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TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Doxil in Platinum Refractory or Resistant Ovarian Cancer

30. maj 2012 opdateret af: Telik

Phase III Randomized Study of TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Liposomal Doxorubicin (Doxil) as Second-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-3]

The purpose of this research study is to determine if TLK286 given in combination with carboplatin is more effective than liposomal doxorubicin in treating women who have recurrent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer, that is refractory or resistant to platinum chemotherapy.

Studieoversigt

Status

Afsluttet

Betingelser

Ovariale neoplasmer

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

244

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Little Rock Hematology Oncology
  - Little Rock, Arkansas, Forenede Stater, 72117
    - Little Rock Hematology Oncology
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Arkansas Oncology Associates
  - Little Rock, Arkansas, Forenede Stater, 72207
    - Arkansas Oncology Associates
- California
  - Anaheim, California, Forenede Stater, 92807
    - Southern California Permanente Medical Group
  - Antioch, California, Forenede Stater, 94509
    - East Bay Oncology/Hematology Medical Associates, Inc.
  - Baldwin Park, California, Forenede Stater, 91706
    - Southern California Permanente Medical Group
  - Bellflower, California, Forenede Stater, 90706
    - Southern California Permanente Medical Group
  - Chula Vista, California, Forenede Stater, 91911
    - Marilyn Norton, M.D.
  - Concord, California, Forenede Stater, 94520
    - Bay Area Cancer Research Group, LLC
  - Concord, California, Forenede Stater, 94520
    - East Bay Oncology/Hematology Medical Associates, Inc.
  - Escondido, California, Forenede Stater, 92025
    - Southwest Cancer Care
  - Fontana, California, Forenede Stater, 92335
    - Southern California Permanente Medical Group
  - Fresno, California, Forenede Stater, 93710
    - California Oncology of the Central Valley
  - Harbor City, California, Forenede Stater, 90710
    - Southern California Permanente Medical Group
  - Hayward, California, Forenede Stater, 94545
    - Kaiser Permanente Medical Center
  - La Jolla, California, Forenede Stater, 92037
    - Gynecologic Oncology Associates
  - La Mesa, California, Forenede Stater, 91942
    - Cancer Center Oncology Medical Group
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Loma Linda, California, Forenede Stater, 92354
    - LLU Faculty Medical Offices
  - Los Angeles, California, Forenede Stater, 90027
    - Southern California Permanente Medical Group
  - Los Angeles, California, Forenede Stater, 90095
    - David Geffen School of Medicine at UCLA
  - Los Angeles, California, Forenede Stater, 90034
    - Southern California Permanente Medical Group
  - Los Angeles, California, Forenede Stater, 90095
    - Bowyer Oncology Center
  - Los Angeles, California, Forenede Stater, 90095
    - OB/GYN Consult Suite
  - Montebello, California, Forenede Stater, 90640
    - Clinical Trials and Research Associates, Inc.
  - Montebello, California, Forenede Stater, 90640
    - Oncology Care Medical Associates
  - Montebello, California, Forenede Stater, 90640
    - Beverly Oncology and Imaging
  - Murrieta, California, Forenede Stater, 92562
    - Southwest Cancer Care
  - Newport Beach, California, Forenede Stater, 92663
    - Hoag Memorial Hospital Presbyterian
  - Newport Beach, California, Forenede Stater, 92663
    - Gynecologic Oncology Associates
  - Newport Beach, California, Forenede Stater, 92660
    - Newport Imaging Center
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Medical Center
  - Oceanside, California, Forenede Stater, 92056
    - N. County Oncology Medical
  - Panorama City, California, Forenede Stater, 91402
    - Southern California Permanente Medical Group
  - Poway, California, Forenede Stater, 92064
    - Southwest Cancer Care
  - Riverside, California, Forenede Stater, 92505
    - Southern California Permanente Medical Group
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Medical Center
  - San Diego, California, Forenede Stater, 92123
    - Sharp Rees-Stealy
  - San Diego, California, Forenede Stater, 92123
    - Medical Oncology Associates
  - San Diego, California, Forenede Stater, 92123
    - Sharp Memorial Hospital - Investigational Pharmacy
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente Medical Center
  - San Gabriel, California, Forenede Stater, 91776
    - Oncology Care Medical Associates
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente Medical Center
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Medical Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente Medical Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente Medical Center
  - Walnut Creek, California, Forenede Stater, 94598
    - Diablo Valley Oncology & Hematology Medical Group, Inc.
  - Whittier, California, Forenede Stater, 90602
    - Oncology Care Medical Associates
  - Woodland Hills, California, Forenede Stater, 91367
    - Southern Permanente Medical Group
- Connecticut
  - Farmington, Connecticut, Forenede Stater, 06030
    - University of Connecticut Health Center/John Dempsey Hospital
- Florida
  - Boca Raton, Florida, Forenede Stater, 33486
    - The Center for Hematology-Oncology
  - Crystal River, Florida, Forenede Stater, 34428
    - Citrus Diagnostic Center
  - Crystal River, Florida, Forenede Stater, 34428
    - Citrus Hematology and Oncology Center
  - Crystal River, Florida, Forenede Stater, 34429
    - Citrus Hematology and Oncology Center
  - Delray Beach, Florida, Forenede Stater, 33484
    - The Center for Hematology-Oncology
  - Hollywood, Florida, Forenede Stater, 33021
    - GYN Oncology Associates, Inc.
  - Inverness, Florida, Forenede Stater, 34452
    - Citrus Hematology and Oncology Center
  - Inverness, Florida, Forenede Stater, 34452
    - Florida Wellcare Alliance, LC
  - Inverness, Florida, Forenede Stater, 34452
    - Citrus Memorial Hospital Radiology Dept.
  - Jacksonville, Florida, Forenede Stater, 32209
    - Shands Jacksonville Medical Center
  - Jupiter, Florida, Forenede Stater, 33458
    - Palm Beach Cancer Institute
  - Lecanto, Florida, Forenede Stater, 34461
    - Cancer and Blood Disease Center
  - Orlando, Florida, Forenede Stater, 32803
    - Florida Hospital
  - Orlando, Florida, Forenede Stater, 32804
    - Gynecology Oncology
  - Ormond Beach, Florida, Forenede Stater, 32174
    - Florida Hospital Memorial System
  - Ormond Beach, Florida, Forenede Stater, 32174
    - Florida Hospital Memorial Division - Cancer Care Center
  - Palm Beach Gardens, Florida, Forenede Stater, 33410
    - Palm Beach Cancer Institute
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - GYN Oncology Associates, Inc.
  - Wellington, Florida, Forenede Stater, 33414
    - Palm Beach Cancer Institute
  - West Palm Beach, Florida, Forenede Stater, 33401
    - Palm Beach Cancer Institute
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30342
    - Southeastern Gynecologic Oncology
  - Lawrenceville, Georgia, Forenede Stater, 30045
    - Southeastern Gynecologic Oncology
  - Marietta, Georgia, Forenede Stater, 30060
    - Southeastern Gynecologic Oncology
  - Riverdale, Georgia, Forenede Stater, 30274
    - Southeastern Gynecologic Oncology
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial Health University Medical Center
  - Tucker, Georgia, Forenede Stater, 30084
    - Southeastern Gynecologic Oncology
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Hawaii
- Illinois
  - Flossmoor, Illinois, Forenede Stater, 60422
    - Joliet Oncology-Hematology Associates, Inc.
  - Joliet, Illinois, Forenede Stater, 60432
    - Joliet Oncology-Hematology Associates, Inc.
  - Joliet, Illinois, Forenede Stater, 60435
    - Joliet Oncology-Hematology Associates, Inc.
  - Kankakee, Illinois, Forenede Stater, 60901
    - Joliet Oncology-Hematology Associates, Inc.
  - Morris, Illinois, Forenede Stater, 60450
    - Joliet Oncology-Hematology Associates, Inc.
- Indiana
  - Elkhart, Indiana, Forenede Stater, 46514
    - Elkhart General Hospital
  - Indianapolis, Indiana, Forenede Stater, 46260
    - St. Vincent Hospital
  - LaPorte, Indiana, Forenede Stater, 46350
    - LaPorte Hospital
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46617
    - Saint Joseph's Regional Medical Center
- Kentucky
  - Louisville, Kentucky, Forenede Stater, 40202
    - James Graham Brown Cancer Center
  - Louisville, Kentucky, Forenede Stater, 40202
    - University Medical Center, Inc. DBA: U of L Hospital
- Louisiana
  - Covington, Louisiana, Forenede Stater, 70433
    - Hematology And Oncology Specialists, Llc
  - Metairie, Louisiana, Forenede Stater, 70002
    - OncRx (Pharmacy)
  - New Orleans, Louisiana, Forenede Stater, 70006
    - Hematology and Oncology Specialist
  - Shreveport, Louisiana, Forenede Stater, 71103
    - LSU Health Sciences Center
- Maine
  - Portland, Maine, Forenede Stater, 04102
    - Maine Medical Center
  - Portland, Maine, Forenede Stater, 04102
    - Maine Medical Center - Brighton Campus
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Medical Center - Scarborough Campus
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Bethesda, Maryland, Forenede Stater, 20817
    - Center for Cancer and Blood Disorders, P. C.
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forenede Stater, 02135
    - Caritas St. Elizabeth's Medical Center
  - Boston, Massachusetts, Forenede Stater, 02115
    - Dana Farber/Partners Cancer Care, Inc.
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center - Center for Cancer and Blood Disorders
  - Waltham, Massachusetts, Forenede Stater, 02451
    - Perceptive Informatics, Inc.
- Michigan
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Health System
  - Niles, Michigan, Forenede Stater, 49120
    - Lakeland Hospital
  - Southfield, Michigan, Forenede Stater, 48075
    - Providence Cancer Institute and Hospital
  - St. Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Hospital
- Minnesota
  - Duluth, Minnesota, Forenede Stater, 55805
    - Duluth Clinic
- Mississippi
  - Olive Branch, Mississippi, Forenede Stater, 38654
    - The Family Cancer Center
- Missouri
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center
  - St. Louis, Missouri, Forenede Stater, 63141
    - St. John's Mercy Medical Center
  - St. Louis, Missouri, Forenede Stater, 63117
    - Saint Louis University
  - St. Louis, Missouri, Forenede Stater, 63141
    - St. John's Mercy-David C. Pratt Cancer Center
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - Deaconess Billings Clinic
- Nebraska
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Hematology & Oncology Consultants, PC
  - Scottsbluff, Nebraska, Forenede Stater, 69361
    - Regional West Medical Center
  - Scottsbluff, Nebraska, Forenede Stater, 69361
    - Odyssey Research
  - Scottsbluff, Nebraska, Forenede Stater, 69361
    - Horizons West Medical Group
  - Scottsbluff, Nebraska, Forenede Stater, 69361
    - The Women's Center of Western Nebraska
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Mary Hitchcock Memorial Hospital/Dartmouth-Hitchcock Medical Center
- New Jersey
  - Edison, New Jersey, Forenede Stater, 08818
    - JFK Medical Center
  - Edison, New Jersey, Forenede Stater, 08818
    - A. Richard Miskoff, DO, PA
  - Neptune, New Jersey, Forenede Stater, 07754
    - Jersey Shore University Medical Center
  - New Brunswick, New Jersey, Forenede Stater, 08901
    - The Cancer Institute of New Jersey
  - New Brunswick, New Jersey, Forenede Stater, 08901
    - Robert Wood Johnson University Hospital
  - West Long Branch, New Jersey, Forenede Stater, 07764
    - Jsumc Ob/Gyn
- New York
  - Babylon, New York, Forenede Stater, 11702
    - Gynecologic Oncology & Minimally Invasive Surgery
  - Cooperstown, New York, Forenede Stater, 13326
    - The Mary Imogene Bassett Hospital
  - East Islip, New York, Forenede Stater, 11730
    - Schwartz Gynecologic Oncology
  - Manhasset, New York, Forenede Stater, 11030
    - North Shore University Hospital
  - New City, New York, Forenede Stater, 10956
    - Hematology-Oncology Associates of Rockland
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - Nyack, New York, Forenede Stater, 10960
    - The Union State Bank Cancer Center
- North Carolina
  - Asheville, North Carolina, Forenede Stater, 28816
    - Hope A Women's Cancer Center
  - Asheville, North Carolina, Forenede Stater, 28801
    - Asheville Radiology
  - Chapel Hill, North Carolina, Forenede Stater, 27599-7570
    - University of North Carolina at Chapel Hill
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Presbyterian Hospital
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Presbyterian Gynecologic Oncology
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Blumenthal Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Inpatient Pharmacy
  - Winston Salem, North Carolina, Forenede Stater, 27103
    - Piedmont Hematology Oncology Associates
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Odyssey Research
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Cancer Care Center - Medcenter One, Inc.
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Cancer Treatment & Research Center - Mid Dakota Clinic, P. C.
  - Fargo, North Dakota, Forenede Stater, 58104
    - Odyssey Research
  - Fargo, North Dakota, Forenede Stater, 58103
    - Dakota Cancer Institute
- Ohio
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219-0501
    - Barrett Cancer Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - UC Physician's Medical Arts Building
  - Cleveland, Ohio, Forenede Stater, 44111
    - Fairview Hospital Moll Pavilion
  - Columbus, Ohio, Forenede Stater, 43213
    - Mid Ohio Onc/Hem (East)
  - Columbus, Ohio, Forenede Stater, 43222
    - GOPSA
  - Columbus, Ohio, Forenede Stater, 43222
    - Mid Ohio Onc/Hem (West)
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital/Cleveland Clinic Health System
  - Toledo, Ohio, Forenede Stater, 43606
    - The Toledo Hospital
  - Toledo, Ohio, Forenede Stater, 43606
    - ProMedica Health System
  - Toledo, Ohio, Forenede Stater, 43606
    - Garth Phibbs, M.D., FACOG
  - Westerville, Ohio, Forenede Stater, 43081
    - Mid Onio Onc/Hem (North)
- Oklahoma
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Cancer Care Associates
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - Cancer Care Associates
- Oregon
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health & Science University
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest Region
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Abington Memorial Hospital
  - Dunmore, Pennsylvania, Forenede Stater, 18512
    - Hematology & Oncology Associates of NEPA
  - Dunmore, Pennsylvania, Forenede Stater, 18512
    - Advance Imaging
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - Magee-Womens Hospital of UPMC
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Community Medical Center
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Moses Taylor Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Viewmont Medical Services
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Mercy Health Partners
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Hematology & Oncology Associates of NEPA
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Associates in Hematology-Oncology, P.C.
- South Carolina
  - Charleston, South Carolina, Forenede Stater, 29407
    - Carolina Center of Gynecologic Oncology, PA
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper Hospital-Department of Radiology
  - Columbia, South Carolina, Forenede Stater, 29210
    - South Carolina Oncology
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Hospital System
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Regional Healthcare System
- South Dakota
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sioux Valley Clinic Oncology
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sioux Valley Hospital - North Center Radiology
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sioux Valley Clinic - Clinical Research Center
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Sioux Valley Clinic OBGYN, Ltd.
- Tennessee
  - Bartlett, Tennessee, Forenede Stater, 38133
    - The Family Cancer Center
  - Chattanooga, Tennessee, Forenede Stater, 37403
    - Chattanooga GYN Oncology
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Parkridge Medical Center
  - Chattanooga, Tennessee, Forenede Stater, 37403
    - Baroness Erlander Hospital
  - Collierville, Tennessee, Forenede Stater, 38017
    - The Family Cancer Center
  - Memphis, Tennessee, Forenede Stater, 38119
    - The Family Cancer Center
- Texas
  - Arlington, Texas, Forenede Stater, 76012
    - Arlington Cancer Center
  - Dallas, Texas, Forenede Stater, 75231
    - Texas Cancer Associates
  - Dallas, Texas, Forenede Stater, 75230
    - Center for Oncology Research and Treatment, PA
  - Plano, Texas, Forenede Stater, 75093
    - Texas Cancer Associates
  - Richardson, Texas, Forenede Stater, 75080
    - Center for Oncology Research and Treatment, PA
- Virginia
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Hematology and Oncology, Inc.
  - Richmond, Virginia, Forenede Stater, 23235
    - VCU Health System at Stony Point
  - Richmond, Virginia, Forenede Stater, 23298
    - VCU Health System-Dalton Oncology Clinic, North Hospital
  - Roanoke, Virginia, Forenede Stater, 24014
    - Carilion GYN Oncology Associates
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Western Washington Oncology, Inc., P.S.
  - Centralia, Washington, Forenede Stater, 98531
    - Western Washington Oncology, Inc., P. S.
  - Covington, Washington, Forenede Stater, 98042-4951
    - Covington MultiCare - Oncology Clinic
  - Gig Harbor, Washington, Forenede Stater, 98335
    - Gig Harbor Medical Oncology
  - Lacey, Washington, Forenede Stater, 98503
    - Western Washington Oncology, Inc., P.S.
  - Shelton, Washington, Forenede Stater, 98584
    - Western Washington Oncology, Inc., P.S.
  - Tacoma, Washington, Forenede Stater, 98405
    - Allenmore Hospital - Hematology Oncology Clinic
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Health System - Medical Oncology
- Wisconsin
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic - Chippewa Falls Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Care - Regional Cancer Center - Sacred Heart Hospital
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic - Lakeland Center
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic - Indianhead Center
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - St. Michael's Hospital
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marchfield Clinic - Wausau Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic Weston Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Beskrivelse

