Study on Skin Microbiome of HFS

Inclusion Criteria:

• age: 18-65 years old
• advanced breast cancer patients
• healthy volunteers

Exclusion Criteria:

• previous skin disease history, or other skin disease activity at present
• various antibiotics, prebiotics, probiotics or lactic acid products used within three months;
• having a history of alcoholism for more than 2 years and smoking for years;
• pregnancy or lactation;
• have oral, respiratory and gastrointestinal diseases;
• other metabolic diseases, such as obesity, hypertension, diabetes, stones, and liver diseases;
• other autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease;
• history of gastrointestinal surgery;
• family genetic history, history of mental illness, etc.;
• the subject is participating in other research projects;
• other reasons are not considered suitable for continued clinical trials.