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Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (ARISTOTLE)

5 giugno 2018 aggiornato da: Bristol-Myers Squibb

A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

Panoramica dello studio

Stato

Completato

Condizioni

Intervento / Trattamento

Tipo di studio

Interventistico

Iscrizione (Effettivo)

20976

Fase

  • Fase 3

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

  • Argentina
      • Buenos Aires, Argentina, 1119
        • Local Institution
      • Buenos Aires, Argentina, C1280AEB
        • Local Institution
      • Buenos Aires, Argentina, 1181
        • Local Institution
      • Buenos Aires, Argentina, C1426ANZ
        • Local Institution
      • Buenos Aires, Argentina, 1280
        • Local Institution
      • Cordoba, Argentina, 5000
        • Local Institution
      • Cordoba, Argentina, X5000EPU
        • Local Institution
      • Cordoba, Argentina, X5008KKF
        • Local Institution
      • Cordoba, Argentina, X5003DCE
        • Local Institution
      • Salta, Argentina, 4400
        • Local Institution
      • Santa Fe, Argentina, 3000
        • Local Institution
      • Tucuman, Argentina, T4000NIL
        • Local Institution
    • Buenos Aires
      • Adrogue, Buenos Aires, Argentina, 1846
        • Local Institution
      • Bahia Blanca, Buenos Aires, Argentina, B8000FTD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, CP1425A WC
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1128AAD
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1128
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, 1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, C1426 EGR
        • Local Institution
      • Ciudad Autonoma, Buenos Aires, Argentina, CP1425AWC
        • Local Institution
      • Ciudad Autonoma De, Buenos Aires, Argentina, 1180
        • Local Institution
      • Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina, CI094AAD
        • Local Institution
      • Coronel Suarez, Buenos Aires, Argentina, B7540GHD
        • Local Institution
      • Haedo, Buenos Aires, Argentina, B1706AJU
        • Local Institution
      • Junin, Buenos Aires, Argentina, 6000
        • Local Institution
      • La Plata, Buenos Aires, Argentina, 1900
        • Local Institution
      • La Plata, Buenos Aires, Argentina, B1900AXI
        • Local Institution
      • La Plata, Buenos Aires, Argentina, 1902
        • Local Institution
      • Mar Del Plata, Buenos Aires, Argentina, 7600
        • Local Institution
      • Merlo, Buenos Aires, Argentina, B1722COV
        • Local Institution
      • Merlo, Buenos Aires, Argentina, 1722
        • Local Institution
      • Olivos, Buenos Aires, Argentina, 1602
        • Local Institution
      • Quilmes, Buenos Aires, Argentina, 1878
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, B1704ESN
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, B1704ETD
        • Local Institution
      • Ramos Mejia, Buenos Aires, Argentina, 1706
        • Local Institution
      • San Justo, Buenos Aires, Argentina, 1754
        • Local Institution
      • San Martin, Buenos Aires, Argentina, 1650
        • Local Institution
      • San Nicolas, Buenos Aires, Argentina, 2900
        • Local Institution
      • Zarate, Buenos Aires, Argentina, 2800
        • Local Institution
      • Zarate, Buenos Aires, Argentina, B2800DGH
        • Local Institution
    • Provincia DE Cordoba
      • Cordoba, Provincia DE Cordoba, Argentina, 5000
        • Local Institution
    • RIO Negro
      • Cipolletti, RIO Negro, Argentina, 8324
        • Local Institution
    • Santa FE
      • Rosario, Santa FE, Argentina, 2000
        • Local Institution
      • Rosario, Santa FE, Argentina, S2000CVB
        • Local Institution
      • Rosario, Santa FE, Argentina, S2001ODA
        • Local Institution
    • Santa Fe
      • Rosario, Santa Fe, Argentina, S2000CVD
        • Local Institution
      • Rosario, Santa Fe, Argentina, S2000 CVD
        • Local Institution
    • Tucuman
      • San Miquel De Tucuman, Tucuman, Argentina, 4000
        • Local Institution
  • Australia
    • New South Wales
      • Coffs Harbour, New South Wales, Australia, 2450
        • Local Institution
      • Concord, New South Wales, Australia, 2139
        • Local Institution
      • Gosford, New South Wales, Australia, 2250
        • Local Institution
      • Kogarah, New South Wales, Australia, 2217
        • Local Institution
      • Miranda, New South Wales, Australia, 2228
        • Local Institution
    • Queensland
      • Auchenflower, Queensland, Australia, 4066
        • Local Institution
      • Brisbane, Queensland, Australia, 4032
        • Local Institution
      • Caboolture, Queensland, Australia, 4510
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      • Herston, Queensland, Australia, 4029
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      • Kippa Ring, Queensland, Australia, 4021
        • Local Institution
      • Nambour, Queensland, Australia, 4560
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      • Sherwood, Queensland, Australia, 4075
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    • South Australia
      • Adelaide, South Australia, Australia, SA 5000
        • Local Institution
      • Ashford, South Australia, Australia, 5035
        • Local Institution
      • Bedford Park, South Australia, Australia, 5042
        • Local Institution
      • Woodville, South Australia, Australia, 5011
        • Local Institution
    • Victoria
      • Box Hill, Victoria, Australia, 3128
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      • Dandenong, Victoria, Australia, 3175
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      • Geelong, Victoria, Australia, 3220
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    • Western Australia
      • Fremantle, Western Australia, Australia, 6160
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  • Austria
      • Graz, Austria, 8036
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      • Aalst, Belgio, 9300
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      • Antwerpen, Belgio, 2020
        • Local Institution
      • Antwerpen, Belgio, 2060
        • Local Institution
      • Arlon, Belgio, 6700
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      • Brugge, Belgio, 8000
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      • Dillingen, Belgio, 66763
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      • Genk, Belgio, 3600
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      • Gent, Belgio, 9000
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      • Gilly, Belgio, 6060
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      • Hasselt, Belgio, 3500
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      • Huy, Belgio, 4500
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      • Kortrijk, Belgio, 8500
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      • Menen, Belgio, 8930
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      • Mol, Belgio, 2400
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      • Montegnee, Belgio, 4420
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      • Verviers, Belgio, 4800
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      • Woluwe- Saint Lambert, Belgio, 1200
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      • Yvoir, Belgio, 5530
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      • Sao Paulo, Brasile, 01323-010
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      • Sao Paulo, Brasile, 04024-002
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      • Sao Paulo, Brasile, 08270
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    • Bahia
      • Salvador, Bahia, Brasile, 40144
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      • Salvador, Bahia, Brasile, 41810
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      • Salvador, Bahia, Brasile, 40144-900
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    • Minas Gerais
      • Belo Horzonte, Minas Gerais, Brasile, 30150-221
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      • Belo Horzonte, Minas Gerais, Brasile, 30150
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brasile, 36021-630
        • Local Institution
      • Juiz De Fora, Minas Gerais, Brasile, 36021
        • Local Institution
      • Uberaba, Minas Gerais, Brasile, 38056 055
        • Local Institution
      • Uberlandia, Minas Gerais, Brasile, 38400-299
        • Local Institution
      • Uberlandia, Minas Gerais, Brasile, 38400
        • Local Institution
    • Para
      • Belem, Para, Brasile, 66087-660
        • Local Institution
      • Belem, Para, Brasile, 66087
        • Local Institution
    • Parana
      • Campina Grande Do Sul, Parana, Brasile, 83430-000
        • Local Institution
      • Campina Grande Do Sul, Parana, Brasile, 83430
        • Local Institution
      • Curitiba, Parana, Brasile, 80010
        • Local Institution
      • Curitiba, Parana, Brasile, 80730
        • Local Institution
      • Curitiba, Parana, Brasile, 80010-030
        • Local Institution
      • Curitiba, Parana, Brasile, 80730-150
        • Local Institution
      • Londrina, Parana, Brasile, 86010-450
        • Local Institution
      • Londrina, Parana, Brasile, 86010
        • Local Institution
    • RIO Grande DO Norte
      • Natal, RIO Grande DO Norte, Brasile, 59020-100
        • Local Institution
    • RIO Grande DO SUL
      • Porte Alegre, RIO Grande DO SUL, Brasile, 90610-000
        • Local Institution
      • Porte Alegre, RIO Grande DO SUL, Brasile, 90880-480
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasile, 90035-903
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasile, 90020-090
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasile, 90620-001
        • Local Institution
      • Porto Alegre, RIO Grande DO SUL, Brasile, 91350-280
        • Local Institution
    • Rio Grande Do Norte
      • Natal, Rio Grande Do Norte, Brasile, 59020
        • Local Institution
    • Rio Grande Do Sul
      • Porte Alegre, Rio Grande Do Sul, Brasile, 90610
        • Local Institution
      • Porte Alegre, Rio Grande Do Sul, Brasile, 90880480
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasile, 90035
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasile, 90020
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasile, 90620
        • Local Institution
      • Porto Alegre, Rio Grande Do Sul, Brasile, 91350
        • Local Institution
    • SAO Paulo
      • Botucatu, SAO Paulo, Brasile, 18618-000
        • Local Institution
      • Campinas, SAO Paulo, Brasile, 13059-740
        • Local Institution
      • Marilia, SAO Paulo, Brasile, 17515-000
        • Local Institution
      • Marilia, SAO Paulo, Brasile, 17515-460
        • Local Institution
      • Marilia, SAO Paulo, Brasile, 17519-000
        • Local Institution
      • San Jose Do Rio Preto, SAO Paulo, Brasile, 15090-000
        • Local Institution
      • Santo Andre, SAO Paulo, Brasile, 09190-610
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brasile, 15015-750
        • Local Institution
      • Sao Jose Do Rio Preto, SAO Paulo, Brasile, 15015-210
        • Local Institution
    • Santa Catarina
      • Blumenau, Santa Catarina, Brasile, 89010
        • Local Institution
      • Blumenau, Santa Catarina, Brasile, 89010-500
        • Local Institution
      • Sao Jose, Santa Catarina, Brasile, 88103
        • Local Institution
      • Sao Jose, Santa Catarina, Brasile, 88103-450
        • Local Institution
    • Sao Paulo
      • Botucatu, Sao Paulo, Brasile, 18618
        • Local Institution
      • Campinas, Sao Paulo, Brasile, 13059
        • Local Institution
      • Marilia, Sao Paulo, Brasile, 17519
        • Local Institution
      • Marilia, Sao Paulo, Brasile, 17515
        • Local Institution
      • San Jose Do Rio Preto, Sao Paulo, Brasile, 15090
        • Local Institution
      • Santo Andre, Sao Paulo, Brasile, 09190
        • Local Institution
      • Sao Jose Do Rio Preto, Sao Paulo, Brasile, 15015
        • Local Institution
  • Canada
      • Quebec, Canada, G1J 1Z6
        • Local Institution
    • Alberta
      • Calgary, Alberta, Canada, T2E 7C5
        • Local Institution
      • Edmonton, Alberta, Canada, T6G 2B7
        • Local Institution
      • Edmonton, Alberta, Canada, T5X 3N5
        • Local Institution
      • Edmonton, Alberta, Canada, TSA 4L8
        • Local Institution
      • Edmonton, Alberta, Canada, T56-3NJ
        • Local Institution
    • British Columbia
      • Burnaby, British Columbia, Canada, V5G 1T4
        • Local Institution
      • Nanaimo, British Columbia, Canada, V9R 3G9
        • Local Institution
      • New Westminster, British Columbia, Canada, V3L 3W4
        • Local Institution
      • North Vancouver, British Columbia, Canada, V7N 4M2
        • Local Institution
      • Victoria, British Columbia, Canada, V8R 4R2
        • Local Institution
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2V 4W3
        • Local Institution
    • New Brunswick
      • Bathurst, New Brunswick, Canada, E2A 4X7
        • Local Institution
    • Newfoundland and Labrador
      • Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
        • Local Institution
      • St Johns, Newfoundland and Labrador, Canada, A1B 3V6
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Canada, A1A 3R5
        • Local Institution
      • St. John'S, Newfoundland and Labrador, Canada, A1E 2C2
        • Local Institution
    • Ontario
      • Brampton, Ontario, Canada, L6Z 4N5
        • Local Institution
      • Burlington, Ontario, Canada, L7M 4Y1
        • Local Institution
      • Cambridge, Ontario, Canada, N1R 7R1
        • Local Institution
      • Cambridge, Ontario, Canada, N1R 6V6
        • Local Institution
      • Hamilton, Ontario, Canada, L8L 2X2
        • Local Institution
      • London, Ontario, Canada, N6G 2V2
        • Local Institution
      • Mississauga, Ontario, Canada, L5B 4A2
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      • Newmarket, Ontario, Canada, L3Y 5G8
        • Local Institution
      • Newmarket, Ontario, Canada, L3Y 8C3
        • Local Institution
      • Niagara Falls, Ontario, Canada, L2E 7H1
        • Local Institution
      • Niagara Falls, Ontario, Canada, L2E7H1
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      • North Bay, Ontario, Canada, P1B 2H3
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      • Oshawa, Ontario, Canada, L1J 2J9
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      • Oshawa, Ontario, Canada, L1J 2K1
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      • Ottawa, Ontario, Canada, K1Y 4E9
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      • Ottawa, Ontario, Canada, K1Y 4W7
        • Local Institution
      • Sarnia, Ontario, Canada, N7T 4X3
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      • Scarborough, Ontario, Canada, M1B 5N1
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      • Sudbury, Ontario, Canada, P3E 3B8
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      • Sudbury, Ontario, Canada, P3C 5K7
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      • Sudbury, Ontario, Canada, P3E 2N8
        • Local Institution
      • Sudbury, Ontario, Canada, P3C5K7
        • Local Institution
      • Toronto, Ontario, Canada, M9W 4L6
        • Local Institution
      • Toronto, Ontario, Canada, M5B 1W8
        • Local Institution
      • Weston, Ontario, Canada, M9N 1W4
        • Local Institution
    • Prince Edward Island
      • Charlottetown, Prince Edward Island, Canada, C1A 5Y9
        • Local Institution
    • Quebec
      • Drummondville, Quebec, Canada, J2B 7T1
        • Local Institution
      • Greenfield Park, Quebec, Canada, J4V 2G8
        • Local Institution
      • Lachine, Quebec, Canada, H8S 2E4
        • Local Institution
      • Levis, Quebec, Canada, G6V 4Z5
        • Local Institution
      • Longueuil, Quebec, Canada, J4K 1C8
        • Local Institution
      • Longueuil, Quebec, Canada, J4N 0C9
        • Local Institution
      • Longueuil, Quebec, Canada, J4N 1C2
        • Local Institution
      • Montreal, Quebec, Canada, H3T 1E2
        • Local Institution
      • Montreal, Quebec, Canada, H3A 1A1
        • Local Institution
      • Montreal, Quebec, Canada, H1T 1C8
        • Local Institution
      • Montreal, Quebec, Canada, H2W 1T8
        • Local Institution
      • Montreal, Quebec, Canada, W3R-153
        • Local Institution
      • Pointe- Claire, Quebec, Canada, H9R 3J1
        • Local Institution
      • St-Lambert, Quebec, Canada, J4P 2H4
        • Local Institution
      • Ste-Foy, Quebec, Canada, G1W 4R4
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    • Saskatchewan
      • Saskatoon, Saskatchewan, Canada, S7L OY7
        • Local Institution
  • Cechia
      • Boskovice, Cechia, 680 21
        • Local Institution
      • Brno, Cechia, 625 00
        • Local Institution
      • Brno-Malomerice, Cechia, 614 00
        • Local Institution
      • Ivancice, Cechia, 664 91
        • Local Institution
      • Kladno, Cechia, 272 59
        • Local Institution
      • Litomysl, Cechia, 570 14
        • Local Institution
      • Mestec Kralove, Cechia, 289 03
        • Local Institution
      • Ostrava, Cechia, 70852
        • Local Institution
      • Prague 13, Cechia, 158 00
        • Local Institution
      • Prague 2, Cechia, 128 08
        • Local Institution
      • Pribram, Cechia, 261 01
        • Local Institution
      • Usti Nad Orlici, Cechia, 562 18
        • Local Institution
  • Chile
    • LOS Lagos
      • Osorno, LOS Lagos, Chile, 5311089
        • Local Institution
      • Osorno, LOS Lagos, Chile, 5311523
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    • Metropolitana
      • Santiago, Metropolitana, Chile, 7500520
        • Local Institution
      • Santiago, Metropolitana, Chile, 7500922
        • Local Institution
      • Santiago, Metropolitana, Chile, 8330074
        • Local Institution
    • Region DE LA Araucania
      • Temuco, Region DE LA Araucania, Chile, 4781176
        • Local Institution
    • Region De La Araucania
      • Temuco, Region De La Araucania, Chile, 4781156
        • Local Institution
    • Valparaiso
      • Temuco, Valparaiso, Chile, 4781173
        • Local Institution
      • Vina Del Mar, Valparaiso, Chile, 2570017
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  • Cina
    • Beijing
      • Beijing, Beijing, Cina, 100050
        • Local Institution
      • Beijing, Beijing, Cina, 100001
        • Local Institution
      • Beijing, Beijing, Cina, 100853
        • Local Institution
      • Beijing, Beijing, Cina, 100020
        • Local Institution
      • Beijing, Beijing, Cina, 100088
        • Local Institution
      • Beijing, Beijing, Cina, 100101
        • Local Institution
    • Gansu
      • Lanzhou, Gansu, Cina, 730000
        • Local Institution
      • Lanzhou, Gansu, Cina, 730030
        • Local Institution
    • Guangdong
      • Guangzhou, Guangdong, Cina, 510080
        • Local Institution
      • Guangzhou, Guangdong, Cina, 510120
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    • Hebei
      • Shijiazhuang, Hebei, Cina, 050000
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    • Heilongjiang
      • Daqing, Heilongjiang, Cina, 163001
        • Local Institution
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        • Local Institution
      • Haerbin, Heilongjiang, Cina, 150001
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    • Hubei
      • Wuhan, Hubei, Cina, 430060
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      • Changsha, Hunan, Cina, 410000
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      • Hangzhou, Jiangsu, Cina, 310009
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      • Dalian, Liaoning, Cina, 116011
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      • Moscow, Federazione Russa, 119992
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      • Moscow, Federazione Russa, 125367
        • Local Institution
      • Moscow, Federazione Russa, 109240
        • Local Institution
      • Moscow, Federazione Russa, 105229
        • Local Institution
      • Moscow, Federazione Russa, 111539
        • Local Institution
      • Moscow, Federazione Russa, 115487
        • Local Institution
      • Moscow, Federazione Russa, 115093
        • Local Institution
      • Moscow, Federazione Russa, 121552
        • Local Institution
      • Moscow, Federazione Russa, 117593
        • Local Institution
      • Moscow, Federazione Russa, 127018
        • Local Institution
      • Moscow, Federazione Russa, 125284
        • Local Institution
      • Moscow, Federazione Russa, 111020
        • Local Institution
      • Moscow, Federazione Russa, 119121
        • Local Institution
      • Moscow, Federazione Russa, 121356
        • Local Institution
      • Moscow, Federazione Russa, 117556
        • Local Institution
      • Moscow, Federazione Russa, 119048
        • Local Institution
      • Moscow, Federazione Russa, 123182
        • Local Institution
      • Moscow, Federazione Russa, 125206
        • Local Institution
      • Moscow, Federazione Russa, 125424
        • Local Institution
      • Moscow, Federazione Russa, 129090
        • Local Institution
      • Nizhni Novgorod, Federazione Russa, 603003
        • Local Institution
      • Nizhni Novgorod, Federazione Russa, 603005
        • Local Institution
      • Novosibirsk, Federazione Russa, 630008
        • Local Institution
      • Novosibirsk, Federazione Russa, 630054
        • Local Institution
      • Odintsovo, Federazione Russa, 143000
        • Local Institution
      • Penza, Federazione Russa, 440026
        • Local Institution
      • Perm, Federazione Russa, 614097
        • Local Institution
      • Rostov-On-Don, Federazione Russa, 344022
        • Local Institution
      • Ryazan, Federazione Russa, 390026
        • Local Institution
      • Saint Petersburg, Federazione Russa, 193312
        • Local Institution
      • Saint Petersburg, Federazione Russa, 193144
        • Local Institution
      • Saint-Petersburg, Federazione Russa, 190103
        • Local Institution
      • Saint-Petersburg, Federazione Russa, 191025
        • Local Institution
      • Saint-Petersburg, Federazione Russa, 193163
        • Local Institution
      • Saint-Petersburg, Federazione Russa, 196601
        • Local Institution
      • Saint-Petersburg, Federazione Russa, 198013
        • Local Institution
      • Samara, Federazione Russa, 443070
        • Local Institution
      • Saratov, Federazione Russa, 410002
        • Local Institution
      • St Petersburg, Federazione Russa, 198013
        • Local Institution
      • St Petersburg, Federazione Russa, 192288
        • Local Institution
      • St-Petersburg, Federazione Russa, 194354
        • Local Institution
      • St-Petersburg, Federazione Russa, 195271
        • Local Institution
      • St. Petersburg, Federazione Russa, 197341
        • Local Institution
      • St. Petersburg, Federazione Russa, 197110
        • Local Institution
      • St.-Petersburg, Federazione Russa, 197341
        • Local Institution
      • St.Petersburg, Federazione Russa, 199106
        • Local Institution
      • Tomsk, Federazione Russa, 634012
        • Local Institution
      • Tumen, Federazione Russa, 625023
        • Local Institution
      • Tver, Federazione Russa, 170036
        • Local Institution
      • Voronezh, Federazione Russa, 394066
        • Local Institution
      • Voronezh, Federazione Russa, 394065
        • Local Institution
      • Yaroslavl, Federazione Russa, 150030
        • Local Institution
      • Yaroslavl, Federazione Russa, 150003
        • Local Institution
      • Yaroslavl, Federazione Russa, 150002
        • Local Institution
      • Zheleznodorozhniy, Federazione Russa, 143920
        • Local Institution
      • Zhukovsky, Federazione Russa, 140160
        • Local Institution
      • Zhukovsky, Federazione Russa, 140180
        • Local Institution
  • Filippine
      • Manila, Filippine, 1000
        • Local Institution
      • Manila, Filippine, 1008
        • Local Institution
      • Naga City, Filippine, 4400
        • Local Institution
      • Pasig City, Filippine, 1600
        • Local Institution
      • Quezon, Filippine, 1100
        • Local Institution
      • Quezon City, Filippine, 1102
        • Local Institution
      • San Juan, Filippine, 1100
        • Local Institution
    • Ilocos Norte
      • Laoag City, Ilocos Norte, Filippine, 2900
        • Local Institution
  • Finlandia
      • Helsinki, Finlandia, 00280
        • Local Institution
      • Helsinki, Finlandia, FI-00280
        • Local Institution
      • Hus, Finlandia, 00029
        • Local Institution
      • Jyvaskyla, Finlandia, 40100
        • Local Institution
      • Kemi, Finlandia, 94100
        • Local Institution
      • Oulu, Finlandia, 90100
        • Local Institution
      • Pori, Finlandia, 28120
        • Local Institution
      • Tampere, Finlandia, 33100
        • Local Institution
  • Francia
      • Amiens Cedex 1, Francia, 80054
        • Local Institution
      • Bordeaux Cedex, Francia, 33075
        • Local Institution
      • Brest, Francia, 29609
        • Local Institution
      • Grenoble Cedex 09, Francia, 38043
        • Local Institution
      • La Seyne Sur Mer, Francia, 83500
        • Local Institution
      • Paris Cedex 18, Francia, 75018
        • Local Institution
      • Six Fours Les Plages, Francia, 83140
        • Local Institution
  • Germania
      • Aachen, Germania, 52074
        • Local Institution
      • Bad Krozingen, Germania, 79189
        • Local Institution
      • Bad Neustadt/ Salle, Germania, 97616
        • Local Institution
      • Bad Oeynhausen, Germania, 32545
        • Local Institution
      • Berlin, Germania, 13353
        • Local Institution
      • Berlin, Germania, 14050
        • Local Institution
      • Berlin, Germania, 10787
        • Local Institution
      • Berlin, Germania, 10789
        • Local Institution
      • Berlin, Germania, 12043
        • Local Institution
      • Berlin-Kopenick, Germania, 12559
        • Local Institution
      • Betzdorf, Germania, 57518
        • Local Institution
      • Bochum, Germania, 44791
        • Local Institution
      • Bochum, Germania, 44789
        • Local Institution
      • Bonn, Germania, 53127
        • Local Institution
      • Coburg, Germania, 96450
        • Local Institution
      • Dillingen, Germania, 66763
        • Local Institution
      • Dresden, Germania, 01099
        • Local Institution
      • Duisburg, Germania, 47139
        • Local Institution
      • Essen, Germania, 45122
        • Local Institution
      • Frankfurt Am Main, Germania, 60594
        • Local Institution
      • Gottingen, Germania, 37075
        • Local Institution
      • Halle/Saale, Germania, 06120
        • Local Institution
      • Hannover, Germania, 30625
        • Local Institution
      • Heidelberg, Germania, 69120
        • Local Institution
      • Heidelberg, Germania, 69115
        • Local Institution
      • Kassel, Germania, 34121
        • Local Institution
      • Lahr, Germania, 77933
        • Local Institution
      • Ludwigshafen, Germania, 67063
        • Local Institution
      • Ludwigshafen, Germania, 67073
        • Local Institution
      • Mannheim, Germania, 68167
        • Local Institution
      • Marburg, Germania, 35043
        • Local Institution
      • Munchen, Germania, 81675
        • Local Institution
      • Munchen, Germania, 80636
        • Local Institution
      • Munchen, Germania, 81545
        • Local Institution
      • Osnabruck, Germania, 49076
        • Local Institution
      • Regensburg, Germania, 93053
        • Local Institution
      • Riesa, Germania, D-01587
        • Local Institution
      • Rostiock, Germania, 18057
        • Local Institution
      • Trier, Germania, 54292
        • Local Institution
      • Waren, Germania, 17192
        • Local Institution
      • Witten, Germania, 58455
        • Local Institution
      • Wolmirstedt, Germania, 39326
        • Local Institution
      • Worms, Germania, 67550
        • Local Institution
  • Giappone
      • Fukui, Giappone, 9100067
        • Local Institution
      • Kagoshima, Giappone, 8920822
        • Local Institution
      • Kyoto, Giappone, 6168152
        • Local Institution
      • Nagasaki, Giappone, 852-8102
        • Local Institution
      • Oita, Giappone, 8700033
        • Local Institution
      • Osaka, Giappone, 558-8558
        • Local Institution
      • Osaka, Giappone, 551-0032
        • Local Institution
      • Osaka, Giappone, 5510032
        • Local Institution
      • Saga, Giappone, 8490917
        • Local Institution
    • Fukuoka
      • Itoshima City, Fukuoka, Giappone, 819-1104
        • Local Institution
      • Kurume, Fukuoka, Giappone, 8390863
        • Local Institution
      • Ohkawa-City, Fukuoka, Giappone, 8310016
        • Local Institution
    • Fukushima
      • Shirakawa City, Fukushima, Giappone, 961-0005
        • Local Institution
    • Gunma
      • Takasaki City, Gunma, Giappone, 3700829
        • Local Institution
    • Hokkaido
      • Asahikawa-Shi, Hokkaido, Giappone, 0788214
        • Local Institution
      • Katou-Gun, Hokkaido, Giappone, 0800111
        • Local Institution
      • Katou-gun, Hokkaido, Giappone, 080111
        • Local Institution
      • Sapporo-Shi, Hokkaido, Giappone, 0028043
        • Local Institution
      • Tomakomai-Shi, Hokkaido, Giappone, 002-8043
        • Local Institution
      • Tomakomai-shi, Hokkaido, Giappone, 0028043
        • Local Institution
      • Yubari, Hokkaido, Giappone, 0680402
        • Local Institution
    • Hyogo
      • Kobe, Hyogo, Giappone, 6540026
        • Local Institution
    • Kagoshima Prefecture
      • Izumi City, Kagoshima Prefecture, Giappone, 8990131
        • Local Institution
    • Kanagawa
      • Isehara, Kanagawa, Giappone, 2591193
        • Local Institution
      • Yokohama, Kanagawa, Giappone, 2458575
        • Local Institution
      • Yokohama City, Kanagawa, Giappone, 2278501
        • Local Institution
      • Yokosuka, Kanagawa, Giappone, 2388567
        • Local Institution
    • Miyagi
      • Sendai City, Miyagi, Giappone, 983-8520
        • Local Institution
    • Nara
      • Nara City, Nara, Giappone, 630-8305
        • Local Institution
    • Osaka
      • Izumi City, Osaka, Giappone, 594-0071
        • Local Institution
      • Osaka City, Osaka, Giappone, 5330022
        • Local Institution
      • Osaka-Shi, Osaka, Giappone, 540-0006
        • Local Institution
      • Osaka-shi, Osaka, Giappone, 5400006
        • Local Institution
      • Suita-City, Osaka, Giappone, 5658565
        • Local Institution
      • Takatsuki City, Osaka, Giappone, 5690852
        • Local Institution
      • Yao, Osaka, Giappone, 5810036
        • Local Institution
    • Saga
      • Saga City, Saga, Giappone, 840-8571
        • Local Institution
      • Saga City, Saga, Giappone, 849-8501
        • Local Institution
    • Saitama
      • Kasukabe-Shi, Saitama, Giappone, 344-0035
        • Local Institution
      • Kasukabe-shi, Saitama, Giappone, 3440035
        • Local Institution
    • Tokyo
      • Itabashi-Ku, Tokyo, Giappone, 173-0015
        • Local Institution
      • Itabashi-ku, Tokyo, Giappone, 1730015
        • Local Institution
      • Meguro-Ku, Tokyo, Giappone, 153-8515
        • Local Institution
      • Meguro-ku, Tokyo, Giappone, 1538515
        • Local Institution
      • Shinagawa-Ku, Tokyo, Giappone, 1428666
        • Local Institution
    • Toyama
      • Toyama City, Toyama, Giappone, 9308550
        • Local Institution
    • Yamaguchi
      • Iwakuni, Yamaguchi, Giappone, 7400021
        • Local Institution
  • Hong Kong
      • Hong Kong, Hong Kong
        • Local Institution
      • Shatin, Hong Kong
        • Local Institution
  • India
      • Ahmedabad, India, 380014
        • Local Institution
      • Annamalainagar, India, 608002
        • Local Institution
      • Bangalore, India, 560052
        • Local Institution
      • Chennai, India, 600006
        • Local Institution
      • Hyderabad, India, 500001
        • Local Institution
      • Hyderabad, India, 500044
        • Local Institution
      • Indore, India, 452014
        • Local Institution
      • Indore, India, 452001
        • Local Institution
      • Kolkata, India, 700054
        • Local Institution
      • Kottayam, India, 686016
        • Local Institution
      • Lucknow, India, 226003
        • Local Institution
      • Mumbai Naka, India, 422005
        • Local Institution
      • Nashik, India, 422002
        • Local Institution
      • New Delhi, India, 110025
        • Local Institution
      • New Delhi, India, 110060
        • Local Institution
      • New Delhi, India, 116025
        • Local Institution
      • Pune, India, 411001
        • Local Institution
      • Pune, India, 411004
        • Local Institution
      • Thrissur, India, 680002
        • Local Institution
      • Vijayawada, India, 520008
        • Local Institution
    • Andhra Pradesh
      • Visakhapatnam, Andhra Pradesh, India, 530003
        • Local Institution
    • Andhrapradesh
      • Visakhapatnam, Andhrapradesh, India, 530002
        • Local Institution
    • Andra Pradesh
      • Hyderabad, Andra Pradesh, India, 500004
        • Local Institution
    • Gujarat
      • Ahmedabad, Gujarat, India, 380060
        • Local Institution
      • Vadodara, Gujarat, India, 390007
        • Local Institution
    • Karnataka
      • Bangalore, Karnataka, India, 560054
        • Local Institution
      • Bangalore, Karnataka, India, 5600034
        • Local Institution
      • Bangalore, Karnataka, India, 560094
        • Local Institution
      • Mysore, Karnataka, India, 570004
        • Local Institution
    • Kerela
      • Calicut, Kerela, India, 673 004
        • Local Institution
    • Maharashta
      • Pune, Maharashta, India, 411011
        • Local Institution
    • Maharashtra
      • Nagpur, Maharashtra, India, 440010
        • Local Institution
      • Nagpur, Maharashtra, India, 440012
        • Local Institution
      • Pune, Maharashtra, India, 411001
        • Local Institution
      • Pune, Maharashtra, India, 421006
        • Local Institution
    • Punjab
      • Jalandhar, Punjab, India, 144008
        • Local Institution
    • Rajasthan
      • Bikaner, Rajasthan, India, 334001
        • Local Institution
      • Bikaner, Rajasthan, India, 334003
        • Local Institution
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, India, 226003
        • Local Institution
  • Israele
      • Afula, Israele, 18101
        • Local Institution
      • Ashkelon, Israele, 78306
        • Local Institution
      • Givatayim, Israele, 53583
        • Local Institution
      • Hadera, Israele, 38100
        • Local Institution
      • Haifa, Israele, 31096
        • Local Institution
      • Haifa, Israele, 34362
        • Local Institution
      • Holon, Israele, 58100
        • Local Institution
      • Jerusalem, Israele, 91120
        • Local Institution
      • Jerusalem, Israele, 91240
        • Local Institution
      • Kfar-Saba, Israele, 44281
        • Local Institution
      • Nazareth, Israele, 16100
        • Local Institution
      • Nazareth, Israele, 16000
        • Local Institution
      • Petach-Tikva, Israele, 49100
        • Local Institution
      • Safed, Israele, 13100
        • Local Institution
      • Tel Aviv, Israele, 64239
        • Local Institution
  • Italia
      • Ascoli Piceno, Italia, 63100
        • Local Institution
      • Campobasso, Italia, 86100
        • Local Institution
      • Chieti, Italia, 66013
        • Local Institution
      • Cremona, Italia, 26100
        • Local Institution
      • Fidenza (Pr), Italia, 43036
        • Local Institution
      • Genova, Italia, 16132
        • Local Institution
      • Isernia, Italia, 86170
        • Local Institution
      • Livorno, Italia, 57100
        • Local Institution
      • Milano, Italia, 20132
        • Local Institution
      • Napoli, Italia, 80131
        • Local Institution
      • Palermo, Italia, 90127
        • Local Institution
      • Reggio Emilia, Italia, 42100
        • Local Institution
      • Roma, Italia, 00168
        • Local Institution
      • San Daniele De Friuli, Italia, 33038
        • Local Institution
      • Torino, Italia, 10153
        • Local Institution
      • Vittorio Veneto (Tv), Italia, 31029
        • Local Institution
    • Lucca
      • Lido Di Camaiore, Lucca, Italia, 55043
        • Local Institution
  • Malaysia
      • Kuala Lumpur, Malaysia, 56000
        • Local Institution
      • Kuala Lumpur, Malaysia, 59100
        • Local Institution
    • Kelantan
      • Kubang Kerian, Kelantan, Malaysia, 16150
        • Local Institution
    • Sarawak
      • Kota Samarahan, Sarawak, Malaysia, 94300
        • Local Institution
    • Selangor
      • Batu Caves, Selangor, Malaysia, 68100
        • Local Institution
  • Messico
      • Puebla, Messico, 11490
        • Local Institution
      • Queretaro, Messico, 76000
        • Local Institution
    • BAJA California
      • Tijuana, BAJA California, Messico, 22500
        • Local Institution
    • Distrito Federal
      • Col. Toriello Guerra, Distrito Federal, Messico, CP 14050
        • Local Institution
      • Mexico City, Distrito Federal, Messico, 06726
        • Local Institution
      • Mexico City, Distrito Federal, Messico, 14080
        • Local Institution
      • Mexico City, Distrito Federal, Messico, 07760
        • Local Institution
      • Mexico City, Distrito Federal, Messico, 06070
        • Local Institution
      • Mexico City, Distrito Federal, Messico, 10700
        • Local Institution
    • Jalisco
      • Guadalajara, Jalisco, Messico, 44200
        • Local Institution
      • Guadalajara, Jalisco, Messico, 44600
        • Local Institution
      • Guadalajara, Jalisco, Messico, 44656
        • Local Institution
    • Michoacan
      • Morelia, Michoacan, Messico, 58000
        • Local Institution
    • Nuevo LEON
      • Monterrey, Nuevo LEON, Messico, 64710
        • Local Institution
      • Monterrey, Nuevo LEON, Messico, 64000
        • Local Institution
      • Monterrey, Nuevo LEON, Messico, 64700
        • Local Institution
    • Sinaloa
      • Culiacan, Sinaloa, Messico, 80020
        • Local Institution
    • Veracruz
      • Jalapa, Veracruz, Messico, 91020
        • Local Institution
  • Norvegia
      • Alesund, Norvegia, 6003
        • Local Institution
      • Bergen, Norvegia, 5021
        • Local Institution
      • Bergen, Norvegia, N-5021
        • Local Institution
      • Elverum, Norvegia, 2408
        • Local Institution
      • Flekkefjord, Norvegia, 4400
        • Local Institution
      • Nesttun, Norvegia, 5221
        • Local Institution
      • Oslo, Norvegia, 0407
        • Local Institution
      • Skien, Norvegia, 3710
        • Local Institution
      • Stavanger, Norvegia, 4064
        • Local Institution
      • Straume, Norvegia, 5353
        • Local Institution
      • Tonsberg, Norvegia, 3116
        • Local Institution
      • Tromso, Norvegia, 9038
        • Local Institution
  • Olanda
      • Breda, Olanda, 4818 CK
        • Local Institution
      • Deventer, Olanda, 7416 SE
        • Local Institution
      • Eindhoven, Olanda, 5623 EJ
        • Local Institution
      • Eindhoven, Olanda, 5623EJ
        • Local Institution
      • Enschede, Olanda, 7513 ER
        • Local Institution
      • Hardenberg, Olanda, 7772 SE
        • Local Institution
      • Hilversum, Olanda, 1213 XZ
        • Local Institution
      • Nijmegen, Olanda, 6525 GA
        • Local Institution
      • Oss, Olanda, 5342 BT
        • Local Institution
      • Rotterdam, Olanda, 3045 PM
        • Local Institution
      • S-Hertogenbosch, Olanda, 5211 NL
        • Local Institution
      • Tiel, Olanda, 4002 WP
        • Local Institution
      • Utrecht, Olanda, 3582 KE
        • Local Institution
      • Velp, Olanda, 6883 AZ
        • Local Institution
  • Perù
      • Lima, Perù, LIMA 33
        • Local Institution
      • Lima, Perù, LIMA 01
        • Local Institution
      • Lima, Perù, LIMA 1
        • Local Institution
    • Callao
      • Bellavista, Callao, Perù, 2176
        • Local Institution
      • Bellavista, Callao, Perù, CALLAO 2
        • Local Institution
    • Lambayeque
      • Chiclayo, Lambayeque, Perù, CIX
        • Local Institution
    • Lima
      • Jesus Maria, Lima, Perù, 11
        • Local Institution
      • Jesus Maria, Lima, Perù, LIMA 11
        • Local Institution
      • Miraflores, Lima, Perù, LIMA 18
        • Local Institution
      • San Borja, Lima, Perù, LIMA 41
        • Local Institution
      • San Martin De Porres, Lima, Perù, LIMA 31
        • Local Institution
  • Polonia
      • Gdynia, Polonia, 81-423
        • Local Institution
      • Gdynia, Polonia, 81-472
        • Local Institution
      • Gdynia, Polonia, 81-519
        • Local Institution
      • Grodzisk Mazowiecki, Polonia, 05-825
        • Local Institution
      • Inowroclaw, Polonia, 88-100
        • Local Institution
      • Kielce, Polonia, 25-736
        • Local Institution
      • Kielce, Polonia, 25-763
        • Local Institution
      • Krakow, Polonia, 31-202
        • Local Institution
      • Krakow, Polonia, 30-092
        • Local Institution
      • Krakow, Polonia, 31-135
        • Local Institution
      • Lodz, Polonia, 91-347
        • Local Institution
      • Lodz, Polonia, 91347
        • Local Institution
      • Piotrkow Trybunalski, Polonia, 97-300
        • Local Institution
      • Plock, Polonia, 09-402
        • Local Institution
      • Plock, Polonia, 09-400
        • Local Institution
      • Plonsk, Polonia, 09-100
        • Local Institution
      • Poznan, Polonia, 60-531
        • Local Institution
      • Poznan, Polonia, 60479
        • Local Institution
      • Ruda Slaska, Polonia, 41-703
        • Local Institution
      • Skierniewice, Polonia, 96-100
        • Local Institution
      • Slupsk, Polonia, 76-200
        • Local Institution
      • Torun, Polonia, 87100
        • Local Institution
      • Warszawa, Polonia, 01-138
        • Local Institution
      • Warszawa, Polonia, 04-073
        • Local Institution
      • Warszawa, Polonia, 04-628
        • Local Institution
      • Warszawa, Polonia, 04-749
        • Local Institution
      • Wegrow, Polonia, 07100
        • Local Institution
  • Porto Rico
      • Cayey, Porto Rico, 00736
        • Local Institution
      • Cidra, Porto Rico, 00739
        • Local Institution
      • Ponce, Porto Rico, 00717
        • Local Institution
  • Regno Unito
      • Antrim, Regno Unito, BT41 2RL
        • Local Institution
      • Blackpool, Regno Unito, FY3 8NR
        • Local Institution
      • Glasgow, Regno Unito, G21 3UW
        • Local Institution
    • Aberdeenshire
      • Aberdeen, Aberdeenshire, Regno Unito, AB25 2ZN
        • Local Institution
      • Glasgow, Aberdeenshire, Regno Unito, G11 6NT
        • Local Institution
    • Antrim
      • Belfast, Antrim, Regno Unito, BT14 6AB
        • Local Institution
    • Armagh
      • Craigavon, Armagh, Regno Unito, BT63 5QQ
        • Local Institution
    • Cambridgeshire
      • Cambridge, Cambridgeshire, Regno Unito, CB2 2QQ
        • Local Institution
      • Peterborough, Cambridgeshire, Regno Unito, PE2 5GP
        • Local Institution
    • Derbyshire
      • Chesterfield, Derbyshire, Regno Unito, S44 5BL
        • Local Institution
      • Chesterfield, Derbyshire, Regno Unito, S40 4TF
        • Local Institution
    • Dorset
      • Bournemouth, Dorset, Regno Unito, BH7 7DW
        • Local Institution
    • Dumbartonshire
      • Glasgow, Dumbartonshire, Regno Unito, G11 6NT
        • Local Institution
    • EAST Sussex
      • Chichester, EAST Sussex, Regno Unito, PO19 6SE
        • Local Institution
    • Essex
      • Colchester, Essex, Regno Unito, C03 4LN
        • Local Institution
      • Romford, Essex, Regno Unito, RH7 0AG
        • Local Institution
    • Greater London
      • Denmark Hill, Greater London, Regno Unito, SE5 9RS
        • Local Institution
      • London, Greater London, Regno Unito, SW17 0RE
        • Local Institution
    • Gwent
      • Newport, Gwent, Regno Unito, NP20 2UB
        • Local Institution
    • Hertfordshire
      • Barnet, Hertfordshire, Regno Unito, EN5 3DJ
        • Local Institution
    • MID Glamorgan
      • Cardiff, MID Glamorgan, Regno Unito, CF14 4XW
        • Local Institution
      • Llandough, MID Glamorgan, Regno Unito, CF64 2XX
        • Local Institution
    • Middlesex
      • Harrow, Middlesex, Regno Unito, HA1 3UJ
        • Local Institution
    • Nottinghamshire
      • Nottingham, Nottinghamshire, Regno Unito, NG5 1PB
        • Local Institution
      • Worksop, Nottinghamshire, Regno Unito, S81 OBD
        • Local Institution
    • Renfrewshire
      • Paisley, Renfrewshire, Regno Unito, PA2 9PN
        • Local Institution
    • South Yorkshire
      • Barnsley, South Yorkshire, Regno Unito, S75 2EP
        • Local Institution
      • Doncaster, South Yorkshire, Regno Unito, DN2 5LT
        • Local Institution
    • Stirlingshire
      • Stirling, Stirlingshire, Regno Unito, FK8 2AU
        • Local Institution
    • Strathclyde
      • Glasgow, Strathclyde, Regno Unito, G51 4TF
        • Local Institution
    • Suffolk
      • Bury St Edmunds, Suffolk, Regno Unito, IP31 2HD
        • Local Institution
      • Bury St Edmunds, Suffolk, Regno Unito, IP33 2QZ
        • Local Institution
      • Bury St. Edmunds, Suffolk, Regno Unito, IP30 9QU
        • Local Institution
      • Ipswich, Suffolk, Regno Unito, IP14 2PU
        • Local Institution
      • Ipswich, Suffolk, Regno Unito, IP7 5DN
        • Local Institution
    • Tyne and Wear
      • Newcastle Upon Tyne, Tyne and Wear, Regno Unito, NE1 4LP
        • Local Institution
    • WEST Glamorgan
      • Swansea, WEST Glamorgan, Regno Unito, SA6 6NL
        • Local Institution
    • WEST Lothian
      • Livingston, WEST Lothian, Regno Unito, EH54 6PP
        • Local Institution
    • WEST Midlands
      • Birmingham, WEST Midlands, Regno Unito, B18 7QH
        • Local Institution
    • Wiltshire
      • Westbury, Wiltshire, Regno Unito, BA 13 3JD
        • Local Institution
      • Westbury, Wiltshire, Regno Unito, BA13 3JD
        • Local Institution
    • Yorkshire
      • York, Yorkshire, Regno Unito, YO31 8HE
        • Local Institution
      • York, Yorkshire, Regno Unito, YO31 HE
        • Local Institution
  • Romania
      • Baia Mare, Romania, 430031
        • Local Institution
      • Bucharest, Romania, 011192
        • Local Institution
      • Bucharest, Romania, 020125
        • Local Institution
      • Bucharest, Romania, 050098
        • Local Institution
      • Bucharest, Romania, 021659
        • Local Institution
      • Bucharest, Romania, 030572
        • Local Institution
      • Cluj Napoca, Romania, 400001
        • Local Institution
      • Cluj Napoca, Romania, 400347
        • Local Institution
      • Iasi, Romania, 700503
        • Local Institution
      • Oradea, Romania, 410169
        • Local Institution
      • Sibiu, Romania, 550245
        • Local Institution
      • Targu-Mures, Romania, 540103
        • Local Institution
      • Timisoara, Romania, 300024
        • Local Institution
      • Timisoara, Romania, 300320
        • Local Institution
      • Tirgu Mures, Romania, 540136
        • Local Institution
  • Singapore
      • Singapore, Singapore, 168752
        • Local Institution
  • Spagna
      • Albacete, Spagna, 02006
        • Local Institution
      • Barcelona, Spagna, 08035
        • Local Institution
      • Barcelona, Spagna, 08003
        • Local Institution
      • Elda, Spagna, 03600
        • Local Institution
      • Figueres, Spagna, 17600
        • Local Institution
      • Gerona, Spagna, 17007
        • Local Institution
      • Las Palmas, Spagna, 35010
        • Local Institution
      • Madrid, Spagna, 28006
        • Local Institution
      • Madrid, Spagna, 28046
        • Local Institution
      • Madrid, Spagna, 28040
        • Local Institution
      • Palma De Mallorca, Spagna, 07010
        • Local Institution
      • San Sebastian De Los Reyes, Spagna, 28703
        • Local Institution
      • Tarragona, Spagna, 43007
        • Local Institution
      • Viladecans, Spagna, 08840
        • Local Institution
    • Alicante
      • San Juan, Alicante, Spagna, 03550
        • Local Institution
      • Torrevieja, Alicante, Spagna, 03186
        • Local Institution
    • Almeria
      • La Canada, Almeria, Spagna, 04120
        • Local Institution
    • Galicia
      • Lugo, Galicia, Spagna, 27003
        • Local Institution
  • Stati Uniti
    • Alabama
      • Birmingham, Alabama, Stati Uniti, 35209
        • Cardiovascular Associates, Pc
      • Birmingham, Alabama, Stati Uniti, 35235
        • Alabama Internal Medicine Pc
      • Birmingham, Alabama, Stati Uniti, 35235
        • Birmingham Heart Clinic P.C.
      • Huntsville, Alabama, Stati Uniti, 35801
        • Heart Center, Inc.
      • Mobile, Alabama, Stati Uniti, 36608
        • Mobile Heart Specialists, PC
      • Mobile, Alabama, Stati Uniti, 36617
        • Clara V. Massey, Md
    • Alaska
      • Anchorage, Alaska, Stati Uniti, 99508
        • Alaska Heart Institute
    • Arizona
      • Phoenix, Arizona, Stati Uniti, 85006
        • Internal Medicine Physicians Associates, P.C.
      • Tucson, Arizona, Stati Uniti, 85723
        • Southern Arizona VA Health Care System
      • Tucson, Arizona, Stati Uniti, 85710
        • Southwest Heart
      • Tucson, Arizona, Stati Uniti, 85745
        • Pima Research Foundation
    • Arkansas
      • Hot Springs, Arkansas, Stati Uniti, 71913
        • Dr. Rajesh Shroff
      • Little Rock, Arkansas, Stati Uniti, 72204
        • Mary K. Richards, Md Pa
    • California
      • Anaheim, California, Stati Uniti, 92801
        • Advanced Clinical Reserach Institute
      • Beverly Hills, California, Stati Uniti, 90210
        • Act/Cardiovascular Research Institute
      • Carmichael, California, Stati Uniti, 95608
        • Capitol Interventional Cardiology
      • Escondido, California, Stati Uniti, 92025
        • Escondido Cardiology Associates, Inc.
      • Healdsburg, California, Stati Uniti, 95448
        • William D. Bowden, D.O.
      • La Mesa, California, Stati Uniti, 91942
        • La Mesa Cardiac Center, A Medical Group
      • Los Angeles, California, Stati Uniti, 90073
        • VA Greater Los Angeles Healthcare System
      • Mission Viejo, California, Stati Uniti, 92691
        • Coastal Cardiology
      • Oceanside, California, Stati Uniti, 92056
        • Kenneth W. Carr Md
      • Palm Springs, California, Stati Uniti, 92262
        • Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
      • Rancho Mirage, California, Stati Uniti, 92270
        • Desert Cardiology Consultants Medical Group, Inc
      • Sacramento, California, Stati Uniti, 95821
        • Northern California Research
      • Sacramento, California, Stati Uniti, 95825
        • Sacramento Heart And Vascular Medical Associates
      • Sacramento, California, Stati Uniti, 95819
        • Regional Cardiolody Associates
      • Santa Barbara, California, Stati Uniti, 93105
        • Arrhythmia Consultants Of The Central Coast Medical Group
      • Santa Rosa, California, Stati Uniti, 95403
        • Northern California Medical Associates
      • Vista, California, Stati Uniti, 92083
        • Progressive Clinical Research
      • Walnut Creek, California, Stati Uniti, 94598
        • Cardivasclular Consultants Medical Group
      • Wildomar, California, Stati Uniti, 92595
        • Shiva Heart Center Medical Group
    • Colorado
      • Colorado Springs, Colorado, Stati Uniti, 80910
        • Electrophysiology Associates, Pc
      • Denver, Colorado, Stati Uniti, 80220
        • Denver VA Medical Center
      • Denver, Colorado, Stati Uniti, 80218
        • Aurora Denver Cardiology Associates, P.C.
      • Golden, Colorado, Stati Uniti, 80401
        • New West Physicians Clinical Research
      • Littleton, Colorado, Stati Uniti, 80120
        • South Denver Cardiology Associates PC
    • Connecticut
      • Bridgeport, Connecticut, Stati Uniti, 06610
        • Bridgeport Hospital
      • Bridgeport, Connecticut, Stati Uniti, 06606
        • Connecticut Clinical Research, Llc
      • Guilford, Connecticut, Stati Uniti, 06437
        • Cardiology Associates Of New Haven,Pc
      • Norwich, Connecticut, Stati Uniti, 06360
        • William W Backus Hospital
      • Norwich, Connecticut, Stati Uniti, 06360
        • The William W. Backus Hospital
      • Stamford, Connecticut, Stati Uniti, 06905
        • Stamford Therapeutics Consortium
      • Waterbury, Connecticut, Stati Uniti, 06708
        • Chase Medical Research, LLC
    • Delaware
      • Newark, Delaware, Stati Uniti, 19713
        • Alfieri Cardiology
    • District of Columbia
      • Washington, District of Columbia, Stati Uniti, 20422
        • Washington VA Medical Center
      • Washington, District of Columbia, Stati Uniti, 20037
        • George Washington University Medical Faculty Associates
    • Florida
      • Atlantis, Florida, Stati Uniti, 33462
        • Medical Specialist Of The Palm Beach
      • Aventura, Florida, Stati Uniti, 33180
        • Miami International Cardiology Consultants
      • Boca Raton, Florida, Stati Uniti, 33431
        • David Charles Mishkel, Md, Pa
      • Clearwater, Florida, Stati Uniti, 33756
        • The Heart & Vascular Institute Of Florida
      • Clearwater, Florida, Stati Uniti, 33756
        • The Heart And Vascular Institute Of Florida
      • Davie, Florida, Stati Uniti, 33324
        • Cardiovascular Specialist Of South Florida
      • Daytona Beach, Florida, Stati Uniti, 32114
        • Daytona Heart Group
      • Fort Lauderdale, Florida, Stati Uniti, 33316
        • Broward General Medical Center
      • Fort Lauderdale, Florida, Stati Uniti, 33308
        • Cardiology Associates Of Fort Lauderdale, P.A.
      • Fort Myers, Florida, Stati Uniti, 33907
        • Florida Heart Associates
      • Gainesville, Florida, Stati Uniti, 32605
        • Florida Research Network, LLC
      • Hollywood, Florida, Stati Uniti, 33021
        • Healthworx
      • Hollywood, Florida, Stati Uniti, 33021
        • Luis Tami, Md
      • Inverness, Florida, Stati Uniti, 34452
        • Nature Coast Clinical Research
      • Jacksonville, Florida, Stati Uniti, 32216
        • Jacksonville Center for Clinical Research
      • Jacksonville, Florida, Stati Uniti, 32216
        • Jacksonville Cardiovascular Center
      • Jacksonville, Florida, Stati Uniti, 32258
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Stati Uniti, 32204
        • St. Vincent'S Ambulatory Care, Inc
      • Jacksonville, Florida, Stati Uniti, 32207
        • Jacksonville Heart Center, Pa
      • Jacksonville, Florida, Stati Uniti, 32216
        • St. Luke'S Cardiology
      • Jacksonville Beach, Florida, Stati Uniti, 32250
        • Jacksonville Heart Center, P.A.
      • Jupiter, Florida, Stati Uniti, 33458
        • Cvms Research Institute, Llc
      • Jupiter, Florida, Stati Uniti, 33458
        • Ricardo Bedoya, M.D.
      • Melbourne, Florida, Stati Uniti, 32901
        • Melbourne Internal Medicine Associates
      • Miami, Florida, Stati Uniti, 33137
        • Miami International Cardiology Consultants
      • Miami, Florida, Stati Uniti, 33137-3732
        • Miami International Cardiology Consultants
      • Naples, Florida, Stati Uniti, 34119
        • Physicians Regional Medical Group
      • Orlando, Florida, Stati Uniti, 32803
        • Florida Heart Group
      • Oviedo, Florida, Stati Uniti, 32765
        • Alpha Medical Research
      • Pensacola, Florida, Stati Uniti, 32501
        • Cardiology Consultants
      • Saint Petersburg, Florida, Stati Uniti, 33709
        • The Heart And Vascular Institute Of Florida
      • Sarasota, Florida, Stati Uniti, 34239
        • Heart & Vascular Center Research, Inc.
      • Sarasota, Florida, Stati Uniti, 34232
        • Niranjan Seshadri, Md
      • Vero Beach, Florida, Stati Uniti, 32960
        • Research, Inc.
    • Georgia
      • Atlanta, Georgia, Stati Uniti, 30342
        • Cardiovascular Specialits, Pc
      • Augusta, Georgia, Stati Uniti, 30901
        • Augusta Cardiology Clinic, P.C.
      • Columbus, Georgia, Stati Uniti, 31909
        • Columbus Cardiology Associates Pc
      • Columbus, Georgia, Stati Uniti, 31909
        • Columbus Cardiology Associates,Pc
      • Covington, Georgia, Stati Uniti, 30014
        • Georgia Heart Specialists, L.L.C.
      • Decatur, Georgia, Stati Uniti, 30030
        • Atlanta Institute For Medical Research, Inc
      • Gainesville, Georgia, Stati Uniti, 30501
        • Northeast Georgia Heart Center, PC
      • Marietta, Georgia, Stati Uniti, 30060
        • Wellstar Cardiovascular Medicine, Pc
    • Illinois
      • Aurora, Illinois, Stati Uniti, 60504
        • Fox Valley Clinical Research Center, LLC
      • Chicago, Illinois, Stati Uniti, 60611
        • Nmff
      • Gurnee, Illinois, Stati Uniti, 60031
        • Clinical Investigation Specialists, Inc
      • Maywood, Illinois, Stati Uniti, 60153
        • Loyola University Medical Center
      • Normal, Illinois, Stati Uniti, 61761
        • Illinois Heart & Lung Research Center, Sc
      • North Chicago, Illinois, Stati Uniti, 60064
        • Cpt. James A Lovell Federal Health Care Center
    • Indiana
      • Anderson, Indiana, Stati Uniti, 46011
        • Community Clinical Research Center
      • Bloomington, Indiana, Stati Uniti, 47403
        • Premier Healthcare, Llc
      • Elkhart, Indiana, Stati Uniti, 46514
        • Elkhart Clinic, LLC
      • Fort Wayne, Indiana, Stati Uniti, 46804
        • Lutheran Medical Group, Llc
      • Fort Wayne, Indiana, Stati Uniti, 46805
        • Fort Wayne Cardiology
      • Indianapolis, Indiana, Stati Uniti, 46290
        • The Care Group, Llc
      • Indianapolis, Indiana, Stati Uniti, 46290
        • The Care Group, Llc.
      • Indianapolis, Indiana, Stati Uniti, 46237
        • St Francis Medical Group - Indiana Heart Physicians
      • Michigan City, Indiana, Stati Uniti, 46360
        • Dali, Sammi
      • South Bend, Indiana, Stati Uniti, 46601
        • Cardiology Associates, Inc.
    • Iowa
      • Ames, Iowa, Stati Uniti, 50010
        • McFarland Clinic PC
    • Kansas
      • Overland Park, Kansas, Stati Uniti, 66209
        • Midwest Cardiology Associates , P.C.
    • Kentucky
      • Elizabethtown, Kentucky, Stati Uniti, 42701
        • Central Cardiology Assoc.
      • Lexington, Kentucky, Stati Uniti, 40504
        • New Lexington Clinic, P.S.C.
      • Louisville, Kentucky, Stati Uniti, 40205
        • Norton Cardiovascular Associates
      • Louisville, Kentucky, Stati Uniti, 40202
        • VA Medical Center
      • Owensboro, Kentucky, Stati Uniti, 42303
        • Owensboro Heart & Vascular
    • Louisiana
      • Alexandria, Louisiana, Stati Uniti, 71301
        • Alexandria Cardiology Clinic
      • Houma, Louisiana, Stati Uniti, 70360
        • Cardiovascular Institute of the South
      • Lacombe, Louisiana, Stati Uniti, 70445
        • Smith, Patel & Amkieh, Llc
      • Lake Charles, Louisiana, Stati Uniti, 70601
        • Imperial Calcasieu Medical Group, Llp
      • Marrero, Louisiana, Stati Uniti, 70072
        • Cardiology Center, Llc
      • Shreveport, Louisiana, Stati Uniti, 71105
        • Cardiology Associates
      • Slidell, Louisiana, Stati Uniti, 70458
        • Louisiana Heart Center
      • Slidell, Louisiana, Stati Uniti, 70458
        • Medical Research Inst, Inc
      • Slidell, Louisiana, Stati Uniti, 70458
        • Medical Research Institute, Inc
      • Ventura, Louisiana, Stati Uniti, 93003
        • Ventura Cardio. Cond. Med. Group, Inc.
    • Maine
      • Lewiston, Maine, Stati Uniti, 04240
        • Central Maine Heart & Vascular Institute
    • Maryland
      • Baltimore, Maryland, Stati Uniti, 21224
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Stati Uniti, 21237
        • Franklin Square Hospital
      • Baltimore, Maryland, Stati Uniti, 21208
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Stati Uniti, 21237
        • Midatlantic Cardiovascular Associates, Pa
      • Baltimore, Maryland, Stati Uniti, 21204
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Stati Uniti, 21218
        • Midatlantic Cardiovascular Associates, P.A.
      • Baltimore, Maryland, Stati Uniti, 21224-2735
        • Johns Hopkins Bayview Medical Center
      • Baltimore, Maryland, Stati Uniti, 21237
        • Midatlantic Cardiovascular Associates, P.A.
      • Bel Air, Maryland, Stati Uniti, 21014
        • Midatlantic Cardiovascular Associates, Pa
      • Columbia, Maryland, Stati Uniti, 21044
        • Cardiovascular Specialists Of Central Maryland, P.A.
      • Reisterstown, Maryland, Stati Uniti, 21136
        • Clinical Associates Research
      • Westminster, Maryland, Stati Uniti, 21157
        • Midatlantic Cardiovascular Associates, Pa
    • Massachusetts
      • Billerica, Massachusetts, Stati Uniti, 01821
        • Burlington Medical Associates
      • Boston, Massachusetts, Stati Uniti, 02135
        • Caritas St. Elizabeth's Medical Center
      • Burlington, Massachusetts, Stati Uniti, 01805
        • Lahey Clinic Medical Center
      • Fall River, Massachusetts, Stati Uniti, 02720
        • Neccr Internal Medicine & Cardiology Associates,Llc
      • Haverhill, Massachusetts, Stati Uniti, 01830
        • Pentucket Medical Associates
      • Haverhill, Massachusetts, Stati Uniti, 01830-6278
        • Pentucket Medical Associates
      • Natick, Massachusetts, Stati Uniti, 01760
        • Charles River Medical Associates
    • Michigan
      • Alpena, Michigan, Stati Uniti, 49707
        • Great Lakes Heart Center Of Alpena
      • Detroit, Michigan, Stati Uniti, 48202
        • Henry Ford Hospital
      • Lansing, Michigan, Stati Uniti, 48910
        • Thoracic And Cardiovascular Healthcare Foundation
      • Livonia, Michigan, Stati Uniti, 48154
        • Advanced Cardiovascular Health Specialists, Pc
      • Petoskey, Michigan, Stati Uniti, 49770
        • Michigan Heart And Vascular Specialists
      • Royal Oak, Michigan, Stati Uniti, 48073
        • William Beaumont Hospital
      • Ypsilanti, Michigan, Stati Uniti, 48197
        • Michigan Heart, P.C.
    • Minnesota
      • Minneapolis, Minnesota, Stati Uniti, 55455
        • University of Minnesota
      • Minneapolis, Minnesota, Stati Uniti, 55417
        • Minneapolis VA Medical Center
      • Robbinsdale, Minnesota, Stati Uniti, 55422
        • North Memorial Health Care
    • Mississippi
      • Olive Branch, Mississippi, Stati Uniti, 38654
        • Olive Branch Family Medical Center
      • Tupelo, Mississippi, Stati Uniti, 38801
        • Tupelo Neurology Clinic, Pa
    • Missouri
      • Columbia, Missouri, Stati Uniti, 65212
        • University of Missouri
      • Kansas City, Missouri, Stati Uniti, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Stati Uniti, 64111
        • Saint Luke's Lipid and Diabetes Research Center
    • Nebraska
      • Grand Island, Nebraska, Stati Uniti, 68803
        • Internal Medical Associates Of Grand Island, P.C
      • Grand Island, Nebraska, Stati Uniti, 68803-4311
        • Internal Medical Associates Of Grand Island, P.C
      • Hastings, Nebraska, Stati Uniti, 68901
        • Nebraska Heart Institute
    • Nevada
      • Las Vegas, Nevada, Stati Uniti, 89106
        • VA Southern Nevada Healthcare System
    • New Jersey
      • Berlin, New Jersey, Stati Uniti, 08009
        • Comprehensive Clinical Research
      • Elmer, New Jersey, Stati Uniti, 08318
        • Cardiovascular Associates Of The Delware Valley, P.A.
      • Haddon Heights, New Jersey, Stati Uniti, 08035
        • Cardiovascular Associates Of The Delaware Valley, P.A.
      • Princeton, New Jersey, Stati Uniti, 08540
        • Princeton Medical Institute
      • Sewell, New Jersey, Stati Uniti, 08080
        • Cardio Assoc Of Del Val, P.A.
      • South Plainfield, New Jersey, Stati Uniti, 07080
        • Central New Jersey Cardiology
    • New Mexico
      • Albuquerque, New Mexico, Stati Uniti, 87012
        • Abq Health Partners, Llc
      • Albuquerque, New Mexico, Stati Uniti, 87131-0001
        • University Of New Mexico/University Hospital
      • Albuquerque, New Mexico, Stati Uniti, 87131
        • University Of New Mexico/University Hospital
    • New York
      • Albany, New York, Stati Uniti, 12205
        • Albany Associates In Cardiology
      • Albany, New York, Stati Uniti, 12205
        • Albany Assoc. In Cardiology
      • Binghamton, New York, Stati Uniti, 13905
        • Cardiology Associates, Pc
      • Buffalo, New York, Stati Uniti, 14215
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Stati Uniti, 14215-1145
        • Buffalo Heart Group, LLP
      • Buffalo, New York, Stati Uniti, 14215
        • Bruce L. Platt Md, Pc
      • Buffalo, New York, Stati Uniti, 14215
        • Bruce L. Platt, Md
      • East Syracuse, New York, Stati Uniti, 13057
        • Heart Care Center, P.C.
      • Huntington, New York, Stati Uniti, 11743
        • Huntington Hospital
      • Liverpool, New York, Stati Uniti, 13088
        • SJH Cardiology Associates
      • Mineola, New York, Stati Uniti, 11501
        • Long Island Heart Associates
      • Saratoga Springs, New York, Stati Uniti, 12866
        • Saratoga Cardiology Associates, Pc
      • Williamsville, New York, Stati Uniti, 14221
        • Office Of Dr. Kozinn
      • Williamsville, New York, Stati Uniti, 14221
        • Suburban Cardiology
    • North Carolina
      • Asheville, North Carolina, Stati Uniti, 28803
        • Asheville Cardiology Associates
      • Burlington, North Carolina, Stati Uniti, 27215
        • Kernodle Clinic, Inc.
      • High Point, North Carolina, Stati Uniti, 27262
        • Carolina Cardiology Associates, Pa
      • Pinehurst, North Carolina, Stati Uniti, 28374
        • Pinehurst Medical Center, Inc
    • North Dakota
      • Fargo, North Dakota, Stati Uniti, 58103
        • Lillestol Research LLC
    • Ohio
      • Akron, Ohio, Stati Uniti, 44304
        • Akron Cardiology Consultants
      • Bucyrus, Ohio, Stati Uniti, 44820
        • Christopher M. Johnson, D.O.
      • Bucyrus, Ohio, Stati Uniti, OHIO
        • Christopher M. Johnson, D.O.
      • Canal Fulton, Ohio, Stati Uniti, 44614
        • Community Health Care, Inc.
      • Canton, Ohio, Stati Uniti, 44710
        • Cardiology Associates
      • Cincinnati, Ohio, Stati Uniti, 45219
        • The Carl & Edyth Lindner Center For R&E At The Christ Hosp
      • Toledo, Ohio, Stati Uniti, 43608
        • Toledo Cardiology Consultants
      • Wadsworth, Ohio, Stati Uniti, 44281
        • Family Practice Center of Wadsworth, Inc.
    • Oklahoma
      • Muskogee, Oklahoma, Stati Uniti, 74401
        • Jack C. Va Medical Center
      • Oklahoma City, Oklahoma, Stati Uniti, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Stati Uniti, 73112
        • Plaza Medical Group, Pc
      • Oklahoma City, Oklahoma, Stati Uniti, 73103
        • COR Clinical Research, LLC
      • Oklahoma City, Oklahoma, Stati Uniti, 73135
        • South Oklahoma Heart Research
      • Oklahoma City, Oklahoma, Stati Uniti, 73120
        • Oklahoma Heart Hospital Physicians
      • Oklahoma City, Oklahoma, Stati Uniti, 73139
        • Eminence Research, LLC
      • Tulsa, Oklahoma, Stati Uniti, 74136
        • Castlerock Clinical Research Consultants, Llc
    • Oregon
      • Bend, Oregon, Stati Uniti, 97701
        • St. Charles Health System, Inc.
      • Bend, Oregon, Stati Uniti, 97701
        • St. Charles Health System, Inc
      • Eugene, Oregon, Stati Uniti, 97401
        • Oregon Medical Group - Clinical Research
      • Hillsboro, Oregon, Stati Uniti, 97123
        • Hillsboro Cardiology Pc
      • Medford, Oregon, Stati Uniti, 97504
        • Rogue Valley Physicians - Clinical Research Group
    • Pennsylvania
      • Abington, Pennsylvania, Stati Uniti, 19001
        • Abington Medical Specialists
      • Altoona, Pennsylvania, Stati Uniti, 16602
        • Blair Medical Associates, Inc.
      • Camp Hill, Pennsylvania, Stati Uniti, 17011
        • Heritage Cardiology Assoc.
      • Doylestown, Pennsylvania, Stati Uniti, 18901
        • Central Bucks Cardiology
      • Erie, Pennsylvania, Stati Uniti, 16509
        • Internal Medicine And Lipid Mgmt.
      • Harrisburg, Pennsylvania, Stati Uniti, 17112
        • Kandra, Fierer, Kuskin Associates
      • Hatfield, Pennsylvania, Stati Uniti, 19440
        • Pivotal Clinical Research, Llc
      • Jersey Shore, Pennsylvania, Stati Uniti, 17740
        • Lycoming Internal Medicine Inc.
      • Sayre, Pennsylvania, Stati Uniti, 18840
        • Guthrie Medical Group, P.C.
      • Sayre, Pennsylvania, Stati Uniti, 18840
        • Guthrie Clinic Ltd.
      • Uniontown, Pennsylvania, Stati Uniti, 15401
        • Preferred Primary Care Physicians
      • West Chester, Pennsylvania, Stati Uniti, 19380
        • West Chester Cardiology, Pc
      • Yardley, Pennsylvania, Stati Uniti, 19067
        • Cardiology Consultants of Philadelphia
    • Rhode Island
      • Providence, Rhode Island, Stati Uniti, 02903
        • Rhode Island Hospital
    • South Carolina
      • Anderson, South Carolina, Stati Uniti, 29621
        • Southeastern Research Associates, Inc
      • Beaufort, South Carolina, Stati Uniti, 29906
        • Lowcountry Medical Group, Llc
      • Beaufort, South Carolina, Stati Uniti, 29906
        • Lowcountry Medical Group
      • Charleston, South Carolina, Stati Uniti, 29425
        • Medical University of South Carolina
      • Columbia, South Carolina, Stati Uniti, 29203
        • Columbia Heart Clinic
      • Greenville, South Carolina, Stati Uniti, 29607
        • Upstate Cardiology
      • Greer, South Carolina, Stati Uniti, 29650
        • Internal Medicine Of Greer
      • Orangeburg, South Carolina, Stati Uniti, 29118
        • Palmetto Nephrology Pa
      • Spartanburg, South Carolina, Stati Uniti, 29303
        • S. Carolina Pharmaceutical Research
    • South Dakota
      • Pierre, South Dakota, Stati Uniti, 57501
        • Avera Medical Associates Clinic
    • Tennessee
      • Bristol, Tennessee, Stati Uniti, 37620
        • Holston Medical Group
      • Kingsport, Tennessee, Stati Uniti, 37660
        • Holston Medical Group
      • Knoxville, Tennessee, Stati Uniti, 37920
        • Volunteer Research Group
      • Knoxville, Tennessee, Stati Uniti, 37916
        • Knoxville Heart Group
      • Knoxville, Tennessee, Stati Uniti, 37920-1502
        • Volunteer Research Group
      • Tullahoma, Tennessee, Stati Uniti, 37388
        • Tennessee Center For Clinical Trials
    • Texas
      • Amarillo, Texas, Stati Uniti, 79106
        • Amarillo Heart Clinical Research Institute Inc.
      • Corsicana, Texas, Stati Uniti, 75110
        • Corsicana Medical Research, PLLC
      • Dallas, Texas, Stati Uniti, 75226
        • Soltero Cardiovascular Research Center
      • Dallas, Texas, Stati Uniti, 75230
        • HeartPlace
      • Fort Worth, Texas, Stati Uniti, 76104
        • Heart Center of North Texas
      • Houston, Texas, Stati Uniti, 77030
        • The Methodist Hospital
      • Houston, Texas, Stati Uniti, 77030
        • The University of Texas MD Anderson Cancer Center
      • Houston, Texas, Stati Uniti, 77030
        • Center For Atrial Fibrillation
      • Houston, Texas, Stati Uniti, 77030
        • The Methodist Hospital Neurology Institute
      • Houston, Texas, Stati Uniti, 77065
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Stati Uniti, 77070
        • Northwest Houston Cardiology, Pa
      • Houston, Texas, Stati Uniti, 77074
        • Francisco R. Maislos
      • Houston, Texas, Stati Uniti, 77090
        • Woodlands North Houston Heart Center
      • Humble, Texas, Stati Uniti, 77338
        • Regional Medical Center And Diagnostic Clinics
      • Lackland Air Force Base, Texas, Stati Uniti, 78236
        • Wilford Hall Medical Center
      • Lackland Air Force Base, Texas, Stati Uniti, 78236-9908
        • Wilford Hall Medical Center
      • Longview, Texas, Stati Uniti, 75605
        • DCOL Center for Clinical Research
      • McKinney, Texas, Stati Uniti, 75069
        • North Dallas Research Associates
      • Plano, Texas, Stati Uniti, 75093
        • North Texas Medical Research
      • Plano, Texas, Stati Uniti, 75024
        • Legacy Heart Center
      • San Antonio, Texas, Stati Uniti, 78229
        • Covenant Clinical Research, Pa
      • San Antonio, Texas, Stati Uniti, 78217
        • Bhs Specialty Network, Inc
      • San Antonio, Texas, Stati Uniti, 78229
        • Star Clinical Trails
      • Seguin, Texas, Stati Uniti, 78155
        • Edward Balli, Md, Pa
      • Tomball, Texas, Stati Uniti, 77375
        • Northwest Heart Center
      • Tyler, Texas, Stati Uniti, 75701
        • Tyler Cardiovascular Consultants
      • Tyler, Texas, Stati Uniti, 75708
        • University of Texas Health Science Center at Tyler
      • Tyler, Texas, Stati Uniti, 75708
        • The Univ. Of Texas Health Science Ctr. At Tyler
    • Utah
      • Layton, Utah, Stati Uniti, 84041
        • Utah Cardiology P.C
    • Virginia
      • Norfolk, Virginia, Stati Uniti, 23510
        • Sentara York Clinical Research
      • Richmond, Virginia, Stati Uniti, 23220
        • Medical Research Initiatives
      • Roanoke, Virginia, Stati Uniti, 24014
        • Roanoke Heart Institute, Plc
      • Virginia Beach, Virginia, Stati Uniti, 23454
        • Cardiovascular Associates
    • Washington
      • Burien, Washington, Stati Uniti, 98166
        • Daniel W. Gottlieb, Md, Ps
      • Burien, Washington, Stati Uniti, 98166
        • Daniel William Gottlieb, Md
      • Spokane, Washington, Stati Uniti, 99202
        • Rockwood Clinic Research Cent.
      • Walla Walla, Washington, Stati Uniti, 99362
        • Walla Walla Clinic
    • West Virginia
      • Lewisburg, West Virginia, Stati Uniti, 24901
        • Lynn N. Smith, Md
    • Wisconsin
      • Green Bay, Wisconsin, Stati Uniti, 54301
        • Cardiology Associates Of Green Bay Ltd-Bellin Hospital
      • Madison, Wisconsin, Stati Uniti, 53715
        • St. Mary's Hospital
      • Madison, Wisconsin, Stati Uniti, 53715
        • St.Mary's Hospital
      • Milwaukee, Wisconsin, Stati Uniti, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Stati Uniti, 53215
        • Aurora Health Care
      • Waukesha, Wisconsin, Stati Uniti, 53188
        • Cardiology Assc. Of Waukesha
  • Sud Africa
    • Bloemfontein
      • Westdene, Bloemfontein, Sud Africa, 9301
        • Local Institution
    • Cape Town
      • Observatory, Cape Town, Sud Africa, 7925
        • Local Institution
    • Gauteng
      • Pretoria, Gauteng, Sud Africa, 0084
        • Local Institution
      • Pretoria, Gauteng, Sud Africa, 0132
        • Local Institution
    • KWA ZULU Natal
      • Richards Bay, KWA ZULU Natal, Sud Africa, 3900
        • Local Institution
    • Western CAPE
      • Bellville Cape Town, Western CAPE, Sud Africa, 7530
        • Local Institution
      • George, Western CAPE, Sud Africa, 6529
        • Local Institution
      • Parow, Western CAPE, Sud Africa, 7505
        • Local Institution
      • Somerset West, Western CAPE, Sud Africa, 7130
        • Local Institution
      • Worcester, Western CAPE, Sud Africa, 6850
        • Local Institution
  • Svezia
      • Goteberg, Svezia, 413 45
        • Local Institution
      • Helsingborg, Svezia, 251 87
        • Local Institution
      • Linkoping, Svezia, 581 85
        • Local Institution
      • Lund, Svezia, 222 21
        • Local Institution
      • Orebro, Svezia, 70185
        • Local Institution
      • Orebro, Svezia, 701 85
        • Local Institution
      • Skelleftea, Svezia, 931 86
        • Local Institution
      • Stockholm, Svezia, 141 86
        • Local Institution
      • Stockholm, Svezia, 171 76
        • Local Institution
      • Stockholm, Svezia, 111 57
        • Local Institution
      • Stockholm, Svezia, 118 83
        • Local Institution
      • Stockholm, Svezia, 111 35
        • Local Institution
      • Uppsala, Svezia, 751 85
        • Local Institution
      • Vaxjo, Svezia, 351 85
        • Local Institution
  • Svizzera
      • Baden, Svizzera, 5404
        • Local Institution
      • Bern, Svizzera, 3010
        • Local Institution
  • Tacchino
      • Ankara, Tacchino, 06100
        • Local Institution
      • Eskisehir, Tacchino, 26480
        • Local Institution
      • Izmir, Tacchino, 35100
        • Local Institution
  • Taiwan
      • Taipei, Taiwan, 100
        • Local Institution
      • Taipei, Taiwan, 112
        • Local Institution
      • Taipei, Taiwan, 111
        • Local Institution
      • Taipei, Taiwan, 220
        • Local Institution
      • Taipei, Taiwan, 10449
        • Local Institution
      • Taipei, Taiwan, 104
        • Local Institution
  • Ucraina
      • Chernivtsy, Ucraina, 58013
        • Local Institution
      • Dnipropetrovsk, Ucraina, 49006
        • Local Institution
      • Dnipropetrovsk, Ucraina, 49060
        • Local Institution
      • Donetsk, Ucraina, 83045
        • Local Institution
      • Donetsk, Ucraina, 83003
        • Local Institution
      • Donetsk, Ucraina, 83114
        • Local Institution
      • Ivano-Frankivsk, Ucraina, 76025
        • Local Institution
      • Kharkiv, Ucraina, 61018
        • Local Institution
      • Kharkiv, Ucraina, 61115
        • Local Institution
      • Kharkov, Ucraina, 61039
        • Local Institution
      • Kharkov, Ucraina, 61002
        • Local Institution
      • Kharkov, Ucraina, 61178
        • Local Institution
      • Kiev, Ucraina, 01032
        • Local Institution
      • Kyiv, Ucraina, 03680
        • Local Institution
      • Kyiv, Ucraina, 02091
        • Local Institution
      • Kyiv, Ucraina, 03049
        • Local Institution
      • Kyiv, Ucraina, 03115
        • Local Institution
      • Kyiv, Ucraina, 04050
        • Local Institution
      • Kyiv, Ucraina, 04107
        • Local Institution
      • Kyiv, Ucraina, 01023
        • Local Institution
      • Kyiv, Ucraina, 02660
        • Local Institution
      • Kyiv, Ucraina, 01103
        • Local Institution
      • Lugansk, Ucraina, 91011
        • Local Institution
      • Lugansk, Ucraina, 91016
        • Local Institution
      • Lutsk, Ucraina, 43024
        • Local Institution
      • Lviv, Ucraina, 79013
        • Local Institution
      • Lviv, Ucraina, 79015
        • Local Institution
      • Mykolayiv, Ucraina, 54003
        • Local Institution
      • Odessa, Ucraina, 65009
        • Local Institution
      • Odessa, Ucraina, 65039
        • Local Institution
      • Odessa, Ucraina, 65114
        • Local Institution
      • Odessa, Ucraina, 65025
        • Local Institution
      • Uzhgorod, Ucraina, 88000
        • Local Institution
      • Vinnitsa, Ucraina, 21029
        • Local Institution
      • Zaporozhye, Ucraina, 69035
        • Local Institution
      • Zhytomyr, Ucraina, 10002
        • Local Institution
  • Ungheria
      • Budapest, Ungheria, 1125
        • Local Institution
      • Budapest, Ungheria, 1023
        • Local Institution
      • Budapest, Ungheria, 1032
        • Local Institution
      • Budapest, Ungheria, 1096
        • Local Institution
      • Budapest, Ungheria, 1085
        • Local Institution
      • Debrecen, Ungheria, 4032
        • Local Institution
      • Dunaujvaros, Ungheria, 2400
        • Local Institution
      • Gyor, Ungheria, 9023
        • Local Institution
      • Gyula, Ungheria, 5700
        • Local Institution
      • Hodmezovasarhely, Ungheria, 6800
        • Local Institution
      • Komarom, Ungheria, 2921
        • Local Institution
      • Mosonmagyarovar, Ungheria, 9200
        • Local Institution
      • Oroshaza, Ungheria, 5900
        • Local Institution
      • Pecs, Ungheria, 7624
        • Local Institution
      • Siofok, Ungheria, 8600
        • Local Institution
      • Siofok, Ungheria, 8601
        • Local Institution
      • Sopron, Ungheria, 9400
        • Local Institution
      • Szentes, Ungheria, 6600
        • Local Institution
      • Zalaegerszeg, Ungheria, 8900
        • Local Institution

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

  • Bambino
  • Adulto
  • Adulto più anziano

Accetta volontari sani

No

Sessi ammissibili allo studio

Tutto

Descrizione

Inclusion Criteria:

  • Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
  • Age ≥ 75, previous stroke
  • transient ischemic attack (TIA) or Systemic Embolism (SE)
  • Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
  • Diabetes mellitus or hypertension requiring pharmacological treatment

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Prevenzione
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Doppio

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Sperimentale: 2
Droga: apixaban
Oral tablets, 5.0 mg or 2.5 mg, twice daily
Altri nomi:
  • BMS-562247
Comparatore attivo: 1
Droga: warfarin
Oral tablets, 2.0 mg, adjusted to an INR of 2.5 (range 2.0 to 3.0)
Altri nomi:
  • Coumadin
  • BMS-565793

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period
Lasso di tempo: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period
Lasso di tempo: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period
Lasso di tempo: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Adjudicated All-Cause Death During the Intended Treatment Period
Lasso di tempo: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period
Lasso di tempo: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period
Lasso di tempo: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period
Lasso di tempo: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period
Lasso di tempo: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
"Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With All Bleeding Events During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of All Bleeding Events During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Altre misure di risultato

Misura del risultato
Misura Descrizione
Lasso di tempo
Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
AE: all SAEs or AEs with onset from first dose through 2 days (AEs) or 30 days (SAEs) after the last dose of blinded study drug (BSD). SAE: all SAEs with onset from first dose through 30 days after the last dose of BSD. Bleeding AE: all serious or non-serious bleeding-related AEs with onset from first dose through 2 days after the last dose of BSD. Discontinuations due to AE: all SAEs or AEs with onset from first dose of BSD and with action taken=drug discontinued. Deaths: all deaths occurring from first dose through 30 days after the last dose of BSD.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated GUSTO bleeding events per 100 patient years. GUSTO Bleeding Criteria: GUSTO severe (or life-threatening) bleeding: either intracranial hemorrhage or bleeding that causes hemodynamic compromise and requires intervention. GUSTO moderate bleeding: bleeding that requires blood transfusion but does not result in hemodynamic compromise.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of adjudicated TIMI bleeding events per 100 patient years. TIMI Bleeding Criteria: Major bleeding=Intracranial bleeding and/or clinically overt bleeding associated with ≥5 gm/dL fall in Hgb or 15% fall in hematocrit (Hct) from baseline, accounting for transfusions. Minor bleeding=Clinically overt bleeding associated with ≥3 gm/dL fall in Hgb or a ≥10% fall in Hct from baseline, accounting for transfusions.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Number of Participants With Net-Clinical Benefit During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding.
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate of Net-Clinical Benefit During Treatment Period
Lasso di tempo: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Rate=number of events of net-clinical benefit per 100 patient years. Net-Clinical Benefit = Composite of stroke, systemic embolism and ISTH major bleeding
"Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Bristol-Myers Squibb

Pubblicazioni e link utili

La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.

Pubblicazioni generali

Collegamenti utili

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

31 dicembre 2006

Completamento primario (Effettivo)

25 maggio 2011

Completamento dello studio (Effettivo)

25 maggio 2011

Date di iscrizione allo studio

Primo inviato

18 dicembre 2006

Primo inviato che soddisfa i criteri di controllo qualità

18 dicembre 2006

Primo Inserito (Stima)

19 dicembre 2006

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

3 luglio 2018

Ultimo aggiornamento inviato che soddisfa i criteri QC

5 giugno 2018

Ultimo verificato

1 maggio 2018

Maggiori informazioni

Termini relativi a questo studio

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • CV185-030

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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