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Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (ARISTOTLE)

5 czerwca 2018 zaktualizowane przez: Bristol-Myers Squibb

A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

Przegląd badań

Status

Zakończony

Warunki

Interwencja / Leczenie

Typ studiów

Interwencyjne

Zapisy (Rzeczywisty)

20976

Faza

  • Faza 3

Kontakty i lokalizacje

Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.

Lokalizacje studiów

  • Afryka Południowa
    • Bloemfontein
      • Westdene, Bloemfontein, Afryka Południowa, 9301
        • Local Institution
    • Cape Town
      • Observatory, Cape Town, Afryka Południowa, 7925
        • Local Institution
    • Gauteng
      • Pretoria, Gauteng, Afryka Południowa, 0084
        • Local Institution
      • Pretoria, Gauteng, Afryka Południowa, 0132
        • Local Institution
    • KWA ZULU Natal
      • Richards Bay, KWA ZULU Natal, Afryka Południowa, 3900
        • Local Institution
    • Western CAPE
      • Bellville Cape Town, Western CAPE, Afryka Południowa, 7530
        • Local Institution
      • George, Western CAPE, Afryka Południowa, 6529
        • Local Institution
      • Parow, Western CAPE, Afryka Południowa, 7505
        • Local Institution
      • Somerset West, Western CAPE, Afryka Południowa, 7130
        • Local Institution
      • Worcester, Western CAPE, Afryka Południowa, 6850
        • Local Institution
  • Argentyna
      • Buenos Aires, Argentyna, 1119
        • Local Institution
      • Buenos Aires, Argentyna, C1280AEB
        • Local Institution
      • Buenos Aires, Argentyna, 1181
        • Local Institution
      • Buenos Aires, Argentyna, C1426ANZ
        • Local Institution
      • Buenos Aires, Argentyna, 1280
        • Local Institution
      • Cordoba, Argentyna, 5000
        • Local Institution
      • Cordoba, Argentyna, X5000EPU
        • Local Institution
      • Cordoba, Argentyna, X5008KKF
        • Local Institution
      • Cordoba, Argentyna, X5003DCE
        • Local Institution
      • Salta, Argentyna, 4400
        • Local Institution
      • Santa Fe, Argentyna, 3000
        • Local Institution
      • Tucuman, Argentyna, T4000NIL
        • Local Institution
    • Buenos Aires
      • Adrogue, Buenos Aires, Argentyna, 1846
        • Local Institution
      • Bahia Blanca, Buenos Aires, Argentyna, B8000FTD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentyna, CP1425A WC
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentyna, 1128AAD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentyna, 1128
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentyna, 1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentyna, C1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentyna, CP1425AWC
        • Local Institution
      • Ciudad Autonoma De, Buenos Aires, Argentyna, 1180
        • Local Institution
      • Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentyna, CI094AAD
        • Local Institution
      • Coronel Suarez, Buenos Aires, Argentyna, B7540GHD
        • Local Institution
      • Haedo, Buenos Aires, Argentyna, B1706AJU
        • Local Institution
      • Junin, Buenos Aires, Argentyna, 6000
        • Local Institution
      • La Plata, Buenos Aires, Argentyna, 1900
        • Local Institution
      • La Plata, Buenos Aires, Argentyna, B1900AXI
        • Local Institution
      • La Plata, Buenos Aires, Argentyna, 1902
        • Local Institution
      • Mar Del Plata, Buenos Aires, Argentyna, 7600
        • Local Institution
      • Merlo, Buenos Aires, Argentyna, B1722COV
        • Local Institution
      • Merlo, Buenos Aires, Argentyna, 1722
        • Local Institution
      • Olivos, Buenos Aires, Argentyna, 1602
        • Local Institution
      • Quilmes, Buenos Aires, Argentyna, 1878
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentyna, B1704ESN
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentyna, B1704ETD
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentyna, 1706
        • Local Institution
      • San Justo, Buenos Aires, Argentyna, 1754
        • Local Institution
      • San Martin, Buenos Aires, Argentyna, 1650
        • Local Institution
      • San Nicolas, Buenos Aires, Argentyna, 2900
        • Local Institution
      • Zarate, Buenos Aires, Argentyna, 2800
        • Local Institution
      • Zarate, Buenos Aires, Argentyna, B2800DGH
        • Local Institution
    • Provincia DE Cordoba
      • Cordoba, Provincia DE Cordoba, Argentyna, 5000
        • Local Institution
    • RIO Negro
      • Cipolletti, RIO Negro, Argentyna, 8324
        • Local Institution
    • Santa FE
      • Rosario, Santa FE, Argentyna, 2000
        • Local Institution
      • Rosario, Santa FE, Argentyna, S2000CVB
        • Local Institution
      • Rosario, Santa FE, Argentyna, S2001ODA
        • Local Institution
    • Santa Fe
      • Rosario, Santa Fe, Argentyna, S2000CVD
        • Local Institution
      • Rosario, Santa Fe, Argentyna, S2000 CVD
        • Local Institution
    • Tucuman
      • San Miquel De Tucuman, Tucuman, Argentyna, 4000
        • Local Institution
  • Australia
    • New South Wales
      • Coffs Harbour, New South Wales, Australia, 2450
        • Local Institution
      • Concord, New South Wales, Australia, 2139
        • Local Institution
      • Gosford, New South Wales, Australia, 2250
        • Local Institution
      • Kogarah, New South Wales, Australia, 2217
        • Local Institution
      • Miranda, New South Wales, Australia, 2228
        • Local Institution
    • Queensland
      • Auchenflower, Queensland, Australia, 4066
        • Local Institution
      • Brisbane, Queensland, Australia, 4032
        • Local Institution
      • Caboolture, Queensland, Australia, 4510
        • Local Institution
      • Herston, Queensland, Australia, 4029
        • Local Institution
      • Kippa Ring, Queensland, Australia, 4021
        • Local Institution
      • Nambour, Queensland, Australia, 4560
        • Local Institution
      • Sherwood, Queensland, Australia, 4075
        • Local Institution
    • South Australia
      • Adelaide, South Australia, Australia, SA 5000
        • Local Institution
      • Ashford, South Australia, Australia, 5035
        • Local Institution
      • Bedford Park, South Australia, Australia, 5042
        • Local Institution
      • Woodville, South Australia, Australia, 5011
        • Local Institution
    • Victoria
      • Box Hill, Victoria, Australia, 3128
        • Local Institution
      • Dandenong, Victoria, Australia, 3175
        • Local Institution
      • Geelong, Victoria, Australia, 3220
        • Local Institution
    • Western Australia
      • Fremantle, Western Australia, Australia, 6160
        • Local Institution
      • Joondalup, Western Australia, Australia, 6027
        • Local Institution
  • Austria
      • Graz, Austria, 8036
        • Local Institution
      • Oberpullendorf, Austria, 7350
        • Local Institution
      • Vienna, Austria, 1160
        • Local Institution
  • Belgia
      • Aalst, Belgia, 9300
        • Local Institution
      • Antwerpen, Belgia, 2020
        • Local Institution
      • Antwerpen, Belgia, 2060
        • Local Institution
      • Arlon, Belgia, 6700
        • Local Institution
      • Brugge, Belgia, 8000
        • Local Institution
      • Brussels, Belgia, 1090
        • Local Institution
      • Dillingen, Belgia, 66763
        • Local Institution
      • Genk, Belgia, 3600
        • Local Institution
      • Gent, Belgia, 9000
        • Local Institution
      • Gilly, Belgia, 6060
        • Local Institution
      • Hasselt, Belgia, 3500
        • Local Institution
      • Huy, Belgia, 4500
        • Local Institution
      • Kortrijk, Belgia, 8500
        • Local Institution
      • Menen, Belgia, 8930
        • Local Institution
      • Mol, Belgia, 2400
        • Local Institution
      • Montegnee, Belgia, 4420
        • Local Institution
      • Verviers, Belgia, 4800
        • Local Institution
      • Woluwe- Saint Lambert, Belgia, 1200
        • Local Institution
      • Yvoir, Belgia, 5530
        • Local Institution
  • Brazylia
      • Rio De Janeiro, Brazylia, 20551
        • Local Institution
      • Rio De Janeiro, Brazylia, 20551-030
        • Local Institution
      • Rio De Janeiro, Brazylia, 22251-030
        • Local Institution
      • Rio De Janeiro, Brazylia, 22251
        • Local Institution
      • Sao Paulo, Brazylia, 01323-010
        • Local Institution
      • Sao Paulo, Brazylia, 01323
        • Local Institution
      • Sao Paulo, Brazylia, 04012
        • Local Institution
      • Sao Paulo, Brazylia, 04024-002
        • Local Institution
      • Sao Paulo, Brazylia, 04038
        • Local Institution
      • Sao Paulo, Brazylia, 01221-900
        • Local Institution
      • Sao Paulo, Brazylia, 01221
        • Local Institution
      • Sao Paulo, Brazylia, 01322-001
        • Local Institution
      • Sao Paulo, Brazylia, 01322
        • Local Institution
      • Sao Paulo, Brazylia, 01323-001
        • Local Institution
      • Sao Paulo, Brazylia, 04012-180
        • Local Institution
      • Sao Paulo, Brazylia, 04024
        • Local Institution
      • Sao Paulo, Brazylia, 04038-031
        • Local Institution
      • Sao Paulo, Brazylia, 08270-070
        • Local Institution
      • Sao Paulo, Brazylia, 08270
        • Local Institution
    • Bahia
      • Salvador, Bahia, Brazylia, 40144
        • Local Institution
      • Salvador, Bahia, Brazylia, 41810
        • Local Institution
      • Salvador, Bahia, Brazylia, 40144-900
        • Local Institution
      • Salvador, Bahia, Brazylia, 41810-010
        • Local Institution
    • Minas Gerais
      • Belo Horzonte, Minas Gerais, Brazylia, 30150-221
        • Local Institution
      • Belo Horzonte, Minas Gerais, Brazylia, 30150
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brazylia, 36021-630
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brazylia, 36021
        • Local Institution
      • Uberaba, Minas Gerais, Brazylia, 38056 055
        • Local Institution
      • Uberlandia, Minas Gerais, Brazylia, 38400-299
        • Local Institution
      • Uberlandia, Minas Gerais, Brazylia, 38400
        • Local Institution
    • Para
      • Belem, Para, Brazylia, 66087-660
        • Local Institution
      • Belem, Para, Brazylia, 66087
        • Local Institution
    • Parana
      • Campina Grande Do Sul, Parana, Brazylia, 83430-000
        • Local Institution
      • Campina Grande Do Sul, Parana, Brazylia, 83430
        • Local Institution
      • Curitiba, Parana, Brazylia, 80010
        • Local Institution
      • Curitiba, Parana, Brazylia, 80730
        • Local Institution
      • Curitiba, Parana, Brazylia, 80010-030
        • Local Institution
      • Curitiba, Parana, Brazylia, 80730-150
        • Local Institution
      • Londrina, Parana, Brazylia, 86010-450
        • Local Institution
      • Londrina, Parana, Brazylia, 86010
        • Local Institution
    • RIO Grande DO Norte
      • Natal, RIO Grande DO Norte, Brazylia, 59020-100
        • Local Institution
    • RIO Grande DO SUL
      • Porte Alegre, RIO Grande DO SUL, Brazylia, 90610-000
        • Local Institution
      • Porte Alegre, RIO Grande DO SUL, Brazylia, 90880-480
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazylia, 90035-903
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazylia, 90020-090
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazylia, 90620-001
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brazylia, 91350-280
        • Local Institution
    • Rio Grande Do Norte
      • Natal, Rio Grande Do Norte, Brazylia, 59020
        • Local Institution
    • Rio Grande Do Sul
      • Porte Alegre, Rio Grande Do Sul, Brazylia, 90610
        • Local Institution
      • Porte Alegre, Rio Grande Do Sul, Brazylia, 90880480
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazylia, 90035
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazylia, 90020
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazylia, 90620
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brazylia, 91350
        • Local Institution
    • SAO Paulo
      • Botucatu, SAO Paulo, Brazylia, 18618-000
        • Local Institution
      • Campinas, SAO Paulo, Brazylia, 13059-740
        • Local Institution
      • Marilia, SAO Paulo, Brazylia, 17515-000
        • Local Institution
      • Marilia, SAO Paulo, Brazylia, 17515-460
        • Local Institution
      • Marilia, SAO Paulo, Brazylia, 17519-000
        • Local Institution
      • San Jose Do Rio Preto, SAO Paulo, Brazylia, 15090-000
        • Local Institution
      • Santo Andre, SAO Paulo, Brazylia, 09190-610
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brazylia, 15015-750
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brazylia, 15015-210
        • Local Institution
    • Santa Catarina
      • Blumenau, Santa Catarina, Brazylia, 89010
        • Local Institution
      • Blumenau, Santa Catarina, Brazylia, 89010-500
        • Local Institution
      • Sao Jose, Santa Catarina, Brazylia, 88103
        • Local Institution
      • Sao Jose, Santa Catarina, Brazylia, 88103-450
        • Local Institution
    • Sao Paulo
      • Botucatu, Sao Paulo, Brazylia, 18618
        • Local Institution
      • Campinas, Sao Paulo, Brazylia, 13059
        • Local Institution
      • Marilia, Sao Paulo, Brazylia, 17519
        • Local Institution
      • Marilia, Sao Paulo, Brazylia, 17515
        • Local Institution
      • San Jose Do Rio Preto, Sao Paulo, Brazylia, 15090
        • Local Institution
      • Santo Andre, Sao Paulo, Brazylia, 09190
        • Local Institution
      • Sao Jose Do Rio Preto, Sao Paulo, Brazylia, 15015
        • Local Institution
  • Chile
    • LOS Lagos
      • Osorno, LOS Lagos, Chile, 5311089
        • Local Institution
      • Osorno, LOS Lagos, Chile, 5311523
        • Local Institution
    • Metropolitana
      • Santiago, Metropolitana, Chile, 7500520
        • Local Institution
      • Santiago, Metropolitana, Chile, 7500922
        • Local Institution
      • Santiago, Metropolitana, Chile, 8330074
        • Local Institution
    • Region DE LA Araucania
      • Temuco, Region DE LA Araucania, Chile, 4781176
        • Local Institution
    • Region De La Araucania
      • Temuco, Region De La Araucania, Chile, 4781156
        • Local Institution
    • Valparaiso
      • Temuco, Valparaiso, Chile, 4781173
        • Local Institution
      • Vina Del Mar, Valparaiso, Chile, 2570017
        • Local Institution
  • Chiny
    • Beijing
      • Beijing, Beijing, Chiny, 100050
        • Local Institution
      • Beijing, Beijing, Chiny, 100001
        • Local Institution
      • Beijing, Beijing, Chiny, 100853
        • Local Institution
      • Beijing, Beijing, Chiny, 100020
        • Local Institution
      • Beijing, Beijing, Chiny, 100088
        • Local Institution
      • Beijing, Beijing, Chiny, 100101
        • Local Institution
    • Gansu
      • Lanzhou, Gansu, Chiny, 730000
        • Local Institution
      • Lanzhou, Gansu, Chiny, 730030
        • Local Institution
    • Guangdong
      • Guangzhou, Guangdong, Chiny, 510080
        • Local Institution
      • Guangzhou, Guangdong, Chiny, 510120
        • Local Institution
    • Hebei
      • Shijiazhuang, Hebei, Chiny, 050000
        • Local Institution
    • Heilongjiang
      • Daqing, Heilongjiang, Chiny, 163001
        • Local Institution
      • Haerbin, Heilongjiang, Chiny, 150086
        • Local Institution
      • Haerbin, Heilongjiang, Chiny, 150001
        • Local Institution
    • Hubei
      • Wuhan, Hubei, Chiny, 430060
        • Local Institution
    • Hunan
      • Changsha, Hunan, Chiny, 410000
        • Local Institution
    • Jiangsu
      • Hangzhou, Jiangsu, Chiny, 310009
        • Local Institution
      • Nanjing, Jiangsu, Chiny, 210029
        • Local Institution
    • Liaoning
      • Dalian, Liaoning, Chiny, 116011
        • Local Institution
      • Dalian, Liaoning, Chiny, 116021
        • Local Institution
      • Dalian, Liaoning, Chiny, 116027
        • Local Institution
      • Shenyang, Liaoning, Chiny, 110016
        • Local Institution
      • Shenyang, Liaoning, Chiny, 110003
        • Local Institution
    • Shandong
      • Jinan, Shandong, Chiny, 250012
        • Local Institution
      • Jinan, Shandong, Chiny, 250033
        • Local Institution
      • Qingdao, Shandong, Chiny, 266011
        • Local Institution
    • Shanghai
      • Shanghai, Shanghai, Chiny, 200080
        • Local Institution
      • Shanghai, Shanghai, Chiny, 200025
        • Local Institution
      • Shanghai, Shanghai, Chiny, 200433
        • Local Institution
      • Shanghai, Shanghai, Chiny, 200011
        • Local Institution
      • Shanghai, Shanghai, Chiny, 200233
        • Local Institution
      • Shanghai, Shanghai, Chiny, 200003
        • Local Institution
      • Shanghai, Shanghai, Chiny, 100037
        • Local Institution
      • Shanghai, Shanghai, Chiny, 200031
        • Local Institution
    • Sichuan
      • Chengdu, Sichuan, Chiny, 610041
        • Local Institution
      • Chongqing, Sichuan, Chiny, 400010
        • Local Institution
    • Zhejiang
      • Hangzhou, Zhejiang, Chiny, 310009
        • Local Institution
  • Czechy
      • Boskovice, Czechy, 680 21
        • Local Institution
      • Brno, Czechy, 625 00
        • Local Institution
      • Brno-Malomerice, Czechy, 614 00
        • Local Institution
      • Ivancice, Czechy, 664 91
        • Local Institution
      • Kladno, Czechy, 272 59
        • Local Institution
      • Litomysl, Czechy, 570 14
        • Local Institution
      • Mestec Kralove, Czechy, 289 03
        • Local Institution
      • Ostrava, Czechy, 70852
        • Local Institution
      • Prague 13, Czechy, 158 00
        • Local Institution
      • Prague 2, Czechy, 128 08
        • Local Institution
      • Pribram, Czechy, 261 01
        • Local Institution
      • Usti Nad Orlici, Czechy, 562 18
        • Local Institution
  • Dania
      • Arhus C, Dania, 8000
        • Local Institution
      • Esbjerg, Dania, 6700
        • Local Institution
      • Frederiksberg, Dania, 2000
        • Local Institution
      • Frederikssund, Dania, 3600
        • Local Institution
      • Gentofte, Dania, 2900
        • Local Institution
      • Haderslev, Dania, 6100
        • Local Institution
      • Hellerup, Dania, 2900
        • Local Institution
      • Herlev, Dania, 2730
        • Local Institution
      • Herning, Dania, 7400
        • Local Institution
      • Hillerod, Dania, 3400
        • Local Institution
      • Hvidovre, Dania, 2650
        • Local Institution
      • Kobenhavn, Dania, 2100
        • Local Institution
      • Kolding, Dania, 6000
        • Local Institution
      • Odense, Dania, 5000
        • Local Institution
      • Silkeborg, Dania, 8600
        • Local Institution
      • Slagelse, Dania, 4200
        • Local Institution
      • Svendborg, Dania, 5700
        • Local Institution
  • Federacja Rosyjska
      • Chelyabinsk, Federacja Rosyjska, 454136
        • Local Institution
      • Chita, Federacja Rosyjska, 672090
        • Local Institution
      • Dzerzhinskiy, Federacja Rosyjska, 140091
        • Local Institution
      • Kazan, Federacja Rosyjska, 420012
        • Local Institution
      • Kemerovo, Federacja Rosyjska, 650002
        • Local Institution
      • Kirovsk, Federacja Rosyjska, 187342
        • Local Institution
      • Krasnodar, Federacja Rosyjska, 350042
        • Local Institution
      • Moscow, Federacja Rosyjska, 119992
        • Local Institution
      • Moscow, Federacja Rosyjska, 125367
        • Local Institution
      • Moscow, Federacja Rosyjska, 109240
        • Local Institution
      • Moscow, Federacja Rosyjska, 105229
        • Local Institution
      • Moscow, Federacja Rosyjska, 111539
        • Local Institution
      • Moscow, Federacja Rosyjska, 115487
        • Local Institution
      • Moscow, Federacja Rosyjska, 115093
        • Local Institution
      • Moscow, Federacja Rosyjska, 121552
        • Local Institution
      • Moscow, Federacja Rosyjska, 117593
        • Local Institution
      • Moscow, Federacja Rosyjska, 127018
        • Local Institution
      • Moscow, Federacja Rosyjska, 125284
        • Local Institution
      • Moscow, Federacja Rosyjska, 111020
        • Local Institution
      • Moscow, Federacja Rosyjska, 119121
        • Local Institution
      • Moscow, Federacja Rosyjska, 121356
        • Local Institution
      • Moscow, Federacja Rosyjska, 117556
        • Local Institution
      • Moscow, Federacja Rosyjska, 119048
        • Local Institution
      • Moscow, Federacja Rosyjska, 123182
        • Local Institution
      • Moscow, Federacja Rosyjska, 125206
        • Local Institution
      • Moscow, Federacja Rosyjska, 125424
        • Local Institution
      • Moscow, Federacja Rosyjska, 129090
        • Local Institution
      • Nizhni Novgorod, Federacja Rosyjska, 603003
        • Local Institution
      • Nizhni Novgorod, Federacja Rosyjska, 603005
        • Local Institution
      • Novosibirsk, Federacja Rosyjska, 630008
        • Local Institution
      • Novosibirsk, Federacja Rosyjska, 630054
        • Local Institution
      • Odintsovo, Federacja Rosyjska, 143000
        • Local Institution
      • Penza, Federacja Rosyjska, 440026
        • Local Institution
      • Perm, Federacja Rosyjska, 614097
        • Local Institution
      • Rostov-On-Don, Federacja Rosyjska, 344022
        • Local Institution
      • Ryazan, Federacja Rosyjska, 390026
        • Local Institution
      • Saint Petersburg, Federacja Rosyjska, 193312
        • Local Institution
      • Saint Petersburg, Federacja Rosyjska, 193144
        • Local Institution
      • Saint-Petersburg, Federacja Rosyjska, 190103
        • Local Institution
      • Saint-Petersburg, Federacja Rosyjska, 191025
        • Local Institution
      • Saint-Petersburg, Federacja Rosyjska, 193163
        • Local Institution
      • Saint-Petersburg, Federacja Rosyjska, 196601
        • Local Institution
      • Saint-Petersburg, Federacja Rosyjska, 198013
        • Local Institution
      • Samara, Federacja Rosyjska, 443070
        • Local Institution
      • Saratov, Federacja Rosyjska, 410002
        • Local Institution
      • St Petersburg, Federacja Rosyjska, 198013
        • Local Institution
      • St Petersburg, Federacja Rosyjska, 192288
        • Local Institution
      • St-Petersburg, Federacja Rosyjska, 194354
        • Local Institution
      • St-Petersburg, Federacja Rosyjska, 195271
        • Local Institution
      • St. Petersburg, Federacja Rosyjska, 197341
        • Local Institution
      • St. Petersburg, Federacja Rosyjska, 197110
        • Local Institution
      • St.-Petersburg, Federacja Rosyjska, 197341
        • Local Institution
      • St.Petersburg, Federacja Rosyjska, 199106
        • Local Institution
      • Tomsk, Federacja Rosyjska, 634012
        • Local Institution
      • Tumen, Federacja Rosyjska, 625023
        • Local Institution
      • Tver, Federacja Rosyjska, 170036
        • Local Institution
      • Voronezh, Federacja Rosyjska, 394066
        • Local Institution
      • Voronezh, Federacja Rosyjska, 394065
        • Local Institution
      • Yaroslavl, Federacja Rosyjska, 150030
        • Local Institution
      • Yaroslavl, Federacja Rosyjska, 150003
        • Local Institution
      • Yaroslavl, Federacja Rosyjska, 150002
        • Local Institution
      • Zheleznodorozhniy, Federacja Rosyjska, 143920
        • Local Institution
      • Zhukovsky, Federacja Rosyjska, 140160
        • Local Institution
      • Zhukovsky, Federacja Rosyjska, 140180
        • Local Institution
  • Filipiny
      • Manila, Filipiny, 1000
        • Local Institution
      • Manila, Filipiny, 1008
        • Local Institution
      • Naga City, Filipiny, 4400
        • Local Institution
      • Pasig City, Filipiny, 1600
        • Local Institution
      • Quezon, Filipiny, 1100
        • Local Institution
      • Quezon City, Filipiny, 1102
        • Local Institution
      • San Juan, Filipiny, 1100
        • Local Institution
    • Ilocos Norte
      • Laoag City, Ilocos Norte, Filipiny, 2900
        • Local Institution
  • Finlandia
      • Helsinki, Finlandia, 00280
        • Local Institution
      • Helsinki, Finlandia, FI-00280
        • Local Institution
      • Hus, Finlandia, 00029
        • Local Institution
      • Jyvaskyla, Finlandia, 40100
        • Local Institution
      • Kemi, Finlandia, 94100
        • Local Institution
      • Oulu, Finlandia, 90100
        • Local Institution
      • Pori, Finlandia, 28120
        • Local Institution
      • Tampere, Finlandia, 33100
        • Local Institution
  • Francja
      • Amiens Cedex 1, Francja, 80054
        • Local Institution
      • Bordeaux Cedex, Francja, 33075
        • Local Institution
      • Brest, Francja, 29609
        • Local Institution
      • Grenoble Cedex 09, Francja, 38043
        • Local Institution
      • La Seyne Sur Mer, Francja, 83500
        • Local Institution
      • Paris Cedex 18, Francja, 75018
        • Local Institution
      • Six Fours Les Plages, Francja, 83140
        • Local Institution
  • Hiszpania
      • Albacete, Hiszpania, 02006
        • Local Institution
      • Barcelona, Hiszpania, 08035
        • Local Institution
      • Barcelona, Hiszpania, 08003
        • Local Institution
      • Elda, Hiszpania, 03600
        • Local Institution
      • Figueres, Hiszpania, 17600
        • Local Institution
      • Gerona, Hiszpania, 17007
        • Local Institution
      • Las Palmas, Hiszpania, 35010
        • Local Institution
      • Madrid, Hiszpania, 28006
        • Local Institution
      • Madrid, Hiszpania, 28046
        • Local Institution
      • Madrid, Hiszpania, 28040
        • Local Institution
      • Palma De Mallorca, Hiszpania, 07010
        • Local Institution
      • San Sebastian De Los Reyes, Hiszpania, 28703
        • Local Institution
      • Tarragona, Hiszpania, 43007
        • Local Institution
      • Viladecans, Hiszpania, 08840
        • Local Institution
    • Alicante
      • San Juan, Alicante, Hiszpania, 03550
        • Local Institution
      • Torrevieja, Alicante, Hiszpania, 03186
        • Local Institution
    • Almeria
      • La Canada, Almeria, Hiszpania, 04120
        • Local Institution
    • Galicia
      • Lugo, Galicia, Hiszpania, 27003
        • Local Institution
  • Holandia
      • Breda, Holandia, 4818 CK
        • Local Institution
      • Deventer, Holandia, 7416 SE
        • Local Institution
      • Eindhoven, Holandia, 5623 EJ
        • Local Institution
      • Eindhoven, Holandia, 5623EJ
        • Local Institution
      • Enschede, Holandia, 7513 ER
        • Local Institution
      • Hardenberg, Holandia, 7772 SE
        • Local Institution
      • Hilversum, Holandia, 1213 XZ
        • Local Institution
      • Nijmegen, Holandia, 6525 GA
        • Local Institution
      • Oss, Holandia, 5342 BT
        • Local Institution
      • Rotterdam, Holandia, 3045 PM
        • Local Institution
      • S-Hertogenbosch, Holandia, 5211 NL
        • Local Institution
      • Tiel, Holandia, 4002 WP
        • Local Institution
      • Utrecht, Holandia, 3582 KE
        • Local Institution
      • Velp, Holandia, 6883 AZ
        • Local Institution
  • Hongkong
      • Hong Kong, Hongkong
        • Local Institution
      • Shatin, Hongkong
        • Local Institution
  • Indie
      • Ahmedabad, Indie, 380014
        • Local Institution
      • Annamalainagar, Indie, 608002
        • Local Institution
      • Bangalore, Indie, 560052
        • Local Institution
      • Chennai, Indie, 600006
        • Local Institution
      • Hyderabad, Indie, 500001
        • Local Institution
      • Hyderabad, Indie, 500044
        • Local Institution
      • Indore, Indie, 452014
        • Local Institution
      • Indore, Indie, 452001
        • Local Institution
      • Kolkata, Indie, 700054
        • Local Institution
      • Kottayam, Indie, 686016
        • Local Institution
      • Lucknow, Indie, 226003
        • Local Institution
      • Mumbai Naka, Indie, 422005
        • Local Institution
      • Nashik, Indie, 422002
        • Local Institution
      • New Delhi, Indie, 110025
        • Local Institution
      • New Delhi, Indie, 110060
        • Local Institution
      • New Delhi, Indie, 116025
        • Local Institution
      • Pune, Indie, 411001
        • Local Institution
      • Pune, Indie, 411004
        • Local Institution
      • Thrissur, Indie, 680002
        • Local Institution
      • Vijayawada, Indie, 520008
        • Local Institution
    • Andhra Pradesh
      • Visakhapatnam, Andhra Pradesh, Indie, 530003
        • Local Institution
    • Andhrapradesh
      • Visakhapatnam, Andhrapradesh, Indie, 530002
        • Local Institution
    • Andra Pradesh
      • Hyderabad, Andra Pradesh, Indie, 500004
        • Local Institution
    • Gujarat
      • Ahmedabad, Gujarat, Indie, 380060
        • Local Institution
      • Vadodara, Gujarat, Indie, 390007
        • Local Institution
    • Karnataka
      • Bangalore, Karnataka, Indie, 560054
        • Local Institution
      • Bangalore, Karnataka, Indie, 5600034
        • Local Institution
      • Bangalore, Karnataka, Indie, 560094
        • Local Institution
      • Mysore, Karnataka, Indie, 570004
        • Local Institution
    • Kerela
      • Calicut, Kerela, Indie, 673 004
        • Local Institution
    • Maharashta
      • Pune, Maharashta, Indie, 411011
        • Local Institution
    • Maharashtra
      • Nagpur, Maharashtra, Indie, 440010
        • Local Institution
      • Nagpur, Maharashtra, Indie, 440012
        • Local Institution
      • Pune, Maharashtra, Indie, 411001
        • Local Institution
      • Pune, Maharashtra, Indie, 421006
        • Local Institution
    • Punjab
      • Jalandhar, Punjab, Indie, 144008
        • Local Institution
    • Rajasthan
      • Bikaner, Rajasthan, Indie, 334001
        • Local Institution
      • Bikaner, Rajasthan, Indie, 334003
        • Local Institution
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, Indie, 226003
        • Local Institution
  • Indyk
      • Ankara, Indyk, 06100
        • Local Institution
      • Eskisehir, Indyk, 26480
        • Local Institution
      • Izmir, Indyk, 35100
        • Local Institution
  • Izrael
      • Afula, Izrael, 18101
        • Local Institution
      • Ashkelon, Izrael, 78306
        • Local Institution
      • Givatayim, Izrael, 53583
        • Local Institution
      • Hadera, Izrael, 38100
        • Local Institution
      • Haifa, Izrael, 31096
        • Local Institution
      • Haifa, Izrael, 34362
        • Local Institution
      • Holon, Izrael, 58100
        • Local Institution
      • Jerusalem, Izrael, 91120
        • Local Institution
      • Jerusalem, Izrael, 91240
        • Local Institution
      • Kfar-Saba, Izrael, 44281
        • Local Institution
      • Nazareth, Izrael, 16100
        • Local Institution
      • Nazareth, Izrael, 16000
        • Local Institution
      • Petach-Tikva, Izrael, 49100
        • Local Institution
      • Safed, Izrael, 13100
        • Local Institution
      • Tel Aviv, Izrael, 64239
        • Local Institution
  • Japonia
      • Fukui, Japonia, 9100067
        • Local Institution
      • Kagoshima, Japonia, 8920822
        • Local Institution
      • Kyoto, Japonia, 6168152
        • Local Institution
      • Nagasaki, Japonia, 852-8102
        • Local Institution
      • Oita, Japonia, 8700033
        • Local Institution
      • Osaka, Japonia, 558-8558
        • Local Institution
      • Osaka, Japonia, 551-0032
        • Local Institution
      • Osaka, Japonia, 5510032
        • Local Institution
      • Saga, Japonia, 8490917
        • Local Institution
    • Fukuoka
      • Itoshima City, Fukuoka, Japonia, 819-1104
        • Local Institution
      • Kurume, Fukuoka, Japonia, 8390863
        • Local Institution
      • Ohkawa-City, Fukuoka, Japonia, 8310016
        • Local Institution
    • Fukushima
      • Shirakawa City, Fukushima, Japonia, 961-0005
        • Local Institution
    • Gunma
      • Takasaki City, Gunma, Japonia, 3700829
        • Local Institution
    • Hokkaido
      • Asahikawa-Shi, Hokkaido, Japonia, 0788214
        • Local Institution
      • Katou-Gun, Hokkaido, Japonia, 0800111
        • Local Institution
      • Katou-gun, Hokkaido, Japonia, 080111
        • Local Institution
      • Sapporo-Shi, Hokkaido, Japonia, 0028043
        • Local Institution
      • Tomakomai-Shi, Hokkaido, Japonia, 002-8043
        • Local Institution
      • Tomakomai-shi, Hokkaido, Japonia, 0028043
        • Local Institution
      • Yubari, Hokkaido, Japonia, 0680402
        • Local Institution
    • Hyogo
      • Kobe, Hyogo, Japonia, 6540026
        • Local Institution
    • Kagoshima Prefecture
      • Izumi City, Kagoshima Prefecture, Japonia, 8990131
        • Local Institution
    • Kanagawa
      • Isehara, Kanagawa, Japonia, 2591193
        • Local Institution
      • Yokohama, Kanagawa, Japonia, 2458575
        • Local Institution
      • Yokohama City, Kanagawa, Japonia, 2278501
        • Local Institution
      • Yokosuka, Kanagawa, Japonia, 2388567
        • Local Institution
    • Miyagi
      • Sendai City, Miyagi, Japonia, 983-8520
        • Local Institution
    • Nara
      • Nara City, Nara, Japonia, 630-8305
        • Local Institution
    • Osaka
      • Izumi City, Osaka, Japonia, 594-0071
        • Local Institution
      • Osaka City, Osaka, Japonia, 5330022
        • Local Institution
      • Osaka-Shi, Osaka, Japonia, 540-0006
        • Local Institution
      • Osaka-shi, Osaka, Japonia, 5400006
        • Local Institution
      • Suita-City, Osaka, Japonia, 5658565
        • Local Institution
      • Takatsuki City, Osaka, Japonia, 5690852
        • Local Institution
      • Yao, Osaka, Japonia, 5810036
        • Local Institution
    • Saga
      • Saga City, Saga, Japonia, 840-8571
        • Local Institution
      • Saga City, Saga, Japonia, 849-8501
        • Local Institution
    • Saitama
      • Kasukabe-Shi, Saitama, Japonia, 344-0035
        • Local Institution
      • Kasukabe-shi, Saitama, Japonia, 3440035
        • Local Institution
    • Tokyo
      • Itabashi-Ku, Tokyo, Japonia, 173-0015
        • Local Institution
      • Itabashi-ku, Tokyo, Japonia, 1730015
        • Local Institution
      • Meguro-Ku, Tokyo, Japonia, 153-8515
        • Local Institution
      • Meguro-ku, Tokyo, Japonia, 1538515
        • Local Institution
      • Shinagawa-Ku, Tokyo, Japonia, 1428666
        • Local Institution
    • Toyama
      • Toyama City, Toyama, Japonia, 9308550
        • Local Institution
    • Yamaguchi
      • Iwakuni, Yamaguchi, Japonia, 7400021
        • Local Institution
  • Kanada
      • Quebec, Kanada, G1J 1Z6
        • Local Institution
    • Alberta
      • Calgary, Alberta, Kanada, T2E 7C5
        • Local Institution
      • Edmonton, Alberta, Kanada, T6G 2B7
        • Local Institution
      • Edmonton, Alberta, Kanada, T5X 3N5
        • Local Institution
      • Edmonton, Alberta, Kanada, TSA 4L8
        • Local Institution
      • Edmonton, Alberta, Kanada, T56-3NJ
        • Local Institution
    • British Columbia
      • Burnaby, British Columbia, Kanada, V5G 1T4
        • Local Institution
      • Nanaimo, British Columbia, Kanada, V9R 3G9
        • Local Institution
      • New Westminster, British Columbia, Kanada, V3L 3W4
        • Local Institution
      • North Vancouver, British Columbia, Kanada, V7N 4M2
        • Local Institution
      • Victoria, British Columbia, Kanada, V8R 4R2
        • Local Institution
    • Manitoba
      • Winnipeg, Manitoba, Kanada, R2V 4W3
        • Local Institution
    • New Brunswick
      • Bathurst, New Brunswick, Kanada, E2A 4X7
        • Local Institution
    • Newfoundland and Labrador
      • Mount Pearl, Newfoundland and Labrador, Kanada, A1N 1W7
        • Local Institution
      • St Johns, Newfoundland and Labrador, Kanada, A1B 3V6
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Kanada, A1A 3R5
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Kanada, A1E 2C2
        • Local Institution
    • Ontario
      • Brampton, Ontario, Kanada, L6Z 4N5
        • Local Institution
      • Burlington, Ontario, Kanada, L7M 4Y1
        • Local Institution
      • Cambridge, Ontario, Kanada, N1R 7R1
        • Local Institution
      • Cambridge, Ontario, Kanada, N1R 6V6
        • Local Institution
      • Hamilton, Ontario, Kanada, L8L 2X2
        • Local Institution
      • London, Ontario, Kanada, N6G 2V2
        • Local Institution
      • Mississauga, Ontario, Kanada, L5B 4A2
        • Local Institution
      • Newmarket, Ontario, Kanada, L3Y 5G8
        • Local Institution
      • Newmarket, Ontario, Kanada, L3Y 8C3
        • Local Institution
      • Niagara Falls, Ontario, Kanada, L2E 7H1
        • Local Institution
      • Niagara Falls, Ontario, Kanada, L2E7H1
        • Local Institution
      • North Bay, Ontario, Kanada, P1B 2H3
        • Local Institution
      • Oshawa, Ontario, Kanada, L1J 2J9
        • Local Institution
      • Oshawa, Ontario, Kanada, L1J 2K1
        • Local Institution
      • Ottawa, Ontario, Kanada, K1Y 4E9
        • Local Institution
      • Ottawa, Ontario, Kanada, K1Y 4W7
        • Local Institution
      • Sarnia, Ontario, Kanada, N7T 4X3
        • Local Institution
      • Scarborough, Ontario, Kanada, M1B 5N1
        • Local Institution
      • Sudbury, Ontario, Kanada, P3E 3B8
        • Local Institution
      • Sudbury, Ontario, Kanada, P3C 5K7
        • Local Institution
      • Sudbury, Ontario, Kanada, P3E 2N8
        • Local Institution
      • Sudbury, Ontario, Kanada, P3C5K7
        • Local Institution
      • Toronto, Ontario, Kanada, M9W 4L6
        • Local Institution
      • Toronto, Ontario, Kanada, M5B 1W8
        • Local Institution
      • Weston, Ontario, Kanada, M9N 1W4
        • Local Institution
    • Prince Edward Island
      • Charlottetown, Prince Edward Island, Kanada, C1A 5Y9
        • Local Institution
    • Quebec
      • Drummondville, Quebec, Kanada, J2B 7T1
        • Local Institution
      • Greenfield Park, Quebec, Kanada, J4V 2G8
        • Local Institution
      • Lachine, Quebec, Kanada, H8S 2E4
        • Local Institution
      • Levis, Quebec, Kanada, G6V 4Z5
        • Local Institution
      • Longueuil, Quebec, Kanada, J4K 1C8
        • Local Institution
      • Longueuil, Quebec, Kanada, J4N 0C9
        • Local Institution
      • Longueuil, Quebec, Kanada, J4N 1C2
        • Local Institution
      • Montreal, Quebec, Kanada, H3T 1E2
        • Local Institution
      • Montreal, Quebec, Kanada, H3A 1A1
        • Local Institution
      • Montreal, Quebec, Kanada, H1T 1C8
        • Local Institution
      • Montreal, Quebec, Kanada, H2W 1T8
        • Local Institution
      • Montreal, Quebec, Kanada, W3R-153
        • Local Institution
      • Pointe- Claire, Quebec, Kanada, H9R 3J1
        • Local Institution
      • St-Lambert, Quebec, Kanada, J4P 2H4
        • Local Institution
      • Ste-Foy, Quebec, Kanada, G1W 4R4
        • Local Institution
    • Saskatchewan
      • Saskatoon, Saskatchewan, Kanada, S7L OY7
        • Local Institution
  • Kolumbia
      • Barranquilla, Kolumbia
        • Local Institution
      • Barranquilla, Kolumbia, XXXXX
        • Local Institution
      • Bogota, Kolumbia
        • Local Institution
      • Bogota, Kolumbia, 000
        • Local Institution
      • Cali, Kolumbia
        • Local Institution
      • Medellin, Kolumbia
        • Local Institution
    • Antioquia
      • Medellin, Antioquia, Kolumbia
        • Local Institution
  • Malezja
      • Kuala Lumpur, Malezja, 56000
        • Local Institution
      • Kuala Lumpur, Malezja, 59100
        • Local Institution
    • Kelantan
      • Kubang Kerian, Kelantan, Malezja, 16150
        • Local Institution
    • Sarawak
      • Kota Samarahan, Sarawak, Malezja, 94300
        • Local Institution
    • Selangor
      • Batu Caves, Selangor, Malezja, 68100
        • Local Institution
  • Meksyk
      • Puebla, Meksyk, 11490
        • Local Institution
      • Queretaro, Meksyk, 76000
        • Local Institution
    • BAJA California
      • Tijuana, BAJA California, Meksyk, 22500
        • Local Institution
    • Distrito Federal
      • Col. Toriello Guerra, Distrito Federal, Meksyk, CP 14050
        • Local Institution
      • Mexico City, Distrito Federal, Meksyk, 06726
        • Local Institution
      • Mexico City, Distrito Federal, Meksyk, 14080
        • Local Institution
      • Mexico City, Distrito Federal, Meksyk, 07760
        • Local Institution
      • Mexico City, Distrito Federal, Meksyk, 06070
        • Local Institution
      • Mexico City, Distrito Federal, Meksyk, 10700
        • Local Institution
    • Jalisco
      • Guadalajara, Jalisco, Meksyk, 44200
        • Local Institution
      • Guadalajara, Jalisco, Meksyk, 44600
        • Local Institution
      • Guadalajara, Jalisco, Meksyk, 44656
        • Local Institution
    • Michoacan
      • Morelia, Michoacan, Meksyk, 58000
        • Local Institution
    • Nuevo LEON
      • Monterrey, Nuevo LEON, Meksyk, 64710
        • Local Institution
      • Monterrey, Nuevo LEON, Meksyk, 64000
        • Local Institution
      • Monterrey, Nuevo LEON, Meksyk, 64700
        • Local Institution
    • Sinaloa
      • Culiacan, Sinaloa, Meksyk, 80020
        • Local Institution
    • Veracruz
      • Jalapa, Veracruz, Meksyk, 91020
        • Local Institution
  • Niemcy
      • Aachen, Niemcy, 52074
        • Local Institution
      • Bad Krozingen, Niemcy, 79189
        • Local Institution
      • Bad Neustadt/ Salle, Niemcy, 97616
        • Local Institution
      • Bad Oeynhausen, Niemcy, 32545
        • Local Institution
      • Berlin, Niemcy, 13353
        • Local Institution
      • Berlin, Niemcy, 14050
        • Local Institution
      • Berlin, Niemcy, 10787
        • Local Institution
      • Berlin, Niemcy, 10789
        • Local Institution
      • Berlin, Niemcy, 12043
        • Local Institution
      • Berlin-Kopenick, Niemcy, 12559
        • Local Institution
      • Betzdorf, Niemcy, 57518
        • Local Institution
      • Bochum, Niemcy, 44791
        • Local Institution
      • Bochum, Niemcy, 44789
        • Local Institution
      • Bonn, Niemcy, 53127
        • Local Institution
      • Coburg, Niemcy, 96450
        • Local Institution
      • Dillingen, Niemcy, 66763
        • Local Institution
      • Dresden, Niemcy, 01099
        • Local Institution
      • Duisburg, Niemcy, 47139
        • Local Institution
      • Essen, Niemcy, 45122
        • Local Institution
      • Frankfurt Am Main, Niemcy, 60594
        • Local Institution
      • Gottingen, Niemcy, 37075
        • Local Institution
      • Halle/Saale, Niemcy, 06120
        • Local Institution
      • Hannover, Niemcy, 30625
        • Local Institution
      • Heidelberg, Niemcy, 69120
        • Local Institution
      • Heidelberg, Niemcy, 69115
        • Local Institution
      • Kassel, Niemcy, 34121
        • Local Institution
      • Lahr, Niemcy, 77933
        • Local Institution
      • Ludwigshafen, Niemcy, 67063
        • Local Institution
      • Ludwigshafen, Niemcy, 67073
        • Local Institution
      • Mannheim, Niemcy, 68167
        • Local Institution
      • Marburg, Niemcy, 35043
        • Local Institution
      • Munchen, Niemcy, 81675
        • Local Institution
      • Munchen, Niemcy, 80636
        • Local Institution
      • Munchen, Niemcy, 81545
        • Local Institution
      • Osnabruck, Niemcy, 49076
        • Local Institution
      • Regensburg, Niemcy, 93053
        • Local Institution
      • Riesa, Niemcy, D-01587
        • Local Institution
      • Rostiock, Niemcy, 18057
        • Local Institution
      • Trier, Niemcy, 54292
        • Local Institution
      • Waren, Niemcy, 17192
        • Local Institution
      • Witten, Niemcy, 58455
        • Local Institution
      • Wolmirstedt, Niemcy, 39326
        • Local Institution
      • Worms, Niemcy, 67550
        • Local Institution
  • Norwegia
      • Alesund, Norwegia, 6003
        • Local Institution
      • Bergen, Norwegia, 5021
        • Local Institution
      • Bergen, Norwegia, N-5021
        • Local Institution
      • Elverum, Norwegia, 2408
        • Local Institution
      • Flekkefjord, Norwegia, 4400
        • Local Institution
      • Nesttun, Norwegia, 5221
        • Local Institution
      • Oslo, Norwegia, 0407
        • Local Institution
      • Skien, Norwegia, 3710
        • Local Institution
      • Stavanger, Norwegia, 4064
        • Local Institution
      • Straume, Norwegia, 5353
        • Local Institution
      • Tonsberg, Norwegia, 3116
        • Local Institution
      • Tromso, Norwegia, 9038
        • Local Institution
  • Peru
      • Lima, Peru, LIMA 33
        • Local Institution
      • Lima, Peru, LIMA 01
        • Local Institution
      • Lima, Peru, LIMA 1
        • Local Institution
    • Callao
      • Bellavista, Callao, Peru, 2176
        • Local Institution
      • Bellavista, Callao, Peru, CALLAO 2
        • Local Institution
    • Lambayeque
      • Chiclayo, Lambayeque, Peru, CIX
        • Local Institution
    • Lima
      • Jesus Maria, Lima, Peru, 11
        • Local Institution
      • Jesus Maria, Lima, Peru, LIMA 11
        • Local Institution
      • Miraflores, Lima, Peru, LIMA 18
        • Local Institution
      • San Borja, Lima, Peru, LIMA 41
        • Local Institution
      • San Martin De Porres, Lima, Peru, LIMA 31
        • Local Institution
  • Polska
      • Gdynia, Polska, 81-423
        • Local Institution
      • Gdynia, Polska, 81-472
        • Local Institution
      • Gdynia, Polska, 81-519
        • Local Institution
      • Grodzisk Mazowiecki, Polska, 05-825
        • Local Institution
      • Inowroclaw, Polska, 88-100
        • Local Institution
      • Kielce, Polska, 25-736
        • Local Institution
      • Kielce, Polska, 25-763
        • Local Institution
      • Krakow, Polska, 31-202
        • Local Institution
      • Krakow, Polska, 30-092
        • Local Institution
      • Krakow, Polska, 31-135
        • Local Institution
      • Lodz, Polska, 91-347
        • Local Institution
      • Lodz, Polska, 91347
        • Local Institution
      • Piotrkow Trybunalski, Polska, 97-300
        • Local Institution
      • Plock, Polska, 09-402
        • Local Institution
      • Plock, Polska, 09-400
        • Local Institution
      • Plonsk, Polska, 09-100
        • Local Institution
      • Poznan, Polska, 60-531
        • Local Institution
      • Poznan, Polska, 60479
        • Local Institution
      • Ruda Slaska, Polska, 41-703
        • Local Institution
      • Skierniewice, Polska, 96-100
        • Local Institution
      • Slupsk, Polska, 76-200
        • Local Institution
      • Torun, Polska, 87100
        • Local Institution
      • Warszawa, Polska, 01-138
        • Local Institution
      • Warszawa, Polska, 04-073
        • Local Institution
      • Warszawa, Polska, 04-628
        • Local Institution
      • Warszawa, Polska, 04-749
        • Local Institution
      • Wegrow, Polska, 07100
        • Local Institution
  • Portoryko
      • Cayey, Portoryko, 00736
        • Local Institution
      • Cidra, Portoryko, 00739
        • Local Institution
      • Ponce, Portoryko, 00717
        • Local Institution
  • Republika Korei
      • Busan, Republika Korei, 602-702
        • Local Institution
      • Daegu, Republika Korei, 700-712
        • Local Institution
      • Daegu, Republika Korei, 705-717
        • Local Institution
      • Daejon, Republika Korei, 302-718
        • Local Institution
      • Goyang, Republika Korei, 411-706
        • Local Institution
      • Gwang Ju, Republika Korei, 501-757
        • Local Institution
      • Gyeonggi, Republika Korei, 463-707
        • Local Institution
      • Pusan, Republika Korei, 602-739
        • Local Institution
      • Scongnam-Si, Republika Korei, 463-712
        • Local Institution
      • Seoul, Republika Korei, 110-744
        • Local Institution
      • Seoul, Republika Korei, 143-729
        • Local Institution
      • Seoul, Republika Korei, 130-709
        • Local Institution
      • Suwon, Republika Korei, 443-721
        • Local Institution
    • Gyeonggi-Do
      • Anyang-Si, Gyeonggi-Do, Republika Korei, 431-070
        • Local Institution
    • Korea
      • Incheon, Korea, Republika Korei, 400-711
        • Local Institution
  • Rumunia
      • Baia Mare, Rumunia, 430031
        • Local Institution