Inclusion Criteria:

Are a woman 18 years of age or older
Have histologically or cytologically confirmed epithelial cancer of the ovary or fallopian tube, or primary peritoneal cancer
Have platinum refractory or resistant cancer
Measurable disease according to radiographic RECIST criteria with documented tumor progression

Exclusion Criteria:

Had treatment with first-line chemotherapy other than platinum-based regimens (carboplatin or cisplatin)
Have clinically significant cardiac disease
Have any sign of intestinal obstruction interfering with nutrition at the time of study entry
Are pregnant or lactating
Had prior treatment with liposomal doxorubicin for ovarian cancer
Had prior treatment with TLK286

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: TLK286 in Combination with Carboplatin	Medicin: TLK286 in Combination with Carboplatin Experimental Arm
Aktiv komparator: Doxorubisin HCl Liposome Injection	Medicin: Doxorubicin HCl Liposome Injection Active Comparator

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Study Objectives Tidsramme: Every 8 Weeks	To demonstrate superiority in the objective response rate (ORR) of TLK286 in combination with carboplatin as compared to active control therapy with liposomal doxorubicin	Every 8 Weeks

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Telik

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. december 2004

Primær færdiggørelse (Faktiske)

1. juli 2008

Studieafslutning (Faktiske)

1. juli 2008

Datoer for studieregistrering

Først indsendt

4. februar 2005

Først indsendt, der opfyldte QC-kriterier

4. februar 2005

Først opslået (Skøn)

7. februar 2005

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

31. maj 2012

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

30. maj 2012

Sidst verificeret

1. juni 2006

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Ovarie

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

TLK286.3024

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Ovariale neoplasmer

Guangzhou First People's Hospital

Afsluttet

Intranasal dexmedetomidin præmedicinering

Benign Neoplasm of Vocal Fold - Glottis

Kina
Asan Medical Center

Rekruttering

Lenvatinib i kombination med nivolumab plus kemoterapi hos metastatiske gastriske kræftpatienter med ondartede ascites

Mavekræft | Mavekræft Adenocarcinom Metastatisk | MAVE NEOPLASM

Sydkorea
Peking Union Medical College Hospital

Rekruttering

Forudsigelse af lægemiddelrespons i mavekræft baseret på 3D-bioprint

MAVE NEOPLASM

Kina
National University Hospital, Singapore
Vanderbilt University Medical Center; National University Cancer Institute...

Ikke rekrutterer endnu

Brug af Pyrvinium til at vende forstadier til mave

MAVE NEOPLASM

Singapore
Leiden University Medical Center

Rekruttering

[18F] F-FAPI PET/CT og laparoskopi i iscenesættelse af avanceret gastrisk kræft (PLASTIC-3)

Mavekræft | PET-CT | Lokalt avanceret gastrisk adenocarcinom | MAVE NEOPLASM

Holland
National Cancer Institute (NCI)

Ikke rekrutterer endnu

Sacituzumab Govitecan med Bevacizumab sammenlignet med sædvanlig kemoterapi (Carboplatin, pegyleret liposomal Doxorubicin og Bevacizumab) til behandling af tilbagevendende platinfølsom æggestokkræft efter PARP-hæmmer vedligeholdelsesterapi

Recidiverende platinfølsomt tuba fallopii højgradigt serøst adenokarcinom | Recidiverende Platinfølsom Ovarie Højgradigt Serøs Adenokarcinom | Recurrent Platinum-Sensitive Primary Peritoneal High Grade Serous Adenocarcinoma | Recurrent Platinum-Sensitive Endometrioid Adenokarcinom i Æggelederen og andre forhold
Chongqing Precision Biotech Co., Ltd

Rekruttering

Klinisk forsøg med CD123-målrettet CAR-NK-terapi for tilbagefald/refraktær AML eller BPDCN

AML (akut myeloid leukæmi) | BPDCN (blastisk Plasmacytoid Dendritic Cell Neoplasm)

Kina

Kliniske forsøg med TLK286 in Combination with Carboplatin

Telik

Afsluttet

Carboplatin, Paclitaxel og TLK286 (Telcyta) som førstelinjebehandling ved avanceret ikke-småcellet lungekræft

Karcinom, ikke-småcellet lunge

Forenede Stater
Roswell Park Cancer Institute
National Cancer Institute (NCI)

Afsluttet

Peripheral Stem Cell Transplantation With or Without Stromagen Following Chemotherapy in Treating Women With Metastatic Breast Cancer

Brystkræft

Forenede Stater
UNICANCER

Afsluttet

Kombination kemoterapi plus perifer stamcelletransplantation til behandling af patienter med småcellet lungekræft

Lungekræft

Frankrig
Memorial Sloan Kettering Cancer Center

Afsluttet

Kombinationskemoterapi efterfulgt af knoglemarvstransplantation ved behandling af patienter med sjælden kræft

Sarkom | Lymfom | Nyrekræft | Testikulær kimcelletumor | Hoved- og halskræft | Livmoderhalskræft | Neuroblastom | Retinoblastom | Leverkræft | Ekstragonadal kimcelletumor | Kimcelletumor i barndommen

Forenede Stater
European Organisation for Research and Treatment...

Afsluttet

Kombination af kemoterapi og strålebehandling med eller uden lapatinib til behandling af patienter med lokalt fremskreden kræft i strubehovedet eller hypopharynx

Hoved- og halskræft

Belgien
Swiss Group for Clinical Cancer Research

Afsluttet

Kemosensitivitetstest for at tildele behandling til patienter med trin III eller trin IV ovariecancer

Livmoderhalskræft

Schweiz
European Organisation for Research and Treatment...

Afsluttet

Cetuximab, kombinationskemoterapi og strålebehandling til behandling af patienter med nydiagnosticeret trin III eller trin IV hoved- og nakkekræft, der ikke kan fjernes ved kirurgi

Hoved- og halskræft

Belgien
Peking University People's Hospital

Rekruttering

Neoadjuverende terapiundersøgelse styret af lægemiddelscreening in vitro for human epidermal vækstfaktor receptor 2 (HER2) negativ tidlig brystkræftpatienter

HER2-negativ tidlig brystkræft

Kina
Emory University
National Cancer Institute (NCI)

Rekruttering

Højdosis strålebehandling med Pembrolizumab og kemoterapi til behandling af patienter med PD-L1 positiv metastatisk tredobbelt negativ brystkræft

Anatomisk fase IV brystkræft AJCC v8 | Metastatisk triple-negativt brystkarcinom

Forenede Stater
Gustave Roussy, Cancer Campus, Grand Paris
Regeneron Pharmaceuticals; MaaT Pharma

Rekruttering

Oral samlet fækal mikrobioterapi (MAAT033) samtidig med cemiplimab versus bedste efterforskeres valg hos patienter med resistens mod behandling på grund af antibiotika-optagelse med avanceret ikke-småcellet lungekræft (IMMUNOLIFE2)

NSCLC (avanceret ikke-småcellet lungekræft)

Frankrig

TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Doxil in Platinum Refractory or Resistant Ovarian Cancer

Phase III Randomized Study of TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Liposomal Doxorubicin (Doxil) as Second-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-3]

Studieoversigt

Status

Betingelser

Intervention / Behandling

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Ovariale neoplasmer

Kliniske forsøg med TLK286 in Combination with Carboplatin

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Bahamas

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer