Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (ARISTOTLE)

June 5, 2018 updated by: Bristol-Myers Squibb

A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

20976

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Buenos Aires, Argentina, 1119
    - Local Institution
  - Buenos Aires, Argentina, C1280AEB
    - Local Institution
  - Buenos Aires, Argentina, 1181
    - Local Institution
  - Buenos Aires, Argentina, C1426ANZ
    - Local Institution
  - Buenos Aires, Argentina, 1280
    - Local Institution
  - Cordoba, Argentina, 5000
    - Local Institution
  - Cordoba, Argentina, X5000EPU
    - Local Institution
  - Cordoba, Argentina, X5008KKF
    - Local Institution
  - Cordoba, Argentina, X5003DCE
    - Local Institution
  - Salta, Argentina, 4400
    - Local Institution
  - Santa Fe, Argentina, 3000
    - Local Institution
  - Tucuman, Argentina, T4000NIL
    - Local Institution
- Buenos Aires
  - Adrogue, Buenos Aires, Argentina, 1846
    - Local Institution
  - Bahia Blanca, Buenos Aires, Argentina, B8000FTD
    - Local Institution
  - Ciudad Autonoma, Buenos Aires, Argentina, CP1425A WC
    - Local Institution
  - Ciudad Autonoma, Buenos Aires, Argentina, 1128AAD
    - Local Institution
  - Ciudad Autonoma, Buenos Aires, Argentina, 1128
    - Local Institution
  - Ciudad Autonoma, Buenos Aires, Argentina, 1426 EGR
    - Local Institution
  - Ciudad Autonoma, Buenos Aires, Argentina, C1426 EGR
    - Local Institution
  - Ciudad Autonoma, Buenos Aires, Argentina, CP1425AWC
    - Local Institution
  - Ciudad Autonoma De, Buenos Aires, Argentina, 1180
    - Local Institution
  - Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina, CI094AAD
    - Local Institution
  - Coronel Suarez, Buenos Aires, Argentina, B7540GHD
    - Local Institution
  - Haedo, Buenos Aires, Argentina, B1706AJU
    - Local Institution
  - Junin, Buenos Aires, Argentina, 6000
    - Local Institution
  - La Plata, Buenos Aires, Argentina, 1900
    - Local Institution
  - La Plata, Buenos Aires, Argentina, B1900AXI
    - Local Institution
  - La Plata, Buenos Aires, Argentina, 1902
    - Local Institution
  - Mar Del Plata, Buenos Aires, Argentina, 7600
    - Local Institution
  - Merlo, Buenos Aires, Argentina, B1722COV
    - Local Institution
  - Merlo, Buenos Aires, Argentina, 1722
    - Local Institution
  - Olivos, Buenos Aires, Argentina, 1602
    - Local Institution
  - Quilmes, Buenos Aires, Argentina, 1878
    - Local Institution
  - Ramos Mejia, Buenos Aires, Argentina, B1704ESN
    - Local Institution
  - Ramos Mejia, Buenos Aires, Argentina, B1704ETD
    - Local Institution
  - Ramos Mejia, Buenos Aires, Argentina, 1706
    - Local Institution
  - San Justo, Buenos Aires, Argentina, 1754
    - Local Institution
  - San Martin, Buenos Aires, Argentina, 1650
    - Local Institution
  - San Nicolas, Buenos Aires, Argentina, 2900
    - Local Institution
  - Zarate, Buenos Aires, Argentina, 2800
    - Local Institution
  - Zarate, Buenos Aires, Argentina, B2800DGH
    - Local Institution
- Provincia DE Cordoba
  - Cordoba, Provincia DE Cordoba, Argentina, 5000
    - Local Institution
- RIO Negro
  - Cipolletti, RIO Negro, Argentina, 8324
    - Local Institution
- Santa FE
  - Rosario, Santa FE, Argentina, 2000
    - Local Institution
  - Rosario, Santa FE, Argentina, S2000CVB
    - Local Institution
  - Rosario, Santa FE, Argentina, S2001ODA
    - Local Institution
- Santa Fe
  - Rosario, Santa Fe, Argentina, S2000CVD
    - Local Institution
  - Rosario, Santa Fe, Argentina, S2000 CVD
    - Local Institution
- Tucuman
  - San Miquel De Tucuman, Tucuman, Argentina, 4000
    - Local Institution
Australia
- New South Wales
  - Coffs Harbour, New South Wales, Australia, 2450
    - Local Institution
  - Concord, New South Wales, Australia, 2139
    - Local Institution
  - Gosford, New South Wales, Australia, 2250
    - Local Institution
  - Kogarah, New South Wales, Australia, 2217
    - Local Institution
  - Miranda, New South Wales, Australia, 2228
    - Local Institution
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Local Institution
  - Brisbane, Queensland, Australia, 4032
    - Local Institution
  - Caboolture, Queensland, Australia, 4510
    - Local Institution
  - Herston, Queensland, Australia, 4029
    - Local Institution
  - Kippa Ring, Queensland, Australia, 4021
    - Local Institution
  - Nambour, Queensland, Australia, 4560
    - Local Institution
  - Sherwood, Queensland, Australia, 4075
    - Local Institution
- South Australia
  - Adelaide, South Australia, Australia, SA 5000
    - Local Institution
  - Ashford, South Australia, Australia, 5035
    - Local Institution
  - Bedford Park, South Australia, Australia, 5042
    - Local Institution
  - Woodville, South Australia, Australia, 5011
    - Local Institution
- Victoria
  - Box Hill, Victoria, Australia, 3128
    - Local Institution
  - Dandenong, Victoria, Australia, 3175
    - Local Institution
  - Geelong, Victoria, Australia, 3220
    - Local Institution
- Western Australia
  - Fremantle, Western Australia, Australia, 6160
    - Local Institution
  - Joondalup, Western Australia, Australia, 6027
    - Local Institution
Austria
- - Graz, Austria, 8036
    - Local Institution
  - Oberpullendorf, Austria, 7350
    - Local Institution
  - Vienna, Austria, 1160
    - Local Institution
Belgium
- - Aalst, Belgium, 9300
    - Local Institution
  - Antwerpen, Belgium, 2020
    - Local Institution
  - Antwerpen, Belgium, 2060
    - Local Institution
  - Arlon, Belgium, 6700
    - Local Institution
  - Brugge, Belgium, 8000
    - Local Institution
  - Brussels, Belgium, 1090
    - Local Institution
  - Dillingen, Belgium, 66763
    - Local Institution
  - Genk, Belgium, 3600
    - Local Institution
  - Gent, Belgium, 9000
    - Local Institution
  - Gilly, Belgium, 6060
    - Local Institution
  - Hasselt, Belgium, 3500
    - Local Institution
  - Huy, Belgium, 4500
    - Local Institution
  - Kortrijk, Belgium, 8500
    - Local Institution
  - Menen, Belgium, 8930
    - Local Institution
  - Mol, Belgium, 2400
    - Local Institution
  - Montegnee, Belgium, 4420
    - Local Institution
  - Verviers, Belgium, 4800
    - Local Institution
  - Woluwe- Saint Lambert, Belgium, 1200
    - Local Institution
  - Yvoir, Belgium, 5530
    - Local Institution
Brazil
- - Rio De Janeiro, Brazil, 20551
    - Local Institution
  - Rio De Janeiro, Brazil, 20551-030
    - Local Institution
  - Rio De Janeiro, Brazil, 22251-030
    - Local Institution
  - Rio De Janeiro, Brazil, 22251
    - Local Institution
  - Sao Paulo, Brazil, 01323-010
    - Local Institution
  - Sao Paulo, Brazil, 01323
    - Local Institution
  - Sao Paulo, Brazil, 04012
    - Local Institution
  - Sao Paulo, Brazil, 04024-002
    - Local Institution
  - Sao Paulo, Brazil, 04038
    - Local Institution
  - Sao Paulo, Brazil, 01221-900
    - Local Institution
  - Sao Paulo, Brazil, 01221
    - Local Institution
  - Sao Paulo, Brazil, 01322-001
    - Local Institution
  - Sao Paulo, Brazil, 01322
    - Local Institution
  - Sao Paulo, Brazil, 01323-001
    - Local Institution
  - Sao Paulo, Brazil, 04012-180
    - Local Institution
  - Sao Paulo, Brazil, 04024
    - Local Institution
  - Sao Paulo, Brazil, 04038-031
    - Local Institution
  - Sao Paulo, Brazil, 08270-070
    - Local Institution
  - Sao Paulo, Brazil, 08270
    - Local Institution
- Bahia
  - Salvador, Bahia, Brazil, 40144
    - Local Institution
  - Salvador, Bahia, Brazil, 41810
    - Local Institution
  - Salvador, Bahia, Brazil, 40144-900
    - Local Institution
  - Salvador, Bahia, Brazil, 41810-010
    - Local Institution
- Minas Gerais
  - Belo Horzonte, Minas Gerais, Brazil, 30150-221
    - Local Institution
  - Belo Horzonte, Minas Gerais, Brazil, 30150
    - Local Institution
  - Juiz De Fora, Minas Gerais, Brazil, 36021-630
    - Local Institution
  - Juiz De Fora, Minas Gerais, Brazil, 36021
    - Local Institution
  - Uberaba, Minas Gerais, Brazil, 38056 055
    - Local Institution
  - Uberlandia, Minas Gerais, Brazil, 38400-299
    - Local Institution
  - Uberlandia, Minas Gerais, Brazil, 38400
    - Local Institution
- Para
  - Belem, Para, Brazil, 66087-660
    - Local Institution
  - Belem, Para, Brazil, 66087
    - Local Institution
- Parana
  - Campina Grande Do Sul, Parana, Brazil, 83430-000
    - Local Institution
  - Campina Grande Do Sul, Parana, Brazil, 83430
    - Local Institution
  - Curitiba, Parana, Brazil, 80010
    - Local Institution
  - Curitiba, Parana, Brazil, 80730
    - Local Institution
  - Curitiba, Parana, Brazil, 80010-030
    - Local Institution
  - Curitiba, Parana, Brazil, 80730-150
    - Local Institution
  - Londrina, Parana, Brazil, 86010-450
    - Local Institution
  - Londrina, Parana, Brazil, 86010
    - Local Institution
- RIO Grande DO Norte
  - Natal, RIO Grande DO Norte, Brazil, 59020-100
    - Local Institution
- RIO Grande DO SUL
  - Porte Alegre, RIO Grande DO SUL, Brazil, 90610-000
    - Local Institution
  - Porte Alegre, RIO Grande DO SUL, Brazil, 90880-480
    - Local Institution
  - Porto Alegre, RIO Grande DO SUL, Brazil, 90035-903
    - Local Institution
  - Porto Alegre, RIO Grande DO SUL, Brazil, 90020-090
    - Local Institution
  - Porto Alegre, RIO Grande DO SUL, Brazil, 90620-001
    - Local Institution
  - Porto Alegre, RIO Grande DO SUL, Brazil, 91350-280
    - Local Institution
- Rio Grande Do Norte
  - Natal, Rio Grande Do Norte, Brazil, 59020
    - Local Institution
- Rio Grande Do Sul
  - Porte Alegre, Rio Grande Do Sul, Brazil, 90610
    - Local Institution
  - Porte Alegre, Rio Grande Do Sul, Brazil, 90880480
    - Local Institution
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90035
    - Local Institution
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90020
    - Local Institution
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90620
    - Local Institution
  - Porto Alegre, Rio Grande Do Sul, Brazil, 91350
    - Local Institution
- SAO Paulo
  - Botucatu, SAO Paulo, Brazil, 18618-000
    - Local Institution
  - Campinas, SAO Paulo, Brazil, 13059-740
    - Local Institution
  - Marilia, SAO Paulo, Brazil, 17515-000
    - Local Institution
  - Marilia, SAO Paulo, Brazil, 17515-460
    - Local Institution
  - Marilia, SAO Paulo, Brazil, 17519-000
    - Local Institution
  - San Jose Do Rio Preto, SAO Paulo, Brazil, 15090-000
    - Local Institution
  - Santo Andre, SAO Paulo, Brazil, 09190-610
    - Local Institution
  - Sao Jose Do Rio Preto, SAO Paulo, Brazil, 15015-750
    - Local Institution
  - Sao Jose Do Rio Preto, SAO Paulo, Brazil, 15015-210
    - Local Institution
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89010
    - Local Institution
  - Blumenau, Santa Catarina, Brazil, 89010-500
    - Local Institution
  - Sao Jose, Santa Catarina, Brazil, 88103
    - Local Institution
  - Sao Jose, Santa Catarina, Brazil, 88103-450
    - Local Institution
- Sao Paulo
  - Botucatu, Sao Paulo, Brazil, 18618
    - Local Institution
  - Campinas, Sao Paulo, Brazil, 13059
    - Local Institution
  - Marilia, Sao Paulo, Brazil, 17519
    - Local Institution
  - Marilia, Sao Paulo, Brazil, 17515
    - Local Institution
  - San Jose Do Rio Preto, Sao Paulo, Brazil, 15090
    - Local Institution
  - Santo Andre, Sao Paulo, Brazil, 09190
    - Local Institution
  - Sao Jose Do Rio Preto, Sao Paulo, Brazil, 15015
    - Local Institution
Canada
- - Quebec, Canada, G1J 1Z6
    - Local Institution
- Alberta
  - Calgary, Alberta, Canada, T2E 7C5
    - Local Institution
  - Edmonton, Alberta, Canada, T6G 2B7
    - Local Institution
  - Edmonton, Alberta, Canada, T5X 3N5
    - Local Institution
  - Edmonton, Alberta, Canada, TSA 4L8
    - Local Institution
  - Edmonton, Alberta, Canada, T56-3NJ
    - Local Institution
- British Columbia
  - Burnaby, British Columbia, Canada, V5G 1T4
    - Local Institution
  - Nanaimo, British Columbia, Canada, V9R 3G9
    - Local Institution
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Local Institution
  - North Vancouver, British Columbia, Canada, V7N 4M2
    - Local Institution
  - Victoria, British Columbia, Canada, V8R 4R2
    - Local Institution
- Manitoba
  - Winnipeg, Manitoba, Canada, R2V 4W3
    - Local Institution
- New Brunswick
  - Bathurst, New Brunswick, Canada, E2A 4X7
    - Local Institution
- Newfoundland and Labrador
  - Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
    - Local Institution
  - St Johns, Newfoundland and Labrador, Canada, A1B 3V6
    - Local Institution
  - St. John'S, Newfoundland and Labrador, Canada, A1A 3R5
    - Local Institution
  - St. John'S, Newfoundland and Labrador, Canada, A1E 2C2
    - Local Institution
- Ontario
  - Brampton, Ontario, Canada, L6Z 4N5
    - Local Institution
  - Burlington, Ontario, Canada, L7M 4Y1
    - Local Institution
  - Cambridge, Ontario, Canada, N1R 7R1
    - Local Institution
  - Cambridge, Ontario, Canada, N1R 6V6
    - Local Institution
  - Hamilton, Ontario, Canada, L8L 2X2
    - Local Institution
  - London, Ontario, Canada, N6G 2V2
    - Local Institution
  - Mississauga, Ontario, Canada, L5B 4A2
    - Local Institution
  - Newmarket, Ontario, Canada, L3Y 5G8
    - Local Institution
  - Newmarket, Ontario, Canada, L3Y 8C3
    - Local Institution
  - Niagara Falls, Ontario, Canada, L2E 7H1
    - Local Institution
  - Niagara Falls, Ontario, Canada, L2E7H1
    - Local Institution
  - North Bay, Ontario, Canada, P1B 2H3
    - Local Institution
  - Oshawa, Ontario, Canada, L1J 2J9
    - Local Institution
  - Oshawa, Ontario, Canada, L1J 2K1
    - Local Institution
  - Ottawa, Ontario, Canada, K1Y 4E9
    - Local Institution
  - Ottawa, Ontario, Canada, K1Y 4W7
    - Local Institution
  - Sarnia, Ontario, Canada, N7T 4X3
    - Local Institution
  - Scarborough, Ontario, Canada, M1B 5N1
    - Local Institution
  - Sudbury, Ontario, Canada, P3E 3B8
    - Local Institution
  - Sudbury, Ontario, Canada, P3C 5K7
    - Local Institution
  - Sudbury, Ontario, Canada, P3E 2N8
    - Local Institution
  - Sudbury, Ontario, Canada, P3C5K7
    - Local Institution
  - Toronto, Ontario, Canada, M9W 4L6
    - Local Institution
  - Toronto, Ontario, Canada, M5B 1W8
    - Local Institution
  - Weston, Ontario, Canada, M9N 1W4
    - Local Institution
- Prince Edward Island
  - Charlottetown, Prince Edward Island, Canada, C1A 5Y9
    - Local Institution
- Quebec
  - Drummondville, Quebec, Canada, J2B 7T1
    - Local Institution
  - Greenfield Park, Quebec, Canada, J4V 2G8
    - Local Institution
  - Lachine, Quebec, Canada, H8S 2E4
    - Local Institution
  - Levis, Quebec, Canada, G6V 4Z5
    - Local Institution
  - Longueuil, Quebec, Canada, J4K 1C8
    - Local Institution
  - Longueuil, Quebec, Canada, J4N 0C9
    - Local Institution
  - Longueuil, Quebec, Canada, J4N 1C2
    - Local Institution
  - Montreal, Quebec, Canada, H3T 1E2
    - Local Institution
  - Montreal, Quebec, Canada, H3A 1A1
    - Local Institution
  - Montreal, Quebec, Canada, H1T 1C8
    - Local Institution
  - Montreal, Quebec, Canada, H2W 1T8
    - Local Institution
  - Montreal, Quebec, Canada, W3R-153
    - Local Institution
  - Pointe- Claire, Quebec, Canada, H9R 3J1
    - Local Institution
  - St-Lambert, Quebec, Canada, J4P 2H4
    - Local Institution
  - Ste-Foy, Quebec, Canada, G1W 4R4
    - Local Institution
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7L OY7
    - Local Institution
Chile
- LOS Lagos
  - Osorno, LOS Lagos, Chile, 5311089
    - Local Institution
  - Osorno, LOS Lagos, Chile, 5311523
    - Local Institution
- Metropolitana
  - Santiago, Metropolitana, Chile, 7500520
    - Local Institution
  - Santiago, Metropolitana, Chile, 7500922
    - Local Institution
  - Santiago, Metropolitana, Chile, 8330074
    - Local Institution
- Region DE LA Araucania
  - Temuco, Region DE LA Araucania, Chile, 4781176
    - Local Institution
- Region De La Araucania
  - Temuco, Region De La Araucania, Chile, 4781156
    - Local Institution
- Valparaiso
  - Temuco, Valparaiso, Chile, 4781173
    - Local Institution
  - Vina Del Mar, Valparaiso, Chile, 2570017
    - Local Institution
China
- Beijing
  - Beijing, Beijing, China, 100050
    - Local Institution
  - Beijing, Beijing, China, 100001
    - Local Institution
  - Beijing, Beijing, China, 100853
    - Local Institution
  - Beijing, Beijing, China, 100020
    - Local Institution
  - Beijing, Beijing, China, 100088
    - Local Institution
  - Beijing, Beijing, China, 100101
    - Local Institution
- Gansu
  - Lanzhou, Gansu, China, 730000
    - Local Institution
  - Lanzhou, Gansu, China, 730030
    - Local Institution
- Guangdong
  - Guangzhou, Guangdong, China, 510080
    - Local Institution
  - Guangzhou, Guangdong, China, 510120
    - Local Institution
- Hebei
  - Shijiazhuang, Hebei, China, 050000
    - Local Institution
- Heilongjiang
  - Daqing, Heilongjiang, China, 163001
    - Local Institution
  - Haerbin, Heilongjiang, China, 150086
    - Local Institution
  - Haerbin, Heilongjiang, China, 150001
    - Local Institution
- Hubei
  - Wuhan, Hubei, China, 430060
    - Local Institution
- Hunan
  - Changsha, Hunan, China, 410000
    - Local Institution
- Jiangsu
  - Hangzhou, Jiangsu, China, 310009
    - Local Institution
  - Nanjing, Jiangsu, China, 210029
    - Local Institution
- Liaoning
  - Dalian, Liaoning, China, 116011
    - Local Institution
  - Dalian, Liaoning, China, 116021
    - Local Institution
  - Dalian, Liaoning, China, 116027
    - Local Institution
  - Shenyang, Liaoning, China, 110016
    - Local Institution
  - Shenyang, Liaoning, China, 110003
    - Local Institution
- Shandong
  - Jinan, Shandong, China, 250012
    - Local Institution
  - Jinan, Shandong, China, 250033
    - Local Institution
  - Qingdao, Shandong, China, 266011
    - Local Institution
- Shanghai
  - Shanghai, Shanghai, China, 200080
    - Local Institution
  - Shanghai, Shanghai, China, 200025
    - Local Institution
  - Shanghai, Shanghai, China, 200433
    - Local Institution
  - Shanghai, Shanghai, China, 200011
    - Local Institution
  - Shanghai, Shanghai, China, 200233
    - Local Institution
  - Shanghai, Shanghai, China, 200003
    - Local Institution
  - Shanghai, Shanghai, China, 100037
    - Local Institution
  - Shanghai, Shanghai, China, 200031
    - Local Institution
- Sichuan
  - Chengdu, Sichuan, China, 610041
    - Local Institution
  - Chongqing, Sichuan, China, 400010
    - Local Institution
- Zhejiang
  - Hangzhou, Zhejiang, China, 310009
    - Local Institution
Colombia
- - Barranquilla, Colombia
    - Local Institution
  - Barranquilla, Colombia, XXXXX
    - Local Institution
  - Bogota, Colombia
    - Local Institution
  - Bogota, Colombia, 000
    - Local Institution
  - Cali, Colombia
    - Local Institution
  - Medellin, Colombia
    - Local Institution
- Antioquia
  - Medellin, Antioquia, Colombia
    - Local Institution
Czechia
- - Boskovice, Czechia, 680 21
    - Local Institution
  - Brno, Czechia, 625 00
    - Local Institution
  - Brno-Malomerice, Czechia, 614 00
    - Local Institution
  - Ivancice, Czechia, 664 91
    - Local Institution
  - Kladno, Czechia, 272 59
    - Local Institution
  - Litomysl, Czechia, 570 14
    - Local Institution
  - Mestec Kralove, Czechia, 289 03
    - Local Institution
  - Ostrava, Czechia, 70852
    - Local Institution
  - Prague 13, Czechia, 158 00
    - Local Institution
  - Prague 2, Czechia, 128 08
    - Local Institution
  - Pribram, Czechia, 261 01
    - Local Institution
  - Usti Nad Orlici, Czechia, 562 18
    - Local Institution
Denmark
- - Arhus C, Denmark, 8000
    - Local Institution
  - Esbjerg, Denmark, 6700
    - Local Institution
  - Frederiksberg, Denmark, 2000
    - Local Institution
  - Frederikssund, Denmark, 3600
    - Local Institution
  - Gentofte, Denmark, 2900
    - Local Institution
  - Haderslev, Denmark, 6100
    - Local Institution
  - Hellerup, Denmark, 2900
    - Local Institution
  - Herlev, Denmark, 2730
    - Local Institution
  - Herning, Denmark, 7400
    - Local Institution
  - Hillerod, Denmark, 3400
    - Local Institution
  - Hvidovre, Denmark, 2650
    - Local Institution
  - Kobenhavn, Denmark, 2100
    - Local Institution
  - Kolding, Denmark, 6000
    - Local Institution
  - Odense, Denmark, 5000
    - Local Institution
  - Silkeborg, Denmark, 8600
    - Local Institution
  - Slagelse, Denmark, 4200
    - Local Institution
  - Svendborg, Denmark, 5700
    - Local Institution
Finland
- - Helsinki, Finland, 00280
    - Local Institution
  - Helsinki, Finland, FI-00280
    - Local Institution
  - Hus, Finland, 00029
    - Local Institution
  - Jyvaskyla, Finland, 40100
    - Local Institution
  - Kemi, Finland, 94100
    - Local Institution
  - Oulu, Finland, 90100
    - Local Institution
  - Pori, Finland, 28120
    - Local Institution
  - Tampere, Finland, 33100
    - Local Institution
France
- - Amiens Cedex 1, France, 80054
    - Local Institution
  - Bordeaux Cedex, France, 33075
    - Local Institution
  - Brest, France, 29609
    - Local Institution
  - Grenoble Cedex 09, France, 38043
    - Local Institution
  - La Seyne Sur Mer, France, 83500
    - Local Institution
  - Paris Cedex 18, France, 75018
    - Local Institution
  - Six Fours Les Plages, France, 83140
    - Local Institution
Germany
- - Aachen, Germany, 52074
    - Local Institution
  - Bad Krozingen, Germany, 79189
    - Local Institution
  - Bad Neustadt/ Salle, Germany, 97616
    - Local Institution
  - Bad Oeynhausen, Germany, 32545
    - Local Institution
  - Berlin, Germany, 13353
    - Local Institution
  - Berlin, Germany, 14050
    - Local Institution
  - Berlin, Germany, 10787
    - Local Institution
  - Berlin, Germany, 10789
    - Local Institution
  - Berlin, Germany, 12043
    - Local Institution
  - Berlin-Kopenick, Germany, 12559
    - Local Institution
  - Betzdorf, Germany, 57518
    - Local Institution
  - Bochum, Germany, 44791
    - Local Institution
  - Bochum, Germany, 44789
    - Local Institution
  - Bonn, Germany, 53127
    - Local Institution
  - Coburg, Germany, 96450
    - Local Institution
  - Dillingen, Germany, 66763
    - Local Institution
  - Dresden, Germany, 01099
    - Local Institution
  - Duisburg, Germany, 47139
    - Local Institution
  - Essen, Germany, 45122
    - Local Institution
  - Frankfurt Am Main, Germany, 60594
    - Local Institution
  - Gottingen, Germany, 37075
    - Local Institution
  - Halle/Saale, Germany, 06120
    - Local Institution
  - Hannover, Germany, 30625
    - Local Institution
  - Heidelberg, Germany, 69120
    - Local Institution
  - Heidelberg, Germany, 69115
    - Local Institution
  - Kassel, Germany, 34121
    - Local Institution
  - Lahr, Germany, 77933
    - Local Institution
  - Ludwigshafen, Germany, 67063
    - Local Institution
  - Ludwigshafen, Germany, 67073
    - Local Institution
  - Mannheim, Germany, 68167
    - Local Institution
  - Marburg, Germany, 35043
    - Local Institution
  - Munchen, Germany, 81675
    - Local Institution
  - Munchen, Germany, 80636
    - Local Institution
  - Munchen, Germany, 81545
    - Local Institution
  - Osnabruck, Germany, 49076
    - Local Institution
  - Regensburg, Germany, 93053
    - Local Institution
  - Riesa, Germany, D-01587
    - Local Institution
  - Rostiock, Germany, 18057
    - Local Institution
  - Trier, Germany, 54292
    - Local Institution
  - Waren, Germany, 17192
    - Local Institution
  - Witten, Germany, 58455
    - Local Institution
  - Wolmirstedt, Germany, 39326
    - Local Institution
  - Worms, Germany, 67550
    - Local Institution
Hong Kong
- - Hong Kong, Hong Kong
    - Local Institution
  - Shatin, Hong Kong
    - Local Institution
Hungary
- - Budapest, Hungary, 1125
    - Local Institution
  - Budapest, Hungary, 1023
    - Local Institution
  - Budapest, Hungary, 1032
    - Local Institution
  - Budapest, Hungary, 1096
    - Local Institution
  - Budapest, Hungary, 1085
    - Local Institution
  - Debrecen, Hungary, 4032
    - Local Institution
  - Dunaujvaros, Hungary, 2400
    - Local Institution
  - Gyor, Hungary, 9023
    - Local Institution
  - Gyula, Hungary, 5700
    - Local Institution
  - Hodmezovasarhely, Hungary, 6800
    - Local Institution
  - Komarom, Hungary, 2921
    - Local Institution
  - Mosonmagyarovar, Hungary, 9200
    - Local Institution
  - Oroshaza, Hungary, 5900
    - Local Institution
  - Pecs, Hungary, 7624
    - Local Institution
  - Siofok, Hungary, 8600
    - Local Institution
  - Siofok, Hungary, 8601
    - Local Institution
  - Sopron, Hungary, 9400
    - Local Institution
  - Szentes, Hungary, 6600
    - Local Institution
  - Zalaegerszeg, Hungary, 8900
    - Local Institution
India
- - Ahmedabad, India, 380014
    - Local Institution
  - Annamalainagar, India, 608002
    - Local Institution
  - Bangalore, India, 560052
    - Local Institution
  - Chennai, India, 600006
    - Local Institution
  - Hyderabad, India, 500001
    - Local Institution
  - Hyderabad, India, 500044
    - Local Institution
  - Indore, India, 452014
    - Local Institution
  - Indore, India, 452001
    - Local Institution
  - Kolkata, India, 700054
    - Local Institution
  - Kottayam, India, 686016
    - Local Institution
  - Lucknow, India, 226003
    - Local Institution
  - Mumbai Naka, India, 422005
    - Local Institution
  - Nashik, India, 422002
    - Local Institution
  - New Delhi, India, 110025
    - Local Institution
  - New Delhi, India, 110060
    - Local Institution
  - New Delhi, India, 116025
    - Local Institution
  - Pune, India, 411001
    - Local Institution
  - Pune, India, 411004
    - Local Institution
  - Thrissur, India, 680002
    - Local Institution
  - Vijayawada, India, 520008
    - Local Institution
- Andhra Pradesh
  - Visakhapatnam, Andhra Pradesh, India, 530003
    - Local Institution
- Andhrapradesh
  - Visakhapatnam, Andhrapradesh, India, 530002
    - Local Institution
- Andra Pradesh
  - Hyderabad, Andra Pradesh, India, 500004
    - Local Institution
- Gujarat
  - Ahmedabad, Gujarat, India, 380060
    - Local Institution
  - Vadodara, Gujarat, India, 390007
    - Local Institution
- Karnataka
  - Bangalore, Karnataka, India, 560054
    - Local Institution
  - Bangalore, Karnataka, India, 5600034
    - Local Institution
  - Bangalore, Karnataka, India, 560094
    - Local Institution
  - Mysore, Karnataka, India, 570004
    - Local Institution
- Kerela
  - Calicut, Kerela, India, 673 004
    - Local Institution
- Maharashta
  - Pune, Maharashta, India, 411011
    - Local Institution
- Maharashtra
  - Nagpur, Maharashtra, India, 440010
    - Local Institution
  - Nagpur, Maharashtra, India, 440012
    - Local Institution
  - Pune, Maharashtra, India, 411001
    - Local Institution
  - Pune, Maharashtra, India, 421006
    - Local Institution
- Punjab
  - Jalandhar, Punjab, India, 144008
    - Local Institution
- Rajasthan
  - Bikaner, Rajasthan, India, 334001
    - Local Institution
  - Bikaner, Rajasthan, India, 334003
    - Local Institution
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, India, 226003
    - Local Institution
Israel
- - Afula, Israel, 18101
    - Local Institution
  - Ashkelon, Israel, 78306
    - Local Institution
  - Givatayim, Israel, 53583
    - Local Institution
  - Hadera, Israel, 38100
    - Local Institution
  - Haifa, Israel, 31096
    - Local Institution
  - Haifa, Israel, 34362
    - Local Institution
  - Holon, Israel, 58100
    - Local Institution
  - Jerusalem, Israel, 91120
    - Local Institution
  - Jerusalem, Israel, 91240
    - Local Institution
  - Kfar-Saba, Israel, 44281
    - Local Institution
  - Nazareth, Israel, 16100
    - Local Institution
  - Nazareth, Israel, 16000
    - Local Institution
  - Petach-Tikva, Israel, 49100
    - Local Institution
  - Safed, Israel, 13100
    - Local Institution
  - Tel Aviv, Israel, 64239
    - Local Institution
Italy
- - Ascoli Piceno, Italy, 63100
    - Local Institution
  - Campobasso, Italy, 86100
    - Local Institution
  - Chieti, Italy, 66013
    - Local Institution
  - Cremona, Italy, 26100
    - Local Institution
  - Fidenza (Pr), Italy, 43036
    - Local Institution
  - Genova, Italy, 16132
    - Local Institution
  - Isernia, Italy, 86170
    - Local Institution
  - Livorno, Italy, 57100
    - Local Institution
  - Milano, Italy, 20132
    - Local Institution
  - Napoli, Italy, 80131
    - Local Institution
  - Palermo, Italy, 90127
    - Local Institution
  - Reggio Emilia, Italy, 42100
    - Local Institution
  - Roma, Italy, 00168
    - Local Institution
  - San Daniele De Friuli, Italy, 33038
    - Local Institution
  - Torino, Italy, 10153
    - Local Institution
  - Vittorio Veneto (Tv), Italy, 31029
    - Local Institution
- Lucca
  - Lido Di Camaiore, Lucca, Italy, 55043
    - Local Institution
Japan
- - Fukui, Japan, 9100067
    - Local Institution
  - Kagoshima, Japan, 8920822
    - Local Institution
  - Kyoto, Japan, 6168152
    - Local Institution
  - Nagasaki, Japan, 852-8102
    - Local Institution
  - Oita, Japan, 8700033
    - Local Institution
  - Osaka, Japan, 558-8558
    - Local Institution
  - Osaka, Japan, 551-0032
    - Local Institution
  - Osaka, Japan, 5510032
    - Local Institution
  - Saga, Japan, 8490917
    - Local Institution
- Fukuoka
  - Itoshima City, Fukuoka, Japan, 819-1104
    - Local Institution
  - Kurume, Fukuoka, Japan, 8390863
    - Local Institution
  - Ohkawa-City, Fukuoka, Japan, 8310016
    - Local Institution
- Fukushima
  - Shirakawa City, Fukushima, Japan, 961-0005
    - Local Institution
- Gunma
  - Takasaki City, Gunma, Japan, 3700829
    - Local Institution
- Hokkaido
  - Asahikawa-Shi, Hokkaido, Japan, 0788214
    - Local Institution
  - Katou-Gun, Hokkaido, Japan, 0800111
    - Local Institution
  - Katou-gun, Hokkaido, Japan, 080111
    - Local Institution
  - Sapporo-Shi, Hokkaido, Japan, 0028043
    - Local Institution
  - Tomakomai-Shi, Hokkaido, Japan, 002-8043
    - Local Institution
  - Tomakomai-shi, Hokkaido, Japan, 0028043
    - Local Institution
  - Yubari, Hokkaido, Japan, 0680402
    - Local Institution
- Hyogo
  - Kobe, Hyogo, Japan, 6540026
    - Local Institution
- Kagoshima Prefecture
  - Izumi City, Kagoshima Prefecture, Japan, 8990131
    - Local Institution
- Kanagawa
  - Isehara, Kanagawa, Japan, 2591193
    - Local Institution
  - Yokohama, Kanagawa, Japan, 2458575
    - Local Institution
  - Yokohama City, Kanagawa, Japan, 2278501
    - Local Institution
  - Yokosuka, Kanagawa, Japan, 2388567
    - Local Institution
- Miyagi
  - Sendai City, Miyagi, Japan, 983-8520
    - Local Institution
- Nara
  - Nara City, Nara, Japan, 630-8305
    - Local Institution
- Osaka
  - Izumi City, Osaka, Japan, 594-0071
    - Local Institution
  - Osaka City, Osaka, Japan, 5330022
    - Local Institution
  - Osaka-Shi, Osaka, Japan, 540-0006
    - Local Institution
  - Osaka-shi, Osaka, Japan, 5400006
    - Local Institution
  - Suita-City, Osaka, Japan, 5658565
    - Local Institution
  - Takatsuki City, Osaka, Japan, 5690852
    - Local Institution
  - Yao, Osaka, Japan, 5810036
    - Local Institution
- Saga
  - Saga City, Saga, Japan, 840-8571
    - Local Institution
  - Saga City, Saga, Japan, 849-8501
    - Local Institution
- Saitama
  - Kasukabe-Shi, Saitama, Japan, 344-0035
    - Local Institution
  - Kasukabe-shi, Saitama, Japan, 3440035
    - Local Institution
- Tokyo
  - Itabashi-Ku, Tokyo, Japan, 173-0015
    - Local Institution
  - Itabashi-ku, Tokyo, Japan, 1730015
    - Local Institution
  - Meguro-Ku, Tokyo, Japan, 153-8515
    - Local Institution
  - Meguro-ku, Tokyo, Japan, 1538515
    - Local Institution
  - Shinagawa-Ku, Tokyo, Japan, 1428666
    - Local Institution
- Toyama
  - Toyama City, Toyama, Japan, 9308550
    - Local Institution
- Yamaguchi
  - Iwakuni, Yamaguchi, Japan, 7400021
    - Local Institution
Korea, Republic of
- - Busan, Korea, Republic of, 602-702
    - Local Institution
  - Daegu, Korea, Republic of, 700-712
    - Local Institution
  - Daegu, Korea, Republic of, 705-717
    - Local Institution
  - Daejon, Korea, Republic of, 302-718
    - Local Institution
  - Goyang, Korea, Republic of, 411-706
    - Local Institution
  - Gwang Ju, Korea, Republic of, 501-757
    - Local Institution
  - Gyeonggi, Korea, Republic of, 463-707
    - Local Institution
  - Pusan, Korea, Republic of, 602-739
    - Local Institution
  - Scongnam-Si, Korea, Republic of, 463-712
    - Local Institution
  - Seoul, Korea, Republic of, 110-744
    - Local Institution
  - Seoul, Korea, Republic of, 143-729
    - Local Institution
  - Seoul, Korea, Republic of, 130-709
    - Local Institution
  - Suwon, Korea, Republic of, 443-721
    - Local Institution
- Gyeonggi-Do
  - Anyang-Si, Gyeonggi-Do, Korea, Republic of, 431-070
    - Local Institution
- Korea
  - Incheon, Korea, Korea, Republic of, 400-711
    - Local Institution
Malaysia
- - Kuala Lumpur, Malaysia, 56000
    - Local Institution
  - Kuala Lumpur, Malaysia, 59100
    - Local Institution
- Kelantan
  - Kubang Kerian, Kelantan, Malaysia, 16150
    - Local Institution
- Sarawak
  - Kota Samarahan, Sarawak, Malaysia, 94300
    - Local Institution
- Selangor
  - Batu Caves, Selangor, Malaysia, 68100
    - Local Institution
Mexico
- - Puebla, Mexico, 11490
    - Local Institution
  - Queretaro, Mexico, 76000
    - Local Institution
- BAJA California
  - Tijuana, BAJA California, Mexico, 22500
    - Local Institution
- Distrito Federal
  - Col. Toriello Guerra, Distrito Federal, Mexico, CP 14050
    - Local Institution
  - Mexico City, Distrito Federal, Mexico, 06726
    - Local Institution
  - Mexico City, Distrito Federal, Mexico, 14080
    - Local Institution
  - Mexico City, Distrito Federal, Mexico, 07760
    - Local Institution
  - Mexico City, Distrito Federal, Mexico, 06070
    - Local Institution
  - Mexico City, Distrito Federal, Mexico, 10700
    - Local Institution
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44200
    - Local Institution
  - Guadalajara, Jalisco, Mexico, 44600
    - Local Institution
  - Guadalajara, Jalisco, Mexico, 44656
    - Local Institution
- Michoacan
  - Morelia, Michoacan, Mexico, 58000
    - Local Institution
- Nuevo LEON
  - Monterrey, Nuevo LEON, Mexico, 64710
    - Local Institution
  - Monterrey, Nuevo LEON, Mexico, 64000
    - Local Institution
  - Monterrey, Nuevo LEON, Mexico, 64700
    - Local Institution
- Sinaloa
  - Culiacan, Sinaloa, Mexico, 80020
    - Local Institution
- Veracruz
  - Jalapa, Veracruz, Mexico, 91020
    - Local Institution
Netherlands
- - Breda, Netherlands, 4818 CK
    - Local Institution
  - Deventer, Netherlands, 7416 SE
    - Local Institution
  - Eindhoven, Netherlands, 5623 EJ
    - Local Institution
  - Eindhoven, Netherlands, 5623EJ
    - Local Institution
  - Enschede, Netherlands, 7513 ER
    - Local Institution
  - Hardenberg, Netherlands, 7772 SE
    - Local Institution
  - Hilversum, Netherlands, 1213 XZ
    - Local Institution
  - Nijmegen, Netherlands, 6525 GA
    - Local Institution
  - Oss, Netherlands, 5342 BT
    - Local Institution
  - Rotterdam, Netherlands, 3045 PM
    - Local Institution
  - S-Hertogenbosch, Netherlands, 5211 NL
    - Local Institution
  - Tiel, Netherlands, 4002 WP
    - Local Institution
  - Utrecht, Netherlands, 3582 KE
    - Local Institution
  - Velp, Netherlands, 6883 AZ
    - Local Institution
Norway
- - Alesund, Norway, 6003
    - Local Institution
  - Bergen, Norway, 5021
    - Local Institution
  - Bergen, Norway, N-5021
    - Local Institution
  - Elverum, Norway, 2408
    - Local Institution
  - Flekkefjord, Norway, 4400
    - Local Institution
  - Nesttun, Norway, 5221
    - Local Institution
  - Oslo, Norway, 0407
    - Local Institution
  - Skien, Norway, 3710
    - Local Institution
  - Stavanger, Norway, 4064
    - Local Institution
  - Straume, Norway, 5353
    - Local Institution
  - Tonsberg, Norway, 3116
    - Local Institution
  - Tromso, Norway, 9038
    - Local Institution
Peru
- - Lima, Peru, LIMA 33
    - Local Institution
  - Lima, Peru, LIMA 01
    - Local Institution
  - Lima, Peru, LIMA 1
    - Local Institution
- Callao
  - Bellavista, Callao, Peru, 2176
    - Local Institution
  - Bellavista, Callao, Peru, CALLAO 2
    - Local Institution
- Lambayeque
  - Chiclayo, Lambayeque, Peru, CIX
    - Local Institution
- Lima
  - Jesus Maria, Lima, Peru, 11
    - Local Institution
  - Jesus Maria, Lima, Peru, LIMA 11
    - Local Institution
  - Miraflores, Lima, Peru, LIMA 18
    - Local Institution
  - San Borja, Lima, Peru, LIMA 41
    - Local Institution
  - San Martin De Porres, Lima, Peru, LIMA 31
    - Local Institution
Philippines
- - Manila, Philippines, 1000
    - Local Institution
  - Manila, Philippines, 1008
    - Local Institution
  - Naga City, Philippines, 4400
    - Local Institution
  - Pasig City, Philippines, 1600
    - Local Institution
  - Quezon, Philippines, 1100
    - Local Institution
  - Quezon City, Philippines, 1102
    - Local Institution
  - San Juan, Philippines, 1100
    - Local Institution
- Ilocos Norte
  - Laoag City, Ilocos Norte, Philippines, 2900
    - Local Institution
Poland
- - Gdynia, Poland, 81-423
    - Local Institution
  - Gdynia, Poland, 81-472
    - Local Institution
  - Gdynia, Poland, 81-519
    - Local Institution
  - Grodzisk Mazowiecki, Poland, 05-825
    - Local Institution
  - Inowroclaw, Poland, 88-100
    - Local Institution
  - Kielce, Poland, 25-736
    - Local Institution
  - Kielce, Poland, 25-763
    - Local Institution
  - Krakow, Poland, 31-202
    - Local Institution
  - Krakow, Poland, 30-092
    - Local Institution
  - Krakow, Poland, 31-135
    - Local Institution
  - Lodz, Poland, 91-347
    - Local Institution
  - Lodz, Poland, 91347
    - Local Institution
  - Piotrkow Trybunalski, Poland, 97-300
    - Local Institution
  - Plock, Poland, 09-402
    - Local Institution
  - Plock, Poland, 09-400
    - Local Institution
  - Plonsk, Poland, 09-100
    - Local Institution
  - Poznan, Poland, 60-531
    - Local Institution
  - Poznan, Poland, 60479
    - Local Institution
  - Ruda Slaska, Poland, 41-703
    - Local Institution
  - Skierniewice, Poland, 96-100
    - Local Institution
  - Slupsk, Poland, 76-200
    - Local Institution
  - Torun, Poland, 87100
    - Local Institution
  - Warszawa, Poland, 01-138
    - Local Institution
  - Warszawa, Poland, 04-073
    - Local Institution
  - Warszawa, Poland, 04-628
    - Local Institution
  - Warszawa, Poland, 04-749
    - Local Institution
  - Wegrow, Poland, 07100
    - Local Institution
Puerto Rico
- - Cayey, Puerto Rico, 00736
    - Local Institution
  - Cidra, Puerto Rico, 00739
    - Local Institution
  - Ponce, Puerto Rico, 00717
    - Local Institution
Romania
- - Baia Mare, Romania, 430031
    - Local Institution
  - Bucharest, Romania, 011192
    - Local Institution
  - Bucharest, Romania, 020125
    - Local Institution
  - Bucharest, Romania, 050098
    - Local Institution
  - Bucharest, Romania, 021659
    - Local Institution
  - Bucharest, Romania, 030572
    - Local Institution
  - Cluj Napoca, Romania, 400001
    - Local Institution
  - Cluj Napoca, Romania, 400347
    - Local Institution
  - Iasi, Romania, 700503
    - Local Institution
  - Oradea, Romania, 410169
    - Local Institution
  - Sibiu, Romania, 550245
    - Local Institution
  - Targu-Mures, Romania, 540103
    - Local Institution
  - Timisoara, Romania, 300024
    - Local Institution
  - Timisoara, Romania, 300320
    - Local Institution
  - Tirgu Mures, Romania, 540136
    - Local Institution
Russian Federation
- - Chelyabinsk, Russian Federation, 454136
    - Local Institution
  - Chita, Russian Federation, 672090
    - Local Institution
  - Dzerzhinskiy, Russian Federation, 140091
    - Local Institution
  - Kazan, Russian Federation, 420012
    - Local Institution
  - Kemerovo, Russian Federation, 650002
    - Local Institution
  - Kirovsk, Russian Federation, 187342
    - Local Institution
  - Krasnodar, Russian Federation, 350042
    - Local Institution
  - Moscow, Russian Federation, 119992
    - Local Institution
  - Moscow, Russian Federation, 125367
    - Local Institution
  - Moscow, Russian Federation, 109240
    - Local Institution
  - Moscow, Russian Federation, 105229
    - Local Institution
  - Moscow, Russian Federation, 111539
    - Local Institution
  - Moscow, Russian Federation, 115487
    - Local Institution
  - Moscow, Russian Federation, 115093
    - Local Institution
  - Moscow, Russian Federation, 121552
    - Local Institution
  - Moscow, Russian Federation, 117593
    - Local Institution
  - Moscow, Russian Federation, 127018
    - Local Institution
  - Moscow, Russian Federation, 125284
    - Local Institution
  - Moscow, Russian Federation, 111020
    - Local Institution
  - Moscow, Russian Federation, 119121
    - Local Institution
  - Moscow, Russian Federation, 121356
    - Local Institution
  - Moscow, Russian Federation, 117556
    - Local Institution
  - Moscow, Russian Federation, 119048
    - Local Institution
  - Moscow, Russian Federation, 123182
    - Local Institution
  - Moscow, Russian Federation, 125206
    - Local Institution
  - Moscow, Russian Federation, 125424
    - Local Institution
  - Moscow, Russian Federation, 129090
    - Local Institution
  - Nizhni Novgorod, Russian Federation, 603003
    - Local Institution
  - Nizhni Novgorod, Russian Federation, 603005
    - Local Institution
  - Novosibirsk, Russian Federation, 630008
    - Local Institution
  - Novosibirsk, Russian Federation, 630054
    - Local Institution
  - Odintsovo, Russian Federation, 143000
    - Local Institution
  - Penza, Russian Federation, 440026
    - Local Institution
  - Perm, Russian Federation, 614097
    - Local Institution
  - Rostov-On-Don, Russian Federation, 344022
    - Local Institution
  - Ryazan, Russian Federation, 390026
    - Local Institution
  - Saint Petersburg, Russian Federation, 193312
    - Local Institution
  - Saint Petersburg, Russian Federation, 193144
    - Local Institution
  - Saint-Petersburg, Russian Federation, 190103
    - Local Institution
  - Saint-Petersburg, Russian Federation, 191025
    - Local Institution
  - Saint-Petersburg, Russian Federation, 193163
    - Local Institution
  - Saint-Petersburg, Russian Federation, 196601
    - Local Institution
  - Saint-Petersburg, Russian Federation, 198013
    - Local Institution
  - Samara, Russian Federation, 443070
    - Local Institution
  - Saratov, Russian Federation, 410002
    - Local Institution
  - St Petersburg, Russian Federation, 198013
    - Local Institution
  - St Petersburg, Russian Federation, 192288
    - Local Institution
  - St-Petersburg, Russian Federation, 194354
    - Local Institution
  - St-Petersburg, Russian Federation, 195271
    - Local Institution
  - St. Petersburg, Russian Federation, 197341
    - Local Institution
  - St. Petersburg, Russian Federation, 197110
    - Local Institution
  - St.-Petersburg, Russian Federation, 197341
    - Local Institution
  - St.Petersburg, Russian Federation, 199106
    - Local Institution
  - Tomsk, Russian Federation, 634012
    - Local Institution
  - Tumen, Russian Federation, 625023
    - Local Institution
  - Tver, Russian Federation, 170036
    - Local Institution
  - Voronezh, Russian Federation, 394066
    - Local Institution
  - Voronezh, Russian Federation, 394065
    - Local Institution
  - Yaroslavl, Russian Federation, 150030
    - Local Institution
  - Yaroslavl, Russian Federation, 150003
    - Local Institution
  - Yaroslavl, Russian Federation, 150002
    - Local Institution
  - Zheleznodorozhniy, Russian Federation, 143920
    - Local Institution
  - Zhukovsky, Russian Federation, 140160
    - Local Institution
  - Zhukovsky, Russian Federation, 140180
    - Local Institution
Singapore
- - Singapore, Singapore, 168752
    - Local Institution
South Africa
- Bloemfontein
  - Westdene, Bloemfontein, South Africa, 9301
    - Local Institution
- Cape Town
  - Observatory, Cape Town, South Africa, 7925
    - Local Institution
- Gauteng
  - Pretoria, Gauteng, South Africa, 0084
    - Local Institution
  - Pretoria, Gauteng, South Africa, 0132
    - Local Institution
- KWA ZULU Natal
  - Richards Bay, KWA ZULU Natal, South Africa, 3900
    - Local Institution
- Western CAPE
  - Bellville Cape Town, Western CAPE, South Africa, 7530
    - Local Institution
  - George, Western CAPE, South Africa, 6529
    - Local Institution
  - Parow, Western CAPE, South Africa, 7505
    - Local Institution
  - Somerset West, Western CAPE, South Africa, 7130
    - Local Institution
  - Worcester, Western CAPE, South Africa, 6850
    - Local Institution
Spain
- - Albacete, Spain, 02006
    - Local Institution
  - Barcelona, Spain, 08035
    - Local Institution
  - Barcelona, Spain, 08003
    - Local Institution
  - Elda, Spain, 03600
    - Local Institution
  - Figueres, Spain, 17600
    - Local Institution
  - Gerona, Spain, 17007
    - Local Institution
  - Las Palmas, Spain, 35010
    - Local Institution
  - Madrid, Spain, 28006
    - Local Institution
  - Madrid, Spain, 28046
    - Local Institution
  - Madrid, Spain, 28040
    - Local Institution
  - Palma De Mallorca, Spain, 07010
    - Local Institution
  - San Sebastian De Los Reyes, Spain, 28703
    - Local Institution
  - Tarragona, Spain, 43007
    - Local Institution
  - Viladecans, Spain, 08840
    - Local Institution
- Alicante
  - San Juan, Alicante, Spain, 03550
    - Local Institution
  - Torrevieja, Alicante, Spain, 03186
    - Local Institution
- Almeria
  - La Canada, Almeria, Spain, 04120
    - Local Institution
- Galicia
  - Lugo, Galicia, Spain, 27003
    - Local Institution
Sweden
- - Goteberg, Sweden, 413 45
    - Local Institution
  - Helsingborg, Sweden, 251 87
    - Local Institution
  - Linkoping, Sweden, 581 85
    - Local Institution
  - Lund, Sweden, 222 21
    - Local Institution
  - Orebro, Sweden, 70185
    - Local Institution
  - Orebro, Sweden, 701 85
    - Local Institution
  - Skelleftea, Sweden, 931 86
    - Local Institution
  - Stockholm, Sweden, 141 86
    - Local Institution
  - Stockholm, Sweden, 171 76
    - Local Institution
  - Stockholm, Sweden, 111 57
    - Local Institution
  - Stockholm, Sweden, 118 83
    - Local Institution
  - Stockholm, Sweden, 111 35
    - Local Institution
  - Uppsala, Sweden, 751 85
    - Local Institution
  - Vaxjo, Sweden, 351 85
    - Local Institution
Switzerland
- - Baden, Switzerland, 5404
    - Local Institution
  - Bern, Switzerland, 3010
    - Local Institution
Taiwan
- - Taipei, Taiwan, 100
    - Local Institution
  - Taipei, Taiwan, 112
    - Local Institution
  - Taipei, Taiwan, 111
    - Local Institution
  - Taipei, Taiwan, 220
    - Local Institution
  - Taipei, Taiwan, 10449
    - Local Institution
  - Taipei, Taiwan, 104
    - Local Institution
Turkey
- - Ankara, Turkey, 06100
    - Local Institution
  - Eskisehir, Turkey, 26480
    - Local Institution
  - Izmir, Turkey, 35100
    - Local Institution
Ukraine
- - Chernivtsy, Ukraine, 58013
    - Local Institution
  - Dnipropetrovsk, Ukraine, 49006
    - Local Institution
  - Dnipropetrovsk, Ukraine, 49060
    - Local Institution
  - Donetsk, Ukraine, 83045
    - Local Institution
  - Donetsk, Ukraine, 83003
    - Local Institution
  - Donetsk, Ukraine, 83114
    - Local Institution
  - Ivano-Frankivsk, Ukraine, 76025
    - Local Institution
  - Kharkiv, Ukraine, 61018
    - Local Institution
  - Kharkiv, Ukraine, 61115
    - Local Institution
  - Kharkov, Ukraine, 61039
    - Local Institution
  - Kharkov, Ukraine, 61002
    - Local Institution
  - Kharkov, Ukraine, 61178
    - Local Institution
  - Kiev, Ukraine, 01032
    - Local Institution
  - Kyiv, Ukraine, 03680
    - Local Institution
  - Kyiv, Ukraine, 02091
    - Local Institution
  - Kyiv, Ukraine, 03049
    - Local Institution
  - Kyiv, Ukraine, 03115
    - Local Institution
  - Kyiv, Ukraine, 04050
    - Local Institution
  - Kyiv, Ukraine, 04107
    - Local Institution
  - Kyiv, Ukraine, 01023
    - Local Institution
  - Kyiv, Ukraine, 02660
    - Local Institution
  - Kyiv, Ukraine, 01103
    - Local Institution
  - Lugansk, Ukraine, 91011
    - Local Institution
  - Lugansk, Ukraine, 91016
    - Local Institution
  - Lutsk, Ukraine, 43024
    - Local Institution
  - Lviv, Ukraine, 79013
    - Local Institution
  - Lviv, Ukraine, 79015
    - Local Institution
  - Mykolayiv, Ukraine, 54003
    - Local Institution
  - Odessa, Ukraine, 65009
    - Local Institution
  - Odessa, Ukraine, 65039
    - Local Institution
  - Odessa, Ukraine, 65114
    - Local Institution
  - Odessa, Ukraine, 65025
    - Local Institution
  - Uzhgorod, Ukraine, 88000
    - Local Institution
  - Vinnitsa, Ukraine, 21029
    - Local Institution
  - Zaporozhye, Ukraine, 69035
    - Local Institution
  - Zhytomyr, Ukraine, 10002
    - Local Institution
United Kingdom
- - Antrim, United Kingdom, BT41 2RL
    - Local Institution
  - Blackpool, United Kingdom, FY3 8NR
    - Local Institution
  - Glasgow, United Kingdom, G21 3UW
    - Local Institution
- Aberdeenshire
  - Aberdeen, Aberdeenshire, United Kingdom, AB25 2ZN
    - Local Institution
  - Glasgow, Aberdeenshire, United Kingdom, G11 6NT
    - Local Institution
- Antrim
  - Belfast, Antrim, United Kingdom, BT14 6AB
    - Local Institution
- Armagh
  - Craigavon, Armagh, United Kingdom, BT63 5QQ
    - Local Institution
- Cambridgeshire
  - Cambridge, Cambridgeshire, United Kingdom, CB2 2QQ
    - Local Institution
  - Peterborough, Cambridgeshire, United Kingdom, PE2 5GP
    - Local Institution
- Derbyshire
  - Chesterfield, Derbyshire, United Kingdom, S44 5BL
    - Local Institution
  - Chesterfield, Derbyshire, United Kingdom, S40 4TF
    - Local Institution
- Dorset
  - Bournemouth, Dorset, United Kingdom, BH7 7DW
    - Local Institution
- Dumbartonshire
  - Glasgow, Dumbartonshire, United Kingdom, G11 6NT
    - Local Institution
- EAST Sussex
  - Chichester, EAST Sussex, United Kingdom, PO19 6SE
    - Local Institution
- Essex
  - Colchester, Essex, United Kingdom, C03 4LN
    - Local Institution
  - Romford, Essex, United Kingdom, RH7 0AG
    - Local Institution
- Greater London
  - Denmark Hill, Greater London, United Kingdom, SE5 9RS
    - Local Institution
  - London, Greater London, United Kingdom, SW17 0RE
    - Local Institution
- Gwent
  - Newport, Gwent, United Kingdom, NP20 2UB
    - Local Institution
- Hertfordshire
  - Barnet, Hertfordshire, United Kingdom, EN5 3DJ
    - Local Institution
- MID Glamorgan
  - Cardiff, MID Glamorgan, United Kingdom, CF14 4XW
    - Local Institution
  - Llandough, MID Glamorgan, United Kingdom, CF64 2XX
    - Local Institution
- Middlesex
  - Harrow, Middlesex, United Kingdom, HA1 3UJ
    - Local Institution
- Nottinghamshire
  - Nottingham, Nottinghamshire, United Kingdom, NG5 1PB
    - Local Institution
  - Worksop, Nottinghamshire, United Kingdom, S81 OBD
    - Local Institution
- Renfrewshire
  - Paisley, Renfrewshire, United Kingdom, PA2 9PN
    - Local Institution
- South Yorkshire
  - Barnsley, South Yorkshire, United Kingdom, S75 2EP
    - Local Institution
  - Doncaster, South Yorkshire, United Kingdom, DN2 5LT
    - Local Institution
- Stirlingshire
  - Stirling, Stirlingshire, United Kingdom, FK8 2AU
    - Local Institution
- Strathclyde
  - Glasgow, Strathclyde, United Kingdom, G51 4TF
    - Local Institution
- Suffolk
  - Bury St Edmunds, Suffolk, United Kingdom, IP31 2HD
    - Local Institution
  - Bury St Edmunds, Suffolk, United Kingdom, IP33 2QZ
    - Local Institution
  - Bury St. Edmunds, Suffolk, United Kingdom, IP30 9QU
    - Local Institution
  - Ipswich, Suffolk, United Kingdom, IP14 2PU
    - Local Institution
  - Ipswich, Suffolk, United Kingdom, IP7 5DN
    - Local Institution
- Tyne and Wear
  - Newcastle Upon Tyne, Tyne and Wear, United Kingdom, NE1 4LP
    - Local Institution
- WEST Glamorgan
  - Swansea, WEST Glamorgan, United Kingdom, SA6 6NL
    - Local Institution
- WEST Lothian
  - Livingston, WEST Lothian, United Kingdom, EH54 6PP
    - Local Institution
- WEST Midlands
  - Birmingham, WEST Midlands, United Kingdom, B18 7QH
    - Local Institution
- Wiltshire
  - Westbury, Wiltshire, United Kingdom, BA 13 3JD
    - Local Institution
  - Westbury, Wiltshire, United Kingdom, BA13 3JD
    - Local Institution
- Yorkshire
  - York, Yorkshire, United Kingdom, YO31 8HE
    - Local Institution
  - York, Yorkshire, United Kingdom, YO31 HE
    - Local Institution
United States
- Alabama
  - Birmingham, Alabama, United States, 35209
    - Cardiovascular Associates, Pc
  - Birmingham, Alabama, United States, 35235
    - Alabama Internal Medicine Pc
  - Birmingham, Alabama, United States, 35235
    - Birmingham Heart Clinic P.C.
  - Huntsville, Alabama, United States, 35801
    - Heart Center, Inc.
  - Mobile, Alabama, United States, 36608
    - Mobile Heart Specialists, PC
  - Mobile, Alabama, United States, 36617
    - Clara V. Massey, Md
- Alaska
  - Anchorage, Alaska, United States, 99508
    - Alaska Heart Institute
- Arizona
  - Phoenix, Arizona, United States, 85006
    - Internal Medicine Physicians Associates, P.C.
  - Tucson, Arizona, United States, 85723
    - Southern Arizona VA Health Care System
  - Tucson, Arizona, United States, 85710
    - Southwest Heart
  - Tucson, Arizona, United States, 85745
    - Pima Research Foundation
- Arkansas
  - Hot Springs, Arkansas, United States, 71913
    - Dr. Rajesh Shroff
  - Little Rock, Arkansas, United States, 72204
    - Mary K. Richards, Md Pa
- California
  - Anaheim, California, United States, 92801
    - Advanced Clinical Reserach Institute
  - Beverly Hills, California, United States, 90210
    - Act/Cardiovascular Research Institute
  - Carmichael, California, United States, 95608
    - Capitol Interventional Cardiology
  - Escondido, California, United States, 92025
    - Escondido Cardiology Associates, Inc.
  - Healdsburg, California, United States, 95448
    - William D. Bowden, D.O.
  - La Mesa, California, United States, 91942
    - La Mesa Cardiac Center, A Medical Group
  - Los Angeles, California, United States, 90073
    - VA Greater Los Angeles Healthcare System
  - Mission Viejo, California, United States, 92691
    - Coastal Cardiology
  - Oceanside, California, United States, 92056
    - Kenneth W. Carr Md
  - Palm Springs, California, United States, 92262
    - Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
  - Rancho Mirage, California, United States, 92270
    - Desert Cardiology Consultants Medical Group, Inc
  - Sacramento, California, United States, 95821
    - Northern California Research
  - Sacramento, California, United States, 95825
    - Sacramento Heart And Vascular Medical Associates
  - Sacramento, California, United States, 95819
    - Regional Cardiolody Associates
  - Santa Barbara, California, United States, 93105
    - Arrhythmia Consultants Of The Central Coast Medical Group
  - Santa Rosa, California, United States, 95403
    - Northern California Medical Associates
  - Vista, California, United States, 92083
    - Progressive Clinical Research
  - Walnut Creek, California, United States, 94598
    - Cardivasclular Consultants Medical Group
  - Wildomar, California, United States, 92595
    - Shiva Heart Center Medical Group
- Colorado
  - Colorado Springs, Colorado, United States, 80910
    - Electrophysiology Associates, Pc
  - Denver, Colorado, United States, 80220
    - Denver VA Medical Center
  - Denver, Colorado, United States, 80218
    - Aurora Denver Cardiology Associates, P.C.
  - Golden, Colorado, United States, 80401
    - New West Physicians Clinical Research
  - Littleton, Colorado, United States, 80120
    - South Denver Cardiology Associates PC
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Bridgeport Hospital
  - Bridgeport, Connecticut, United States, 06606
    - Connecticut Clinical Research, Llc
  - Guilford, Connecticut, United States, 06437
    - Cardiology Associates Of New Haven,Pc
  - Norwich, Connecticut, United States, 06360
    - William W Backus Hospital
  - Norwich, Connecticut, United States, 06360
    - The William W. Backus Hospital
  - Stamford, Connecticut, United States, 06905
    - Stamford Therapeutics Consortium
  - Waterbury, Connecticut, United States, 06708
    - Chase Medical Research, LLC
- Delaware
  - Newark, Delaware, United States, 19713
    - Alfieri Cardiology
- District of Columbia
  - Washington, District of Columbia, United States, 20422
    - Washington VA Medical Center
  - Washington, District of Columbia, United States, 20037
    - George Washington University Medical Faculty Associates
- Florida
  - Atlantis, Florida, United States, 33462
    - Medical Specialist Of The Palm Beach
  - Aventura, Florida, United States, 33180
    - Miami International Cardiology Consultants
  - Boca Raton, Florida, United States, 33431
    - David Charles Mishkel, Md, Pa
  - Clearwater, Florida, United States, 33756
    - The Heart & Vascular Institute Of Florida
  - Clearwater, Florida, United States, 33756
    - The Heart And Vascular Institute Of Florida
  - Davie, Florida, United States, 33324
    - Cardiovascular Specialist Of South Florida
  - Daytona Beach, Florida, United States, 32114
    - Daytona Heart Group
  - Fort Lauderdale, Florida, United States, 33316
    - Broward General Medical Center
  - Fort Lauderdale, Florida, United States, 33308
    - Cardiology Associates Of Fort Lauderdale, P.A.
  - Fort Myers, Florida, United States, 33907
    - Florida Heart Associates
  - Gainesville, Florida, United States, 32605
    - Florida Research Network, LLC
  - Hollywood, Florida, United States, 33021
    - Healthworx
  - Hollywood, Florida, United States, 33021
    - Luis Tami, Md
  - Inverness, Florida, United States, 34452
    - Nature Coast Clinical Research
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Center for Clinical Research
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Cardiovascular Center
  - Jacksonville, Florida, United States, 32258
    - Jacksonville Heart Center, Pa
  - Jacksonville, Florida, United States, 32204
    - St. Vincent'S Ambulatory Care, Inc
  - Jacksonville, Florida, United States, 32207
    - Jacksonville Heart Center, Pa
  - Jacksonville, Florida, United States, 32216
    - St. Luke'S Cardiology
  - Jacksonville Beach, Florida, United States, 32250
    - Jacksonville Heart Center, P.A.
  - Jupiter, Florida, United States, 33458
    - Cvms Research Institute, Llc
  - Jupiter, Florida, United States, 33458
    - Ricardo Bedoya, M.D.
  - Melbourne, Florida, United States, 32901
    - Melbourne Internal Medicine Associates
  - Miami, Florida, United States, 33137
    - Miami International Cardiology Consultants
  - Miami, Florida, United States, 33137-3732
    - Miami International Cardiology Consultants
  - Naples, Florida, United States, 34119
    - Physicians Regional Medical Group
  - Orlando, Florida, United States, 32803
    - Florida Heart Group
  - Oviedo, Florida, United States, 32765
    - Alpha Medical Research
  - Pensacola, Florida, United States, 32501
    - Cardiology Consultants
  - Saint Petersburg, Florida, United States, 33709
    - The Heart And Vascular Institute Of Florida
  - Sarasota, Florida, United States, 34239
    - Heart & Vascular Center Research, Inc.
  - Sarasota, Florida, United States, 34232
    - Niranjan Seshadri, Md
  - Vero Beach, Florida, United States, 32960
    - Research, Inc.
- Georgia
  - Atlanta, Georgia, United States, 30342
    - Cardiovascular Specialits, Pc
  - Augusta, Georgia, United States, 30901
    - Augusta Cardiology Clinic, P.C.
  - Columbus, Georgia, United States, 31909
    - Columbus Cardiology Associates Pc
  - Columbus, Georgia, United States, 31909
    - Columbus Cardiology Associates,Pc
  - Covington, Georgia, United States, 30014
    - Georgia Heart Specialists, L.L.C.
  - Decatur, Georgia, United States, 30030
    - Atlanta Institute For Medical Research, Inc
  - Gainesville, Georgia, United States, 30501
    - Northeast Georgia Heart Center, PC
  - Marietta, Georgia, United States, 30060
    - Wellstar Cardiovascular Medicine, Pc
- Illinois
  - Aurora, Illinois, United States, 60504
    - Fox Valley Clinical Research Center, LLC
  - Chicago, Illinois, United States, 60611
    - Nmff
  - Gurnee, Illinois, United States, 60031
    - Clinical Investigation Specialists, Inc
  - Maywood, Illinois, United States, 60153
    - Loyola University Medical Center
  - Normal, Illinois, United States, 61761
    - Illinois Heart & Lung Research Center, Sc
  - North Chicago, Illinois, United States, 60064
    - Cpt. James A Lovell Federal Health Care Center
- Indiana
  - Anderson, Indiana, United States, 46011
    - Community Clinical Research Center
  - Bloomington, Indiana, United States, 47403
    - Premier Healthcare, Llc
  - Elkhart, Indiana, United States, 46514
    - Elkhart Clinic, LLC
  - Fort Wayne, Indiana, United States, 46804
    - Lutheran Medical Group, Llc
  - Fort Wayne, Indiana, United States, 46805
    - Fort Wayne Cardiology
  - Indianapolis, Indiana, United States, 46290
    - The Care Group, Llc
  - Indianapolis, Indiana, United States, 46290
    - The Care Group, Llc.
  - Indianapolis, Indiana, United States, 46237
    - St Francis Medical Group - Indiana Heart Physicians
  - Michigan City, Indiana, United States, 46360
    - Dali, Sammi
  - South Bend, Indiana, United States, 46601
    - Cardiology Associates, Inc.
- Iowa
  - Ames, Iowa, United States, 50010
    - McFarland Clinic PC
- Kansas
  - Overland Park, Kansas, United States, 66209
    - Midwest Cardiology Associates , P.C.
- Kentucky
  - Elizabethtown, Kentucky, United States, 42701
    - Central Cardiology Assoc.
  - Lexington, Kentucky, United States, 40504
    - New Lexington Clinic, P.S.C.
  - Louisville, Kentucky, United States, 40205
    - Norton Cardiovascular Associates
  - Louisville, Kentucky, United States, 40202
    - VA Medical Center
  - Owensboro, Kentucky, United States, 42303
    - Owensboro Heart & Vascular
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Alexandria Cardiology Clinic
  - Houma, Louisiana, United States, 70360
    - Cardiovascular Institute of the South
  - Lacombe, Louisiana, United States, 70445
    - Smith, Patel & Amkieh, Llc
  - Lake Charles, Louisiana, United States, 70601
    - Imperial Calcasieu Medical Group, Llp
  - Marrero, Louisiana, United States, 70072
    - Cardiology Center, Llc
  - Shreveport, Louisiana, United States, 71105
    - Cardiology Associates
  - Slidell, Louisiana, United States, 70458
    - Louisiana Heart Center
  - Slidell, Louisiana, United States, 70458
    - Medical Research Inst, Inc
  - Slidell, Louisiana, United States, 70458
    - Medical Research Institute, Inc
  - Ventura, Louisiana, United States, 93003
    - Ventura Cardio. Cond. Med. Group, Inc.
- Maine
  - Lewiston, Maine, United States, 04240
    - Central Maine Heart & Vascular Institute
- Maryland
  - Baltimore, Maryland, United States, 21224
    - Johns Hopkins Bayview Medical Center
  - Baltimore, Maryland, United States, 21237
    - Franklin Square Hospital
  - Baltimore, Maryland, United States, 21208
    - Midatlantic Cardiovascular Associates, Pa
  - Baltimore, Maryland, United States, 21237
    - Midatlantic Cardiovascular Associates, Pa
  - Baltimore, Maryland, United States, 21204
    - Midatlantic Cardiovascular Associates, P.A.
  - Baltimore, Maryland, United States, 21218
    - Midatlantic Cardiovascular Associates, P.A.
  - Baltimore, Maryland, United States, 21224-2735
    - Johns Hopkins Bayview Medical Center
  - Baltimore, Maryland, United States, 21237
    - Midatlantic Cardiovascular Associates, P.A.
  - Bel Air, Maryland, United States, 21014
    - Midatlantic Cardiovascular Associates, Pa
  - Columbia, Maryland, United States, 21044
    - Cardiovascular Specialists Of Central Maryland, P.A.
  - Reisterstown, Maryland, United States, 21136
    - Clinical Associates Research
  - Westminster, Maryland, United States, 21157
    - Midatlantic Cardiovascular Associates, Pa
- Massachusetts
  - Billerica, Massachusetts, United States, 01821
    - Burlington Medical Associates
  - Boston, Massachusetts, United States, 02135
    - Caritas St. Elizabeth's Medical Center
  - Burlington, Massachusetts, United States, 01805
    - Lahey Clinic Medical Center
  - Fall River, Massachusetts, United States, 02720
    - Neccr Internal Medicine & Cardiology Associates,Llc
  - Haverhill, Massachusetts, United States, 01830
    - Pentucket Medical Associates
  - Haverhill, Massachusetts, United States, 01830-6278
    - Pentucket Medical Associates
  - Natick, Massachusetts, United States, 01760
    - Charles River Medical Associates
- Michigan
  - Alpena, Michigan, United States, 49707
    - Great Lakes Heart Center Of Alpena
  - Detroit, Michigan, United States, 48202
    - Henry Ford Hospital
  - Lansing, Michigan, United States, 48910
    - Thoracic And Cardiovascular Healthcare Foundation
  - Livonia, Michigan, United States, 48154
    - Advanced Cardiovascular Health Specialists, Pc
  - Petoskey, Michigan, United States, 49770
    - Michigan Heart And Vascular Specialists
  - Royal Oak, Michigan, United States, 48073
    - William Beaumont Hospital
  - Ypsilanti, Michigan, United States, 48197
    - Michigan Heart, P.C.
- Minnesota
  - Minneapolis, Minnesota, United States, 55455
    - University of Minnesota
  - Minneapolis, Minnesota, United States, 55417
    - Minneapolis VA Medical Center
  - Robbinsdale, Minnesota, United States, 55422
    - North Memorial Health Care
- Mississippi
  - Olive Branch, Mississippi, United States, 38654
    - Olive Branch Family Medical Center
  - Tupelo, Mississippi, United States, 38801
    - Tupelo Neurology Clinic, Pa
- Missouri
  - Columbia, Missouri, United States, 65212
    - University of Missouri
  - Kansas City, Missouri, United States, 64108
    - Truman Medical Center
  - Kansas City, Missouri, United States, 64111
    - Saint Luke's Lipid and Diabetes Research Center
- Nebraska
  - Grand Island, Nebraska, United States, 68803
    - Internal Medical Associates Of Grand Island, P.C
  - Grand Island, Nebraska, United States, 68803-4311
    - Internal Medical Associates Of Grand Island, P.C
  - Hastings, Nebraska, United States, 68901
    - Nebraska Heart Institute
- Nevada
  - Las Vegas, Nevada, United States, 89106
    - VA Southern Nevada Healthcare System
- New Jersey
  - Berlin, New Jersey, United States, 08009
    - Comprehensive Clinical Research
  - Elmer, New Jersey, United States, 08318
    - Cardiovascular Associates Of The Delware Valley, P.A.
  - Haddon Heights, New Jersey, United States, 08035
    - Cardiovascular Associates Of The Delaware Valley, P.A.
  - Princeton, New Jersey, United States, 08540
    - Princeton Medical Institute
  - Sewell, New Jersey, United States, 08080
    - Cardio Assoc Of Del Val, P.A.
  - South Plainfield, New Jersey, United States, 07080
    - Central New Jersey Cardiology
- New Mexico
  - Albuquerque, New Mexico, United States, 87012
    - Abq Health Partners, Llc
  - Albuquerque, New Mexico, United States, 87131-0001
    - University Of New Mexico/University Hospital
  - Albuquerque, New Mexico, United States, 87131
    - University Of New Mexico/University Hospital
- New York
  - Albany, New York, United States, 12205
    - Albany Associates In Cardiology
  - Albany, New York, United States, 12205
    - Albany Assoc. In Cardiology
  - Binghamton, New York, United States, 13905
    - Cardiology Associates, Pc
  - Buffalo, New York, United States, 14215
    - Buffalo Heart Group, LLP
  - Buffalo, New York, United States, 14215-1145
    - Buffalo Heart Group, LLP
  - Buffalo, New York, United States, 14215
    - Bruce L. Platt Md, Pc
  - Buffalo, New York, United States, 14215
    - Bruce L. Platt, Md
  - East Syracuse, New York, United States, 13057
    - Heart Care Center, P.C.
  - Huntington, New York, United States, 11743
    - Huntington Hospital
  - Liverpool, New York, United States, 13088
    - SJH Cardiology Associates
  - Mineola, New York, United States, 11501
    - Long Island Heart Associates
  - Saratoga Springs, New York, United States, 12866
    - Saratoga Cardiology Associates, Pc
  - Williamsville, New York, United States, 14221
    - Office Of Dr. Kozinn
  - Williamsville, New York, United States, 14221
    - Suburban Cardiology
- North Carolina
  - Asheville, North Carolina, United States, 28803
    - Asheville Cardiology Associates
  - Burlington, North Carolina, United States, 27215
    - Kernodle Clinic, Inc.
  - High Point, North Carolina, United States, 27262
    - Carolina Cardiology Associates, Pa
  - Pinehurst, North Carolina, United States, 28374
    - Pinehurst Medical Center, Inc
- North Dakota
  - Fargo, North Dakota, United States, 58103
    - Lillestol Research LLC
- Ohio
  - Akron, Ohio, United States, 44304
    - Akron Cardiology Consultants
  - Bucyrus, Ohio, United States, 44820
    - Christopher M. Johnson, D.O.
  - Bucyrus, Ohio, United States, OHIO
    - Christopher M. Johnson, D.O.
  - Canal Fulton, Ohio, United States, 44614
    - Community Health Care, Inc.
  - Canton, Ohio, United States, 44710
    - Cardiology Associates
  - Cincinnati, Ohio, United States, 45219
    - The Carl & Edyth Lindner Center For R&E At The Christ Hosp
  - Toledo, Ohio, United States, 43608
    - Toledo Cardiology Consultants
  - Wadsworth, Ohio, United States, 44281
    - Family Practice Center of Wadsworth, Inc.
- Oklahoma
  - Muskogee, Oklahoma, United States, 74401
    - Jack C. Va Medical Center
  - Oklahoma City, Oklahoma, United States, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, United States, 73112
    - Plaza Medical Group, Pc
  - Oklahoma City, Oklahoma, United States, 73103
    - COR Clinical Research, LLC
  - Oklahoma City, Oklahoma, United States, 73135
    - South Oklahoma Heart Research
  - Oklahoma City, Oklahoma, United States, 73120
    - Oklahoma Heart Hospital Physicians
  - Oklahoma City, Oklahoma, United States, 73139
    - Eminence Research, LLC
  - Tulsa, Oklahoma, United States, 74136
    - Castlerock Clinical Research Consultants, Llc
- Oregon
  - Bend, Oregon, United States, 97701
    - St. Charles Health System, Inc.
  - Bend, Oregon, United States, 97701
    - St. Charles Health System, Inc
  - Eugene, Oregon, United States, 97401
    - Oregon Medical Group - Clinical Research
  - Hillsboro, Oregon, United States, 97123
    - Hillsboro Cardiology Pc
  - Medford, Oregon, United States, 97504
    - Rogue Valley Physicians - Clinical Research Group
- Pennsylvania
  - Abington, Pennsylvania, United States, 19001
    - Abington Medical Specialists
  - Altoona, Pennsylvania, United States, 16602
    - Blair Medical Associates, Inc.
  - Camp Hill, Pennsylvania, United States, 17011
    - Heritage Cardiology Assoc.
  - Doylestown, Pennsylvania, United States, 18901
    - Central Bucks Cardiology
  - Erie, Pennsylvania, United States, 16509
    - Internal Medicine And Lipid Mgmt.
  - Harrisburg, Pennsylvania, United States, 17112
    - Kandra, Fierer, Kuskin Associates
  - Hatfield, Pennsylvania, United States, 19440
    - Pivotal Clinical Research, Llc
  - Jersey Shore, Pennsylvania, United States, 17740
    - Lycoming Internal Medicine Inc.
  - Sayre, Pennsylvania, United States, 18840
    - Guthrie Medical Group, P.C.
  - Sayre, Pennsylvania, United States, 18840
    - Guthrie Clinic Ltd.
  - Uniontown, Pennsylvania, United States, 15401
    - Preferred Primary Care Physicians
  - West Chester, Pennsylvania, United States, 19380
    - West Chester Cardiology, Pc
  - Yardley, Pennsylvania, United States, 19067
    - Cardiology Consultants of Philadelphia
- Rhode Island
  - Providence, Rhode Island, United States, 02903
    - Rhode Island Hospital
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - Southeastern Research Associates, Inc
  - Beaufort, South Carolina, United States, 29906
    - Lowcountry Medical Group, Llc
  - Beaufort, South Carolina, United States, 29906
    - Lowcountry Medical Group
  - Charleston, South Carolina, United States, 29425
    - Medical University of South Carolina
  - Columbia, South Carolina, United States, 29203
    - Columbia Heart Clinic
  - Greenville, South Carolina, United States, 29607
    - Upstate Cardiology
  - Greer, South Carolina, United States, 29650
    - Internal Medicine Of Greer
  - Orangeburg, South Carolina, United States, 29118
    - Palmetto Nephrology Pa
  - Spartanburg, South Carolina, United States, 29303
    - S. Carolina Pharmaceutical Research
- South Dakota
  - Pierre, South Dakota, United States, 57501
    - Avera Medical Associates Clinic
- Tennessee
  - Bristol, Tennessee, United States, 37620
    - Holston Medical Group
  - Kingsport, Tennessee, United States, 37660
    - Holston Medical Group
  - Knoxville, Tennessee, United States, 37920
    - Volunteer Research Group
  - Knoxville, Tennessee, United States, 37916
    - Knoxville Heart Group
  - Knoxville, Tennessee, United States, 37920-1502
    - Volunteer Research Group
  - Tullahoma, Tennessee, United States, 37388
    - Tennessee Center For Clinical Trials
- Texas
  - Amarillo, Texas, United States, 79106
    - Amarillo Heart Clinical Research Institute Inc.
  - Corsicana, Texas, United States, 75110
    - Corsicana Medical Research, PLLC
  - Dallas, Texas, United States, 75226
    - Soltero Cardiovascular Research Center
  - Dallas, Texas, United States, 75230
    - HeartPlace
  - Fort Worth, Texas, United States, 76104
    - Heart Center of North Texas
  - Houston, Texas, United States, 77030
    - The Methodist Hospital
  - Houston, Texas, United States, 77030
    - The University of Texas MD Anderson Cancer Center
  - Houston, Texas, United States, 77030
    - Center For Atrial Fibrillation
  - Houston, Texas, United States, 77030
    - The Methodist Hospital Neurology Institute
  - Houston, Texas, United States, 77065
    - Northwest Houston Cardiology, Pa
  - Houston, Texas, United States, 77070
    - Northwest Houston Cardiology, Pa
  - Houston, Texas, United States, 77074
    - Francisco R. Maislos
  - Houston, Texas, United States, 77090
    - Woodlands North Houston Heart Center
  - Humble, Texas, United States, 77338
    - Regional Medical Center And Diagnostic Clinics
  - Lackland Air Force Base, Texas, United States, 78236
    - Wilford Hall Medical Center
  - Lackland Air Force Base, Texas, United States, 78236-9908
    - Wilford Hall Medical Center
  - Longview, Texas, United States, 75605
    - DCOL Center for Clinical Research
  - McKinney, Texas, United States, 75069
    - North Dallas Research Associates
  - Plano, Texas, United States, 75093
    - North Texas Medical Research
  - Plano, Texas, United States, 75024
    - Legacy Heart Center
  - San Antonio, Texas, United States, 78229
    - Covenant Clinical Research, Pa
  - San Antonio, Texas, United States, 78217
    - Bhs Specialty Network, Inc
  - San Antonio, Texas, United States, 78229
    - Star Clinical Trails
  - Seguin, Texas, United States, 78155
    - Edward Balli, Md, Pa
  - Tomball, Texas, United States, 77375
    - Northwest Heart Center
  - Tyler, Texas, United States, 75701
    - Tyler Cardiovascular Consultants
  - Tyler, Texas, United States, 75708
    - University of Texas Health Science Center at Tyler
  - Tyler, Texas, United States, 75708
    - The Univ. Of Texas Health Science Ctr. At Tyler
- Utah
  - Layton, Utah, United States, 84041
    - Utah Cardiology P.C
- Virginia
  - Norfolk, Virginia, United States, 23510
    - Sentara York Clinical Research
  - Richmond, Virginia, United States, 23220
    - Medical Research Initiatives
  - Roanoke, Virginia, United States, 24014
    - Roanoke Heart Institute, Plc
  - Virginia Beach, Virginia, United States, 23454
    - Cardiovascular Associates
- Washington
  - Burien, Washington, United States, 98166
    - Daniel W. Gottlieb, Md, Ps
  - Burien, Washington, United States, 98166
    - Daniel William Gottlieb, Md
  - Spokane, Washington, United States, 99202
    - Rockwood Clinic Research Cent.
  - Walla Walla, Washington, United States, 99362
    - Walla Walla Clinic
- West Virginia
  - Lewisburg, West Virginia, United States, 24901
    - Lynn N. Smith, Md
- Wisconsin
  - Green Bay, Wisconsin, United States, 54301
    - Cardiology Associates Of Green Bay Ltd-Bellin Hospital
  - Madison, Wisconsin, United States, 53715
    - St. Mary's Hospital
  - Madison, Wisconsin, United States, 53715
    - St.Mary's Hospital
  - Milwaukee, Wisconsin, United States, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, United States, 53215
    - Aurora Health Care
  - Waukesha, Wisconsin, United States, 53188
    - Cardiology Assc. Of Waukesha

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Child
Adult
Older Adult

Accepts Healthy Volunteers

Genders Eligible for Study

All

Description

Inclusion Criteria:

Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
Age ≥ 75, previous stroke
transient ischemic attack (TIA) or Systemic Embolism (SE)
Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
Diabetes mellitus or hypertension requiring pharmacological treatment

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 2	Drug: apixaban Oral tablets, 5.0 mg or 2.5 mg, twice daily Other Names: BMS-562247
Active Comparator: 1	Drug: warfarin Oral tablets, 2.0 mg, adjusted to an INR of 2.5 (range 2.0 to 3.0) Other Names: Coumadin BMS-565793

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period Time Frame: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).	All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.	Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period Time Frame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).	Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.	"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period Time Frame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).	Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).	"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated All-Cause Death During the Intended Treatment Period Time Frame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).	All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).	"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period Time Frame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).	Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.	"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period Time Frame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).	Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.	"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period Time Frame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).	For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.	"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period Time Frame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).		"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With All Bleeding Events During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of All Bleeding Events During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	AE: all SAEs or AEs with onset from first dose through 2 days (AEs) or 30 days (SAEs) after the last dose of blinded study drug (BSD). SAE: all SAEs with onset from first dose through 30 days after the last dose of BSD. Bleeding AE: all serious or non-serious bleeding-related AEs with onset from first dose through 2 days after the last dose of BSD. Discontinuations due to AE: all SAEs or AEs with onset from first dose of BSD and with action taken=drug discontinued. Deaths: all deaths occurring from first dose through 30 days after the last dose of BSD.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Rate=number of adjudicated GUSTO bleeding events per 100 patient years. GUSTO Bleeding Criteria: GUSTO severe (or life-threatening) bleeding: either intracranial hemorrhage or bleeding that causes hemodynamic compromise and requires intervention. GUSTO moderate bleeding: bleeding that requires blood transfusion but does not result in hemodynamic compromise.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Rate=number of adjudicated TIMI bleeding events per 100 patient years. TIMI Bleeding Criteria: Major bleeding=Intracranial bleeding and/or clinically overt bleeding associated with ≥5 gm/dL fall in Hgb or 15% fall in hematocrit (Hct) from baseline, accounting for transfusions. Minor bleeding=Clinically overt bleeding associated with ≥3 gm/dL fall in Hgb or a ≥10% fall in Hct from baseline, accounting for transfusions.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Net-Clinical Benefit During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding.	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Net-Clinical Benefit During Treatment Period Time Frame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.	Rate=number of events of net-clinical benefit per 100 patient years. Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding	"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bristol-Myers Squibb

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

BMS Clinical Trial Patient Recruiting

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 31, 2006

Primary Completion (Actual)

May 25, 2011

Study Completion (Actual)

May 25, 2011

Study Registration Dates

First Submitted

December 18, 2006

First Submitted That Met QC Criteria

December 18, 2006

First Posted (Estimate)

December 19, 2006

Study Record Updates

Last Update Posted (Actual)

July 3, 2018

Last Update Submitted That Met QC Criteria

June 5, 2018

Last Verified

May 1, 2018

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

CV185-030

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Other Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimate)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Clinical Trials on Atrial Fibrillation

Clinical Trials on warfarin

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