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S9926 Temozolomide in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors

2. januar 2013 opdateret af: Southwest Oncology Group

Phase II Study of Temozolomide in Unresectable or Metastatic Gastrointestinal Stromal Tumors (GIST)

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of temozolomide in treating patients who have unresectable or metastatic gastrointestinal stromal tumors.

Studieoversigt

Status

Afsluttet

Betingelser

Gastrointestinal stromal tumor

Intervention / Behandling

Medicin: temozolomide

Detaljeret beskrivelse

OBJECTIVES:

Determine the complete and partial response (confirmed and unconfirmed) in patients with unresectable or metastatic gastrointestinal stromal tumors treated with temozolomide.
Determine the qualitative or quantitative toxic effects of this regimen in these patients.

OUTLINE: This is a multicenter study.

Patients receive oral temozolomide once daily on days 1-5. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity. Patients achieving a confirmed complete response (CR) receive 2 additional courses after a confirmed CR.

Patients are followed every 3 months for 1 year and then every 6 months for 2 years.

PROJECTED ACCRUAL: A total of 20-40 patients will be accrued for this study within 13-27 months.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

Fase

Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alabama
  - Mobile, Alabama, Forenede Stater, 36688
    - MBCCOP - Gulf Coast
- Arizona
  - Phoenix, Arizona, Forenede Stater, 85006-2726
    - CCOP - Western Regional, Arizona
  - Phoenix, Arizona, Forenede Stater, 85012
    - Veterans Affairs Medical Center - Phoenix (Carl T. Hayden)
  - Tucson, Arizona, Forenede Stater, 85723
    - Veterans Affairs Medical Center - Tucson
  - Tucson, Arizona, Forenede Stater, 85724
    - Arizona Cancer Center at University of Arizona Health Sciences Center
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Veterans Affairs Medical Center - Little Rock (McClellan)
- California
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Long Beach, California, Forenede Stater, 90822
    - Veterans Affairs Medical Center - Long Beach
  - Los Angeles, California, Forenede Stater, 90095-1781
    - Jonsson Comprehensive Cancer Center, UCLA
  - Los Angeles, California, Forenede Stater, 90033-0804
    - USC/Norris Comprehensive Cancer Center and Hospital
  - Los Angeles, California, Forenede Stater, 90073
    - Veterans Affairs Medical Center - West Los Angeles
  - Martinez, California, Forenede Stater, 94553
    - Veterans Affairs Outpatient Clinic - Martinez
  - Oakland, California, Forenede Stater, 94609-3305
    - CCOP - Bay Area Tumor Institute
  - Orange, California, Forenede Stater, 92868
    - Chao Family Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Cancer Center
  - San Francisco, California, Forenede Stater, 94143-0128
    - UCSF Comprehensive Cancer Center
  - Santa Rosa, California, Forenede Stater, 95403
    - CCOP - Santa Rosa Memorial Hospital
  - Travis Air Force Base, California, Forenede Stater, 94535
    - David Grant Medical Center
- Colorado
  - Denver, Colorado, Forenede Stater, 80220
    - Veterans Affairs Medical Center - Denver
  - Denver, Colorado, Forenede Stater, 80010
    - University of Colorado Cancer Center at University of Colorado Health Sciences Center
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20060
    - MBCCOP - Howard University Cancer Center
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30342-1701
    - CCOP - Atlanta Regional
  - Fort Gordon, Georgia, Forenede Stater, 30905-5650
    - Dwight David Eisenhower Army Medical Center
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96859-5000
    - Tripler Army Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - MBCCOP - Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96813-2424
    - Cancer Research Center of Hawaii
- Illinois
  - Chicago, Illinois, Forenede Stater, 60612-7323
    - MBCCOP - University of Illinois at Chicago
  - Chicago, Illinois, Forenede Stater, 60612
    - Veterans Affairs Medical Center - Chicago (Westside Hospital)
  - Decatur, Illinois, Forenede Stater, 62526
    - CCOP - Central Illinois
  - Hines, Illinois, Forenede Stater, 60141
    - Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
  - Maywood, Illinois, Forenede Stater, 60153-5500
    - Loyola University Medical Center
- Kansas
  - Kansas City, Kansas, Forenede Stater, 66160-7353
    - University of Kansas Medical Center
  - Wichita, Kansas, Forenede Stater, 67214-3882
    - CCOP - Wichita
  - Wichita, Kansas, Forenede Stater, 67218
    - Veterans Affairs Medical Center - Wichita
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40536-0084
    - Albert B. Chandler Medical Center, University of Kentucky
  - Lexington, Kentucky, Forenede Stater, 40502-2236
    - Veterans Affairs Medical Center - Lexington
- Louisiana
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Veterans Affairs Medical Center - New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - MBCCOP - LSU Health Sciences Center
  - Shreveport, Louisiana, Forenede Stater, 71130-3932
    - Louisiana State University Health Sciences Center - Shreveport
  - Shreveport, Louisiana, Forenede Stater, 71130
    - Veterans Affairs Medical Center - Shreveport
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Jamaica Plain, Massachusetts, Forenede Stater, 02130
    - Veterans Affairs Medical Center - Boston (Jamaica Plain)
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48105
    - Veterans Affairs Medical Center - Ann Arbor
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Ann Arbor, Michigan, Forenede Stater, 48109-0912
    - University of Michigan Comprehensive Cancer Center
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201-1379
    - Barbara Ann Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48201-1932
    - Veterans Affairs Medical Center - Detroit
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - CCOP - Grand Rapids
  - Royal Oak, Michigan, Forenede Stater, 48073-6769
    - CCOP - Beaumont
  - Southfield, Michigan, Forenede Stater, 48075-9975
    - Providence Hospital - Southfield
- Minnesota
  - Duluth, Minnesota, Forenede Stater, 55805
    - CCOP - Duluth
- Mississippi
  - Biloxi, Mississippi, Forenede Stater, 39531-2410
    - Veterans Affairs Medical Center - Biloxi
  - Jackson, Mississippi, Forenede Stater, 39216-4505
    - University of Mississippi Medical Center
  - Jackson, Mississippi, Forenede Stater, 39216
    - Veterans Affairs Medical Center - Jackson
- Missouri
  - Kansas City, Missouri, Forenede Stater, 64128
    - Veterans Affairs Medical Center - Kansas City
  - Kansas City, Missouri, Forenede Stater, 64131
    - CCOP - Kansas City
  - Saint Louis, Missouri, Forenede Stater, 63141
    - CCOP - St. Louis-Cape Girardeau
  - Saint Louis, Missouri, Forenede Stater, 63110
    - St. Louis University Health Sciences Center
  - Springfield, Missouri, Forenede Stater, 65807
    - CCOP - Cancer Research for the Ozarks
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87108-5138
    - Veterans Affairs Medical Center - Albuquerque
  - Albuquerque, New Mexico, Forenede Stater, 87131
    - MBCCOP - University of New Mexico HSC
- New York
  - Albany, New York, Forenede Stater, 12208
    - Veterans Affairs Medical Center - Albany
  - New York, New York, Forenede Stater, 10032
    - Herbert Irving Comprehensive Cancer Center at Columbia University
  - Rochester, New York, Forenede Stater, 14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
- North Carolina
  - Winston-Salem, North Carolina, Forenede Stater, 27104-4241
    - CCOP - Southeast Cancer Control Consortium
- Ohio
  - Cincinnati, Ohio, Forenede Stater, 45220-2288
    - Veterans Affairs Medical Center - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45267-0501
    - Barrett Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44195-9001
    - Cleveland Clinic Taussig Cancer Center
  - Columbus, Ohio, Forenede Stater, 43206
    - CCOP - Columbus
  - Dayton, Ohio, Forenede Stater, 45428
    - Veterans Affairs Medical Center - Dayton
  - Dayton, Ohio, Forenede Stater, 45429
    - CCOP - Dayton
  - Toledo, Ohio, Forenede Stater, 43623-3456
    - CCOP - Toledo Community Hospital
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - Veterans Affairs Medical Center - Oklahoma City
- Oregon
  - Portland, Oregon, Forenede Stater, 97207
    - Veterans Affairs Medical Center - Portland
  - Portland, Oregon, Forenede Stater, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Forenede Stater, 97201-3098
    - Oregon Cancer Institute
- South Carolina
  - Charleston, South Carolina, Forenede Stater, 29425
    - Hollings Cancer Center at Medical University of South Carolina
  - Charleston, South Carolina, Forenede Stater, 29401-5799
    - Veterans Affairs Medical Center - Charleston
  - Greenville, South Carolina, Forenede Stater, 29615
    - CCOP - Greenville
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - CCOP - Upstate Carolina
- Tennessee
  - Memphis, Tennessee, Forenede Stater, 38103
    - University of Tennessee Cancer Institute
  - Memphis, Tennessee, Forenede Stater, 38104
    - Danville Radiation Therapy Center
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - Harrington Cancer Center
  - Amarillo, Texas, Forenede Stater, 79106
    - Veterans Affairs Medical Center - Amarillo
  - Dallas, Texas, Forenede Stater, 75216
    - Veterans Affairs Medical Center - Dallas
  - Fort Sam Houston, Texas, Forenede Stater, 78234-6200
    - Brooke Army Medical Center
  - Galveston, Texas, Forenede Stater, 77555-0565
    - University of Texas Medical Branch
  - Houston, Texas, Forenede Stater, 77030
    - Veterans Affairs Medical Center - Houston
  - San Antonio, Texas, Forenede Stater, 78229-3900
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Forenede Stater, 78229
    - Veterans Affairs Medical Center - San Antonio (Murphy)
  - Temple, Texas, Forenede Stater, 76504
    - Veterans Affairs Medical Center - Temple
  - Temple, Texas, Forenede Stater, 76508
    - CCOP - Scott and White Hospital
- Utah
  - Salt Lake City, Utah, Forenede Stater, 84148
    - Veterans Affairs Medical Center - Salt Lake City
  - Salt Lake City, Utah, Forenede Stater, 84112-5550
    - Huntsman Cancer Institute
- Vermont
  - Burlington, Vermont, Forenede Stater, 05401
    - Fletcher Allen Health Care - University Health Center Campus
- Virginia
  - Richmond, Virginia, Forenede Stater, 23298-0037
    - MBCCOP - Massey Cancer Center
- Washington
  - Seattle, Washington, Forenede Stater, 98101
    - CCOP - Virginia Mason Research Center
  - Seattle, Washington, Forenede Stater, 98108
    - Veterans Affairs Medical Center - Seattle
  - Seattle, Washington, Forenede Stater, 98104
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Tacoma, Washington, Forenede Stater, 98431-5000
    - Madigan Army Medical Center
  - Tacoma, Washington, Forenede Stater, 98405-0986
    - CCOP - Northwest

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

DISEASE CHARACTERISTICS:

Histologically or cytologically confirmed unresectable or metastatic gastrointestinal stromal tumor (GIST)
- Primary (gastrointestinal or intra-abdominal origin) tumor
At least 1 measurable lesion by x-ray, CT, MRI, ultrasound, or physical examination
- If lesions within prior radiation port are used as target lesions for response assessment, those lesions must have demonstrated clear progression after completion of radiotherapy
No uterine or retroperitoneal sarcomas or non-intra-abdominal leiomyosarcomas

PATIENT CHARACTERISTICS:

Age:

Not specified

Performance status:

Zubrod 0-2

Life expectancy:

Not specified

Hematopoietic:

WBC (white blood count) at least 3,000/mm^3
Platelet count at least 100,000/mm^3

Hepatic:

Bilirubin no greater than 2 times upper limit of normal (ULN)

Renal:

Creatinine no greater than 1.5 times ULN

Other:

Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
No medical or psychological conditions that would preclude study participation
No major infection requiring systemic antibiotics
No uncontrolled bacterial, viral, or fungal infection
No other prior malignancy within the past 5 years except:
- Adequately treated basal cell or squamous cell skin cancer
- Adequately treated stage I or II cancer in complete remission
- Carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

Biologic therapy:

At least 30 days since prior biologic therapy
Prior imatinib mesylate as adjuvant therapy or for metastatic disease allowed

Chemotherapy:

No prior chemotherapy for GIST
At least 30 days since other prior chemotherapy

Endocrine therapy:

Not specified

Radiotherapy:

See Disease Characteristics
No prior radiotherapy for GIST
No concurrent radiotherapy for GIST
Concurrent palliative radiotherapy for painful metastases (encompassing a total portal of no greater than 5 x 5 cm) allowed

Surgery:

See Disease Characteristics
At least 4 weeks since prior major surgery and recovered

Other:

At least 30 days since prior investigational drugs

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: N/A
Interventionel model: Enkelt gruppeopgave
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Temozolomide 200 mg/m^2/day, PO, on Days 1-5 of each 28 day cycle.	Medicin: temozolomide 200 mg/m^2/day, PO, on Days 1-5 of each 28 day cycle. Andre navne: NSC-362856

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Tidsramme
Assess response (confirmed & unconfirmed, complete & partial response) Tidsramme: 3 years	3 years

Sekundære resultatmål

Resultatmål	Tidsramme
Toxicities Tidsramme: 3 years	3 years

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Southwest Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Studiestol: Mark M. Zalupski, MD, University of Michigan Rogel Cancer Center

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. april 2000

Primær færdiggørelse (Faktiske)

1. oktober 2005

Studieafslutning (Faktiske)

1. oktober 2005

Datoer for studieregistrering

Først indsendt

2. maj 2000

Først indsendt, der opfyldte QC-kriterier

26. januar 2003

Først opslået (Skøn)

27. januar 2003

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

3. januar 2013

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

2. januar 2013

Sidst verificeret

1. januar 2013

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

gastrointestinal stromal tumor

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CDR0000067710
U10CA032102 (U.S. NIH-bevilling/kontrakt)
S9926 (Anden identifikator: SWOG)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Gastrointestinal stromal tumor

Hospital Universitario Virgen de la Arrixaca

Ikke rekrutterer endnu

Levertransplantation for ikke-operable GIST-levermetastaser (TRANSGIST)

Leversygdomme | Levertransplantation | Neoplasmer i leveren | Gastrointestinale stromale tumorer | Metastase | Levermetastaser | Levertransplantation; Komplikationer | Leverkræft | Levertransplantationslidelse | Leverkarcinom | GIST, ondartet | GIST | Metastaser | Metastatisk leverkræft | Gastrointestinal stromal tumor i... og andre forhold

Spanien
Kura Oncology, Inc.

Rekruttering

En undersøgelse af Ziftomenib, en oral meninhæmmer, i kombination med imatinib hos patienter med avancerede gastrointestinale stromale tumorer (GIST)

Gastrointestinal stromal tumor (GIST) | Gastrointestinal stromal neoplasma | Gastrointestinal stromal tumor, ondartet | Gastrointestinal stromal cancer | Gastrointestinale stromalcelletumorer

Forenede Stater
Centre Leon Berard

Rekruttering

En prospektiv, randomiseret, multicenter, sammenlignende undersøgelse af effektiviteten af genoptagelse af imatinib kombineret med atezolizumab versus genoptagelse af imatinib alene hos patienter med ikke-operable avancerede gastrointestinale stromale tumorer (GIST) efter svigt af standardbehandlinger (ATEZOGIST)

Metastatisk gastrointestinal stromal tumor | Ikke-operabel gastrointestinal stromal tumor (GIST) | Lokalt avanceret gastrointestinal stromal tumor (GIST)

Frankrig
Joal Beane

Ikke rekrutterer endnu

Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors

Metastatisk gastrointestinal stromal tumor | Lokalt avanceret gastrointestinal stromal tumor | Ikke-operable ondartet gastrointestinal stromaltumor | Recurrent Gastrointestinal Stromal Tumor | Refractory Malignant Gastrointestinal Stromal Tumor

Forenede Stater
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Test af anticancerlægemidlet, Rogaratinib (BAY 1163877), til behandling af avanceret sarkom med ændring i fibroblastvækstfaktorreceptoren (FGFR 1-4) og hos patienter med SDH-defekt gastrointestinal stromal tumor (GIST)

Metastatisk gastrointestinal stromal tumor | Metastatisk sarkom | Lokalt avanceret sarkom | Lokalt avanceret gastrointestinal stromal tumor | Fase III gastrisk og omental gastrointestinal stromal tumor AJCC v8 | Stadie III tyndtarm, esophageal, kolorektal, mesenterisk og peritoneal gastrointestinal... og andre forhold

Forenede Stater
Kumquat Biosciences Inc.

Rekruttering

KQB198 i kombination med imatinib hos deltagere med fremskreden/metastatisk GIST i 1. behandlingslinje

GIST | Gastrointestinale tumorer | GIST - Gastrointestinal Stromal Tumor | Gastrointestinal stromal tumor | GIST Metastatisk kræft

Forenede Stater
Centre Leon Berard

Rekruttering

Effektivitet af imatinib-behandling efter 10 års behandling hos patienter med gastrointestinale stromale tumorer (GIST) (Gist-Ten)

C-KIT mutation | Metastatisk gastrointestinal stromal tumor (GIST) | Avanceret gastrointestinal stromal tumor (GIST)

Frankrig
ARCAGY/ GINECO GROUP
Roche Pharma AG

Afsluttet

Effekt og sikkerhed af Bevacizumab (Avastin®) kombineret med ugentlig paclitaxel efterfulgt af Bevacizumab (Avastin®) alene hos patienter med recidiverende ovarie-kønsstrengstromale tumorer (ALIENOR) (ALIENOR)

Ovarie kønsstreng Stromal Tumor

Frankrig
National Cancer Institute (NCI)

Rekruttering

Kirurgi i gastrointestinale stromale tumorer (GIST'er) til behandling, tumormodellering og genomisk analyse

Mavekræft | Mave-neoplasma | Gastrointestinal stromal tumor (GIST) | Gastrointestinal stromal sarkom | Gastrointestinal stromal neoplasma

Forenede Stater
Universität Duisburg-Essen

Ikke rekrutterer endnu

Et Omfattende, Multinationalt GIST-register (reGISTTry)

GIST - Gastrointestinal Stromal Tumor | Gastrointestinal stromaltumor (GIST)

Tyskland

Kliniske forsøg med temozolomide

The Cooper Health System
Georgetown University; University of Virginia; Virginia Commonwealth University og andre samarbejdspartnere

Ikke rekrutterer endnu

Kemoterapi før strålebehandling for nyopdaget højgradigt gliom. (PRC)

Glioblastom | Astrocytom | Oligodendrogliom | Gliomer af høj grad
Bradmer Pharmaceuticals Inc.

Afsluttet

Glioblastoma Multiforme (GBM) Locoregional Agent Survival Study - Anti-tenascin radioaktivt mærket antistofterapi (Glass-Art)

Glioblastoma Multiforme
Novartis Pharmaceuticals

Afsluttet

Et fase I-dosiseskaleringsstudie af BKM120 med strålebehandling og temozolomid hos patienter med nyligt diagnosticeret glioblastom

Glioblastom

Australien, Spanien, Canada, Forenede Stater
Activartis Biotech

Afsluttet

Dendritisk cellekræftvaccine for højgradigt gliom (GBM-Vax)

Glioblastoma Multiforme

Østrig
AHS Cancer Control Alberta
Alberta Cancer Foundation

Rekruttering

Kemoradioterapi versus biomarkør-guidet terapi til ældre og svage GBM-patienter

Glioblastoma Multiforme

Canada
Peking Union Medical College Hospital
Beijing Tiantan Hospital; Tianjin Medical University General Hospital

Ukendt

Effekt og sikkerhed af TMZ Plus CDDP hos patienter med tilbagevendende maligne gliomer

Ondartede gliomer

Kina
Ruijin Hospital

Rekruttering

En klinisk undersøgelse af effektiviteten og sikkerheden af methotrexat (MTX) eller ThioTepa (for MTX -intolerance) eller temozolomid (TMZ) kombineret med orelabrutinib og selinexor i tilbagefald/ildfast primær eller sekundært centralnervesystem lymfom （Selina atter (SELINA)

Lymfom Cns

Kina
Merck Sharp & Dohme LLC

Afsluttet

Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)

Karcinom, ikke-småcellet lunge | Neoplasmer i hjernen | Metastaser, Neoplasma
Case Comprehensive Cancer Center
National Cancer Institute (NCI); Schering-Plough

Afsluttet

Temozolomid til behandling af patienter med metastatisk ikke-småcellet lungekræft

Lungekræft

Forenede Stater
Fox Chase Cancer Center
National Cancer Institute (NCI)

Afsluttet

Temozolomid til behandling af patienter med recidiverende eller progressiv småcellet lungekræft

Lungekræft

Forenede Stater

S9926 Temozolomide in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors

Phase II Study of Temozolomide in Unresectable or Metastatic Gastrointestinal Stromal Tumors (GIST)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Tidsramme

Sekundære resultatmål

Resultatmål

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Gastrointestinal stromal tumor

Kliniske forsøg med temozolomide

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Uzbekistan

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer