Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Carotid Artery Thickness in HIV Infected and Uninfected Adults

16. september 2008 opdateret af: National Institute of Allergy and Infectious Diseases (NIAID)

Carotid Artery Intima-Media Thickness in HIV-Infected and Uninfected Adults: A Pilot Study

The intima-media thickness (IMT) test is a low cost, non-invasive way to measure the thickness of the carotid artery (the large artery in the neck). The purpose of this study is to compare the thickness of the carotid artery among HIV infected adults taking protease inhibitors (PIs), HIV infected adults not taking PIs, and HIV uninfected adults, and to examine how the thickness may change over time.

Studieoversigt

Status

Afsluttet

Betingelser

Detaljeret beskrivelse

Determination of clinical, lipid, and non-lipid risk factors has been the traditional approach for gauging an individual's risk for coronary artery disease (CAD). However, the IMT test, which uses sound waves to measure the thickness of the carotid artery, has been found to diagnose CAD and predict a person's risk for heart disease as well as or better than lipid and non-lipid risk factors. This study will use the IMT test to see if anti-HIV treatment and HIV infection affect a patient's risk of developing atherosclerosis (hardening of the arteries) by comparing carotid artery thickness among HIV infected adults taking PIs, HIV infected adults not taking PIs, and HIV uninfected adults.

There are 3 groups in this study. Group 1 will comprise HIV infected participants currently taking a PI-containing regimen. Group 2 will comprise HIV infected participants who are not taking PIs. Group 3 will comprise HIV uninfected participants. At each site, participants will be enrolled by "triads" consisting of an individual from each group. Each member of the triad will be closely matched by gender, age, smoking and menopausal status, race, and normal or hypertensive blood pressure. All 3 members of the triad must be identified before participants are registered to the study.

All participants will visit the clinic at Weeks 1, 24, 48, 72, 96, and 144 (3 years). At each visit, participants will have a physical exam, medical history and waist/hip ratio assessment, blood collection, and an IMT test. The absolute value for carotid IMT will be compared among the 3 groups. Viral load and CD4 counts will also be measured in Group 1 and 2 participants.

Undersøgelsestype

Observationel

Tilmelding

132

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • California
      • Harbor City, California, Forenede Stater, 90710
        • Kaiser Foundation Hosp
      • Los Angeles, California, Forenede Stater, 90095
        • UCLA CARE Ctr
      • Los Angeles, California, Forenede Stater, 900331079
        • Univ of Southern California / LA County USC Med Ctr
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente LAMC
      • San Diego, California, Forenede Stater, 92103
        • Univ of California, San Diego
      • Torrance, California, Forenede Stater, 90502
        • Harbor UCLA Med Ctr
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96816
        • Univ of Hawaii
    • Minnesota
      • Minneapolis, Minnesota, Forenede Stater, 55455
        • Univ of Minnesota
    • Pennsylvania
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • Univ of Pennsylvania
    • Washington
      • Seattle, Washington, Forenede Stater, 98104
        • Univ of Washington

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria for Group 1

  • HIV infected
  • Have taken at least 1 PI continuously for 2 or more years and are currently taking at least 1 PI. Stopping therapy for 4 weeks or less for management of side effects or to change therapy is allowed.
  • Viral load of 10,000 copies/ml or less

Inclusion Criteria for Group 2

  • HIV infected
  • Not currently receiving PIs or have not taken PIs in at least 3 months
  • Not planning to initiate PI therapy in the few months following study entry
  • Viral load of 10,000 copies/ml or less
  • If not currently on anti-HIV treatment, must have been on treatment for at least 6 months in the past

Inclusion Criteria for Group 3

  • HIV uninfected

Exclusion Criteria for All Groups

  • Diabetes or current use of oral medications for diabetes
  • Kidney disease
  • ALT or AST greater than 2.5 times the upper limit of normal
  • Hypothyroidism
  • Family history (parents, brothers, sisters, or children) of heart attacks before age 55 in males and age 65 in females
  • Alcohol or drug abuse
  • Pregnant or plan to become pregnant during the study
  • Body mass index (BMI) greater than 30
  • Systemic chemotherapy or radiation therapy
  • Systemic steroids (prednisone or equivalent) at doses greater than 5 mg/day for more than 30 consecutive days
  • History of coronary heart disease or stroke (including chest pain, heart attack, or abnormal stress test)
  • Uncontrolled hypertension

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Efterforskere

  • Studiestol: Judith S. Currier, MD, MSc, University of California, Los Angeles
  • Studiestol: Howard N. Hodis, MD, Atherosclerosis Research Unit, University of Southern California

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Datoer for studieregistrering

Først indsendt

16. december 2000

Først indsendt, der opfyldte QC-kriterier

30. august 2001

Først opslået (Skøn)

31. august 2001

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

17. september 2008

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

16. september 2008

Sidst verificeret

1. maj 2006

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • ACTG A5078
  • AACTG A5078

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner