
      • Slidell, Louisiana, Forenede Stater, 70458
        • Medical Research Institute, Inc
      • Ventura, Louisiana, Forenede Stater, 93003
        • Ventura Cardio. Cond. Med. Group, Inc.
    • Maine
      • Lewiston, Maine, Forenede Stater, 04240
        • Central Maine Heart & Vascular Institute
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21224
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Forenede Stater, 21237
        • Franklin Square Hospital
      • Baltimore, Maryland, Forenede Stater, 21208
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Forenede Stater, 21237
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Forenede Stater, 21204
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Forenede Stater, 21218
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Forenede Stater, 21224-2735
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Forenede Stater, 21237
        • Midatlantic Cardiovascular Associates, P.A.
      • Bel Air, Maryland, Forenede Stater, 21014
        • Midatlantic Cardiovascular Associates, Pa
      • Columbia, Maryland, Forenede Stater, 21044
        • Cardiovascular Specialists Of Central Maryland, P.A.
      • Reisterstown, Maryland, Forenede Stater, 21136
        • Clinical Associates Research
      • Westminster, Maryland, Forenede Stater, 21157
        • Midatlantic Cardiovascular Associates, Pa
    • Massachusetts
      • Billerica, Massachusetts, Forenede Stater, 01821
        • Burlington Medical Associates
      • Boston, Massachusetts, Forenede Stater, 02135
        • Caritas St. Elizabeth's Medical Center
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Lahey Clinic Medical Center
      • Fall River, Massachusetts, Forenede Stater, 02720
        • Neccr Internal Medicine & Cardiology Associates,Llc
      • Haverhill, Massachusetts, Forenede Stater, 01830
        • Pentucket Medical Associates
      • Haverhill, Massachusetts, Forenede Stater, 01830-6278
        • Pentucket Medical Associates
      • Natick, Massachusetts, Forenede Stater, 01760
        • Charles River Medical Associates
    • Michigan
      • Alpena, Michigan, Forenede Stater, 49707
        • Great Lakes Heart Center Of Alpena
      • Detroit, Michigan, Forenede Stater, 48202
        • Henry Ford Hospital
      • Lansing, Michigan, Forenede Stater, 48910
        • Thoracic And Cardiovascular Healthcare Foundation
      • Livonia, Michigan, Forenede Stater, 48154
        • Advanced Cardiovascular Health Specialists, Pc
      • Petoskey, Michigan, Forenede Stater, 49770
        • Michigan Heart And Vascular Specialists
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Michigan Heart, P.C.
    • Minnesota
      • Minneapolis, Minnesota, Forenede Stater, 55455
        • University of Minnesota
      • Minneapolis, Minnesota, Forenede Stater, 55417
        • Minneapolis VA Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Health Care
    • Mississippi
      • Olive Branch, Mississippi, Forenede Stater, 38654
        • Olive Branch Family Medical Center
      • Tupelo, Mississippi, Forenede Stater, 38801
        • Tupelo Neurology Clinic, Pa
    • Missouri
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri
      • Kansas City, Missouri, Forenede Stater, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Lipid and Diabetes Research Center
    • Nebraska
      • Grand Island, Nebraska, Forenede Stater, 68803
        • Internal Medical Associates Of Grand Island, P.C
      • Grand Island, Nebraska, Forenede Stater, 68803-4311
        • Internal Medical Associates Of Grand Island, P.C
      • Hastings, Nebraska, Forenede Stater, 68901
        • Nebraska Heart Institute
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • VA Southern Nevada Healthcare System
    • New Jersey
      • Berlin, New Jersey, Forenede Stater, 08009
        • Comprehensive Clinical Research
      • Elmer, New Jersey, Forenede Stater, 08318
        • Cardiovascular Associates Of The Delware Valley, P.A.
      • Haddon Heights, New Jersey, Forenede Stater, 08035
        • Cardiovascular Associates Of The Delaware Valley, P.A.
      • Princeton, New Jersey, Forenede Stater, 08540
        • Princeton Medical Institute
      • Sewell, New Jersey, Forenede Stater, 08080
        • Cardio Assoc Of Del Val, P.A.
      • South Plainfield, New Jersey, Forenede Stater, 07080
        • Central New Jersey Cardiology
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87012
        • Abq Health Partners, Llc
      • Albuquerque, New Mexico, Forenede Stater, 87131-0001
        • University Of New Mexico/University Hospital
      • Albuquerque, New Mexico, Forenede Stater, 87131
        • University Of New Mexico/University Hospital
    • New York
      • Albany, New York, Forenede Stater, 12205
        • Albany Associates In Cardiology
      • Albany, New York, Forenede Stater, 12205
        • Albany Assoc. In Cardiology
      • Binghamton, New York, Forenede Stater, 13905
        • Cardiology Associates, Pc
      • Buffalo, New York, Forenede Stater, 14215
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Forenede Stater, 14215-1145
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Forenede Stater, 14215
        • Bruce L. Platt Md, Pc
      • Buffalo, New York, Forenede Stater, 14215
        • Bruce L. Platt, Md
      • East Syracuse, New York, Forenede Stater, 13057
        • Heart Care Center, P.C.
      • Huntington, New York, Forenede Stater, 11743
        • Huntington Hospital
      • Liverpool, New York, Forenede Stater, 13088
        • SJH Cardiology Associates
      • Mineola, New York, Forenede Stater, 11501
        • Long Island Heart Associates
      • Saratoga Springs, New York, Forenede Stater, 12866
        • Saratoga Cardiology Associates, Pc
      • Williamsville, New York, Forenede Stater, 14221
        • Office Of Dr. Kozinn
      • Williamsville, New York, Forenede Stater, 14221
        • Suburban Cardiology
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28803
        • Asheville Cardiology Associates
      • Burlington, North Carolina, Forenede Stater, 27215
        • Kernodle Clinic, Inc.
      • High Point, North Carolina, Forenede Stater, 27262
        • Carolina Cardiology Associates, Pa
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • Pinehurst Medical Center, Inc
    • North Dakota
      • Fargo, North Dakota, Forenede Stater, 58103
        • Lillestol Research LLC
    • Ohio
      • Akron, Ohio, Forenede Stater, 44304
        • Akron Cardiology Consultants
      • Bucyrus, Ohio, Forenede Stater, 44820
        • Christopher M. Johnson, D.O.
      • Bucyrus, Ohio, Forenede Stater, OHIO
        • Christopher M. Johnson, D.O.
      • Canal Fulton, Ohio, Forenede Stater, 44614
        • Community Health Care, Inc.
      • Canton, Ohio, Forenede Stater, 44710
        • Cardiology Associates
      • Cincinnati, Ohio, Forenede Stater, 45219
        • The Carl & Edyth Lindner Center For R&E At The Christ Hosp
      • Toledo, Ohio, Forenede Stater, 43608
        • Toledo Cardiology Consultants
      • Wadsworth, Ohio, Forenede Stater, 44281
        • Family Practice Center of Wadsworth, Inc.
    • Oklahoma
      • Muskogee, Oklahoma, Forenede Stater, 74401
        • Jack C. Va Medical Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73112
        • Plaza Medical Group, Pc
      • Oklahoma City, Oklahoma, Forenede Stater, 73103
        • COR Clinical Research, LLC
      • Oklahoma City, Oklahoma, Forenede Stater, 73135
        • South Oklahoma Heart Research
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Oklahoma Heart Hospital Physicians
      • Oklahoma City, Oklahoma, Forenede Stater, 73139
        • Eminence Research, LLC
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • Castlerock Clinical Research Consultants, Llc
    • Oregon
      • Bend, Oregon, Forenede Stater, 97701
        • St. Charles Health System, Inc.
      • Bend, Oregon, Forenede Stater, 97701
        • St. Charles Health System, Inc
      • Eugene, Oregon, Forenede Stater, 97401
        • Oregon Medical Group - Clinical Research
      • Hillsboro, Oregon, Forenede Stater, 97123
        • Hillsboro Cardiology Pc
      • Medford, Oregon, Forenede Stater, 97504
        • Rogue Valley Physicians - Clinical Research Group
    • Pennsylvania
      • Abington, Pennsylvania, Forenede Stater, 19001
        • Abington Medical Specialists
      • Altoona, Pennsylvania, Forenede Stater, 16602
        • Blair Medical Associates, Inc.
      • Camp Hill, Pennsylvania, Forenede Stater, 17011
        • Heritage Cardiology Assoc.
      • Doylestown, Pennsylvania, Forenede Stater, 18901
        • Central Bucks Cardiology
      • Erie, Pennsylvania, Forenede Stater, 16509
        • Internal Medicine And Lipid Mgmt.
      • Harrisburg, Pennsylvania, Forenede Stater, 17112
        • Kandra, Fierer, Kuskin Associates
      • Hatfield, Pennsylvania, Forenede Stater, 19440
        • Pivotal Clinical Research, Llc
      • Jersey Shore, Pennsylvania, Forenede Stater, 17740
        • Lycoming Internal Medicine Inc.
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Guthrie Medical Group, P.C.
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Guthrie Clinic Ltd.
      • Uniontown, Pennsylvania, Forenede Stater, 15401
        • Preferred Primary Care Physicians
      • West Chester, Pennsylvania, Forenede Stater, 19380
        • West Chester Cardiology, Pc
      • Yardley, Pennsylvania, Forenede Stater, 19067
        • Cardiology Consultants of Philadelphia
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02903
        • Rhode Island Hospital
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • Southeastern Research Associates, Inc
      • Beaufort, South Carolina, Forenede Stater, 29906
        • Lowcountry Medical Group, Llc
      • Beaufort, South Carolina, Forenede Stater, 29906
        • Lowcountry Medical Group
      • Charleston, South Carolina, Forenede Stater, 29425
        • Medical University of South Carolina
      • Columbia, South Carolina, Forenede Stater, 29203
        • Columbia Heart Clinic
      • Greenville, South Carolina, Forenede Stater, 29607
        • Upstate Cardiology
      • Greer, South Carolina, Forenede Stater, 29650
        • Internal Medicine Of Greer
      • Orangeburg, South Carolina, Forenede Stater, 29118
        • Palmetto Nephrology Pa
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • S. Carolina Pharmaceutical Research
    • South Dakota
      • Pierre, South Dakota, Forenede Stater, 57501
        • Avera Medical Associates Clinic
    • Tennessee
      • Bristol, Tennessee, Forenede Stater, 37620
        • Holston Medical Group
      • Kingsport, Tennessee, Forenede Stater, 37660
        • Holston Medical Group
      • Knoxville, Tennessee, Forenede Stater, 37920
        • Volunteer Research Group
      • Knoxville, Tennessee, Forenede Stater, 37916
        • Knoxville Heart Group
      • Knoxville, Tennessee, Forenede Stater, 37920-1502
        • Volunteer Research Group
      • Tullahoma, Tennessee, Forenede Stater, 37388
        • Tennessee Center For Clinical Trials
    • Texas
      • Amarillo, Texas, Forenede Stater, 79106
        • Amarillo Heart Clinical Research Institute Inc.
      • Corsicana, Texas, Forenede Stater, 75110
        • Corsicana Medical Research, PLLC
      • Dallas, Texas, Forenede Stater, 75226
        • Soltero Cardiovascular Research Center
      • Dallas, Texas, Forenede Stater, 75230
        • HeartPlace
      • Fort Worth, Texas, Forenede Stater, 76104
        • Heart Center of North Texas
      • Houston, Texas, Forenede Stater, 77030
        • The Methodist Hospital
      • Houston, Texas, Forenede Stater, 77030
        • The University of Texas MD Anderson Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • Center For Atrial Fibrillation
      • Houston, Texas, Forenede Stater, 77030
        • The Methodist Hospital Neurology Institute
      • Houston, Texas, Forenede Stater, 77065
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Forenede Stater, 77070
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Forenede Stater, 77074
        • Francisco R. Maislos
      • Houston, Texas, Forenede Stater, 77090
        • Woodlands North Houston Heart Center
      • Humble, Texas, Forenede Stater, 77338
        • Regional Medical Center And Diagnostic Clinics
      • Lackland Air Force Base, Texas, Forenede Stater, 78236
        • Wilford Hall Medical Center
      • Lackland Air Force Base, Texas, Forenede Stater, 78236-9908
        • Wilford Hall Medical Center
      • Longview, Texas, Forenede Stater, 75605
        • DCOL Center for Clinical Research
      • McKinney, Texas, Forenede Stater, 75069
        • North Dallas Research Associates
      • Plano, Texas, Forenede Stater, 75093
        • North Texas Medical Research
      • Plano, Texas, Forenede Stater, 75024
        • Legacy Heart Center
      • San Antonio, Texas, Forenede Stater, 78229
        • Covenant Clinical Research, Pa
      • San Antonio, Texas, Forenede Stater, 78217
        • Bhs Specialty Network, Inc
      • San Antonio, Texas, Forenede Stater, 78229
        • Star Clinical Trails
      • Seguin, Texas, Forenede Stater, 78155
        • Edward Balli, Md, Pa
      • Tomball, Texas, Forenede Stater, 77375
        • Northwest Heart Center
      • Tyler, Texas, Forenede Stater, 75701
        • Tyler Cardiovascular Consultants
      • Tyler, Texas, Forenede Stater, 75708
        • University of Texas Health Science Center at Tyler
      • Tyler, Texas, Forenede Stater, 75708
        • The Univ. Of Texas Health Science Ctr. At Tyler
    • Utah
      • Layton, Utah, Forenede Stater, 84041
        • Utah Cardiology P.C
    • Virginia
      • Norfolk, Virginia, Forenede Stater, 23510
        • Sentara York Clinical Research
      • Richmond, Virginia, Forenede Stater, 23220
        • Medical Research Initiatives
      • Roanoke, Virginia, Forenede Stater, 24014
        • Roanoke Heart Institute, Plc
      • Virginia Beach, Virginia, Forenede Stater, 23454
        • Cardiovascular Associates
    • Washington
      • Burien, Washington, Forenede Stater, 98166
        • Daniel W. Gottlieb, Md, Ps
      • Burien, Washington, Forenede Stater, 98166
        • Daniel William Gottlieb, Md
      • Spokane, Washington, Forenede Stater, 99202
        • Rockwood Clinic Research Cent.
      • Walla Walla, Washington, Forenede Stater, 99362
        • Walla Walla Clinic
    • West Virginia
      • Lewisburg, West Virginia, Forenede Stater, 24901
        • Lynn N. Smith, Md
    • Wisconsin
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Cardiology Associates Of Green Bay Ltd-Bellin Hospital
      • Madison, Wisconsin, Forenede Stater, 53715
        • St. Mary's Hospital
      • Madison, Wisconsin, Forenede Stater, 53715
        • St.Mary's Hospital
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Health Care
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Cardiology Assc. Of Waukesha
  • Frankrig
      • Amiens Cedex 1, Frankrig, 80054
        • Local Institution
      • Bordeaux Cedex, Frankrig, 33075
        • Local Institution
      • Brest, Frankrig, 29609
        • Local Institution
      • Grenoble Cedex 09, Frankrig, 38043
        • Local Institution
      • La Seyne Sur Mer, Frankrig, 83500
        • Local Institution
      • Paris Cedex 18, Frankrig, 75018
        • Local Institution
      • Six Fours Les Plages, Frankrig, 83140
        • Local Institution
  • Holland
      • Breda, Holland, 4818 CK
        • Local Institution
      • Deventer, Holland, 7416 SE
        • Local Institution
      • Eindhoven, Holland, 5623 EJ
        • Local Institution
      • Eindhoven, Holland, 5623EJ
        • Local Institution
      • Enschede, Holland, 7513 ER
        • Local Institution
      • Hardenberg, Holland, 7772 SE
        • Local Institution
      • Hilversum, Holland, 1213 XZ
        • Local Institution
      • Nijmegen, Holland, 6525 GA
        • Local Institution
      • Oss, Holland, 5342 BT
        • Local Institution
      • Rotterdam, Holland, 3045 PM
        • Local Institution
      • S-Hertogenbosch, Holland, 5211 NL
        • Local Institution
      • Tiel, Holland, 4002 WP
        • Local Institution
      • Utrecht, Holland, 3582 KE
        • Local Institution
      • Velp, Holland, 6883 AZ
        • Local Institution
  • Hong Kong
      • Hong Kong, Hong Kong
        • Local Institution
      • Shatin, Hong Kong
        • Local Institution
  • Indien
      • Ahmedabad, Indien, 380014
        • Local Institution
      • Annamalainagar, Indien, 608002
        • Local Institution
      • Bangalore, Indien, 560052
        • Local Institution
      • Chennai, Indien, 600006
        • Local Institution
      • Hyderabad, Indien, 500001
        • Local Institution
      • Hyderabad, Indien, 500044
        • Local Institution
      • Indore, Indien, 452014
        • Local Institution
      • Indore, Indien, 452001
        • Local Institution
      • Kolkata, Indien, 700054
        • Local Institution
      • Kottayam, Indien, 686016
        • Local Institution
      • Lucknow, Indien, 226003
        • Local Institution
      • Mumbai Naka, Indien, 422005
        • Local Institution
      • Nashik, Indien, 422002
        • Local Institution
      • New Delhi, Indien, 110025
        • Local Institution
      • New Delhi, Indien, 110060
        • Local Institution
      • New Delhi, Indien, 116025
        • Local Institution
      • Pune, Indien, 411001
        • Local Institution
      • Pune, Indien, 411004
        • Local Institution
      • Thrissur, Indien, 680002
        • Local Institution
      • Vijayawada, Indien, 520008
        • Local Institution
    • Andhra Pradesh
      • Visakhapatnam, Andhra Pradesh, Indien, 530003
        • Local Institution
    • Andhrapradesh
      • Visakhapatnam, Andhrapradesh, Indien, 530002
        • Local Institution
    • Andra Pradesh
      • Hyderabad, Andra Pradesh, Indien, 500004
        • Local Institution
    • Gujarat
      • Ahmedabad, Gujarat, Indien, 380060
        • Local Institution
      • Vadodara, Gujarat, Indien, 390007
        • Local Institution
    • Karnataka
      • Bangalore, Karnataka, Indien, 560054
        • Local Institution
      • Bangalore, Karnataka, Indien, 5600034
        • Local Institution
      • Bangalore, Karnataka, Indien, 560094
        • Local Institution
      • Mysore, Karnataka, Indien, 570004
        • Local Institution
    • Kerela
      • Calicut, Kerela, Indien, 673 004
        • Local Institution
    • Maharashta
      • Pune, Maharashta, Indien, 411011
        • Local Institution
    • Maharashtra
      • Nagpur, Maharashtra, Indien, 440010
        • Local Institution
      • Nagpur, Maharashtra, Indien, 440012
        • Local Institution
      • Pune, Maharashtra, Indien, 411001
        • Local Institution
      • Pune, Maharashtra, Indien, 421006
        • Local Institution
    • Punjab
      • Jalandhar, Punjab, Indien, 144008
        • Local Institution
    • Rajasthan
      • Bikaner, Rajasthan, Indien, 334001
        • Local Institution
      • Bikaner, Rajasthan, Indien, 334003
        • Local Institution
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, Indien, 226003
        • Local Institution
  • Israel
      • Afula, Israel, 18101
        • Local Institution
      • Ashkelon, Israel, 78306
        • Local Institution
      • Givatayim, Israel, 53583
        • Local Institution
      • Hadera, Israel, 38100
        • Local Institution
      • Haifa, Israel, 31096
        • Local Institution
      • Haifa, Israel, 34362
        • Local Institution
      • Holon, Israel, 58100
        • Local Institution
      • Jerusalem, Israel, 91120
        • Local Institution
      • Jerusalem, Israel, 91240
        • Local Institution
      • Kfar-Saba, Israel, 44281
        • Local Institution
      • Nazareth, Israel, 16100
        • Local Institution
      • Nazareth, Israel, 16000
        • Local Institution
      • Petach-Tikva, Israel, 49100
        • Local Institution
      • Safed, Israel, 13100
        • Local Institution
      • Tel Aviv, Israel, 64239
        • Local Institution
  • Italien
      • Ascoli Piceno, Italien, 63100
        • Local Institution
      • Campobasso, Italien, 86100
        • Local Institution
      • Chieti, Italien, 66013
        • Local Institution
      • Cremona, Italien, 26100
        • Local Institution
      • Fidenza (Pr), Italien, 43036
        • Local Institution
      • Genova, Italien, 16132
        • Local Institution
      • Isernia, Italien, 86170
        • Local Institution
      • Livorno, Italien, 57100
        • Local Institution
      • Milano, Italien, 20132
        • Local Institution
      • Napoli, Italien, 80131
        • Local Institution
      • Palermo, Italien, 90127
        • Local Institution
      • Reggio Emilia, Italien, 42100
        • Local Institution
      • Roma, Italien, 00168
        • Local Institution
      • San Daniele De Friuli, Italien, 33038
        • Local Institution
      • Torino, Italien, 10153
        • Local Institution
      • Vittorio Veneto (Tv), Italien, 31029
        • Local Institution
    • Lucca
      • Lido Di Camaiore, Lucca, Italien, 55043
        • Local Institution
  • Japan
      • Fukui, Japan, 9100067
        • Local Institution
      • Kagoshima, Japan, 8920822
        • Local Institution
      • Kyoto, Japan, 6168152
        • Local Institution
      • Nagasaki, Japan, 852-8102
        • Local Institution
      • Oita, Japan, 8700033
        • Local Institution
      • Osaka, Japan, 558-8558
        • Local Institution
      • Osaka, Japan, 551-0032
        • Local Institution
      • Osaka, Japan, 5510032
        • Local Institution
      • Saga, Japan, 8490917
        • Local Institution
    • Fukuoka
      • Itoshima City, Fukuoka, Japan, 819-1104
        • Local Institution
      • Kurume, Fukuoka, Japan, 8390863
        • Local Institution
      • Ohkawa-City, Fukuoka, Japan, 8310016
        • Local Institution
    • Fukushima
      • Shirakawa City, Fukushima, Japan, 961-0005
        • Local Institution
    • Gunma
      • Takasaki City, Gunma, Japan, 3700829
        • Local Institution
    • Hokkaido
      • Asahikawa-Shi, Hokkaido, Japan, 0788214
        • Local Institution
      • Katou-Gun, Hokkaido, Japan, 0800111
        • Local Institution
      • Katou-gun, Hokkaido, Japan, 080111
        • Local Institution
      • Sapporo-Shi, Hokkaido, Japan, 0028043
        • Local Institution
      • Tomakomai-Shi, Hokkaido, Japan, 002-8043
        • Local Institution
      • Tomakomai-shi, Hokkaido, Japan, 0028043
        • Local Institution
      • Yubari, Hokkaido, Japan, 0680402
        • Local Institution
    • Hyogo
      • Kobe, Hyogo, Japan, 6540026
        • Local Institution
    • Kagoshima Prefecture
      • Izumi City, Kagoshima Prefecture, Japan, 8990131
        • Local Institution
    • Kanagawa
      • Isehara, Kanagawa, Japan, 2591193
        • Local Institution
      • Yokohama, Kanagawa, Japan, 2458575
        • Local Institution
      • Yokohama City, Kanagawa, Japan, 2278501
        • Local Institution
      • Yokosuka, Kanagawa, Japan, 2388567
        • Local Institution
    • Miyagi
      • Sendai City, Miyagi, Japan, 983-8520
        • Local Institution
    • Nara
      • Nara City, Nara, Japan, 630-8305
        • Local Institution
    • Osaka
      • Izumi City, Osaka, Japan, 594-0071
        • Local Institution
      • Osaka City, Osaka, Japan, 5330022
        • Local Institution
      • Osaka-Shi, Osaka, Japan, 540-0006
        • Local Institution
      • Osaka-shi, Osaka, Japan, 5400006
        • Local Institution
      • Suita-City, Osaka, Japan, 5658565
        • Local Institution
      • Takatsuki City, Osaka, Japan, 5690852
        • Local Institution
      • Yao, Osaka, Japan, 5810036
        • Local Institution
    • Saga
      • Saga City, Saga, Japan, 840-8571
        • Local Institution
      • Saga City, Saga, Japan, 849-8501
        • Local Institution
    • Saitama
      • Kasukabe-Shi, Saitama, Japan, 344-0035
        • Local Institution
      • Kasukabe-shi, Saitama, Japan, 3440035
        • Local Institution
    • Tokyo
      • Itabashi-Ku, Tokyo, Japan, 173-0015
        • Local Institution
      • Itabashi-ku, Tokyo, Japan, 1730015
        • Local Institution
      • Meguro-Ku, Tokyo, Japan, 153-8515
        • Local Institution
      • Meguro-ku, Tokyo, Japan, 1538515
        • Local Institution
      • Shinagawa-Ku, Tokyo, Japan, 1428666
        • Local Institution
    • Toyama
      • Toyama City, Toyama, Japan, 9308550
        • Local Institution
    • Yamaguchi
      • Iwakuni, Yamaguchi, Japan, 7400021
        • Local Institution
  • Kalkun
      • Ankara, Kalkun, 06100
        • Local Institution
      • Eskisehir, Kalkun, 26480
        • Local Institution
      • Izmir, Kalkun, 35100
        • Local Institution
  • Kina
    • Beijing
      • Beijing, Beijing, Kina, 100050
        • Local Institution
      • Beijing, Beijing, Kina, 100001
        • Local Institution
      • Beijing, Beijing, Kina, 100853
        • Local Institution
      • Beijing, Beijing, Kina, 100020
        • Local Institution
      • Beijing, Beijing, Kina, 100088
        • Local Institution
      • Beijing, Beijing, Kina, 100101
        • Local Institution
    • Gansu
      • Lanzhou, Gansu, Kina, 730000
        • Local Institution
      • Lanzhou, Gansu, Kina, 730030
        • Local Institution
    • Guangdong
      • Guangzhou, Guangdong, Kina, 510080
        • Local Institution
      • Guangzhou, Guangdong, Kina, 510120
        • Local Institution
    • Hebei
      • Shijiazhuang, Hebei, Kina, 050000
        • Local Institution
    • Heilongjiang
      • Daqing, Heilongjiang, Kina, 163001
        • Local Institution
      • Haerbin, Heilongjiang, Kina, 150086
        • Local Institution
      • Haerbin, Heilongjiang, Kina, 150001
        • Local Institution
    • Hubei
      • Wuhan, Hubei, Kina, 430060
        • Local Institution
    • Hunan
      • Changsha, Hunan, Kina, 410000
        • Local Institution
    • Jiangsu
      • Hangzhou, Jiangsu, Kina, 310009
        • Local Institution
      • Nanjing, Jiangsu, Kina, 210029
        • Local Institution
    • Liaoning
      • Dalian, Liaoning, Kina, 116011
        • Local Institution
      • Dalian, Liaoning, Kina, 116021
        • Local Institution
      • Dalian, Liaoning, Kina, 116027
        • Local Institution
      • Shenyang, Liaoning, Kina, 110016
        • Local Institution
      • Shenyang, Liaoning, Kina, 110003
        • Local Institution
    • Shandong
      • Jinan, Shandong, Kina, 250012
        • Local Institution
      • Jinan, Shandong, Kina, 250033
        • Local Institution
      • Qingdao, Shandong, Kina, 266011
        • Local Institution
    • Shanghai
      • Shanghai, Shanghai, Kina, 200080
        • Local Institution
      • Shanghai, Shanghai, Kina, 200025
        • Local Institution
      • Shanghai, Shanghai, Kina, 200433
        • Local Institution
      • Shanghai, Shanghai, Kina, 200011
        • Local Institution
      • Shanghai, Shanghai, Kina, 200233
        • Local Institution
      • Shanghai, Shanghai, Kina, 200003
        • Local Institution
      • Shanghai, Shanghai, Kina, 100037
        • Local Institution
      • Shanghai, Shanghai, Kina, 200031
        • Local Institution
    • Sichuan
      • Chengdu, Sichuan, Kina, 610041
        • Local Institution
      • Chongqing, Sichuan, Kina, 400010
        • Local Institution
    • Zhejiang
      • Hangzhou, Zhejiang, Kina, 310009
        • Local Institution
  • Korea, Republikken
      • Busan, Korea, Republikken, 602-702
        • Local Institution
      • Daegu, Korea, Republikken, 700-712
        • Local Institution
      • Daegu, Korea, Republikken, 705-717
        • Local Institution
      • Daejon, Korea, Republikken, 302-718
        • Local Institution
      • Goyang, Korea, Republikken, 411-706
        • Local Institution
      • Gwang Ju, Korea, Republikken, 501-757
        • Local Institution
      • Gyeonggi, Korea, Republikken, 463-707
        • Local Institution
      • Pusan, Korea, Republikken, 602-739
        • Local Institution
      • Scongnam-Si, Korea, Republikken, 463-712
        • Local Institution
      • Seoul, Korea, Republikken, 110-744
        • Local Institution
      • Seoul, Korea, Republikken, 143-729
        • Local Institution
      • Seoul, Korea, Republikken, 130-709
        • Local Institution
      • Suwon, Korea, Republikken, 443-721
        • Local Institution
    • Gyeonggi-Do
      • Anyang-Si, Gyeonggi-Do, Korea, Republikken, 431-070
        • Local Institution
    • Korea
      • Incheon, Korea, Korea, Republikken, 400-711
        • Local Institution
  • Malaysia
      • Kuala Lumpur, Malaysia, 56000
        • Local Institution
      • Kuala Lumpur, Malaysia, 59100
        • Local Institution
    • Kelantan
      • Kubang Kerian, Kelantan, Malaysia, 16150
        • Local Institution
    • Sarawak
      • Kota Samarahan, Sarawak, Malaysia, 94300
        • Local Institution
    • Selangor
      • Batu Caves, Selangor, Malaysia, 68100
        • Local Institution
  • Mexico
      • Puebla, Mexico, 11490
        • Local Institution
      • Queretaro, Mexico, 76000
        • Local Institution
    • BAJA California
      • Tijuana, BAJA California, Mexico, 22500
        • Local Institution
    • Distrito Federal
      • Col. Toriello Guerra, Distrito Federal, Mexico, CP 14050
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 06726
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 14080
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 07760
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 06070
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 10700
        • Local Institution
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44200
        • Local Institution
      • Guadalajara, Jalisco, Mexico, 44600
        • Local Institution
      • Guadalajara, Jalisco, Mexico, 44656
        • Local Institution
    • Michoacan
      • Morelia, Michoacan, Mexico, 58000
        • Local Institution
    • Nuevo LEON
      • Monterrey, Nuevo LEON, Mexico, 64710
        • Local Institution
      • Monterrey, Nuevo LEON, Mexico, 64000
        • Local Institution
      • Monterrey, Nuevo LEON, Mexico, 64700
        • Local Institution
    • Sinaloa
      • Culiacan, Sinaloa, Mexico, 80020
        • Local Institution
    • Veracruz
      • Jalapa, Veracruz, Mexico, 91020
        • Local Institution
  • Norge
      • Alesund, Norge, 6003
        • Local Institution
      • Bergen, Norge, 5021
        • Local Institution
      • Bergen, Norge, N-5021
        • Local Institution
      • Elverum, Norge, 2408
        • Local Institution
      • Flekkefjord, Norge, 4400
        • Local Institution
      • Nesttun, Norge, 5221
        • Local Institution
      • Oslo, Norge, 0407
        • Local Institution
      • Skien, Norge, 3710
        • Local Institution
      • Stavanger, Norge, 4064
        • Local Institution
      • Straume, Norge, 5353
        • Local Institution
      • Tonsberg, Norge, 3116
        • Local Institution
      • Tromso, Norge, 9038
        • Local Institution
  • Peru
      • Lima, Peru, LIMA 33
        • Local Institution
      • Lima, Peru, LIMA 01
        • Local Institution
      • Lima, Peru, LIMA 1
        • Local Institution
    • Callao
      • Bellavista, Callao, Peru, 2176
        • Local Institution
      • Bellavista, Callao, Peru, CALLAO 2
        • Local Institution
    • Lambayeque
      • Chiclayo, Lambayeque, Peru, CIX
        • Local Institution
    • Lima
      • Jesus Maria, Lima, Peru, 11
        • Local Institution
      • Jesus Maria, Lima, Peru, LIMA 11
        • Local Institution
      • Miraflores, Lima, Peru, LIMA 18
        • Local Institution
      • San Borja, Lima, Peru, LIMA 41
        • Local Institution
      • San Martin De Porres, Lima, Peru, LIMA 31
        • Local Institution
  • Polen
      • Gdynia, Polen, 81-423
        • Local Institution
      • Gdynia, Polen, 81-472
        • Local Institution
      • Gdynia, Polen, 81-519
        • Local Institution
      • Grodzisk Mazowiecki, Polen, 05-825
        • Local Institution
      • Inowroclaw, Polen, 88-100
        • Local Institution
      • Kielce, Polen, 25-736
        • Local Institution
      • Kielce, Polen, 25-763
        • Local Institution
      • Krakow, Polen, 31-202
        • Local Institution
      • Krakow, Polen, 30-092
        • Local Institution
      • Krakow, Polen, 31-135
        • Local Institution
      • Lodz, Polen, 91-347
        • Local Institution
      • Lodz, Polen, 91347
        • Local Institution
      • Piotrkow Trybunalski, Polen, 97-300
        • Local Institution
      • Plock, Polen, 09-402
        • Local Institution
      • Plock, Polen, 09-400
        • Local Institution
      • Plonsk, Polen, 09-100
        • Local Institution
      • Poznan, Polen, 60-531
        • Local Institution
      • Poznan, Polen, 60479
        • Local Institution
      • Ruda Slaska, Polen, 41-703
        • Local Institution
      • Skierniewice, Polen, 96-100
        • Local Institution
      • Slupsk, Polen, 76-200
        • Local Institution
      • Torun, Polen, 87100
        • Local Institution
      • Warszawa, Polen, 01-138
        • Local Institution
      • Warszawa, Polen, 04-073
        • Local Institution
      • Warszawa, Polen, 04-628
        • Local Institution
      • Warszawa, Polen, 04-749
        • Local Institution
      • Wegrow, Polen, 07100
        • Local Institution
  • Puerto Rico
      • Cayey, Puerto Rico, 00736
        • Local Institution
      • Cidra, Puerto Rico, 00739
        • Local Institution
      • Ponce, Puerto Rico, 00717
        • Local Institution
  • Rumænien
      • Baia Mare, Rumænien, 430031
        • Local Institution
      • Bucharest, Rumænien, 011192
        • Local Institution
      • Bucharest, Rumænien, 020125
        • Local Institution
      • Bucharest, Rumænien, 050098
        • Local Institution
      • Bucharest, Rumænien, 021659
        • Local Institution
      • Bucharest, Rumænien, 030572
        • Local Institution
      • Cluj Napoca, Rumænien, 400001
        • Local Institution
      • Cluj Napoca, Rumænien, 400347
        • Local Institution
      • Iasi, Rumænien, 700503
        • Local Institution
      • Oradea, Rumænien, 410169
        • Local Institution
      • Sibiu, Rumænien, 550245
        • Local Institution
      • Targu-Mures, Rumænien, 540103
        • Local Institution
      • Timisoara, Rumænien, 300024
        • Local Institution
      • Timisoara, Rumænien, 300320
        • Local Institution
      • Tirgu Mures, Rumænien, 540136
        • Local Institution
  • Schweiz
      • Baden, Schweiz, 5404
        • Local Institution
      • Bern, Schweiz, 3010
        • Local Institution
  • Singapore
      • Singapore, Singapore, 168752
        • Local Institution
  • Spanien
      • Albacete, Spanien, 02006
        • Local Institution
      • Barcelona, Spanien, 08035
        • Local Institution
      • Barcelona, Spanien, 08003
        • Local Institution
      • Elda, Spanien, 03600
        • Local Institution
      • Figueres, Spanien, 17600
        • Local Institution
      • Gerona, Spanien, 17007
        • Local Institution
      • Las Palmas, Spanien, 35010
        • Local Institution
      • Madrid, Spanien, 28006
        • Local Institution
      • Madrid, Spanien, 28046
        • Local Institution
      • Madrid, Spanien, 28040
        • Local Institution
      • Palma De Mallorca, Spanien, 07010
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        • Local Institution
      • Tarragona, Spanien, 43007
        • Local Institution
      • Viladecans, Spanien, 08840
        • Local Institution
    • Alicante
      • San Juan, Alicante, Spanien, 03550
        • Local Institution
      • Torrevieja, Alicante, Spanien, 03186
        • Local Institution
    • Almeria
      • La Canada, Almeria, Spanien, 04120
        • Local Institution
    • Galicia
      • Lugo, Galicia, Spanien, 27003
        • Local Institution
  • Sverige
      • Goteberg, Sverige, 413 45
        • Local Institution
      • Helsingborg, Sverige, 251 87
        • Local Institution
      • Linkoping, Sverige, 581 85
        • Local Institution
      • Lund, Sverige, 222 21
        • Local Institution
      • Orebro, Sverige, 70185
        • Local Institution
      • Orebro, Sverige, 701 85
        • Local Institution
      • Skelleftea, Sverige, 931 86
        • Local Institution
      • Stockholm, Sverige, 141 86
        • Local Institution
      • Stockholm, Sverige, 171 76
        • Local Institution
      • Stockholm, Sverige, 111 57
        • Local Institution
      • Stockholm, Sverige, 118 83
        • Local Institution
      • Stockholm, Sverige, 111 35
        • Local Institution
      • Uppsala, Sverige, 751 85
        • Local Institution
      • Vaxjo, Sverige, 351 85
        • Local Institution
  • Sydafrika
    • Bloemfontein
      • Westdene, Bloemfontein, Sydafrika, 9301
        • Local Institution
    • Cape Town
      • Observatory, Cape Town, Sydafrika, 7925
        • Local Institution
    • Gauteng
      • Pretoria, Gauteng, Sydafrika, 0084
        • Local Institution
      • Pretoria, Gauteng, Sydafrika, 0132
        • Local Institution
    • KWA ZULU Natal
      • Richards Bay, KWA ZULU Natal, Sydafrika, 3900
        • Local Institution
    • Western CAPE
      • Bellville Cape Town, Western CAPE, Sydafrika, 7530
        • Local Institution
      • George, Western CAPE, Sydafrika, 6529
        • Local Institution
      • Parow, Western CAPE, Sydafrika, 7505
        • Local Institution
      • Somerset West, Western CAPE, Sydafrika, 7130
        • Local Institution
      • Worcester, Western CAPE, Sydafrika, 6850
        • Local Institution
  • Taiwan
      • Taipei, Taiwan, 100
        • Local Institution
      • Taipei, Taiwan, 112
        • Local Institution
      • Taipei, Taiwan, 111
        • Local Institution
      • Taipei, Taiwan, 220
        • Local Institution
      • Taipei, Taiwan, 10449
        • Local Institution
      • Taipei, Taiwan, 104
        • Local Institution
  • Tjekkiet
      • Boskovice, Tjekkiet, 680 21
        • Local Institution
      • Brno, Tjekkiet, 625 00
        • Local Institution
      • Brno-Malomerice, Tjekkiet, 614 00
        • Local Institution
      • Ivancice, Tjekkiet, 664 91
        • Local Institution
      • Kladno, Tjekkiet, 272 59
        • Local Institution
      • Litomysl, Tjekkiet, 570 14
        • Local Institution
      • Mestec Kralove, Tjekkiet, 289 03
        • Local Institution
      • Ostrava, Tjekkiet, 70852
        • Local Institution
      • Prague 13, Tjekkiet, 158 00
        • Local Institution
      • Prague 2, Tjekkiet, 128 08
        • Local Institution
      • Pribram, Tjekkiet, 261 01
        • Local Institution
      • Usti Nad Orlici, Tjekkiet, 562 18
        • Local Institution
  • Tyskland
      • Aachen, Tyskland, 52074
        • Local Institution
      • Bad Krozingen, Tyskland, 79189
        • Local Institution
      • Bad Neustadt/ Salle, Tyskland, 97616
        • Local Institution
      • Bad Oeynhausen, Tyskland, 32545
        • Local Institution
      • Berlin, Tyskland, 13353
        • Local Institution
      • Berlin, Tyskland, 14050
        • Local Institution
      • Berlin, Tyskland, 10787
        • Local Institution
      • Berlin, Tyskland, 10789
        • Local Institution
      • Berlin, Tyskland, 12043
        • Local Institution
      • Berlin-Kopenick, Tyskland, 12559
        • Local Institution
      • Betzdorf, Tyskland, 57518
        • Local Institution
      • Bochum, Tyskland, 44791
        • Local Institution
      • Bochum, Tyskland, 44789
        • Local Institution
      • Bonn, Tyskland, 53127
        • Local Institution
      • Coburg, Tyskland, 96450
        • Local Institution
      • Dillingen, Tyskland, 66763
        • Local Institution
      • Dresden, Tyskland, 01099
        • Local Institution
      • Duisburg, Tyskland, 47139
        • Local Institution
      • Essen, Tyskland, 45122
        • Local Institution
      • Frankfurt Am Main, Tyskland, 60594
        • Local Institution
      • Gottingen, Tyskland, 37075
        • Local Institution
      • Halle/Saale, Tyskland, 06120
        • Local Institution
      • Hannover, Tyskland, 30625
        • Local Institution
      • Heidelberg, Tyskland, 69120
        • Local Institution
      • Heidelberg, Tyskland, 69115
        • Local Institution
      • Kassel, Tyskland, 34121
        • Local Institution
      • Lahr, Tyskland, 77933
        • Local Institution
      • Ludwigshafen, Tyskland, 67063
        • Local Institution
      • Ludwigshafen, Tyskland, 67073
        • Local Institution
      • Mannheim, Tyskland, 68167
        • Local Institution
      • Marburg, Tyskland, 35043
        • Local Institution
      • Munchen, Tyskland, 81675
        • Local Institution
      • Munchen, Tyskland, 80636
        • Local Institution
      • Munchen, Tyskland, 81545
        • Local Institution
      • Osnabruck, Tyskland, 49076
        • Local Institution
      • Regensburg, Tyskland, 93053
        • Local Institution
      • Riesa, Tyskland, D-01587
        • Local Institution
      • Rostiock, Tyskland, 18057
        • Local Institution
      • Trier, Tyskland, 54292
        • Local Institution
      • Waren, Tyskland, 17192
        • Local Institution
      • Witten, Tyskland, 58455
        • Local Institution
      • Wolmirstedt, Tyskland, 39326
        • Local Institution
      • Worms, Tyskland, 67550
        • Local Institution
  • Ukraine
      • Chernivtsy, Ukraine, 58013
        • Local Institution
      • Dnipropetrovsk, Ukraine, 49006
        • Local Institution
      • Dnipropetrovsk, Ukraine, 49060
        • Local Institution
      • Donetsk, Ukraine, 83045
        • Local Institution
      • Donetsk, Ukraine, 83003
        • Local Institution
      • Donetsk, Ukraine, 83114
        • Local Institution
      • Ivano-Frankivsk, Ukraine, 76025
        • Local Institution
      • Kharkiv, Ukraine, 61018
        • Local Institution
      • Kharkiv, Ukraine, 61115
        • Local Institution
      • Kharkov, Ukraine, 61039
        • Local Institution
      • Kharkov, Ukraine, 61002
        • Local Institution
      • Kharkov, Ukraine, 61178
        • Local Institution
      • Kiev, Ukraine, 01032
        • Local Institution
      • Kyiv, Ukraine, 03680
        • Local Institution
      • Kyiv, Ukraine, 02091
        • Local Institution
      • Kyiv, Ukraine, 03049
        • Local Institution
      • Kyiv, Ukraine, 03115
        • Local Institution
      • Kyiv, Ukraine, 04050
        • Local Institution
      • Kyiv, Ukraine, 04107
        • Local Institution
      • Kyiv, Ukraine, 01023
        • Local Institution
      • Kyiv, Ukraine, 02660
        • Local Institution
      • Kyiv, Ukraine, 01103
        • Local Institution
      • Lugansk, Ukraine, 91011
        • Local Institution
      • Lugansk, Ukraine, 91016
        • Local Institution
      • Lutsk, Ukraine, 43024
        • Local Institution
      • Lviv, Ukraine, 79013
        • Local Institution
      • Lviv, Ukraine, 79015
        • Local Institution
      • Mykolayiv, Ukraine, 54003
        • Local Institution
      • Odessa, Ukraine, 65009
        • Local Institution
      • Odessa, Ukraine, 65039
        • Local Institution
      • Odessa, Ukraine, 65114
        • Local Institution
      • Odessa, Ukraine, 65025
        • Local Institution
      • Uzhgorod, Ukraine, 88000
        • Local Institution
      • Vinnitsa, Ukraine, 21029
        • Local Institution
      • Zaporozhye, Ukraine, 69035
        • Local Institution
      • Zhytomyr, Ukraine, 10002
        • Local Institution
  • Ungarn
      • Budapest, Ungarn, 1125
        • Local Institution
      • Budapest, Ungarn, 1023
        • Local Institution
      • Budapest, Ungarn, 1032
        • Local Institution
      • Budapest, Ungarn, 1096
        • Local Institution
      • Budapest, Ungarn, 1085
        • Local Institution
      • Debrecen, Ungarn, 4032
        • Local Institution
      • Dunaujvaros, Ungarn, 2400
        • Local Institution
      • Gyor, Ungarn, 9023
        • Local Institution
      • Gyula, Ungarn, 5700
        • Local Institution
      • Hodmezovasarhely, Ungarn, 6800
        • Local Institution
      • Komarom, Ungarn, 2921
        • Local Institution
      • Mosonmagyarovar, Ungarn, 9200
        • Local Institution
      • Oroshaza, Ungarn, 5900
        • Local Institution
      • Pecs, Ungarn, 7624
        • Local Institution
      • Siofok, Ungarn, 8600
        • Local Institution
      • Siofok, Ungarn, 8601
        • Local Institution
      • Sopron, Ungarn, 9400
        • Local Institution
      • Szentes, Ungarn, 6600
        • Local Institution
      • Zalaegerszeg, Ungarn, 8900
        • Local Institution
  • Østrig
      • Graz, Østrig, 8036
        • Local Institution
      • Oberpullendorf, Østrig, 7350
        • Local Institution
      • Vienna, Østrig, 1160
        • Local Institution

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
  • Age ≥ 75, previous stroke
  • transient ischemic attack (TIA) or Systemic Embolism (SE)
  • Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
  • Diabetes mellitus or hypertension requiring pharmacological treatment

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Forebyggelse
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: 2
Medicin: apixaban
Oral tablets, 5.0 mg or 2.5 mg, twice daily
Andre navne:
  • BMS-562247
Aktiv komparator: 1
Medicin: warfarin
Oral tablets, 2.0 mg, adjusted to an INR of 2.5 (range 2.0 to 3.0)
Andre navne:
  • Coumadin
  • BMS-565793

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period
Tidsramme: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period
Tidsramme: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period
Tidsramme: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated All-Cause Death During the Intended Treatment Period
Tidsramme: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period
Tidsramme: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period
Tidsramme: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period
Tidsramme: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period
Tidsramme: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With All Bleeding Events During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of All Bleeding Events During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Andre resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
AE: all SAEs or AEs with onset from first dose through 2 days (AEs) or 30 days (SAEs) after the last dose of blinded study drug (BSD). SAE: all SAEs with onset from first dose through 30 days after the last dose of BSD. Bleeding AE: all serious or non-serious bleeding-related AEs with onset from first dose through 2 days after the last dose of BSD. Discontinuations due to AE: all SAEs or AEs with onset from first dose of BSD and with action taken=drug discontinued. Deaths: all deaths occurring from first dose through 30 days after the last dose of BSD.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated GUSTO bleeding events per 100 patient years. GUSTO Bleeding Criteria: GUSTO severe (or life-threatening) bleeding: either intracranial hemorrhage or bleeding that causes hemodynamic compromise and requires intervention. GUSTO moderate bleeding: bleeding that requires blood transfusion but does not result in hemodynamic compromise.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated TIMI bleeding events per 100 patient years. TIMI Bleeding Criteria: Major bleeding=Intracranial bleeding and/or clinically overt bleeding associated with ≥5 gm/dL fall in Hgb or 15% fall in hematocrit (Hct) from baseline, accounting for transfusions. Minor bleeding=Clinically overt bleeding associated with ≥3 gm/dL fall in Hgb or a ≥10% fall in Hct from baseline, accounting for transfusions.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Net-Clinical Benefit During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Net-Clinical Benefit During Treatment Period
Tidsramme: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of events of net-clinical benefit per 100 patient years. Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Bristol-Myers Squibb

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

31. december 2006

Primær færdiggørelse (Faktiske)

25. maj 2011

Studieafslutning (Faktiske)

25. maj 2011

Datoer for studieregistrering

Først indsendt

18. december 2006

Først indsendt, der opfyldte QC-kriterier

18. december 2006

Først opslået (Skøn)

19. december 2006

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

3. juli 2018

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

5. juni 2018

Sidst verificeret

1. maj 2018

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • CV185-030

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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