      • Bucharest, Rumunia, 011192
        • Local Institution
      • Bucharest, Rumunia, 020125
        • Local Institution
      • Bucharest, Rumunia, 050098
        • Local Institution
      • Bucharest, Rumunia, 021659
        • Local Institution
      • Bucharest, Rumunia, 030572
        • Local Institution
      • Cluj Napoca, Rumunia, 400001
        • Local Institution
      • Cluj Napoca, Rumunia, 400347
        • Local Institution
      • Iasi, Rumunia, 700503
        • Local Institution
      • Oradea, Rumunia, 410169
        • Local Institution
      • Sibiu, Rumunia, 550245
        • Local Institution
      • Targu-Mures, Rumunia, 540103
        • Local Institution
      • Timisoara, Rumunia, 300024
        • Local Institution
      • Timisoara, Rumunia, 300320
        • Local Institution
      • Tirgu Mures, Rumunia, 540136
        • Local Institution
  • Singapur
      • Singapore, Singapur, 168752
        • Local Institution
  • Stany Zjednoczone
    • Alabama
      • Birmingham, Alabama, Stany Zjednoczone, 35209
        • Cardiovascular Associates, Pc
      • Birmingham, Alabama, Stany Zjednoczone, 35235
        • Alabama Internal Medicine Pc
      • Birmingham, Alabama, Stany Zjednoczone, 35235
        • Birmingham Heart Clinic P.C.
      • Huntsville, Alabama, Stany Zjednoczone, 35801
        • Heart Center, Inc.
      • Mobile, Alabama, Stany Zjednoczone, 36608
        • Mobile Heart Specialists, PC
      • Mobile, Alabama, Stany Zjednoczone, 36617
        • Clara V. Massey, Md
    • Alaska
      • Anchorage, Alaska, Stany Zjednoczone, 99508
        • Alaska Heart Institute
    • Arizona
      • Phoenix, Arizona, Stany Zjednoczone, 85006
        • Internal Medicine Physicians Associates, P.C.
      • Tucson, Arizona, Stany Zjednoczone, 85723
        • Southern Arizona VA Health Care System
      • Tucson, Arizona, Stany Zjednoczone, 85710
        • Southwest Heart
      • Tucson, Arizona, Stany Zjednoczone, 85745
        • Pima Research Foundation
    • Arkansas
      • Hot Springs, Arkansas, Stany Zjednoczone, 71913
        • Dr. Rajesh Shroff
      • Little Rock, Arkansas, Stany Zjednoczone, 72204
        • Mary K. Richards, Md Pa
    • California
      • Anaheim, California, Stany Zjednoczone, 92801
        • Advanced Clinical Reserach Institute
      • Beverly Hills, California, Stany Zjednoczone, 90210
        • Act/Cardiovascular Research Institute
      • Carmichael, California, Stany Zjednoczone, 95608
        • Capitol Interventional Cardiology
      • Escondido, California, Stany Zjednoczone, 92025
        • Escondido Cardiology Associates, Inc.
      • Healdsburg, California, Stany Zjednoczone, 95448
        • William D. Bowden, D.O.
      • La Mesa, California, Stany Zjednoczone, 91942
        • La Mesa Cardiac Center, A Medical Group
      • Los Angeles, California, Stany Zjednoczone, 90073
        • VA Greater Los Angeles Healthcare System
      • Mission Viejo, California, Stany Zjednoczone, 92691
        • Coastal Cardiology
      • Oceanside, California, Stany Zjednoczone, 92056
        • Kenneth W. Carr Md
      • Palm Springs, California, Stany Zjednoczone, 92262
        • Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
      • Rancho Mirage, California, Stany Zjednoczone, 92270
        • Desert Cardiology Consultants Medical Group, Inc
      • Sacramento, California, Stany Zjednoczone, 95821
        • Northern California Research
      • Sacramento, California, Stany Zjednoczone, 95825
        • Sacramento Heart And Vascular Medical Associates
      • Sacramento, California, Stany Zjednoczone, 95819
        • Regional Cardiolody Associates
      • Santa Barbara, California, Stany Zjednoczone, 93105
        • Arrhythmia Consultants Of The Central Coast Medical Group
      • Santa Rosa, California, Stany Zjednoczone, 95403
        • Northern California Medical Associates
      • Vista, California, Stany Zjednoczone, 92083
        • Progressive Clinical Research
      • Walnut Creek, California, Stany Zjednoczone, 94598
        • Cardivasclular Consultants Medical Group
      • Wildomar, California, Stany Zjednoczone, 92595
        • Shiva Heart Center Medical Group
    • Colorado
      • Colorado Springs, Colorado, Stany Zjednoczone, 80910
        • Electrophysiology Associates, Pc
      • Denver, Colorado, Stany Zjednoczone, 80220
        • Denver VA Medical Center
      • Denver, Colorado, Stany Zjednoczone, 80218
        • Aurora Denver Cardiology Associates, P.C.
      • Golden, Colorado, Stany Zjednoczone, 80401
        • New West Physicians Clinical Research
      • Littleton, Colorado, Stany Zjednoczone, 80120
        • South Denver Cardiology Associates PC
    • Connecticut
      • Bridgeport, Connecticut, Stany Zjednoczone, 06610
        • Bridgeport Hospital
      • Bridgeport, Connecticut, Stany Zjednoczone, 06606
        • Connecticut Clinical Research, Llc
      • Guilford, Connecticut, Stany Zjednoczone, 06437
        • Cardiology Associates Of New Haven,Pc
      • Norwich, Connecticut, Stany Zjednoczone, 06360
        • William W Backus Hospital
      • Norwich, Connecticut, Stany Zjednoczone, 06360
        • The William W. Backus Hospital
      • Stamford, Connecticut, Stany Zjednoczone, 06905
        • Stamford Therapeutics Consortium
      • Waterbury, Connecticut, Stany Zjednoczone, 06708
        • Chase Medical Research, LLC
    • Delaware
      • Newark, Delaware, Stany Zjednoczone, 19713
        • Alfieri Cardiology
    • District of Columbia
      • Washington, District of Columbia, Stany Zjednoczone, 20422
        • Washington VA Medical Center
      • Washington, District of Columbia, Stany Zjednoczone, 20037
        • George Washington University Medical Faculty Associates
    • Florida
      • Atlantis, Florida, Stany Zjednoczone, 33462
        • Medical Specialist Of The Palm Beach
      • Aventura, Florida, Stany Zjednoczone, 33180
        • Miami International Cardiology Consultants
      • Boca Raton, Florida, Stany Zjednoczone, 33431
        • David Charles Mishkel, Md, Pa
      • Clearwater, Florida, Stany Zjednoczone, 33756
        • The Heart & Vascular Institute Of Florida
      • Clearwater, Florida, Stany Zjednoczone, 33756
        • The Heart And Vascular Institute Of Florida
      • Davie, Florida, Stany Zjednoczone, 33324
        • Cardiovascular Specialist Of South Florida
      • Daytona Beach, Florida, Stany Zjednoczone, 32114
        • Daytona Heart Group
      • Fort Lauderdale, Florida, Stany Zjednoczone, 33316
        • Broward General Medical Center
      • Fort Lauderdale, Florida, Stany Zjednoczone, 33308
        • Cardiology Associates Of Fort Lauderdale, P.A.
      • Fort Myers, Florida, Stany Zjednoczone, 33907
        • Florida Heart Associates
      • Gainesville, Florida, Stany Zjednoczone, 32605
        • Florida Research Network, LLC
      • Hollywood, Florida, Stany Zjednoczone, 33021
        • Healthworx
      • Hollywood, Florida, Stany Zjednoczone, 33021
        • Luis Tami, Md
      • Inverness, Florida, Stany Zjednoczone, 34452
        • Nature Coast Clinical Research
      • Jacksonville, Florida, Stany Zjednoczone, 32216
        • Jacksonville Center for Clinical Research
      • Jacksonville, Florida, Stany Zjednoczone, 32216
        • Jacksonville Cardiovascular Center
      • Jacksonville, Florida, Stany Zjednoczone, 32258
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Stany Zjednoczone, 32204
        • St. Vincent'S Ambulatory Care, Inc
      • Jacksonville, Florida, Stany Zjednoczone, 32207
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Stany Zjednoczone, 32216
        • St. Luke'S Cardiology
      • Jacksonville Beach, Florida, Stany Zjednoczone, 32250
        • Jacksonville Heart Center, P.A.
      • Jupiter, Florida, Stany Zjednoczone, 33458
        • Cvms Research Institute, Llc
      • Jupiter, Florida, Stany Zjednoczone, 33458
        • Ricardo Bedoya, M.D.
      • Melbourne, Florida, Stany Zjednoczone, 32901
        • Melbourne Internal Medicine Associates
      • Miami, Florida, Stany Zjednoczone, 33137
        • Miami International Cardiology Consultants
      • Miami, Florida, Stany Zjednoczone, 33137-3732
        • Miami International Cardiology Consultants
      • Naples, Florida, Stany Zjednoczone, 34119
        • Physicians Regional Medical Group
      • Orlando, Florida, Stany Zjednoczone, 32803
        • Florida Heart Group
      • Oviedo, Florida, Stany Zjednoczone, 32765
        • Alpha Medical Research
      • Pensacola, Florida, Stany Zjednoczone, 32501
        • Cardiology Consultants
      • Saint Petersburg, Florida, Stany Zjednoczone, 33709
        • The Heart And Vascular Institute Of Florida
      • Sarasota, Florida, Stany Zjednoczone, 34239
        • Heart & Vascular Center Research, Inc.
      • Sarasota, Florida, Stany Zjednoczone, 34232
        • Niranjan Seshadri, Md
      • Vero Beach, Florida, Stany Zjednoczone, 32960
        • Research, Inc.
    • Georgia
      • Atlanta, Georgia, Stany Zjednoczone, 30342
        • Cardiovascular Specialits, Pc
      • Augusta, Georgia, Stany Zjednoczone, 30901
        • Augusta Cardiology Clinic, P.C.
      • Columbus, Georgia, Stany Zjednoczone, 31909
        • Columbus Cardiology Associates Pc
      • Columbus, Georgia, Stany Zjednoczone, 31909
        • Columbus Cardiology Associates,Pc
      • Covington, Georgia, Stany Zjednoczone, 30014
        • Georgia Heart Specialists, L.L.C.
      • Decatur, Georgia, Stany Zjednoczone, 30030
        • Atlanta Institute For Medical Research, Inc
      • Gainesville, Georgia, Stany Zjednoczone, 30501
        • Northeast Georgia Heart Center, PC
      • Marietta, Georgia, Stany Zjednoczone, 30060
        • Wellstar Cardiovascular Medicine, Pc
    • Illinois
      • Aurora, Illinois, Stany Zjednoczone, 60504
        • Fox Valley Clinical Research Center, LLC
      • Chicago, Illinois, Stany Zjednoczone, 60611
        • Nmff
      • Gurnee, Illinois, Stany Zjednoczone, 60031
        • Clinical Investigation Specialists, Inc
      • Maywood, Illinois, Stany Zjednoczone, 60153
        • Loyola University Medical Center
      • Normal, Illinois, Stany Zjednoczone, 61761
        • Illinois Heart & Lung Research Center, Sc
      • North Chicago, Illinois, Stany Zjednoczone, 60064
        • Cpt. James A Lovell Federal Health Care Center
    • Indiana
      • Anderson, Indiana, Stany Zjednoczone, 46011
        • Community Clinical Research Center
      • Bloomington, Indiana, Stany Zjednoczone, 47403
        • Premier Healthcare, Llc
      • Elkhart, Indiana, Stany Zjednoczone, 46514
        • Elkhart Clinic, LLC
      • Fort Wayne, Indiana, Stany Zjednoczone, 46804
        • Lutheran Medical Group, Llc
      • Fort Wayne, Indiana, Stany Zjednoczone, 46805
        • Fort Wayne Cardiology
      • Indianapolis, Indiana, Stany Zjednoczone, 46290
        • The Care Group, Llc
      • Indianapolis, Indiana, Stany Zjednoczone, 46290
        • The Care Group, Llc.
      • Indianapolis, Indiana, Stany Zjednoczone, 46237
        • St Francis Medical Group - Indiana Heart Physicians
      • Michigan City, Indiana, Stany Zjednoczone, 46360
        • Dali, Sammi
      • South Bend, Indiana, Stany Zjednoczone, 46601
        • Cardiology Associates, Inc.
    • Iowa
      • Ames, Iowa, Stany Zjednoczone, 50010
        • McFarland Clinic PC
    • Kansas
      • Overland Park, Kansas, Stany Zjednoczone, 66209
        • Midwest Cardiology Associates , P.C.
    • Kentucky
      • Elizabethtown, Kentucky, Stany Zjednoczone, 42701
        • Central Cardiology Assoc.
      • Lexington, Kentucky, Stany Zjednoczone, 40504
        • New Lexington Clinic, P.S.C.
      • Louisville, Kentucky, Stany Zjednoczone, 40205
        • Norton Cardiovascular Associates
      • Louisville, Kentucky, Stany Zjednoczone, 40202
        • VA Medical Center
      • Owensboro, Kentucky, Stany Zjednoczone, 42303
        • Owensboro Heart & Vascular
    • Louisiana
      • Alexandria, Louisiana, Stany Zjednoczone, 71301
        • Alexandria Cardiology Clinic
      • Houma, Louisiana, Stany Zjednoczone, 70360
        • Cardiovascular Institute of the South
      • Lacombe, Louisiana, Stany Zjednoczone, 70445
        • Smith, Patel & Amkieh, Llc
      • Lake Charles, Louisiana, Stany Zjednoczone, 70601
        • Imperial Calcasieu Medical Group, Llp
      • Marrero, Louisiana, Stany Zjednoczone, 70072
        • Cardiology Center, Llc
      • Shreveport, Louisiana, Stany Zjednoczone, 71105
        • Cardiology Associates
      • Slidell, Louisiana, Stany Zjednoczone, 70458
        • Louisiana Heart Center
      • Slidell, Louisiana, Stany Zjednoczone, 70458
        • Medical Research Inst, Inc
      • Slidell, Louisiana, Stany Zjednoczone, 70458
        • Medical Research Institute, Inc
      • Ventura, Louisiana, Stany Zjednoczone, 93003
        • Ventura Cardio. Cond. Med. Group, Inc.
    • Maine
      • Lewiston, Maine, Stany Zjednoczone, 04240
        • Central Maine Heart & Vascular Institute
    • Maryland
      • Baltimore, Maryland, Stany Zjednoczone, 21224
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Stany Zjednoczone, 21237
        • Franklin Square Hospital
      • Baltimore, Maryland, Stany Zjednoczone, 21208
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Stany Zjednoczone, 21237
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Stany Zjednoczone, 21204
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Stany Zjednoczone, 21218
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Stany Zjednoczone, 21224-2735
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Stany Zjednoczone, 21237
        • Midatlantic Cardiovascular Associates, P.A.
      • Bel Air, Maryland, Stany Zjednoczone, 21014
        • Midatlantic Cardiovascular Associates, Pa
      • Columbia, Maryland, Stany Zjednoczone, 21044
        • Cardiovascular Specialists Of Central Maryland, P.A.
      • Reisterstown, Maryland, Stany Zjednoczone, 21136
        • Clinical Associates Research
      • Westminster, Maryland, Stany Zjednoczone, 21157
        • Midatlantic Cardiovascular Associates, Pa
    • Massachusetts
      • Billerica, Massachusetts, Stany Zjednoczone, 01821
        • Burlington Medical Associates
      • Boston, Massachusetts, Stany Zjednoczone, 02135
        • Caritas St. Elizabeth's Medical Center
      • Burlington, Massachusetts, Stany Zjednoczone, 01805
        • Lahey Clinic Medical Center
      • Fall River, Massachusetts, Stany Zjednoczone, 02720
        • Neccr Internal Medicine & Cardiology Associates,Llc
      • Haverhill, Massachusetts, Stany Zjednoczone, 01830
        • Pentucket Medical Associates
      • Haverhill, Massachusetts, Stany Zjednoczone, 01830-6278
        • Pentucket Medical Associates
      • Natick, Massachusetts, Stany Zjednoczone, 01760
        • Charles River Medical Associates
    • Michigan
      • Alpena, Michigan, Stany Zjednoczone, 49707
        • Great Lakes Heart Center Of Alpena
      • Detroit, Michigan, Stany Zjednoczone, 48202
        • Henry Ford Hospital
      • Lansing, Michigan, Stany Zjednoczone, 48910
        • Thoracic And Cardiovascular Healthcare Foundation
      • Livonia, Michigan, Stany Zjednoczone, 48154
        • Advanced Cardiovascular Health Specialists, Pc
      • Petoskey, Michigan, Stany Zjednoczone, 49770
        • Michigan Heart And Vascular Specialists
      • Royal Oak, Michigan, Stany Zjednoczone, 48073
        • William Beaumont Hospital
      • Ypsilanti, Michigan, Stany Zjednoczone, 48197
        • Michigan Heart, P.C.
    • Minnesota
      • Minneapolis, Minnesota, Stany Zjednoczone, 55455
        • University of Minnesota
      • Minneapolis, Minnesota, Stany Zjednoczone, 55417
        • Minneapolis VA Medical Center
      • Robbinsdale, Minnesota, Stany Zjednoczone, 55422
        • North Memorial Health Care
    • Mississippi
      • Olive Branch, Mississippi, Stany Zjednoczone, 38654
        • Olive Branch Family Medical Center
      • Tupelo, Mississippi, Stany Zjednoczone, 38801
        • Tupelo Neurology Clinic, Pa
    • Missouri
      • Columbia, Missouri, Stany Zjednoczone, 65212
        • University of Missouri
      • Kansas City, Missouri, Stany Zjednoczone, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Stany Zjednoczone, 64111
        • Saint Luke's Lipid and Diabetes Research Center
    • Nebraska
      • Grand Island, Nebraska, Stany Zjednoczone, 68803
        • Internal Medical Associates Of Grand Island, P.C
      • Grand Island, Nebraska, Stany Zjednoczone, 68803-4311
        • Internal Medical Associates Of Grand Island, P.C
      • Hastings, Nebraska, Stany Zjednoczone, 68901
        • Nebraska Heart Institute
    • Nevada
      • Las Vegas, Nevada, Stany Zjednoczone, 89106
        • VA Southern Nevada Healthcare System
    • New Jersey
      • Berlin, New Jersey, Stany Zjednoczone, 08009
        • Comprehensive Clinical Research
      • Elmer, New Jersey, Stany Zjednoczone, 08318
        • Cardiovascular Associates Of The Delware Valley, P.A.
      • Haddon Heights, New Jersey, Stany Zjednoczone, 08035
        • Cardiovascular Associates Of The Delaware Valley, P.A.
      • Princeton, New Jersey, Stany Zjednoczone, 08540
        • Princeton Medical Institute
      • Sewell, New Jersey, Stany Zjednoczone, 08080
        • Cardio Assoc Of Del Val, P.A.
      • South Plainfield, New Jersey, Stany Zjednoczone, 07080
        • Central New Jersey Cardiology
    • New Mexico
      • Albuquerque, New Mexico, Stany Zjednoczone, 87012
        • Abq Health Partners, Llc
      • Albuquerque, New Mexico, Stany Zjednoczone, 87131-0001
        • University Of New Mexico/University Hospital
      • Albuquerque, New Mexico, Stany Zjednoczone, 87131
        • University Of New Mexico/University Hospital
    • New York
      • Albany, New York, Stany Zjednoczone, 12205
        • Albany Associates In Cardiology
      • Albany, New York, Stany Zjednoczone, 12205
        • Albany Assoc. In Cardiology
      • Binghamton, New York, Stany Zjednoczone, 13905
        • Cardiology Associates, Pc
      • Buffalo, New York, Stany Zjednoczone, 14215
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Stany Zjednoczone, 14215-1145
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Stany Zjednoczone, 14215
        • Bruce L. Platt Md, Pc
      • Buffalo, New York, Stany Zjednoczone, 14215
        • Bruce L. Platt, Md
      • East Syracuse, New York, Stany Zjednoczone, 13057
        • Heart Care Center, P.C.
      • Huntington, New York, Stany Zjednoczone, 11743
        • Huntington Hospital
      • Liverpool, New York, Stany Zjednoczone, 13088
        • SJH Cardiology Associates
      • Mineola, New York, Stany Zjednoczone, 11501
        • Long Island Heart Associates
      • Saratoga Springs, New York, Stany Zjednoczone, 12866
        • Saratoga Cardiology Associates, Pc
      • Williamsville, New York, Stany Zjednoczone, 14221
        • Office Of Dr. Kozinn
      • Williamsville, New York, Stany Zjednoczone, 14221
        • Suburban Cardiology
    • North Carolina
      • Asheville, North Carolina, Stany Zjednoczone, 28803
        • Asheville Cardiology Associates
      • Burlington, North Carolina, Stany Zjednoczone, 27215
        • Kernodle Clinic, Inc.
      • High Point, North Carolina, Stany Zjednoczone, 27262
        • Carolina Cardiology Associates, Pa
      • Pinehurst, North Carolina, Stany Zjednoczone, 28374
        • Pinehurst Medical Center, Inc
    • North Dakota
      • Fargo, North Dakota, Stany Zjednoczone, 58103
        • Lillestol Research LLC
    • Ohio
      • Akron, Ohio, Stany Zjednoczone, 44304
        • Akron Cardiology Consultants
      • Bucyrus, Ohio, Stany Zjednoczone, 44820
        • Christopher M. Johnson, D.O.
      • Bucyrus, Ohio, Stany Zjednoczone, OHIO
        • Christopher M. Johnson, D.O.
      • Canal Fulton, Ohio, Stany Zjednoczone, 44614
        • Community Health Care, Inc.
      • Canton, Ohio, Stany Zjednoczone, 44710
        • Cardiology Associates
      • Cincinnati, Ohio, Stany Zjednoczone, 45219
        • The Carl & Edyth Lindner Center For R&E At The Christ Hosp
      • Toledo, Ohio, Stany Zjednoczone, 43608
        • Toledo Cardiology Consultants
      • Wadsworth, Ohio, Stany Zjednoczone, 44281
        • Family Practice Center of Wadsworth, Inc.
    • Oklahoma
      • Muskogee, Oklahoma, Stany Zjednoczone, 74401
        • Jack C. Va Medical Center
      • Oklahoma City, Oklahoma, Stany Zjednoczone, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Stany Zjednoczone, 73112
        • Plaza Medical Group, Pc
      • Oklahoma City, Oklahoma, Stany Zjednoczone, 73103
        • COR Clinical Research, LLC
      • Oklahoma City, Oklahoma, Stany Zjednoczone, 73135
        • South Oklahoma Heart Research
      • Oklahoma City, Oklahoma, Stany Zjednoczone, 73120
        • Oklahoma Heart Hospital Physicians
      • Oklahoma City, Oklahoma, Stany Zjednoczone, 73139
        • Eminence Research, LLC
      • Tulsa, Oklahoma, Stany Zjednoczone, 74136
        • Castlerock Clinical Research Consultants, Llc
    • Oregon
      • Bend, Oregon, Stany Zjednoczone, 97701
        • St. Charles Health System, Inc.
      • Bend, Oregon, Stany Zjednoczone, 97701
        • St. Charles Health System, Inc
      • Eugene, Oregon, Stany Zjednoczone, 97401
        • Oregon Medical Group - Clinical Research
      • Hillsboro, Oregon, Stany Zjednoczone, 97123
        • Hillsboro Cardiology Pc
      • Medford, Oregon, Stany Zjednoczone, 97504
        • Rogue Valley Physicians - Clinical Research Group
    • Pennsylvania
      • Abington, Pennsylvania, Stany Zjednoczone, 19001
        • Abington Medical Specialists
      • Altoona, Pennsylvania, Stany Zjednoczone, 16602
        • Blair Medical Associates, Inc.
      • Camp Hill, Pennsylvania, Stany Zjednoczone, 17011
        • Heritage Cardiology Assoc.
      • Doylestown, Pennsylvania, Stany Zjednoczone, 18901
        • Central Bucks Cardiology
      • Erie, Pennsylvania, Stany Zjednoczone, 16509
        • Internal Medicine And Lipid Mgmt.
      • Harrisburg, Pennsylvania, Stany Zjednoczone, 17112
        • Kandra, Fierer, Kuskin Associates
      • Hatfield, Pennsylvania, Stany Zjednoczone, 19440
        • Pivotal Clinical Research, Llc
      • Jersey Shore, Pennsylvania, Stany Zjednoczone, 17740
        • Lycoming Internal Medicine Inc.
      • Sayre, Pennsylvania, Stany Zjednoczone, 18840
        • Guthrie Medical Group, P.C.
      • Sayre, Pennsylvania, Stany Zjednoczone, 18840
        • Guthrie Clinic Ltd.
      • Uniontown, Pennsylvania, Stany Zjednoczone, 15401
        • Preferred Primary Care Physicians
      • West Chester, Pennsylvania, Stany Zjednoczone, 19380
        • West Chester Cardiology, Pc
      • Yardley, Pennsylvania, Stany Zjednoczone, 19067
        • Cardiology Consultants of Philadelphia
    • Rhode Island
      • Providence, Rhode Island, Stany Zjednoczone, 02903
        • Rhode Island Hospital
    • South Carolina
      • Anderson, South Carolina, Stany Zjednoczone, 29621
        • Southeastern Research Associates, Inc
      • Beaufort, South Carolina, Stany Zjednoczone, 29906
        • Lowcountry Medical Group, Llc
      • Beaufort, South Carolina, Stany Zjednoczone, 29906
        • Lowcountry Medical Group
      • Charleston, South Carolina, Stany Zjednoczone, 29425
        • Medical University of South Carolina
      • Columbia, South Carolina, Stany Zjednoczone, 29203
        • Columbia Heart Clinic
      • Greenville, South Carolina, Stany Zjednoczone, 29607
        • Upstate Cardiology
      • Greer, South Carolina, Stany Zjednoczone, 29650
        • Internal Medicine Of Greer
      • Orangeburg, South Carolina, Stany Zjednoczone, 29118
        • Palmetto Nephrology Pa
      • Spartanburg, South Carolina, Stany Zjednoczone, 29303
        • S. Carolina Pharmaceutical Research
    • South Dakota
      • Pierre, South Dakota, Stany Zjednoczone, 57501
        • Avera Medical Associates Clinic
    • Tennessee
      • Bristol, Tennessee, Stany Zjednoczone, 37620
        • Holston Medical Group
      • Kingsport, Tennessee, Stany Zjednoczone, 37660
        • Holston Medical Group
      • Knoxville, Tennessee, Stany Zjednoczone, 37920
        • Volunteer Research Group
      • Knoxville, Tennessee, Stany Zjednoczone, 37916
        • Knoxville Heart Group
      • Knoxville, Tennessee, Stany Zjednoczone, 37920-1502
        • Volunteer Research Group
      • Tullahoma, Tennessee, Stany Zjednoczone, 37388
        • Tennessee Center for Clinical Trials
    • Texas
      • Amarillo, Texas, Stany Zjednoczone, 79106
        • Amarillo Heart Clinical Research Institute Inc.
      • Corsicana, Texas, Stany Zjednoczone, 75110
        • Corsicana Medical Research, PLLC
      • Dallas, Texas, Stany Zjednoczone, 75226
        • Soltero Cardiovascular Research Center
      • Dallas, Texas, Stany Zjednoczone, 75230
        • HeartPlace
      • Fort Worth, Texas, Stany Zjednoczone, 76104
        • Heart Center of North Texas
      • Houston, Texas, Stany Zjednoczone, 77030
        • The Methodist Hospital
      • Houston, Texas, Stany Zjednoczone, 77030
        • The University of Texas MD Anderson Cancer Center
      • Houston, Texas, Stany Zjednoczone, 77030
        • Center For Atrial Fibrillation
      • Houston, Texas, Stany Zjednoczone, 77030
        • The Methodist Hospital Neurology Institute
      • Houston, Texas, Stany Zjednoczone, 77065
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Stany Zjednoczone, 77070
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Stany Zjednoczone, 77074
        • Francisco R. Maislos
      • Houston, Texas, Stany Zjednoczone, 77090
        • Woodlands North Houston Heart Center
      • Humble, Texas, Stany Zjednoczone, 77338
        • Regional Medical Center And Diagnostic Clinics
      • Lackland Air Force Base, Texas, Stany Zjednoczone, 78236
        • Wilford Hall Medical Center
      • Lackland Air Force Base, Texas, Stany Zjednoczone, 78236-9908
        • Wilford Hall Medical Center
      • Longview, Texas, Stany Zjednoczone, 75605
        • DCOL Center for Clinical Research
      • McKinney, Texas, Stany Zjednoczone, 75069
        • North Dallas Research Associates
      • Plano, Texas, Stany Zjednoczone, 75093
        • North Texas Medical Research
      • Plano, Texas, Stany Zjednoczone, 75024
        • Legacy Heart Center
      • San Antonio, Texas, Stany Zjednoczone, 78229
        • Covenant Clinical Research, Pa
      • San Antonio, Texas, Stany Zjednoczone, 78217
        • Bhs Specialty Network, Inc
      • San Antonio, Texas, Stany Zjednoczone, 78229
        • Star Clinical Trails
      • Seguin, Texas, Stany Zjednoczone, 78155
        • Edward Balli, Md, Pa
      • Tomball, Texas, Stany Zjednoczone, 77375
        • Northwest Heart Center
      • Tyler, Texas, Stany Zjednoczone, 75701
        • Tyler Cardiovascular Consultants
      • Tyler, Texas, Stany Zjednoczone, 75708
        • University of Texas Health Science Center at Tyler
      • Tyler, Texas, Stany Zjednoczone, 75708
        • The Univ. Of Texas Health Science Ctr. At Tyler
    • Utah
      • Layton, Utah, Stany Zjednoczone, 84041
        • Utah Cardiology P.C
    • Virginia
      • Norfolk, Virginia, Stany Zjednoczone, 23510
        • Sentara York Clinical Research
      • Richmond, Virginia, Stany Zjednoczone, 23220
        • Medical Research Initiatives
      • Roanoke, Virginia, Stany Zjednoczone, 24014
        • Roanoke Heart Institute, Plc
      • Virginia Beach, Virginia, Stany Zjednoczone, 23454
        • Cardiovascular Associates
    • Washington
      • Burien, Washington, Stany Zjednoczone, 98166
        • Daniel W. Gottlieb, Md, Ps
      • Burien, Washington, Stany Zjednoczone, 98166
        • Daniel William Gottlieb, Md
      • Spokane, Washington, Stany Zjednoczone, 99202
        • Rockwood Clinic Research Cent.
      • Walla Walla, Washington, Stany Zjednoczone, 99362
        • Walla Walla Clinic
    • West Virginia
      • Lewisburg, West Virginia, Stany Zjednoczone, 24901
        • Lynn N. Smith, Md
    • Wisconsin
      • Green Bay, Wisconsin, Stany Zjednoczone, 54301
        • Cardiology Associates Of Green Bay Ltd-Bellin Hospital
      • Madison, Wisconsin, Stany Zjednoczone, 53715
        • St. Mary's Hospital
      • Madison, Wisconsin, Stany Zjednoczone, 53715
        • St.Mary's Hospital
      • Milwaukee, Wisconsin, Stany Zjednoczone, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Stany Zjednoczone, 53215
        • Aurora Health Care
      • Waukesha, Wisconsin, Stany Zjednoczone, 53188
        • Cardiology Assc. Of Waukesha
  • Szwajcaria
      • Baden, Szwajcaria, 5404
        • Local Institution
      • Bern, Szwajcaria, 3010
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  • Szwecja
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      • Skelleftea, Szwecja, 931 86
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        • Local Institution
      • Stockholm, Szwecja, 118 83
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      • Stockholm, Szwecja, 111 35
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      • Uppsala, Szwecja, 751 85
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      • Vaxjo, Szwecja, 351 85
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  • Tajwan
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        • Local Institution
      • Taipei, Tajwan, 111
        • Local Institution
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  • Ukraina
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      • Odessa, Ukraina, 65039
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      • Odessa, Ukraina, 65025
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      • Uzhgorod, Ukraina, 88000
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      • Vinnitsa, Ukraina, 21029
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      • Zaporozhye, Ukraina, 69035
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      • Zhytomyr, Ukraina, 10002
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  • Węgry
      • Budapest, Węgry, 1125
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      • Budapest, Węgry, 1023
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      • Budapest, Węgry, 1032
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      • Budapest, Węgry, 1096
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      • Debrecen, Węgry, 4032
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      • Dunaujvaros, Węgry, 2400
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      • Gyor, Węgry, 9023
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      • Gyula, Węgry, 5700
        • Local Institution
      • Hodmezovasarhely, Węgry, 6800
        • Local Institution
      • Komarom, Węgry, 2921
        • Local Institution
      • Mosonmagyarovar, Węgry, 9200
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      • Oroshaza, Węgry, 5900
        • Local Institution
      • Pecs, Węgry, 7624
        • Local Institution
      • Siofok, Węgry, 8600
        • Local Institution
      • Siofok, Węgry, 8601
        • Local Institution
      • Sopron, Węgry, 9400
        • Local Institution
      • Szentes, Węgry, 6600
        • Local Institution
      • Zalaegerszeg, Węgry, 8900
        • Local Institution
  • Włochy
      • Ascoli Piceno, Włochy, 63100
        • Local Institution
      • Campobasso, Włochy, 86100
        • Local Institution
      • Chieti, Włochy, 66013
        • Local Institution
      • Cremona, Włochy, 26100
        • Local Institution
      • Fidenza (Pr), Włochy, 43036
        • Local Institution
      • Genova, Włochy, 16132
        • Local Institution
      • Isernia, Włochy, 86170
        • Local Institution
      • Livorno, Włochy, 57100
        • Local Institution
      • Milano, Włochy, 20132
        • Local Institution
      • Napoli, Włochy, 80131
        • Local Institution
      • Palermo, Włochy, 90127
        • Local Institution
      • Reggio Emilia, Włochy, 42100
        • Local Institution
      • Roma, Włochy, 00168
        • Local Institution
      • San Daniele De Friuli, Włochy, 33038
        • Local Institution
      • Torino, Włochy, 10153
        • Local Institution
      • Vittorio Veneto (Tv), Włochy, 31029
        • Local Institution
    • Lucca
      • Lido Di Camaiore, Lucca, Włochy, 55043
        • Local Institution
  • Zjednoczone Królestwo
      • Antrim, Zjednoczone Królestwo, BT41 2RL
        • Local Institution
      • Blackpool, Zjednoczone Królestwo, FY3 8NR
        • Local Institution
      • Glasgow, Zjednoczone Królestwo, G21 3UW
        • Local Institution
    • Aberdeenshire
      • Aberdeen, Aberdeenshire, Zjednoczone Królestwo, AB25 2ZN
        • Local Institution
      • Glasgow, Aberdeenshire, Zjednoczone Królestwo, G11 6NT
        • Local Institution
    • Antrim
      • Belfast, Antrim, Zjednoczone Królestwo, BT14 6AB
        • Local Institution
    • Armagh
      • Craigavon, Armagh, Zjednoczone Królestwo, BT63 5QQ
        • Local Institution
    • Cambridgeshire
      • Cambridge, Cambridgeshire, Zjednoczone Królestwo, CB2 2QQ
        • Local Institution
      • Peterborough, Cambridgeshire, Zjednoczone Królestwo, PE2 5GP
        • Local Institution
    • Derbyshire
      • Chesterfield, Derbyshire, Zjednoczone Królestwo, S44 5BL
        • Local Institution
      • Chesterfield, Derbyshire, Zjednoczone Królestwo, S40 4TF
        • Local Institution
    • Dorset
      • Bournemouth, Dorset, Zjednoczone Królestwo, BH7 7DW
        • Local Institution
    • Dumbartonshire
      • Glasgow, Dumbartonshire, Zjednoczone Królestwo, G11 6NT
        • Local Institution
    • EAST Sussex
      • Chichester, EAST Sussex, Zjednoczone Królestwo, PO19 6SE
        • Local Institution
    • Essex
      • Colchester, Essex, Zjednoczone Królestwo, C03 4LN
        • Local Institution
      • Romford, Essex, Zjednoczone Królestwo, RH7 0AG
        • Local Institution
    • Greater London
      • Denmark Hill, Greater London, Zjednoczone Królestwo, SE5 9RS
        • Local Institution
      • London, Greater London, Zjednoczone Królestwo, SW17 0RE
        • Local Institution
    • Gwent
      • Newport, Gwent, Zjednoczone Królestwo, NP20 2UB
        • Local Institution
    • Hertfordshire
      • Barnet, Hertfordshire, Zjednoczone Królestwo, EN5 3DJ
        • Local Institution
    • MID Glamorgan
      • Cardiff, MID Glamorgan, Zjednoczone Królestwo, CF14 4XW
        • Local Institution
      • Llandough, MID Glamorgan, Zjednoczone Królestwo, CF64 2XX
        • Local Institution
    • Middlesex
      • Harrow, Middlesex, Zjednoczone Królestwo, HA1 3UJ
        • Local Institution
    • Nottinghamshire
      • Nottingham, Nottinghamshire, Zjednoczone Królestwo, NG5 1PB
        • Local Institution
      • Worksop, Nottinghamshire, Zjednoczone Królestwo, S81 OBD
        • Local Institution
    • Renfrewshire
      • Paisley, Renfrewshire, Zjednoczone Królestwo, PA2 9PN
        • Local Institution
    • South Yorkshire
      • Barnsley, South Yorkshire, Zjednoczone Królestwo, S75 2EP
        • Local Institution
      • Doncaster, South Yorkshire, Zjednoczone Królestwo, DN2 5LT
        • Local Institution
    • Stirlingshire
      • Stirling, Stirlingshire, Zjednoczone Królestwo, FK8 2AU
        • Local Institution
    • Strathclyde
      • Glasgow, Strathclyde, Zjednoczone Królestwo, G51 4TF
        • Local Institution
    • Suffolk
      • Bury St Edmunds, Suffolk, Zjednoczone Królestwo, IP31 2HD
        • Local Institution
      • Bury St Edmunds, Suffolk, Zjednoczone Królestwo, IP33 2QZ
        • Local Institution
      • Bury St. Edmunds, Suffolk, Zjednoczone Królestwo, IP30 9QU
        • Local Institution
      • Ipswich, Suffolk, Zjednoczone Królestwo, IP14 2PU
        • Local Institution
      • Ipswich, Suffolk, Zjednoczone Królestwo, IP7 5DN
        • Local Institution
    • Tyne and Wear
      • Newcastle Upon Tyne, Tyne and Wear, Zjednoczone Królestwo, NE1 4LP
        • Local Institution
    • WEST Glamorgan
      • Swansea, WEST Glamorgan, Zjednoczone Królestwo, SA6 6NL
        • Local Institution
    • WEST Lothian
      • Livingston, WEST Lothian, Zjednoczone Królestwo, EH54 6PP
        • Local Institution
    • WEST Midlands
      • Birmingham, WEST Midlands, Zjednoczone Królestwo, B18 7QH
        • Local Institution
    • Wiltshire
      • Westbury, Wiltshire, Zjednoczone Królestwo, BA 13 3JD
        • Local Institution
      • Westbury, Wiltshire, Zjednoczone Królestwo, BA13 3JD
        • Local Institution
    • Yorkshire
      • York, Yorkshire, Zjednoczone Królestwo, YO31 8HE
        • Local Institution
      • York, Yorkshire, Zjednoczone Królestwo, YO31 HE
        • Local Institution

Kryteria uczestnictwa

Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.

Kryteria kwalifikacji

Wiek uprawniający do nauki

  • Dziecko
  • Dorosły
  • Starszy dorosły

Akceptuje zdrowych ochotników

Nie

Płeć kwalifikująca się do nauki

Wszystko

Opis

Inclusion Criteria:

  • Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
  • Age ≥ 75, previous stroke
  • transient ischemic attack (TIA) or Systemic Embolism (SE)
  • Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
  • Diabetes mellitus or hypertension requiring pharmacological treatment

Plan studiów

Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.

Jak projektuje się badanie?

Szczegóły projektu

  • Główny cel: Zapobieganie
  • Przydział: Randomizowane
  • Model interwencyjny: Przydział równoległy
  • Maskowanie: Podwójnie

Broń i interwencje

Grupa uczestników / Arm
Interwencja / Leczenie
Eksperymentalny: 2
Lek: apixaban
Oral tablets, 5.0 mg or 2.5 mg, twice daily
Inne nazwy:
  • BMS-562247
Aktywny komparator: 1
Lek: warfarin
Oral tablets, 2.0 mg, adjusted to an INR of 2.5 (range 2.0 to 3.0)
Inne nazwy:
  • Kumadyna
  • BMS-565793

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku
Opis środka
Ramy czasowe
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period
Ramy czasowe: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period
Ramy czasowe: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

Miary wyników drugorzędnych

Miara wyniku
Opis środka
Ramy czasowe
Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period
Ramy czasowe: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated All-Cause Death During the Intended Treatment Period
Ramy czasowe: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period
Ramy czasowe: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period
Ramy czasowe: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period
Ramy czasowe: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period
Ramy czasowe: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With All Bleeding Events During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of All Bleeding Events During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Inne miary wyników

Miara wyniku
Opis środka
Ramy czasowe
Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
AE: all SAEs or AEs with onset from first dose through 2 days (AEs) or 30 days (SAEs) after the last dose of blinded study drug (BSD). SAE: all SAEs with onset from first dose through 30 days after the last dose of BSD. Bleeding AE: all serious or non-serious bleeding-related AEs with onset from first dose through 2 days after the last dose of BSD. Discontinuations due to AE: all SAEs or AEs with onset from first dose of BSD and with action taken=drug discontinued. Deaths: all deaths occurring from first dose through 30 days after the last dose of BSD.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated GUSTO bleeding events per 100 patient years. GUSTO Bleeding Criteria: GUSTO severe (or life-threatening) bleeding: either intracranial hemorrhage or bleeding that causes hemodynamic compromise and requires intervention. GUSTO moderate bleeding: bleeding that requires blood transfusion but does not result in hemodynamic compromise.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated TIMI bleeding events per 100 patient years. TIMI Bleeding Criteria: Major bleeding=Intracranial bleeding and/or clinically overt bleeding associated with ≥5 gm/dL fall in Hgb or 15% fall in hematocrit (Hct) from baseline, accounting for transfusions. Minor bleeding=Clinically overt bleeding associated with ≥3 gm/dL fall in Hgb or a ≥10% fall in Hct from baseline, accounting for transfusions.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Net-Clinical Benefit During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Net-Clinical Benefit During Treatment Period
Ramy czasowe: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of events of net-clinical benefit per 100 patient years. Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

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Sponsor

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Publikacje i pomocne linki

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Publikacje ogólne

Przydatne linki

Daty zapisu na studia

Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.

Główne daty studiów

Rozpoczęcie studiów (Rzeczywisty)

31 grudnia 2006

Zakończenie podstawowe (Rzeczywisty)

25 maja 2011

Ukończenie studiów (Rzeczywisty)

25 maja 2011

Daty rejestracji na studia

Pierwszy przesłany

18 grudnia 2006

Pierwszy przesłany, który spełnia kryteria kontroli jakości

18 grudnia 2006

Pierwszy wysłany (Oszacować)

19 grudnia 2006

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

3 lipca 2018

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

5 czerwca 2018

Ostatnia weryfikacja

1 maja 2018

Więcej informacji

Terminy związane z tym badaniem

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

  • CV185-030

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