Deze pagina is automatisch vertaald en de nauwkeurigheid van de vertaling kan niet worden gegarandeerd. Raadpleeg de Engelse versie voor een brontekst.

Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (ARISTOTLE)

5 juni 2018 bijgewerkt door: Bristol-Myers Squibb

A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

Studie Overzicht

Toestand

Voltooid

Conditie

Interventie / Behandeling

Studietype

Ingrijpend

Inschrijving (Werkelijk)

20976

Fase

  • Fase 3

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

  • Argentinië
      • Buenos Aires, Argentinië, 1119
        • Local Institution
      • Buenos Aires, Argentinië, C1280AEB
        • Local Institution
      • Buenos Aires, Argentinië, 1181
        • Local Institution
      • Buenos Aires, Argentinië, C1426ANZ
        • Local Institution
      • Buenos Aires, Argentinië, 1280
        • Local Institution
      • Cordoba, Argentinië, 5000
        • Local Institution
      • Cordoba, Argentinië, X5000EPU
        • Local Institution
      • Cordoba, Argentinië, X5008KKF
        • Local Institution
      • Cordoba, Argentinië, X5003DCE
        • Local Institution
      • Salta, Argentinië, 4400
        • Local Institution
      • Santa Fe, Argentinië, 3000
        • Local Institution
      • Tucuman, Argentinië, T4000NIL
        • Local Institution
    • Buenos Aires
      • Adrogue, Buenos Aires, Argentinië, 1846
        • Local Institution
      • Bahia Blanca, Buenos Aires, Argentinië, B8000FTD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentinië, CP1425A WC
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentinië, 1128AAD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentinië, 1128
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentinië, 1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentinië, C1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentinië, CP1425AWC
        • Local Institution
      • Ciudad Autonoma De, Buenos Aires, Argentinië, 1180
        • Local Institution
      • Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentinië, CI094AAD
        • Local Institution
      • Coronel Suarez, Buenos Aires, Argentinië, B7540GHD
        • Local Institution
      • Haedo, Buenos Aires, Argentinië, B1706AJU
        • Local Institution
      • Junin, Buenos Aires, Argentinië, 6000
        • Local Institution
      • La Plata, Buenos Aires, Argentinië, 1900
        • Local Institution
      • La Plata, Buenos Aires, Argentinië, B1900AXI
        • Local Institution
      • La Plata, Buenos Aires, Argentinië, 1902
        • Local Institution
      • Mar Del Plata, Buenos Aires, Argentinië, 7600
        • Local Institution
      • Merlo, Buenos Aires, Argentinië, B1722COV
        • Local Institution
      • Merlo, Buenos Aires, Argentinië, 1722
        • Local Institution
      • Olivos, Buenos Aires, Argentinië, 1602
        • Local Institution
      • Quilmes, Buenos Aires, Argentinië, 1878
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentinië, B1704ESN
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentinië, B1704ETD
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentinië, 1706
        • Local Institution
      • San Justo, Buenos Aires, Argentinië, 1754
        • Local Institution
      • San Martin, Buenos Aires, Argentinië, 1650
        • Local Institution
      • San Nicolas, Buenos Aires, Argentinië, 2900
        • Local Institution
      • Zarate, Buenos Aires, Argentinië, 2800
        • Local Institution
      • Zarate, Buenos Aires, Argentinië, B2800DGH
        • Local Institution
    • Provincia DE Cordoba
      • Cordoba, Provincia DE Cordoba, Argentinië, 5000
        • Local Institution
    • RIO Negro
      • Cipolletti, RIO Negro, Argentinië, 8324
        • Local Institution
    • Santa FE
      • Rosario, Santa FE, Argentinië, 2000
        • Local Institution
      • Rosario, Santa FE, Argentinië, S2000CVB
        • Local Institution
      • Rosario, Santa FE, Argentinië, S2001ODA
        • Local Institution
    • Santa Fe
      • Rosario, Santa Fe, Argentinië, S2000CVD
        • Local Institution
      • Rosario, Santa Fe, Argentinië, S2000 CVD
        • Local Institution
    • Tucuman
      • San Miquel De Tucuman, Tucuman, Argentinië, 4000
        • Local Institution
  • Australië
    • New South Wales
      • Coffs Harbour, New South Wales, Australië, 2450
        • Local Institution
      • Concord, New South Wales, Australië, 2139
        • Local Institution
      • Gosford, New South Wales, Australië, 2250
        • Local Institution
      • Kogarah, New South Wales, Australië, 2217
        • Local Institution
      • Miranda, New South Wales, Australië, 2228
        • Local Institution
    • Queensland
      • Auchenflower, Queensland, Australië, 4066
        • Local Institution
      • Brisbane, Queensland, Australië, 4032
        • Local Institution
      • Caboolture, Queensland, Australië, 4510
        • Local Institution
      • Herston, Queensland, Australië, 4029
        • Local Institution
      • Kippa Ring, Queensland, Australië, 4021
        • Local Institution
      • Nambour, Queensland, Australië, 4560
        • Local Institution
      • Sherwood, Queensland, Australië, 4075
        • Local Institution
    • South Australia
      • Adelaide, South Australia, Australië, SA 5000
        • Local Institution
      • Ashford, South Australia, Australië, 5035
        • Local Institution
      • Bedford Park, South Australia, Australië, 5042
        • Local Institution
      • Woodville, South Australia, Australië, 5011
        • Local Institution
    • Victoria
      • Box Hill, Victoria, Australië, 3128
        • Local Institution
      • Dandenong, Victoria, Australië, 3175
        • Local Institution
      • Geelong, Victoria, Australië, 3220
        • Local Institution
    • Western Australia
      • Fremantle, Western Australia, Australië, 6160
        • Local Institution
      • Joondalup, Western Australia, Australië, 6027
        • Local Institution
  • België
      • Aalst, België, 9300
        • Local Institution
      • Antwerpen, België, 2020
        • Local Institution
      • Antwerpen, België, 2060
        • Local Institution
      • Arlon, België, 6700
        • Local Institution
      • Brugge, België, 8000
        • Local Institution
      • Brussels, België, 1090
        • Local Institution
      • Dillingen, België, 66763
        • Local Institution
      • Genk, België, 3600
        • Local Institution
      • Gent, België, 9000
        • Local Institution
      • Gilly, België, 6060
        • Local Institution
      • Hasselt, België, 3500
        • Local Institution
      • Huy, België, 4500
        • Local Institution
      • Kortrijk, België, 8500
        • Local Institution
      • Menen, België, 8930
        • Local Institution
      • Mol, België, 2400
        • Local Institution
      • Montegnee, België, 4420
        • Local Institution
      • Verviers, België, 4800
        • Local Institution
      • Woluwe- Saint Lambert, België, 1200
        • Local Institution
      • Yvoir, België, 5530
        • Local Institution
  • Brazilië
      • Rio De Janeiro, Brazilië, 20551
        • Local Institution
      • Rio De Janeiro, Brazilië, 20551-030
        • Local Institution
      • Rio De Janeiro, Brazilië, 22251-030
        • Local Institution
      • Rio De Janeiro, Brazilië, 22251
        • Local Institution
      • Sao Paulo, Brazilië, 01323-010
        • Local Institution
      • Sao Paulo, Brazilië, 01323
        • Local Institution
      • Sao Paulo, Brazilië, 04012
        • Local Institution
      • Sao Paulo, Brazilië, 04024-002
        • Local Institution
      • Sao Paulo, Brazilië, 04038
        • Local Institution
      • Sao Paulo, Brazilië, 01221-900
        • Local Institution
      • Sao Paulo, Brazilië, 01221
        • Local Institution
      • Sao Paulo, Brazilië, 01322-001
        • Local Institution
      • Sao Paulo, Brazilië, 01322
        • Local Institution
      • Sao Paulo, Brazilië, 01323-001
        • Local Institution
      • Sao Paulo, Brazilië, 04012-180
        • Local Institution
      • Sao Paulo, Brazilië, 04024
        • Local Institution
      • Sao Paulo, Brazilië, 04038-031
        • Local Institution
      • Sao Paulo, Brazilië, 08270-070
        • Local Institution
      • Sao Paulo, Brazilië, 08270
        • Local Institution
    • Bahia
      • Salvador, Bahia, Brazilië, 40144
        • Local Institution
      • Salvador, Bahia, Brazilië, 41810
        • Local Institution
      • Salvador, Bahia, Brazilië, 40144-900
        • Local Institution
      • Salvador, Bahia, Brazilië, 41810-010
        • Local Institution
    • Minas Gerais
      • Belo Horzonte, Minas Gerais, Brazilië, 30150-221
        • Local Institution
      • Belo Horzonte, Minas Gerais, Brazilië, 30150
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brazilië, 36021-630
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brazilië, 36021
        • Local Institution
      • Uberaba, Minas Gerais, Brazilië, 38056 055
        • Local Institution
      • Uberlandia, Minas Gerais, Brazilië, 38400-299
        • Local Institution
      • Uberlandia, Minas Gerais, Brazilië, 38400
        • Local Institution
    • Para
      • Belem, Para, Brazilië, 66087-660
        • Local Institution
      • Belem, Para, Brazilië, 66087
        • Local Institution
    • Parana
      • Campina Grande Do Sul, Parana, Brazilië, 83430-000
        • Local Institution
      • Campina Grande Do Sul, Parana, Brazilië, 83430
        • Local Institution
      • Curitiba, Parana, Brazilië, 80010
        • Local Institution
      • Curitiba, Parana, Brazilië, 80730
        • Local Institution
      • Curitiba, Parana, Brazilië, 80010-030
        • Local Institution
      • Curitiba, Parana, Brazilië, 80730-150
        • Local Institution
      • Londrina, Parana, Brazilië, 86010-450
        • Local Institution
      • Londrina, Parana, Brazilië, 86010
        • Local Institution
    • RIO Grande DO Norte
      • Natal, RIO Grande DO Norte, Brazilië, 59020-100
        • Local Institution
    • RIO Grande DO SUL
      • Porte Alegre, RIO Grande DO SUL, Brazilië, 90610-000
        • Local Institution
      • Porte Alegre, RIO Grande DO SUL, Brazilië, 90880-480
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazilië, 90035-903
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazilië, 90020-090
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazilië, 90620-001
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazilië, 91350-280
        • Local Institution
    • Rio Grande Do Norte
      • Natal, Rio Grande Do Norte, Brazilië, 59020
        • Local Institution
    • Rio Grande Do Sul
      • Porte Alegre, Rio Grande Do Sul, Brazilië, 90610
        • Local Institution
      • Porte Alegre, Rio Grande Do Sul, Brazilië, 90880480
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazilië, 90035
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazilië, 90020
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazilië, 90620
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazilië, 91350
        • Local Institution
    • SAO Paulo
      • Botucatu, SAO Paulo, Brazilië, 18618-000
        • Local Institution
      • Campinas, SAO Paulo, Brazilië, 13059-740
        • Local Institution
      • Marilia, SAO Paulo, Brazilië, 17515-000
        • Local Institution
      • Marilia, SAO Paulo, Brazilië, 17515-460
        • Local Institution
      • Marilia, SAO Paulo, Brazilië, 17519-000
        • Local Institution
      • San Jose Do Rio Preto, SAO Paulo, Brazilië, 15090-000
        • Local Institution
      • Santo Andre, SAO Paulo, Brazilië, 09190-610
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brazilië, 15015-750
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brazilië, 15015-210
        • Local Institution
    • Santa Catarina
      • Blumenau, Santa Catarina, Brazilië, 89010
        • Local Institution
      • Blumenau, Santa Catarina, Brazilië, 89010-500
        • Local Institution
      • Sao Jose, Santa Catarina, Brazilië, 88103
        • Local Institution
      • Sao Jose, Santa Catarina, Brazilië, 88103-450
        • Local Institution
    • Sao Paulo
      • Botucatu, Sao Paulo, Brazilië, 18618
        • Local Institution
      • Campinas, Sao Paulo, Brazilië, 13059
        • Local Institution
      • Marilia, Sao Paulo, Brazilië, 17519
        • Local Institution
      • Marilia, Sao Paulo, Brazilië, 17515
        • Local Institution
      • San Jose Do Rio Preto, Sao Paulo, Brazilië, 15090
        • Local Institution
      • Santo Andre, Sao Paulo, Brazilië, 09190
        • Local Institution
      • Sao Jose Do Rio Preto, Sao Paulo, Brazilië, 15015
        • Local Institution
  • Canada
      • Quebec, Canada, G1J 1Z6
        • Local Institution
    • Alberta
      • Calgary, Alberta, Canada, T2E 7C5
        • Local Institution
      • Edmonton, Alberta, Canada, T6G 2B7
        • Local Institution
      • Edmonton, Alberta, Canada, T5X 3N5
        • Local Institution
      • Edmonton, Alberta, Canada, TSA 4L8
        • Local Institution
      • Edmonton, Alberta, Canada, T56-3NJ
        • Local Institution
    • British Columbia
      • Burnaby, British Columbia, Canada, V5G 1T4
        • Local Institution
      • Nanaimo, British Columbia, Canada, V9R 3G9
        • Local Institution
      • New Westminster, British Columbia, Canada, V3L 3W4
        • Local Institution
      • North Vancouver, British Columbia, Canada, V7N 4M2
        • Local Institution
      • Victoria, British Columbia, Canada, V8R 4R2
        • Local Institution
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2V 4W3
        • Local Institution
    • New Brunswick
      • Bathurst, New Brunswick, Canada, E2A 4X7
        • Local Institution
    • Newfoundland and Labrador
      • Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
        • Local Institution
      • St Johns, Newfoundland and Labrador, Canada, A1B 3V6
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Canada, A1A 3R5
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Canada, A1E 2C2
        • Local Institution
    • Ontario
      • Brampton, Ontario, Canada, L6Z 4N5
        • Local Institution
      • Burlington, Ontario, Canada, L7M 4Y1
        • Local Institution
      • Cambridge, Ontario, Canada, N1R 7R1
        • Local Institution
      • Cambridge, Ontario, Canada, N1R 6V6
        • Local Institution
      • Hamilton, Ontario, Canada, L8L 2X2
        • Local Institution
      • London, Ontario, Canada, N6G 2V2
        • Local Institution
      • Mississauga, Ontario, Canada, L5B 4A2
        • Local Institution
      • Newmarket, Ontario, Canada, L3Y 5G8
        • Local Institution
      • Newmarket, Ontario, Canada, L3Y 8C3
        • Local Institution
      • Niagara Falls, Ontario, Canada, L2E 7H1
        • Local Institution
      • Niagara Falls, Ontario, Canada, L2E7H1
        • Local Institution
      • North Bay, Ontario, Canada, P1B 2H3
        • Local Institution
      • Oshawa, Ontario, Canada, L1J 2J9
        • Local Institution
      • Oshawa, Ontario, Canada, L1J 2K1
        • Local Institution
      • Ottawa, Ontario, Canada, K1Y 4E9
        • Local Institution
      • Ottawa, Ontario, Canada, K1Y 4W7
        • Local Institution
      • Sarnia, Ontario, Canada, N7T 4X3
        • Local Institution
      • Scarborough, Ontario, Canada, M1B 5N1
        • Local Institution
      • Sudbury, Ontario, Canada, P3E 3B8
        • Local Institution
      • Sudbury, Ontario, Canada, P3C 5K7
        • Local Institution
      • Sudbury, Ontario, Canada, P3E 2N8
        • Local Institution
      • Sudbury, Ontario, Canada, P3C5K7
        • Local Institution
      • Toronto, Ontario, Canada, M9W 4L6
        • Local Institution
      • Toronto, Ontario, Canada, M5B 1W8
        • Local Institution
      • Weston, Ontario, Canada, M9N 1W4
        • Local Institution
    • Prince Edward Island
      • Charlottetown, Prince Edward Island, Canada, C1A 5Y9
        • Local Institution
    • Quebec
      • Drummondville, Quebec, Canada, J2B 7T1
        • Local Institution
      • Greenfield Park, Quebec, Canada, J4V 2G8
        • Local Institution
      • Lachine, Quebec, Canada, H8S 2E4
        • Local Institution
      • Levis, Quebec, Canada, G6V 4Z5
        • Local Institution
      • Longueuil, Quebec, Canada, J4K 1C8
        • Local Institution
      • Longueuil, Quebec, Canada, J4N 0C9
        • Local Institution
      • Longueuil, Quebec, Canada, J4N 1C2
        • Local Institution
      • Montreal, Quebec, Canada, H3T 1E2
        • Local Institution
      • Montreal, Quebec, Canada, H3A 1A1
        • Local Institution
      • Montreal, Quebec, Canada, H1T 1C8
        • Local Institution
      • Montreal, Quebec, Canada, H2W 1T8
        • Local Institution
      • Montreal, Quebec, Canada, W3R-153
        • Local Institution
      • Pointe- Claire, Quebec, Canada, H9R 3J1
        • Local Institution
      • St-Lambert, Quebec, Canada, J4P 2H4
        • Local Institution
      • Ste-Foy, Quebec, Canada, G1W 4R4
        • Local Institution
    • Saskatchewan
      • Saskatoon, Saskatchewan, Canada, S7L OY7
        • Local Institution
  • Chili
    • LOS Lagos
      • Osorno, LOS Lagos, Chili, 5311089
        • Local Institution
      • Osorno, LOS Lagos, Chili, 5311523
        • Local Institution
    • Metropolitana
      • Santiago, Metropolitana, Chili, 7500520
        • Local Institution
      • Santiago, Metropolitana, Chili, 7500922
        • Local Institution
      • Santiago, Metropolitana, Chili, 8330074
        • Local Institution
    • Region DE LA Araucania
      • Temuco, Region DE LA Araucania, Chili, 4781176
        • Local Institution
    • Region De La Araucania
      • Temuco, Region De La Araucania, Chili, 4781156
        • Local Institution
    • Valparaiso
      • Temuco, Valparaiso, Chili, 4781173
        • Local Institution
      • Vina Del Mar, Valparaiso, Chili, 2570017
        • Local Institution
  • China
    • Beijing
      • Beijing, Beijing, China, 100050
        • Local Institution
      • Beijing, Beijing, China, 100001
        • Local Institution
      • Beijing, Beijing, China, 100853
        • Local Institution
      • Beijing, Beijing, China, 100020
        • Local Institution
      • Beijing, Beijing, China, 100088
        • Local Institution
      • Beijing, Beijing, China, 100101
        • Local Institution
    • Gansu
      • Lanzhou, Gansu, China, 730000
        • Local Institution
      • Lanzhou, Gansu, China, 730030
        • Local Institution
    • Guangdong
      • Guangzhou, Guangdong, China, 510080
        • Local Institution
      • Guangzhou, Guangdong, China, 510120
        • Local Institution
    • Hebei
      • Shijiazhuang, Hebei, China, 050000
        • Local Institution
    • Heilongjiang
      • Daqing, Heilongjiang, China, 163001
        • Local Institution
      • Haerbin, Heilongjiang, China, 150086
        • Local Institution
      • Haerbin, Heilongjiang, China, 150001
        • Local Institution
    • Hubei
      • Wuhan, Hubei, China, 430060
        • Local Institution
    • Hunan
      • Changsha, Hunan, China, 410000
        • Local Institution
    • Jiangsu
      • Hangzhou, Jiangsu, China, 310009
        • Local Institution
      • Nanjing, Jiangsu, China, 210029
        • Local Institution
    • Liaoning
      • Dalian, Liaoning, China, 116011
        • Local Institution
      • Dalian, Liaoning, China, 116021
        • Local Institution
      • Dalian, Liaoning, China, 116027
        • Local Institution
      • Shenyang, Liaoning, China, 110016
        • Local Institution
      • Shenyang, Liaoning, China, 110003
        • Local Institution
    • Shandong
      • Jinan, Shandong, China, 250012
        • Local Institution
      • Jinan, Shandong, China, 250033
        • Local Institution
      • Qingdao, Shandong, China, 266011
        • Local Institution
    • Shanghai
      • Shanghai, Shanghai, China, 200080
        • Local Institution
      • Shanghai, Shanghai, China, 200025
        • Local Institution
      • Shanghai, Shanghai, China, 200433
        • Local Institution
      • Shanghai, Shanghai, China, 200011
        • Local Institution
      • Shanghai, Shanghai, China, 200233
        • Local Institution
      • Shanghai, Shanghai, China, 200003
        • Local Institution
      • Shanghai, Shanghai, China, 100037
        • Local Institution
      • Shanghai, Shanghai, China, 200031
        • Local Institution
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • Local Institution
      • Chongqing, Sichuan, China, 400010
        • Local Institution
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310009
        • Local Institution
  • Colombia
      • Barranquilla, Colombia
        • Local Institution
      • Barranquilla, Colombia, XXXXX
        • Local Institution
      • Bogota, Colombia
        • Local Institution
      • Bogota, Colombia, 000
        • Local Institution
      • Cali, Colombia
        • Local Institution
      • Medellin, Colombia
        • Local Institution
    • Antioquia
      • Medellin, Antioquia, Colombia
        • Local Institution
  • Denemarken
      • Arhus C, Denemarken, 8000
        • Local Institution
      • Esbjerg, Denemarken, 6700
        • Local Institution
      • Frederiksberg, Denemarken, 2000
        • Local Institution
      • Frederikssund, Denemarken, 3600
        • Local Institution
      • Gentofte, Denemarken, 2900
        • Local Institution
      • Haderslev, Denemarken, 6100
        • Local Institution
      • Hellerup, Denemarken, 2900
        • Local Institution
      • Herlev, Denemarken, 2730
        • Local Institution
      • Herning, Denemarken, 7400
        • Local Institution
      • Hillerod, Denemarken, 3400
        • Local Institution
      • Hvidovre, Denemarken, 2650
        • Local Institution
      • Kobenhavn, Denemarken, 2100
        • Local Institution
      • Kolding, Denemarken, 6000
        • Local Institution
      • Odense, Denemarken, 5000
        • Local Institution
      • Silkeborg, Denemarken, 8600
        • Local Institution
      • Slagelse, Denemarken, 4200
        • Local Institution
      • Svendborg, Denemarken, 5700
        • Local Institution
  • Duitsland
      • Aachen, Duitsland, 52074
        • Local Institution
      • Bad Krozingen, Duitsland, 79189
        • Local Institution
      • Bad Neustadt/ Salle, Duitsland, 97616
        • Local Institution
      • Bad Oeynhausen, Duitsland, 32545
        • Local Institution
      • Berlin, Duitsland, 13353
        • Local Institution
      • Berlin, Duitsland, 14050
        • Local Institution
      • Berlin, Duitsland, 10787
        • Local Institution
      • Berlin, Duitsland, 10789
        • Local Institution
      • Berlin, Duitsland, 12043
        • Local Institution
      • Berlin-Kopenick, Duitsland, 12559
        • Local Institution
      • Betzdorf, Duitsland, 57518
        • Local Institution
      • Bochum, Duitsland, 44791
        • Local Institution
      • Bochum, Duitsland, 44789
        • Local Institution
      • Bonn, Duitsland, 53127
        • Local Institution
      • Coburg, Duitsland, 96450
        • Local Institution
      • Dillingen, Duitsland, 66763
        • Local Institution
      • Dresden, Duitsland, 01099
        • Local Institution
      • Duisburg, Duitsland, 47139
        • Local Institution
      • Essen, Duitsland, 45122
        • Local Institution
      • Frankfurt Am Main, Duitsland, 60594
        • Local Institution
      • Gottingen, Duitsland, 37075
        • Local Institution
      • Halle/Saale, Duitsland, 06120
        • Local Institution
      • Hannover, Duitsland, 30625
        • Local Institution
      • Heidelberg, Duitsland, 69120
        • Local Institution
      • Heidelberg, Duitsland, 69115
        • Local Institution
      • Kassel, Duitsland, 34121
        • Local Institution
      • Lahr, Duitsland, 77933
        • Local Institution
      • Ludwigshafen, Duitsland, 67063
        • Local Institution
      • Ludwigshafen, Duitsland, 67073
        • Local Institution
      • Mannheim, Duitsland, 68167
        • Local Institution
      • Marburg, Duitsland, 35043
        • Local Institution
      • Munchen, Duitsland, 81675
        • Local Institution
      • Munchen, Duitsland, 80636
        • Local Institution
      • Munchen, Duitsland, 81545
        • Local Institution
      • Osnabruck, Duitsland, 49076
        • Local Institution
      • Regensburg, Duitsland, 93053
        • Local Institution
      • Riesa, Duitsland, D-01587
        • Local Institution
      • Rostiock, Duitsland, 18057
        • Local Institution
      • Trier, Duitsland, 54292
        • Local Institution
      • Waren, Duitsland, 17192
        • Local Institution
      • Witten, Duitsland, 58455
        • Local Institution
      • Wolmirstedt, Duitsland, 39326
        • Local Institution
      • Worms, Duitsland, 67550
        • Local Institution
  • Filippijnen
      • Manila, Filippijnen, 1000
        • Local Institution
      • Manila, Filippijnen, 1008
        • Local Institution
      • Naga City, Filippijnen, 4400
        • Local Institution
      • Pasig City, Filippijnen, 1600
        • Local Institution
      • Quezon, Filippijnen, 1100
        • Local Institution
      • Quezon City, Filippijnen, 1102
        • Local Institution
      • San Juan, Filippijnen, 1100
        • Local Institution
    • Ilocos Norte
      • Laoag City, Ilocos Norte, Filippijnen, 2900
        • Local Institution
  • Finland
      • Helsinki, Finland, 00280
        • Local Institution
      • Helsinki, Finland, FI-00280
        • Local Institution
      • Hus, Finland, 00029
        • Local Institution
      • Jyvaskyla, Finland, 40100
        • Local Institution
      • Kemi, Finland, 94100
        • Local Institution
      • Oulu, Finland, 90100
        • Local Institution
      • Pori, Finland, 28120
        • Local Institution
      • Tampere, Finland, 33100
        • Local Institution
  • Frankrijk
      • Amiens Cedex 1, Frankrijk, 80054
        • Local Institution
      • Bordeaux Cedex, Frankrijk, 33075
        • Local Institution
      • Brest, Frankrijk, 29609
        • Local Institution
      • Grenoble Cedex 09, Frankrijk, 38043
        • Local Institution
      • La Seyne Sur Mer, Frankrijk, 83500
        • Local Institution
      • Paris Cedex 18, Frankrijk, 75018
        • Local Institution
      • Six Fours Les Plages, Frankrijk, 83140
        • Local Institution
  • Hongarije
      • Budapest, Hongarije, 1125
        • Local Institution
      • Budapest, Hongarije, 1023
        • Local Institution
      • Budapest, Hongarije, 1032
        • Local Institution
      • Budapest, Hongarije, 1096
        • Local Institution
      • Budapest, Hongarije, 1085
        • Local Institution
      • Debrecen, Hongarije, 4032
        • Local Institution
      • Dunaujvaros, Hongarije, 2400
        • Local Institution
      • Gyor, Hongarije, 9023
        • Local Institution
      • Gyula, Hongarije, 5700
        • Local Institution
      • Hodmezovasarhely, Hongarije, 6800
        • Local Institution
      • Komarom, Hongarije, 2921
        • Local Institution
      • Mosonmagyarovar, Hongarije, 9200
        • Local Institution
      • Oroshaza, Hongarije, 5900
        • Local Institution
      • Pecs, Hongarije, 7624
        • Local Institution
      • Siofok, Hongarije, 8600
        • Local Institution
      • Siofok, Hongarije, 8601
        • Local Institution
      • Sopron, Hongarije, 9400
        • Local Institution
      • Szentes, Hongarije, 6600
        • Local Institution
      • Zalaegerszeg, Hongarije, 8900
        • Local Institution
  • Hongkong
      • Hong Kong, Hongkong
        • Local Institution
      • Shatin, Hongkong
        • Local Institution
  • Indië
      • Ahmedabad, Indië, 380014
        • Local Institution
      • Annamalainagar, Indië, 608002
        • Local Institution
      • Bangalore, Indië, 560052
        • Local Institution
      • Chennai, Indië, 600006
        • Local Institution
      • Hyderabad, Indië, 500001
        • Local Institution
      • Hyderabad, Indië, 500044
        • Local Institution
      • Indore, Indië, 452014
        • Local Institution
      • Indore, Indië, 452001
        • Local Institution
      • Kolkata, Indië, 700054
        • Local Institution
      • Kottayam, Indië, 686016
        • Local Institution
      • Lucknow, Indië, 226003
        • Local Institution
      • Mumbai Naka, Indië, 422005
        • Local Institution
      • Nashik, Indië, 422002
        • Local Institution
      • New Delhi, Indië, 110025
        • Local Institution
      • New Delhi, Indië, 110060
        • Local Institution
      • New Delhi, Indië, 116025
        • Local Institution
      • Pune, Indië, 411001
        • Local Institution
      • Pune, Indië, 411004
        • Local Institution
      • Thrissur, Indië, 680002
        • Local Institution
      • Vijayawada, Indië, 520008
        • Local Institution
    • Andhra Pradesh
      • Visakhapatnam, Andhra Pradesh, Indië, 530003
        • Local Institution
    • Andhrapradesh
      • Visakhapatnam, Andhrapradesh, Indië, 530002
        • Local Institution
    • Andra Pradesh
      • Hyderabad, Andra Pradesh, Indië, 500004
        • Local Institution
    • Gujarat
      • Ahmedabad, Gujarat, Indië, 380060
        • Local Institution
      • Vadodara, Gujarat, Indië, 390007
        • Local Institution
    • Karnataka
      • Bangalore, Karnataka, Indië, 560054
        • Local Institution
      • Bangalore, Karnataka, Indië, 5600034
        • Local Institution
      • Bangalore, Karnataka, Indië, 560094
        • Local Institution
      • Mysore, Karnataka, Indië, 570004
        • Local Institution
    • Kerela
      • Calicut, Kerela, Indië, 673 004
        • Local Institution
    • Maharashta
      • Pune, Maharashta, Indië, 411011
        • Local Institution
    • Maharashtra
      • Nagpur, Maharashtra, Indië, 440010
        • Local Institution
      • Nagpur, Maharashtra, Indië, 440012
        • Local Institution
      • Pune, Maharashtra, Indië, 411001
        • Local Institution
      • Pune, Maharashtra, Indië, 421006
        • Local Institution
    • Punjab
      • Jalandhar, Punjab, Indië, 144008
        • Local Institution
    • Rajasthan
      • Bikaner, Rajasthan, Indië, 334001
        • Local Institution
      • Bikaner, Rajasthan, Indië, 334003
        • Local Institution
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, Indië, 226003
        • Local Institution
  • Israël
      • Afula, Israël, 18101
        • Local Institution
      • Ashkelon, Israël, 78306
        • Local Institution
      • Givatayim, Israël, 53583
        • Local Institution
      • Hadera, Israël, 38100
        • Local Institution
      • Haifa, Israël, 31096
        • Local Institution
      • Haifa, Israël, 34362
        • Local Institution
      • Holon, Israël, 58100
        • Local Institution
      • Jerusalem, Israël, 91120
        • Local Institution
      • Jerusalem, Israël, 91240
        • Local Institution
      • Kfar-Saba, Israël, 44281
        • Local Institution
      • Nazareth, Israël, 16100
        • Local Institution
      • Nazareth, Israël, 16000
        • Local Institution
      • Petach-Tikva, Israël, 49100
        • Local Institution
      • Safed, Israël, 13100
        • Local Institution
      • Tel Aviv, Israël, 64239
        • Local Institution
  • Italië
      • Ascoli Piceno, Italië, 63100
        • Local Institution
      • Campobasso, Italië, 86100
        • Local Institution
      • Chieti, Italië, 66013
        • Local Institution
      • Cremona, Italië, 26100
        • Local Institution
      • Fidenza (Pr), Italië, 43036
        • Local Institution
      • Genova, Italië, 16132
        • Local Institution
      • Isernia, Italië, 86170
        • Local Institution
      • Livorno, Italië, 57100
        • Local Institution
      • Milano, Italië, 20132
        • Local Institution
      • Napoli, Italië, 80131
        • Local Institution
      • Palermo, Italië, 90127
        • Local Institution
      • Reggio Emilia, Italië, 42100
        • Local Institution
      • Roma, Italië, 00168
        • Local Institution
      • San Daniele De Friuli, Italië, 33038
        • Local Institution
      • Torino, Italië, 10153
        • Local Institution
      • Vittorio Veneto (Tv), Italië, 31029
        • Local Institution
    • Lucca
      • Lido Di Camaiore, Lucca, Italië, 55043
        • Local Institution
  • Japan
      • Fukui, Japan, 9100067
        • Local Institution
      • Kagoshima, Japan, 8920822
        • Local Institution
      • Kyoto, Japan, 6168152
        • Local Institution
      • Nagasaki, Japan, 852-8102
        • Local Institution
      • Oita, Japan, 8700033
        • Local Institution
      • Osaka, Japan, 558-8558
        • Local Institution
      • Osaka, Japan, 551-0032
        • Local Institution
      • Osaka, Japan, 5510032
        • Local Institution
      • Saga, Japan, 8490917
        • Local Institution
    • Fukuoka
      • Itoshima City, Fukuoka, Japan, 819-1104
        • Local Institution
      • Kurume, Fukuoka, Japan, 8390863
        • Local Institution
      • Ohkawa-City, Fukuoka, Japan, 8310016
        • Local Institution
    • Fukushima
      • Shirakawa City, Fukushima, Japan, 961-0005
        • Local Institution
    • Gunma
      • Takasaki City, Gunma, Japan, 3700829
        • Local Institution
    • Hokkaido
      • Asahikawa-Shi, Hokkaido, Japan, 0788214
        • Local Institution
      • Katou-Gun, Hokkaido, Japan, 0800111
        • Local Institution
      • Katou-gun, Hokkaido, Japan, 080111
        • Local Institution
      • Sapporo-Shi, Hokkaido, Japan, 0028043
        • Local Institution
      • Tomakomai-Shi, Hokkaido, Japan, 002-8043
        • Local Institution
      • Tomakomai-shi, Hokkaido, Japan, 0028043
        • Local Institution
      • Yubari, Hokkaido, Japan, 0680402
        • Local Institution
    • Hyogo
      • Kobe, Hyogo, Japan, 6540026
        • Local Institution
    • Kagoshima Prefecture
      • Izumi City, Kagoshima Prefecture, Japan, 8990131
        • Local Institution
    • Kanagawa
      • Isehara, Kanagawa, Japan, 2591193
        • Local Institution
      • Yokohama, Kanagawa, Japan, 2458575
        • Local Institution
      • Yokohama City, Kanagawa, Japan, 2278501
        • Local Institution
      • Yokosuka, Kanagawa, Japan, 2388567
        • Local Institution
    • Miyagi
      • Sendai City, Miyagi, Japan, 983-8520
        • Local Institution
    • Nara
      • Nara City, Nara, Japan, 630-8305
        • Local Institution
    • Osaka
      • Izumi City, Osaka, Japan, 594-0071
        • Local Institution
      • Osaka City, Osaka, Japan, 5330022
        • Local Institution
      • Osaka-Shi, Osaka, Japan, 540-0006
        • Local Institution
      • Osaka-shi, Osaka, Japan, 5400006
        • Local Institution
      • Suita-City, Osaka, Japan, 5658565
        • Local Institution
      • Takatsuki City, Osaka, Japan, 5690852
        • Local Institution
      • Yao, Osaka, Japan, 5810036
        • Local Institution
    • Saga
      • Saga City, Saga, Japan, 840-8571
        • Local Institution
      • Saga City, Saga, Japan, 849-8501
        • Local Institution
    • Saitama
      • Kasukabe-Shi, Saitama, Japan, 344-0035
        • Local Institution
      • Kasukabe-shi, Saitama, Japan, 3440035
        • Local Institution
    • Tokyo
      • Itabashi-Ku, Tokyo, Japan, 173-0015
        • Local Institution
      • Itabashi-ku, Tokyo, Japan, 1730015
        • Local Institution
      • Meguro-Ku, Tokyo, Japan, 153-8515
        • Local Institution
      • Meguro-ku, Tokyo, Japan, 1538515
        • Local Institution
      • Shinagawa-Ku, Tokyo, Japan, 1428666
        • Local Institution
    • Toyama
      • Toyama City, Toyama, Japan, 9308550
        • Local Institution
    • Yamaguchi
      • Iwakuni, Yamaguchi, Japan, 7400021
        • Local Institution
  • Kalkoen
      • Ankara, Kalkoen, 06100
        • Local Institution
      • Eskisehir, Kalkoen, 26480
        • Local Institution
      • Izmir, Kalkoen, 35100
        • Local Institution
  • Korea, republiek van
      • Busan, Korea, republiek van, 602-702
        • Local Institution
      • Daegu, Korea, republiek van, 700-712
        • Local Institution
      • Daegu, Korea, republiek van, 705-717
        • Local Institution
      • Daejon, Korea, republiek van, 302-718
        • Local Institution
      • Goyang, Korea, republiek van, 411-706
        • Local Institution
      • Gwang Ju, Korea, republiek van, 501-757
        • Local Institution
      • Gyeonggi, Korea, republiek van, 463-707
        • Local Institution
      • Pusan, Korea, republiek van, 602-739
        • Local Institution
      • Scongnam-Si, Korea, republiek van, 463-712
        • Local Institution
      • Seoul, Korea, republiek van, 110-744
        • Local Institution
      • Seoul, Korea, republiek van, 143-729
        • Local Institution
      • Seoul, Korea, republiek van, 130-709
        • Local Institution
      • Suwon, Korea, republiek van, 443-721
        • Local Institution
    • Gyeonggi-Do
      • Anyang-Si, Gyeonggi-Do, Korea, republiek van, 431-070
        • Local Institution
    • Korea
      • Incheon, Korea, Korea, republiek van, 400-711
        • Local Institution
  • Maleisië
      • Kuala Lumpur, Maleisië, 56000
        • Local Institution
      • Kuala Lumpur, Maleisië, 59100
        • Local Institution
    • Kelantan
      • Kubang Kerian, Kelantan, Maleisië, 16150
        • Local Institution
    • Sarawak
      • Kota Samarahan, Sarawak, Maleisië, 94300
        • Local Institution
    • Selangor
      • Batu Caves, Selangor, Maleisië, 68100
        • Local Institution
  • Mexico
      • Puebla, Mexico, 11490
        • Local Institution
      • Queretaro, Mexico, 76000
        • Local Institution
    • BAJA California
      • Tijuana, BAJA California, Mexico, 22500
        • Local Institution
    • Distrito Federal
      • Col. Toriello Guerra, Distrito Federal, Mexico, CP 14050
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 06726
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 14080
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 07760
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 06070
        • Local Institution
      • Mexico City, Distrito Federal, Mexico, 10700
        • Local Institution
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44200
        • Local Institution
      • Guadalajara, Jalisco, Mexico, 44600
        • Local Institution
      • Guadalajara, Jalisco, Mexico, 44656
        • Local Institution
    • Michoacan
      • Morelia, Michoacan, Mexico, 58000
        • Local Institution
    • Nuevo LEON
      • Monterrey, Nuevo LEON, Mexico, 64710
        • Local Institution
      • Monterrey, Nuevo LEON, Mexico, 64000
        • Local Institution
      • Monterrey, Nuevo LEON, Mexico, 64700
        • Local Institution
    • Sinaloa
      • Culiacan, Sinaloa, Mexico, 80020
        • Local Institution
    • Veracruz
      • Jalapa, Veracruz, Mexico, 91020
        • Local Institution
  • Nederland
      • Breda, Nederland, 4818 CK
        • Local Institution
      • Deventer, Nederland, 7416 SE
        • Local Institution
      • Eindhoven, Nederland, 5623 EJ
        • Local Institution
      • Eindhoven, Nederland, 5623EJ
        • Local Institution
      • Enschede, Nederland, 7513 ER
        • Local Institution
      • Hardenberg, Nederland, 7772 SE
        • Local Institution
      • Hilversum, Nederland, 1213 XZ
        • Local Institution
      • Nijmegen, Nederland, 6525 GA
        • Local Institution
      • Oss, Nederland, 5342 BT
        • Local Institution
      • Rotterdam, Nederland, 3045 PM
        • Local Institution
      • S-Hertogenbosch, Nederland, 5211 NL
        • Local Institution
      • Tiel, Nederland, 4002 WP
        • Local Institution
      • Utrecht, Nederland, 3582 KE
        • Local Institution
      • Velp, Nederland, 6883 AZ
        • Local Institution
  • Noorwegen
      • Alesund, Noorwegen, 6003
        • Local Institution
      • Bergen, Noorwegen, 5021
        • Local Institution
      • Bergen, Noorwegen, N-5021
        • Local Institution
      • Elverum, Noorwegen, 2408
        • Local Institution
      • Flekkefjord, Noorwegen, 4400
        • Local Institution
      • Nesttun, Noorwegen, 5221
        • Local Institution
      • Oslo, Noorwegen, 0407
        • Local Institution
      • Skien, Noorwegen, 3710
        • Local Institution
      • Stavanger, Noorwegen, 4064
        • Local Institution
      • Straume, Noorwegen, 5353
        • Local Institution
      • Tonsberg, Noorwegen, 3116
        • Local Institution
      • Tromso, Noorwegen, 9038
        • Local Institution
  • Oekraïne
      • Chernivtsy, Oekraïne, 58013
        • Local Institution
      • Dnipropetrovsk, Oekraïne, 49006
        • Local Institution
      • Dnipropetrovsk, Oekraïne, 49060
        • Local Institution
      • Donetsk, Oekraïne, 83045
        • Local Institution
      • Donetsk, Oekraïne, 83003
        • Local Institution
      • Donetsk, Oekraïne, 83114
        • Local Institution
      • Ivano-Frankivsk, Oekraïne, 76025
        • Local Institution
      • Kharkiv, Oekraïne, 61018
        • Local Institution
      • Kharkiv, Oekraïne, 61115
        • Local Institution
      • Kharkov, Oekraïne, 61039
        • Local Institution
      • Kharkov, Oekraïne, 61002
        • Local Institution
      • Kharkov, Oekraïne, 61178
        • Local Institution
      • Kiev, Oekraïne, 01032
        • Local Institution
      • Kyiv, Oekraïne, 03680
        • Local Institution
      • Kyiv, Oekraïne, 02091
        • Local Institution
      • Kyiv, Oekraïne, 03049
        • Local Institution
      • Kyiv, Oekraïne, 03115
        • Local Institution
      • Kyiv, Oekraïne, 04050
        • Local Institution
      • Kyiv, Oekraïne, 04107
        • Local Institution
      • Kyiv, Oekraïne, 01023
        • Local Institution
      • Kyiv, Oekraïne, 02660
        • Local Institution
      • Kyiv, Oekraïne, 01103
        • Local Institution
      • Lugansk, Oekraïne, 91011
        • Local Institution
      • Lugansk, Oekraïne, 91016
        • Local Institution
      • Lutsk, Oekraïne, 43024
        • Local Institution
      • Lviv, Oekraïne, 79013
        • Local Institution
      • Lviv, Oekraïne, 79015
        • Local Institution
      • Mykolayiv, Oekraïne, 54003
        • Local Institution
      • Odessa, Oekraïne, 65009
        • Local Institution
      • Odessa, Oekraïne, 65039
        • Local Institution
      • Odessa, Oekraïne, 65114
        • Local Institution
      • Odessa, Oekraïne, 65025
        • Local Institution
      • Uzhgorod, Oekraïne, 88000
        • Local Institution
      • Vinnitsa, Oekraïne, 21029
        • Local Institution
      • Zaporozhye, Oekraïne, 69035
        • Local Institution
      • Zhytomyr, Oekraïne, 10002
        • Local Institution
  • Oostenrijk
      • Graz, Oostenrijk, 8036
        • Local Institution
      • Oberpullendorf, Oostenrijk, 7350
        • Local Institution
      • Vienna, Oostenrijk, 1160
        • Local Institution
  • Peru
      • Lima, Peru, LIMA 33
        • Local Institution
      • Lima, Peru, LIMA 01
        • Local Institution
      • Lima, Peru, LIMA 1
        • Local Institution
    • Callao
      • Bellavista, Callao, Peru, 2176
        • Local Institution
      • Bellavista, Callao, Peru, CALLAO 2
        • Local Institution
    • Lambayeque
      • Chiclayo, Lambayeque, Peru, CIX
        • Local Institution
    • Lima
      • Jesus Maria, Lima, Peru, 11
        • Local Institution
      • Jesus Maria, Lima, Peru, LIMA 11
        • Local Institution
      • Miraflores, Lima, Peru, LIMA 18
        • Local Institution
      • San Borja, Lima, Peru, LIMA 41
        • Local Institution
      • San Martin De Porres, Lima, Peru, LIMA 31
        • Local Institution
  • Polen
      • Gdynia, Polen, 81-423
        • Local Institution
      • Gdynia, Polen, 81-472
        • Local Institution
      • Gdynia, Polen, 81-519
        • Local Institution
      • Grodzisk Mazowiecki, Polen, 05-825
        • Local Institution
      • Inowroclaw, Polen, 88-100
        • Local Institution
      • Kielce, Polen, 25-736
        • Local Institution
      • Kielce, Polen, 25-763
        • Local Institution
      • Krakow, Polen, 31-202
        • Local Institution
      • Krakow, Polen, 30-092
        • Local Institution
      • Krakow, Polen, 31-135
        • Local Institution
      • Lodz, Polen, 91-347
        • Local Institution
      • Lodz, Polen, 91347
        • Local Institution
      • Piotrkow Trybunalski, Polen, 97-300
        • Local Institution
      • Plock, Polen, 09-402
        • Local Institution
      • Plock, Polen, 09-400
        • Local Institution
      • Plonsk, Polen, 09-100
        • Local Institution
      • Poznan, Polen, 60-531
        • Local Institution
      • Poznan, Polen, 60479
        • Local Institution
      • Ruda Slaska, Polen, 41-703
        • Local Institution
      • Skierniewice, Polen, 96-100
        • Local Institution
      • Slupsk, Polen, 76-200
        • Local Institution
      • Torun, Polen, 87100
        • Local Institution
      • Warszawa, Polen, 01-138
        • Local Institution
      • Warszawa, Polen, 04-073
        • Local Institution
      • Warszawa, Polen, 04-628
        • Local Institution
      • Warszawa, Polen, 04-749
        • Local Institution
      • Wegrow, Polen, 07100
        • Local Institution
  • Puerto Rico
      • Cayey, Puerto Rico, 00736
        • Local Institution
      • Cidra, Puerto Rico, 00739
        • Local Institution
      • Ponce, Puerto Rico, 00717
        • Local Institution
  • Roemenië
      • Baia Mare, Roemenië, 430031
        • Local Institution
      • Bucharest, Roemenië, 011192
        • Local Institution
      • Bucharest, Roemenië, 020125
        • Local Institution
      • Bucharest, Roemenië, 050098
        • Local Institution
      • Bucharest, Roemenië, 021659
        • Local Institution
      • Bucharest, Roemenië, 030572
        • Local Institution
      • Cluj Napoca, Roemenië, 400001
        • Local Institution
      • Cluj Napoca, Roemenië, 400347
        • Local Institution
      • Iasi, Roemenië, 700503
        • Local Institution
      • Oradea, Roemenië, 410169
        • Local Institution
      • Sibiu, Roemenië, 550245
        • Local Institution
      • Targu-Mures, Roemenië, 540103
        • Local Institution
      • Timisoara, Roemenië, 300024
        • Local Institution
      • Timisoara, Roemenië, 300320
        • Local Institution
      • Tirgu Mures, Roemenië, 540136
        • Local Institution
  • Russische Federatie
      • Chelyabinsk, Russische Federatie, 454136
        • Local Institution
      • Chita, Russische Federatie, 672090
        • Local Institution
      • Dzerzhinskiy, Russische Federatie, 140091
        • Local Institution
      • Kazan, Russische Federatie, 420012
        • Local Institution
      • Kemerovo, Russische Federatie, 650002
        • Local Institution
      • Kirovsk, Russische Federatie, 187342
        • Local Institution
      • Krasnodar, Russische Federatie, 350042
        • Local Institution
      • Moscow, Russische Federatie, 119992
        • Local Institution
      • Moscow, Russische Federatie, 125367
        • Local Institution
      • Moscow, Russische Federatie, 109240
        • Local Institution
      • Moscow, Russische Federatie, 105229
        • Local Institution
      • Moscow, Russische Federatie, 111539
        • Local Institution
      • Moscow, Russische Federatie, 115487
        • Local Institution
      • Moscow, Russische Federatie, 115093
        • Local Institution
      • Moscow, Russische Federatie, 121552
        • Local Institution
      • Moscow, Russische Federatie, 117593
        • Local Institution
      • Moscow, Russische Federatie, 127018
        • Local Institution
      • Moscow, Russische Federatie, 125284
        • Local Institution
      • Moscow, Russische Federatie, 111020
        • Local Institution
      • Moscow, Russische Federatie, 119121
        • Local Institution
      • Moscow, Russische Federatie, 121356
        • Local Institution
      • Moscow, Russische Federatie, 117556
        • Local Institution
      • Moscow, Russische Federatie, 119048
        • Local Institution
      • Moscow, Russische Federatie, 123182
        • Local Institution
      • Moscow, Russische Federatie, 125206
        • Local Institution
      • Moscow, Russische Federatie, 125424
        • Local Institution
      • Moscow, Russische Federatie, 129090
        • Local Institution
      • Nizhni Novgorod, Russische Federatie, 603003
        • Local Institution
      • Nizhni Novgorod, Russische Federatie, 603005
        • Local Institution
      • Novosibirsk, Russische Federatie, 630008
        • Local Institution
      • Novosibirsk, Russische Federatie, 630054
        • Local Institution
      • Odintsovo, Russische Federatie, 143000
        • Local Institution
      • Penza, Russische Federatie, 440026
        • Local Institution
      • Perm, Russische Federatie, 614097
        • Local Institution
      • Rostov-On-Don, Russische Federatie, 344022
        • Local Institution
      • Ryazan, Russische Federatie, 390026
        • Local Institution
      • Saint Petersburg, Russische Federatie, 193312
        • Local Institution
      • Saint Petersburg, Russische Federatie, 193144
        • Local Institution
      • Saint-Petersburg, Russische Federatie, 190103
        • Local Institution
      • Saint-Petersburg, Russische Federatie, 191025
        • Local Institution
      • Saint-Petersburg, Russische Federatie, 193163
        • Local Institution
      • Saint-Petersburg, Russische Federatie, 196601
        • Local Institution
      • Saint-Petersburg, Russische Federatie, 198013
        • Local Institution
      • Samara, Russische Federatie, 443070
        • Local Institution
      • Saratov, Russische Federatie, 410002
        • Local Institution
      • St Petersburg, Russische Federatie, 198013
        • Local Institution
      • St Petersburg, Russische Federatie, 192288
        • Local Institution
      • St-Petersburg, Russische Federatie, 194354
        • Local Institution
      • St-Petersburg, Russische Federatie, 195271
        • Local Institution
      • St. Petersburg, Russische Federatie, 197341
        • Local Institution
      • St. Petersburg, Russische Federatie, 197110
        • Local Institution
      • St.-Petersburg, Russische Federatie, 197341
        • Local Institution
      • St.Petersburg, Russische Federatie, 199106
        • Local Institution
      • Tomsk, Russische Federatie, 634012
        • Local Institution
      • Tumen, Russische Federatie, 625023
        • Local Institution
      • Tver, Russische Federatie, 170036
        • Local Institution
      • Voronezh, Russische Federatie, 394066
        • Local Institution
      • Voronezh, Russische Federatie, 394065
        • Local Institution
      • Yaroslavl, Russische Federatie, 150030
        • Local Institution
      • Yaroslavl, Russische Federatie, 150003
        • Local Institution
      • Yaroslavl, Russische Federatie, 150002
        • Local Institution
      • Zheleznodorozhniy, Russische Federatie, 143920
        • Local Institution
      • Zhukovsky, Russische Federatie, 140160
        • Local Institution
      • Zhukovsky, Russische Federatie, 140180
        • Local Institution
  • Singapore
      • Singapore, Singapore, 168752
        • Local Institution
  • Spanje
      • Albacete, Spanje, 02006
        • Local Institution
      • Barcelona, Spanje, 08035
        • Local Institution
      • Barcelona, Spanje, 08003
        • Local Institution
      • Elda, Spanje, 03600
        • Local Institution
      • Figueres, Spanje, 17600
        • Local Institution
      • Gerona, Spanje, 17007
        • Local Institution
      • Las Palmas, Spanje, 35010
        • Local Institution
      • Madrid, Spanje, 28006
        • Local Institution
      • Madrid, Spanje, 28046
        • Local Institution
      • Madrid, Spanje, 28040
        • Local Institution
      • Palma De Mallorca, Spanje, 07010
        • Local Institution
      • San Sebastian De Los Reyes, Spanje, 28703
        • Local Institution
      • Tarragona, Spanje, 43007
        • Local Institution
      • Viladecans, Spanje, 08840
        • Local Institution
    • Alicante
      • San Juan, Alicante, Spanje, 03550
        • Local Institution
      • Torrevieja, Alicante, Spanje, 03186
        • Local Institution
    • Almeria
      • La Canada, Almeria, Spanje, 04120
        • Local Institution
    • Galicia
      • Lugo, Galicia, Spanje, 27003
        • Local Institution
  • Taiwan
      • Taipei, Taiwan, 100
        • Local Institution
      • Taipei, Taiwan, 112
        • Local Institution
      • Taipei, Taiwan, 111
        • Local Institution
      • Taipei, Taiwan, 220
        • Local Institution
      • Taipei, Taiwan, 10449
        • Local Institution
      • Taipei, Taiwan, 104
        • Local Institution
  • Tsjechië
      • Boskovice, Tsjechië, 680 21
        • Local Institution
      • Brno, Tsjechië, 625 00
        • Local Institution
      • Brno-Malomerice, Tsjechië, 614 00
        • Local Institution
      • Ivancice, Tsjechië, 664 91
        • Local Institution
      • Kladno, Tsjechië, 272 59
        • Local Institution
      • Litomysl, Tsjechië, 570 14
        • Local Institution
      • Mestec Kralove, Tsjechië, 289 03
        • Local Institution
      • Ostrava, Tsjechië, 70852
        • Local Institution
      • Prague 13, Tsjechië, 158 00
        • Local Institution
      • Prague 2, Tsjechië, 128 08
        • Local Institution
      • Pribram, Tsjechië, 261 01
        • Local Institution
      • Usti Nad Orlici, Tsjechië, 562 18
        • Local Institution
  • Verenigd Koninkrijk
      • Antrim, Verenigd Koninkrijk, BT41 2RL
        • Local Institution
      • Blackpool, Verenigd Koninkrijk, FY3 8NR
        • Local Institution
      • Glasgow, Verenigd Koninkrijk, G21 3UW
        • Local Institution
    • Aberdeenshire
      • Aberdeen, Aberdeenshire, Verenigd Koninkrijk, AB25 2ZN
        • Local Institution
      • Glasgow, Aberdeenshire, Verenigd Koninkrijk, G11 6NT
        • Local Institution
    • Antrim
      • Belfast, Antrim, Verenigd Koninkrijk, BT14 6AB
        • Local Institution
    • Armagh
      • Craigavon, Armagh, Verenigd Koninkrijk, BT63 5QQ
        • Local Institution
    • Cambridgeshire
      • Cambridge, Cambridgeshire, Verenigd Koninkrijk, CB2 2QQ
        • Local Institution
      • Peterborough, Cambridgeshire, Verenigd Koninkrijk, PE2 5GP
        • Local Institution
    • Derbyshire
      • Chesterfield, Derbyshire, Verenigd Koninkrijk, S44 5BL
        • Local Institution
      • Chesterfield, Derbyshire, Verenigd Koninkrijk, S40 4TF
        • Local Institution
    • Dorset
      • Bournemouth, Dorset, Verenigd Koninkrijk, BH7 7DW
        • Local Institution
    • Dumbartonshire
      • Glasgow, Dumbartonshire, Verenigd Koninkrijk, G11 6NT
        • Local Institution
    • EAST Sussex
      • Chichester, EAST Sussex, Verenigd Koninkrijk, PO19 6SE
        • Local Institution
    • Essex
      • Colchester, Essex, Verenigd Koninkrijk, C03 4LN
        • Local Institution
      • Romford, Essex, Verenigd Koninkrijk, RH7 0AG
        • Local Institution
    • Greater London
      • Denmark Hill, Greater London, Verenigd Koninkrijk, SE5 9RS
        • Local Institution
      • London, Greater London, Verenigd Koninkrijk, SW17 0RE
        • Local Institution
    • Gwent
      • Newport, Gwent, Verenigd Koninkrijk, NP20 2UB
        • Local Institution
    • Hertfordshire
      • Barnet, Hertfordshire, Verenigd Koninkrijk, EN5 3DJ
        • Local Institution
    • MID Glamorgan
      • Cardiff, MID Glamorgan, Verenigd Koninkrijk, CF14 4XW
        • Local Institution
      • Llandough, MID Glamorgan, Verenigd Koninkrijk, CF64 2XX
        • Local Institution
    • Middlesex
      • Harrow, Middlesex, Verenigd Koninkrijk, HA1 3UJ
        • Local Institution
    • Nottinghamshire
      • Nottingham, Nottinghamshire, Verenigd Koninkrijk, NG5 1PB
        • Local Institution
      • Worksop, Nottinghamshire, Verenigd Koninkrijk, S81 OBD
        • Local Institution
    • Renfrewshire
      • Paisley, Renfrewshire, Verenigd Koninkrijk, PA2 9PN
        • Local Institution
    • South Yorkshire
      • Barnsley, South Yorkshire, Verenigd Koninkrijk, S75 2EP
        • Local Institution
      • Doncaster, South Yorkshire, Verenigd Koninkrijk, DN2 5LT
        • Local Institution
    • Stirlingshire
      • Stirling, Stirlingshire, Verenigd Koninkrijk, FK8 2AU
        • Local Institution
    • Strathclyde
      • Glasgow, Strathclyde, Verenigd Koninkrijk, G51 4TF
        • Local Institution
    • Suffolk
      • Bury St Edmunds, Suffolk, Verenigd Koninkrijk, IP31 2HD
        • Local Institution
      • Bury St Edmunds, Suffolk, Verenigd Koninkrijk, IP33 2QZ
        • Local Institution
      • Bury St. Edmunds, Suffolk, Verenigd Koninkrijk, IP30 9QU
        • Local Institution
      • Ipswich, Suffolk, Verenigd Koninkrijk, IP14 2PU
        • Local Institution
      • Ipswich, Suffolk, Verenigd Koninkrijk, IP7 5DN
        • Local Institution
    • Tyne and Wear
      • Newcastle Upon Tyne, Tyne and Wear, Verenigd Koninkrijk, NE1 4LP
        • Local Institution
    • WEST Glamorgan
      • Swansea, WEST Glamorgan, Verenigd Koninkrijk, SA6 6NL
        • Local Institution
    • WEST Lothian
      • Livingston, WEST Lothian, Verenigd Koninkrijk, EH54 6PP
        • Local Institution
    • WEST Midlands
      • Birmingham, WEST Midlands, Verenigd Koninkrijk, B18 7QH
        • Local Institution
    • Wiltshire
      • Westbury, Wiltshire, Verenigd Koninkrijk, BA 13 3JD
        • Local Institution
      • Westbury, Wiltshire, Verenigd Koninkrijk, BA13 3JD
        • Local Institution
    • Yorkshire
      • York, Yorkshire, Verenigd Koninkrijk, YO31 8HE
        • Local Institution
      • York, Yorkshire, Verenigd Koninkrijk, YO31 HE
        • Local Institution
  • Verenigde Staten
    • Alabama
      • Birmingham, Alabama, Verenigde Staten, 35209
        • Cardiovascular Associates, Pc
      • Birmingham, Alabama, Verenigde Staten, 35235
        • Alabama Internal Medicine Pc
      • Birmingham, Alabama, Verenigde Staten, 35235
        • Birmingham Heart Clinic P.C.
      • Huntsville, Alabama, Verenigde Staten, 35801
        • Heart Center, Inc.
      • Mobile, Alabama, Verenigde Staten, 36608
        • Mobile Heart Specialists, PC
      • Mobile, Alabama, Verenigde Staten, 36617
        • Clara V. Massey, Md
    • Alaska
      • Anchorage, Alaska, Verenigde Staten, 99508
        • Alaska Heart Institute
    • Arizona
      • Phoenix, Arizona, Verenigde Staten, 85006
        • Internal Medicine Physicians Associates, P.C.
      • Tucson, Arizona, Verenigde Staten, 85723
        • Southern Arizona VA Health Care System
      • Tucson, Arizona, Verenigde Staten, 85710
        • Southwest Heart
      • Tucson, Arizona, Verenigde Staten, 85745
        • Pima Research Foundation
    • Arkansas
      • Hot Springs, Arkansas, Verenigde Staten, 71913
        • Dr. Rajesh Shroff
      • Little Rock, Arkansas, Verenigde Staten, 72204
        • Mary K. Richards, Md Pa
    • California
      • Anaheim, California, Verenigde Staten, 92801
        • Advanced Clinical Reserach Institute
      • Beverly Hills, California, Verenigde Staten, 90210
        • Act/Cardiovascular Research Institute
      • Carmichael, California, Verenigde Staten, 95608
        • Capitol Interventional Cardiology
      • Escondido, California, Verenigde Staten, 92025
        • Escondido Cardiology Associates, Inc.
      • Healdsburg, California, Verenigde Staten, 95448
        • William D. Bowden, D.O.
      • La Mesa, California, Verenigde Staten, 91942
        • La Mesa Cardiac Center, A Medical Group
      • Los Angeles, California, Verenigde Staten, 90073
        • VA Greater Los Angeles Healthcare System
      • Mission Viejo, California, Verenigde Staten, 92691
        • Coastal Cardiology
      • Oceanside, California, Verenigde Staten, 92056
        • Kenneth W. Carr Md
      • Palm Springs, California, Verenigde Staten, 92262
        • Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
      • Rancho Mirage, California, Verenigde Staten, 92270
        • Desert Cardiology Consultants Medical Group, Inc
      • Sacramento, California, Verenigde Staten, 95821
        • Northern California Research
      • Sacramento, California, Verenigde Staten, 95825
        • Sacramento Heart And Vascular Medical Associates
      • Sacramento, California, Verenigde Staten, 95819
        • Regional Cardiolody Associates
      • Santa Barbara, California, Verenigde Staten, 93105
        • Arrhythmia Consultants Of The Central Coast Medical Group
      • Santa Rosa, California, Verenigde Staten, 95403
        • Northern California Medical Associates
      • Vista, California, Verenigde Staten, 92083
        • Progressive Clinical Research
      • Walnut Creek, California, Verenigde Staten, 94598
        • Cardivasclular Consultants Medical Group
      • Wildomar, California, Verenigde Staten, 92595
        • Shiva Heart Center Medical Group
    • Colorado
      • Colorado Springs, Colorado, Verenigde Staten, 80910
        • Electrophysiology Associates, Pc
      • Denver, Colorado, Verenigde Staten, 80220
        • Denver VA Medical Center
      • Denver, Colorado, Verenigde Staten, 80218
        • Aurora Denver Cardiology Associates, P.C.
      • Golden, Colorado, Verenigde Staten, 80401
        • New West Physicians Clinical Research
      • Littleton, Colorado, Verenigde Staten, 80120
        • South Denver Cardiology Associates PC
    • Connecticut
      • Bridgeport, Connecticut, Verenigde Staten, 06610
        • Bridgeport Hospital
      • Bridgeport, Connecticut, Verenigde Staten, 06606
        • Connecticut Clinical Research, Llc
      • Guilford, Connecticut, Verenigde Staten, 06437
        • Cardiology Associates Of New Haven,Pc
      • Norwich, Connecticut, Verenigde Staten, 06360
        • William W Backus Hospital
      • Norwich, Connecticut, Verenigde Staten, 06360
        • The William W. Backus Hospital
      • Stamford, Connecticut, Verenigde Staten, 06905
        • Stamford Therapeutics Consortium
      • Waterbury, Connecticut, Verenigde Staten, 06708
        • Chase Medical Research, LLC
    • Delaware
      • Newark, Delaware, Verenigde Staten, 19713
        • Alfieri Cardiology
    • District of Columbia
      • Washington, District of Columbia, Verenigde Staten, 20422
        • Washington VA Medical Center
      • Washington, District of Columbia, Verenigde Staten, 20037
        • George Washington University Medical Faculty Associates
    • Florida
      • Atlantis, Florida, Verenigde Staten, 33462
        • Medical Specialist Of The Palm Beach
      • Aventura, Florida, Verenigde Staten, 33180
        • Miami International Cardiology Consultants
      • Boca Raton, Florida, Verenigde Staten, 33431
        • David Charles Mishkel, Md, Pa
      • Clearwater, Florida, Verenigde Staten, 33756
        • The Heart & Vascular Institute Of Florida
      • Clearwater, Florida, Verenigde Staten, 33756
        • The Heart And Vascular Institute Of Florida
      • Davie, Florida, Verenigde Staten, 33324
        • Cardiovascular Specialist Of South Florida
      • Daytona Beach, Florida, Verenigde Staten, 32114
        • Daytona Heart Group
      • Fort Lauderdale, Florida, Verenigde Staten, 33316
        • Broward General Medical Center
      • Fort Lauderdale, Florida, Verenigde Staten, 33308
        • Cardiology Associates Of Fort Lauderdale, P.A.
      • Fort Myers, Florida, Verenigde Staten, 33907
        • Florida Heart Associates
      • Gainesville, Florida, Verenigde Staten, 32605
        • Florida Research Network, LLC
      • Hollywood, Florida, Verenigde Staten, 33021
        • Healthworx
      • Hollywood, Florida, Verenigde Staten, 33021
        • Luis Tami, Md
      • Inverness, Florida, Verenigde Staten, 34452
        • Nature Coast Clinical Research
      • Jacksonville, Florida, Verenigde Staten, 32216
        • Jacksonville Center for Clinical Research
      • Jacksonville, Florida, Verenigde Staten, 32216
        • Jacksonville Cardiovascular Center
      • Jacksonville, Florida, Verenigde Staten, 32258
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Verenigde Staten, 32204
        • St. Vincent'S Ambulatory Care, Inc
      • Jacksonville, Florida, Verenigde Staten, 32207
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Verenigde Staten, 32216
        • St. Luke'S Cardiology
      • Jacksonville Beach, Florida, Verenigde Staten, 32250
        • Jacksonville Heart Center, P.A.
      • Jupiter, Florida, Verenigde Staten, 33458
        • Cvms Research Institute, Llc
      • Jupiter, Florida, Verenigde Staten, 33458
        • Ricardo Bedoya, M.D.
      • Melbourne, Florida, Verenigde Staten, 32901
        • Melbourne Internal Medicine Associates
      • Miami, Florida, Verenigde Staten, 33137
        • Miami International Cardiology Consultants
      • Miami, Florida, Verenigde Staten, 33137-3732
        • Miami International Cardiology Consultants
      • Naples, Florida, Verenigde Staten, 34119
        • Physicians Regional Medical Group
      • Orlando, Florida, Verenigde Staten, 32803
        • Florida Heart Group
      • Oviedo, Florida, Verenigde Staten, 32765
        • Alpha Medical Research
      • Pensacola, Florida, Verenigde Staten, 32501
        • Cardiology Consultants
      • Saint Petersburg, Florida, Verenigde Staten, 33709
        • The Heart And Vascular Institute Of Florida
      • Sarasota, Florida, Verenigde Staten, 34239
        • Heart & Vascular Center Research, Inc.
      • Sarasota, Florida, Verenigde Staten, 34232
        • Niranjan Seshadri, Md
      • Vero Beach, Florida, Verenigde Staten, 32960
        • Research, Inc.
    • Georgia
      • Atlanta, Georgia, Verenigde Staten, 30342
        • Cardiovascular Specialits, Pc
      • Augusta, Georgia, Verenigde Staten, 30901
        • Augusta Cardiology Clinic, P.C.
      • Columbus, Georgia, Verenigde Staten, 31909
        • Columbus Cardiology Associates Pc
      • Columbus, Georgia, Verenigde Staten, 31909
        • Columbus Cardiology Associates,Pc
      • Covington, Georgia, Verenigde Staten, 30014
        • Georgia Heart Specialists, L.L.C.
      • Decatur, Georgia, Verenigde Staten, 30030
        • Atlanta Institute For Medical Research, Inc
      • Gainesville, Georgia, Verenigde Staten, 30501
        • Northeast Georgia Heart Center, PC
      • Marietta, Georgia, Verenigde Staten, 30060
        • Wellstar Cardiovascular Medicine, Pc
    • Illinois
      • Aurora, Illinois, Verenigde Staten, 60504
        • Fox Valley Clinical Research Center, LLC
      • Chicago, Illinois, Verenigde Staten, 60611
        • Nmff
      • Gurnee, Illinois, Verenigde Staten, 60031
        • Clinical Investigation Specialists, Inc
      • Maywood, Illinois, Verenigde Staten, 60153
        • Loyola University Medical Center
      • Normal, Illinois, Verenigde Staten, 61761
        • Illinois Heart & Lung Research Center, Sc
      • North Chicago, Illinois, Verenigde Staten, 60064
        • Cpt. James A Lovell Federal Health Care Center
    • Indiana
      • Anderson, Indiana, Verenigde Staten, 46011
        • Community Clinical Research Center
      • Bloomington, Indiana, Verenigde Staten, 47403
        • Premier Healthcare, Llc
      • Elkhart, Indiana, Verenigde Staten, 46514
        • Elkhart Clinic, LLC
      • Fort Wayne, Indiana, Verenigde Staten, 46804
        • Lutheran Medical Group, Llc
      • Fort Wayne, Indiana, Verenigde Staten, 46805
        • Fort Wayne Cardiology
      • Indianapolis, Indiana, Verenigde Staten, 46290
        • The Care Group, Llc
      • Indianapolis, Indiana, Verenigde Staten, 46290
        • The Care Group, Llc.
      • Indianapolis, Indiana, Verenigde Staten, 46237
        • St Francis Medical Group - Indiana Heart Physicians
      • Michigan City, Indiana, Verenigde Staten, 46360
        • Dali, Sammi
      • South Bend, Indiana, Verenigde Staten, 46601
        • Cardiology Associates, Inc.
    • Iowa
      • Ames, Iowa, Verenigde Staten, 50010
        • McFarland Clinic PC
    • Kansas
      • Overland Park, Kansas, Verenigde Staten, 66209
        • Midwest Cardiology Associates , P.C.
    • Kentucky
      • Elizabethtown, Kentucky, Verenigde Staten, 42701
        • Central Cardiology Assoc.
      • Lexington, Kentucky, Verenigde Staten, 40504
        • New Lexington Clinic, P.S.C.
      • Louisville, Kentucky, Verenigde Staten, 40205
        • Norton Cardiovascular Associates
      • Louisville, Kentucky, Verenigde Staten, 40202
        • VA Medical Center
      • Owensboro, Kentucky, Verenigde Staten, 42303
        • Owensboro Heart & Vascular
    • Louisiana
      • Alexandria, Louisiana, Verenigde Staten, 71301
        • Alexandria Cardiology Clinic
      • Houma, Louisiana, Verenigde Staten, 70360
        • Cardiovascular Institute of the South
      • Lacombe, Louisiana, Verenigde Staten, 70445
        • Smith, Patel & Amkieh, Llc
      • Lake Charles, Louisiana, Verenigde Staten, 70601
        • Imperial Calcasieu Medical Group, Llp
      • Marrero, Louisiana, Verenigde Staten, 70072
        • Cardiology Center, Llc
      • Shreveport, Louisiana, Verenigde Staten, 71105
        • Cardiology Associates
      • Slidell, Louisiana, Verenigde Staten, 70458
        • Louisiana Heart Center
      • Slidell, Louisiana, Verenigde Staten, 70458
        • Medical Research Inst, Inc
      • Slidell, Louisiana, Verenigde Staten, 70458
        • Medical Research Institute, Inc
      • Ventura, Louisiana, Verenigde Staten, 93003
        • Ventura Cardio. Cond. Med. Group, Inc.
    • Maine
      • Lewiston, Maine, Verenigde Staten, 04240
        • Central Maine Heart & Vascular Institute
    • Maryland
      • Baltimore, Maryland, Verenigde Staten, 21224
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Verenigde Staten, 21237
        • Franklin Square Hospital
      • Baltimore, Maryland, Verenigde Staten, 21208
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Verenigde Staten, 21237
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Verenigde Staten, 21204
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Verenigde Staten, 21218
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Verenigde Staten, 21224-2735
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Verenigde Staten, 21237
        • Midatlantic Cardiovascular Associates, P.A.
      • Bel Air, Maryland, Verenigde Staten, 21014
        • Midatlantic Cardiovascular Associates, Pa
      • Columbia, Maryland, Verenigde Staten, 21044
        • Cardiovascular Specialists Of Central Maryland, P.A.
      • Reisterstown, Maryland, Verenigde Staten, 21136
        • Clinical Associates Research
      • Westminster, Maryland, Verenigde Staten, 21157
        • Midatlantic Cardiovascular Associates, Pa
    • Massachusetts
      • Billerica, Massachusetts, Verenigde Staten, 01821
        • Burlington Medical Associates
      • Boston, Massachusetts, Verenigde Staten, 02135
        • Caritas St. Elizabeth's Medical Center
      • Burlington, Massachusetts, Verenigde Staten, 01805
        • Lahey Clinic Medical Center
      • Fall River, Massachusetts, Verenigde Staten, 02720
        • Neccr Internal Medicine & Cardiology Associates,Llc
      • Haverhill, Massachusetts, Verenigde Staten, 01830
        • Pentucket Medical Associates
      • Haverhill, Massachusetts, Verenigde Staten, 01830-6278
        • Pentucket Medical Associates
      • Natick, Massachusetts, Verenigde Staten, 01760
        • Charles River Medical Associates
    • Michigan
      • Alpena, Michigan, Verenigde Staten, 49707
        • Great Lakes Heart Center Of Alpena
      • Detroit, Michigan, Verenigde Staten, 48202
        • Henry Ford Hospital
      • Lansing, Michigan, Verenigde Staten, 48910
        • Thoracic And Cardiovascular Healthcare Foundation
      • Livonia, Michigan, Verenigde Staten, 48154
        • Advanced Cardiovascular Health Specialists, Pc
      • Petoskey, Michigan, Verenigde Staten, 49770
        • Michigan Heart And Vascular Specialists
      • Royal Oak, Michigan, Verenigde Staten, 48073
        • William Beaumont Hospital
      • Ypsilanti, Michigan, Verenigde Staten, 48197
        • Michigan Heart, P.C.
    • Minnesota
      • Minneapolis, Minnesota, Verenigde Staten, 55455
        • University of Minnesota
      • Minneapolis, Minnesota, Verenigde Staten, 55417
        • Minneapolis VA Medical Center
      • Robbinsdale, Minnesota, Verenigde Staten, 55422
        • North Memorial Health Care
    • Mississippi
      • Olive Branch, Mississippi, Verenigde Staten, 38654
        • Olive Branch Family Medical Center
      • Tupelo, Mississippi, Verenigde Staten, 38801
        • Tupelo Neurology Clinic, Pa
    • Missouri
      • Columbia, Missouri, Verenigde Staten, 65212
        • University of Missouri
      • Kansas City, Missouri, Verenigde Staten, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Verenigde Staten, 64111
        • Saint Luke's Lipid and Diabetes Research Center
    • Nebraska
      • Grand Island, Nebraska, Verenigde Staten, 68803
        • Internal Medical Associates Of Grand Island, P.C
      • Grand Island, Nebraska, Verenigde Staten, 68803-4311
        • Internal Medical Associates Of Grand Island, P.C
      • Hastings, Nebraska, Verenigde Staten, 68901
        • Nebraska Heart Institute
    • Nevada
      • Las Vegas, Nevada, Verenigde Staten, 89106
        • VA Southern Nevada Healthcare System
    • New Jersey
      • Berlin, New Jersey, Verenigde Staten, 08009
        • Comprehensive Clinical Research
      • Elmer, New Jersey, Verenigde Staten, 08318
        • Cardiovascular Associates Of The Delware Valley, P.A.
      • Haddon Heights, New Jersey, Verenigde Staten, 08035
        • Cardiovascular Associates Of The Delaware Valley, P.A.
      • Princeton, New Jersey, Verenigde Staten, 08540
        • Princeton Medical Institute
      • Sewell, New Jersey, Verenigde Staten, 08080
        • Cardio Assoc Of Del Val, P.A.
      • South Plainfield, New Jersey, Verenigde Staten, 07080
        • Central New Jersey Cardiology
    • New Mexico
      • Albuquerque, New Mexico, Verenigde Staten, 87012
        • Abq Health Partners, Llc
      • Albuquerque, New Mexico, Verenigde Staten, 87131-0001
        • University Of New Mexico/University Hospital
      • Albuquerque, New Mexico, Verenigde Staten, 87131
        • University Of New Mexico/University Hospital
    • New York
      • Albany, New York, Verenigde Staten, 12205
        • Albany Associates In Cardiology
      • Albany, New York, Verenigde Staten, 12205
        • Albany Assoc. In Cardiology
      • Binghamton, New York, Verenigde Staten, 13905
        • Cardiology Associates, Pc
      • Buffalo, New York, Verenigde Staten, 14215
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Verenigde Staten, 14215-1145
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Verenigde Staten, 14215
        • Bruce L. Platt Md, Pc
      • Buffalo, New York, Verenigde Staten, 14215
        • Bruce L. Platt, Md
      • East Syracuse, New York, Verenigde Staten, 13057
        • Heart Care Center, P.C.
      • Huntington, New York, Verenigde Staten, 11743
        • Huntington Hospital
      • Liverpool, New York, Verenigde Staten, 13088
        • SJH Cardiology Associates
      • Mineola, New York, Verenigde Staten, 11501
        • Long Island Heart Associates
      • Saratoga Springs, New York, Verenigde Staten, 12866
        • Saratoga Cardiology Associates, Pc
      • Williamsville, New York, Verenigde Staten, 14221
        • Office Of Dr. Kozinn
      • Williamsville, New York, Verenigde Staten, 14221
        • Suburban Cardiology
    • North Carolina
      • Asheville, North Carolina, Verenigde Staten, 28803
        • Asheville Cardiology Associates
      • Burlington, North Carolina, Verenigde Staten, 27215
        • Kernodle Clinic, Inc.
      • High Point, North Carolina, Verenigde Staten, 27262
        • Carolina Cardiology Associates, Pa
      • Pinehurst, North Carolina, Verenigde Staten, 28374
        • Pinehurst Medical Center, Inc
    • North Dakota
      • Fargo, North Dakota, Verenigde Staten, 58103
        • Lillestol Research LLC
    • Ohio
      • Akron, Ohio, Verenigde Staten, 44304
        • Akron Cardiology Consultants
      • Bucyrus, Ohio, Verenigde Staten, 44820
        • Christopher M. Johnson, D.O.
      • Bucyrus, Ohio, Verenigde Staten, OHIO
        • Christopher M. Johnson, D.O.
      • Canal Fulton, Ohio, Verenigde Staten, 44614
        • Community Health Care, Inc.
      • Canton, Ohio, Verenigde Staten, 44710
        • Cardiology Associates
      • Cincinnati, Ohio, Verenigde Staten, 45219
        • The Carl & Edyth Lindner Center For R&E At The Christ Hosp
      • Toledo, Ohio, Verenigde Staten, 43608
        • Toledo Cardiology Consultants
      • Wadsworth, Ohio, Verenigde Staten, 44281
        • Family Practice Center of Wadsworth, Inc.
    • Oklahoma
      • Muskogee, Oklahoma, Verenigde Staten, 74401
        • Jack C. Va Medical Center
      • Oklahoma City, Oklahoma, Verenigde Staten, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Verenigde Staten, 73112
        • Plaza Medical Group, Pc
      • Oklahoma City, Oklahoma, Verenigde Staten, 73103
        • COR Clinical Research, LLC
      • Oklahoma City, Oklahoma, Verenigde Staten, 73135
        • South Oklahoma Heart Research
      • Oklahoma City, Oklahoma, Verenigde Staten, 73120
        • Oklahoma Heart Hospital Physicians
      • Oklahoma City, Oklahoma, Verenigde Staten, 73139
        • Eminence Research, LLC
      • Tulsa, Oklahoma, Verenigde Staten, 74136
        • Castlerock Clinical Research Consultants, Llc
    • Oregon
      • Bend, Oregon, Verenigde Staten, 97701
        • St. Charles Health System, Inc.
      • Bend, Oregon, Verenigde Staten, 97701
        • St. Charles Health System, Inc
      • Eugene, Oregon, Verenigde Staten, 97401
        • Oregon Medical Group - Clinical Research
      • Hillsboro, Oregon, Verenigde Staten, 97123
        • Hillsboro Cardiology Pc
      • Medford, Oregon, Verenigde Staten, 97504
        • Rogue Valley Physicians - Clinical Research Group
    • Pennsylvania
      • Abington, Pennsylvania, Verenigde Staten, 19001
        • Abington Medical Specialists
      • Altoona, Pennsylvania, Verenigde Staten, 16602
        • Blair Medical Associates, Inc.
      • Camp Hill, Pennsylvania, Verenigde Staten, 17011
        • Heritage Cardiology Assoc.
      • Doylestown, Pennsylvania, Verenigde Staten, 18901
        • Central Bucks Cardiology
      • Erie, Pennsylvania, Verenigde Staten, 16509
        • Internal Medicine And Lipid Mgmt.
      • Harrisburg, Pennsylvania, Verenigde Staten, 17112
        • Kandra, Fierer, Kuskin Associates
      • Hatfield, Pennsylvania, Verenigde Staten, 19440
        • Pivotal Clinical Research, Llc
      • Jersey Shore, Pennsylvania, Verenigde Staten, 17740
        • Lycoming Internal Medicine Inc.
      • Sayre, Pennsylvania, Verenigde Staten, 18840
        • Guthrie Medical Group, P.C.
      • Sayre, Pennsylvania, Verenigde Staten, 18840
        • Guthrie Clinic Ltd.
      • Uniontown, Pennsylvania, Verenigde Staten, 15401
        • Preferred Primary Care Physicians
      • West Chester, Pennsylvania, Verenigde Staten, 19380
        • West Chester Cardiology, Pc
      • Yardley, Pennsylvania, Verenigde Staten, 19067
        • Cardiology Consultants of Philadelphia
    • Rhode Island
      • Providence, Rhode Island, Verenigde Staten, 02903
        • Rhode Island Hospital
    • South Carolina
      • Anderson, South Carolina, Verenigde Staten, 29621
        • Southeastern Research Associates, Inc
      • Beaufort, South Carolina, Verenigde Staten, 29906
        • Lowcountry Medical Group, Llc
      • Beaufort, South Carolina, Verenigde Staten, 29906
        • Lowcountry Medical Group
      • Charleston, South Carolina, Verenigde Staten, 29425
        • Medical University of South Carolina
      • Columbia, South Carolina, Verenigde Staten, 29203
        • Columbia Heart Clinic
      • Greenville, South Carolina, Verenigde Staten, 29607
        • Upstate Cardiology
      • Greer, South Carolina, Verenigde Staten, 29650
        • Internal Medicine Of Greer
      • Orangeburg, South Carolina, Verenigde Staten, 29118
        • Palmetto Nephrology Pa
      • Spartanburg, South Carolina, Verenigde Staten, 29303
        • S. Carolina Pharmaceutical Research
    • South Dakota
      • Pierre, South Dakota, Verenigde Staten, 57501
        • Avera Medical Associates Clinic
    • Tennessee
      • Bristol, Tennessee, Verenigde Staten, 37620
        • Holston Medical Group
      • Kingsport, Tennessee, Verenigde Staten, 37660
        • Holston Medical Group
      • Knoxville, Tennessee, Verenigde Staten, 37920
        • Volunteer Research Group
      • Knoxville, Tennessee, Verenigde Staten, 37916
        • Knoxville Heart Group
      • Knoxville, Tennessee, Verenigde Staten, 37920-1502
        • Volunteer Research Group
      • Tullahoma, Tennessee, Verenigde Staten, 37388
        • Tennessee Center for Clinical Trials
    • Texas
      • Amarillo, Texas, Verenigde Staten, 79106
        • Amarillo Heart Clinical Research Institute Inc.
      • Corsicana, Texas, Verenigde Staten, 75110
        • Corsicana Medical Research, PLLC
      • Dallas, Texas, Verenigde Staten, 75226
        • Soltero Cardiovascular Research Center
      • Dallas, Texas, Verenigde Staten, 75230
        • HeartPlace
      • Fort Worth, Texas, Verenigde Staten, 76104
        • Heart Center of North Texas
      • Houston, Texas, Verenigde Staten, 77030
        • The Methodist Hospital
      • Houston, Texas, Verenigde Staten, 77030
        • The University of Texas MD Anderson Cancer Center
      • Houston, Texas, Verenigde Staten, 77030
        • Center For Atrial Fibrillation
      • Houston, Texas, Verenigde Staten, 77030
        • The Methodist Hospital Neurology Institute
      • Houston, Texas, Verenigde Staten, 77065
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Verenigde Staten, 77070
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Verenigde Staten, 77074
        • Francisco R. Maislos
      • Houston, Texas, Verenigde Staten, 77090
        • Woodlands North Houston Heart Center
      • Humble, Texas, Verenigde Staten, 77338
        • Regional Medical Center And Diagnostic Clinics
      • Lackland Air Force Base, Texas, Verenigde Staten, 78236
        • Wilford Hall Medical Center
      • Lackland Air Force Base, Texas, Verenigde Staten, 78236-9908
        • Wilford Hall Medical Center
      • Longview, Texas, Verenigde Staten, 75605
        • DCOL Center for Clinical Research
      • McKinney, Texas, Verenigde Staten, 75069
        • North Dallas Research Associates
      • Plano, Texas, Verenigde Staten, 75093
        • North Texas Medical Research
      • Plano, Texas, Verenigde Staten, 75024
        • Legacy Heart Center
      • San Antonio, Texas, Verenigde Staten, 78229
        • Covenant Clinical Research, Pa
      • San Antonio, Texas, Verenigde Staten, 78217
        • Bhs Specialty Network, Inc
      • San Antonio, Texas, Verenigde Staten, 78229
        • Star Clinical Trails
      • Seguin, Texas, Verenigde Staten, 78155
        • Edward Balli, Md, Pa
      • Tomball, Texas, Verenigde Staten, 77375
        • Northwest Heart Center
      • Tyler, Texas, Verenigde Staten, 75701
        • Tyler Cardiovascular Consultants
      • Tyler, Texas, Verenigde Staten, 75708
        • University of Texas Health Science Center at Tyler
      • Tyler, Texas, Verenigde Staten, 75708
        • The Univ. Of Texas Health Science Ctr. At Tyler
    • Utah
      • Layton, Utah, Verenigde Staten, 84041
        • Utah Cardiology P.C
    • Virginia
      • Norfolk, Virginia, Verenigde Staten, 23510
        • Sentara York Clinical Research
      • Richmond, Virginia, Verenigde Staten, 23220
        • Medical Research Initiatives
      • Roanoke, Virginia, Verenigde Staten, 24014
        • Roanoke Heart Institute, Plc
      • Virginia Beach, Virginia, Verenigde Staten, 23454
        • Cardiovascular Associates
    • Washington
      • Burien, Washington, Verenigde Staten, 98166
        • Daniel W. Gottlieb, Md, Ps
      • Burien, Washington, Verenigde Staten, 98166
        • Daniel William Gottlieb, Md
      • Spokane, Washington, Verenigde Staten, 99202
        • Rockwood Clinic Research Cent.
      • Walla Walla, Washington, Verenigde Staten, 99362
        • Walla Walla Clinic
    • West Virginia
      • Lewisburg, West Virginia, Verenigde Staten, 24901
        • Lynn N. Smith, Md
    • Wisconsin
      • Green Bay, Wisconsin, Verenigde Staten, 54301
        • Cardiology Associates Of Green Bay Ltd-Bellin Hospital
      • Madison, Wisconsin, Verenigde Staten, 53715
        • St. Mary's Hospital
      • Madison, Wisconsin, Verenigde Staten, 53715
        • St.Mary's Hospital
      • Milwaukee, Wisconsin, Verenigde Staten, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Verenigde Staten, 53215
        • Aurora Health Care
      • Waukesha, Wisconsin, Verenigde Staten, 53188
        • Cardiology Assc. Of Waukesha
  • Zuid-Afrika
    • Bloemfontein
      • Westdene, Bloemfontein, Zuid-Afrika, 9301
        • Local Institution
    • Cape Town
      • Observatory, Cape Town, Zuid-Afrika, 7925
        • Local Institution
    • Gauteng
      • Pretoria, Gauteng, Zuid-Afrika, 0084
        • Local Institution
      • Pretoria, Gauteng, Zuid-Afrika, 0132
        • Local Institution
    • KWA ZULU Natal
      • Richards Bay, KWA ZULU Natal, Zuid-Afrika, 3900
        • Local Institution
    • Western CAPE
      • Bellville Cape Town, Western CAPE, Zuid-Afrika, 7530
        • Local Institution
      • George, Western CAPE, Zuid-Afrika, 6529
        • Local Institution
      • Parow, Western CAPE, Zuid-Afrika, 7505
        • Local Institution
      • Somerset West, Western CAPE, Zuid-Afrika, 7130
        • Local Institution
      • Worcester, Western CAPE, Zuid-Afrika, 6850
        • Local Institution
  • Zweden
      • Goteberg, Zweden, 413 45
        • Local Institution
      • Helsingborg, Zweden, 251 87
        • Local Institution
      • Linkoping, Zweden, 581 85
        • Local Institution
      • Lund, Zweden, 222 21
        • Local Institution
      • Orebro, Zweden, 70185
        • Local Institution
      • Orebro, Zweden, 701 85
        • Local Institution
      • Skelleftea, Zweden, 931 86
        • Local Institution
      • Stockholm, Zweden, 141 86
        • Local Institution
      • Stockholm, Zweden, 171 76
        • Local Institution
      • Stockholm, Zweden, 111 57
        • Local Institution
      • Stockholm, Zweden, 118 83
        • Local Institution
      • Stockholm, Zweden, 111 35
        • Local Institution
      • Uppsala, Zweden, 751 85
        • Local Institution
      • Vaxjo, Zweden, 351 85
        • Local Institution
  • Zwitserland
      • Baden, Zwitserland, 5404
        • Local Institution
      • Bern, Zwitserland, 3010
        • Local Institution

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Kind
  • Volwassen
  • Oudere volwassene

Accepteert gezonde vrijwilligers

Nee

Geslachten die in aanmerking komen voor studie

Allemaal

Beschrijving

Inclusion Criteria:

  • Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
  • Age ≥ 75, previous stroke
  • transient ischemic attack (TIA) or Systemic Embolism (SE)
  • Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
  • Diabetes mellitus or hypertension requiring pharmacological treatment

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Preventie
  • Toewijzing: Gerandomiseerd
  • Interventioneel model: Parallelle opdracht
  • Masker: Dubbele

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Experimenteel: 2
Geneesmiddel: apixaban
Oral tablets, 5.0 mg or 2.5 mg, twice daily
Andere namen:
  • BMS-562247
Actieve vergelijker: 1
Geneesmiddel: warfarin
Oral tablets, 2.0 mg, adjusted to an INR of 2.5 (range 2.0 to 3.0)
Andere namen:
  • Coumadin
  • BMS-565793

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period
Tijdsspanne: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period
Tijdsspanne: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period
Tijdsspanne: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated All-Cause Death During the Intended Treatment Period
Tijdsspanne: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period
Tijdsspanne: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period
Tijdsspanne: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period
Tijdsspanne: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period
Tijdsspanne: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With All Bleeding Events During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of All Bleeding Events During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Andere uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
AE: all SAEs or AEs with onset from first dose through 2 days (AEs) or 30 days (SAEs) after the last dose of blinded study drug (BSD). SAE: all SAEs with onset from first dose through 30 days after the last dose of BSD. Bleeding AE: all serious or non-serious bleeding-related AEs with onset from first dose through 2 days after the last dose of BSD. Discontinuations due to AE: all SAEs or AEs with onset from first dose of BSD and with action taken=drug discontinued. Deaths: all deaths occurring from first dose through 30 days after the last dose of BSD.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated GUSTO bleeding events per 100 patient years. GUSTO Bleeding Criteria: GUSTO severe (or life-threatening) bleeding: either intracranial hemorrhage or bleeding that causes hemodynamic compromise and requires intervention. GUSTO moderate bleeding: bleeding that requires blood transfusion but does not result in hemodynamic compromise.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated TIMI bleeding events per 100 patient years. TIMI Bleeding Criteria: Major bleeding=Intracranial bleeding and/or clinically overt bleeding associated with ≥5 gm/dL fall in Hgb or 15% fall in hematocrit (Hct) from baseline, accounting for transfusions. Minor bleeding=Clinically overt bleeding associated with ≥3 gm/dL fall in Hgb or a ≥10% fall in Hct from baseline, accounting for transfusions.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Net-Clinical Benefit During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Net-Clinical Benefit During Treatment Period
Tijdsspanne: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of events of net-clinical benefit per 100 patient years. Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Bristol-Myers Squibb

Publicaties en nuttige links

De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.

Algemene publicaties

Nuttige links

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

31 december 2006

Primaire voltooiing (Werkelijk)

25 mei 2011

Studie voltooiing (Werkelijk)

25 mei 2011

Studieregistratiedata

Eerst ingediend

18 december 2006

Eerst ingediend dat voldeed aan de QC-criteria

18 december 2006

Eerst geplaatst (Schatting)

19 december 2006

Updates van studierecords

Laatste update geplaatst (Werkelijk)

3 juli 2018

Laatste update ingediend die voldeed aan QC-criteria

5 juni 2018

Laatst geverifieerd

1 mei 2018

Meer informatie

Termen gerelateerd aan deze studie

Aanvullende relevante MeSH-voorwaarden

Andere studie-ID-nummers

  • CV185-030

Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .

Abonneren