TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Doxil in Platinum Refractory or Resistant Ovarian Cancer

May 30, 2012 updated by: Telik

Phase III Randomized Study of TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Liposomal Doxorubicin (Doxil) as Second-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-3]

The purpose of this research study is to determine if TLK286 given in combination with carboplatin is more effective than liposomal doxorubicin in treating women who have recurrent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer, that is refractory or resistant to platinum chemotherapy.

Study Overview

Status

Completed

Conditions

Ovarian Neoplasms

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

244

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

United States
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, United States, 72205
    - Little Rock Hematology Oncology
  - Little Rock, Arkansas, United States, 72117
    - Little Rock Hematology Oncology
  - Little Rock, Arkansas, United States, 72205
    - Arkansas Oncology Associates
  - Little Rock, Arkansas, United States, 72207
    - Arkansas Oncology Associates
- California
  - Anaheim, California, United States, 92807
    - Southern California Permanente Medical Group
  - Antioch, California, United States, 94509
    - East Bay Oncology/Hematology Medical Associates, Inc.
  - Baldwin Park, California, United States, 91706
    - Southern California Permanente Medical Group
  - Bellflower, California, United States, 90706
    - Southern California Permanente Medical Group
  - Chula Vista, California, United States, 91911
    - Marilyn Norton, M.D.
  - Concord, California, United States, 94520
    - Bay Area Cancer Research Group, LLC
  - Concord, California, United States, 94520
    - East Bay Oncology/Hematology Medical Associates, Inc.
  - Escondido, California, United States, 92025
    - Southwest Cancer Care
  - Fontana, California, United States, 92335
    - Southern California Permanente Medical Group
  - Fresno, California, United States, 93710
    - California Oncology of the Central Valley
  - Harbor City, California, United States, 90710
    - Southern California Permanente Medical Group
  - Hayward, California, United States, 94545
    - Kaiser Permanente Medical Center
  - La Jolla, California, United States, 92037
    - Gynecologic Oncology Associates
  - La Mesa, California, United States, 91942
    - Cancer Center Oncology Medical Group
  - Loma Linda, California, United States, 92354
    - Loma Linda University Medical Center
  - Loma Linda, California, United States, 92354
    - LLU Faculty Medical Offices
  - Los Angeles, California, United States, 90027
    - Southern California Permanente Medical Group
  - Los Angeles, California, United States, 90095
    - David Geffen School of Medicine at UCLA
  - Los Angeles, California, United States, 90034
    - Southern California Permanente Medical Group
  - Los Angeles, California, United States, 90095
    - Bowyer Oncology Center
  - Los Angeles, California, United States, 90095
    - OB/GYN Consult Suite
  - Montebello, California, United States, 90640
    - Clinical Trials and Research Associates, Inc.
  - Montebello, California, United States, 90640
    - Oncology Care Medical Associates
  - Montebello, California, United States, 90640
    - Beverly Oncology and Imaging
  - Murrieta, California, United States, 92562
    - Southwest Cancer Care
  - Newport Beach, California, United States, 92663
    - HOAG Memorial Hospital Presbyterian
  - Newport Beach, California, United States, 92663
    - Gynecologic Oncology Associates
  - Newport Beach, California, United States, 92660
    - Newport Imaging Center
  - Oakland, California, United States, 94611
    - Kaiser Permanente Medical Center
  - Oceanside, California, United States, 92056
    - N. County Oncology Medical
  - Panorama City, California, United States, 91402
    - Southern California Permanente Medical Group
  - Poway, California, United States, 92064
    - Southwest Cancer Care
  - Riverside, California, United States, 92505
    - Southern California Permanente Medical Group
  - Sacramento, California, United States, 95825
    - Kaiser Permanente Medical Center
  - San Diego, California, United States, 92123
    - Sharp Rees-Stealy
  - San Diego, California, United States, 92123
    - Medical Oncology Associates
  - San Diego, California, United States, 92123
    - Sharp Memorial Hospital - Investigational Pharmacy
  - San Francisco, California, United States, 94115
    - Kaiser Permanente Medical Center
  - San Gabriel, California, United States, 91776
    - Oncology Care Medical Associates
  - San Jose, California, United States, 95119
    - Kaiser Permanente Medical Center
  - Santa Clara, California, United States, 95051
    - Kaiser Permanente Medical Center
  - South San Francisco, California, United States, 94080
    - Kaiser Permanente Medical Center
  - Vallejo, California, United States, 94589
    - Kaiser Permanente Medical Center
  - Walnut Creek, California, United States, 94596
    - Kaiser Permanente Medical Center
  - Walnut Creek, California, United States, 94598
    - Diablo Valley Oncology & Hematology Medical Group, Inc.
  - Whittier, California, United States, 90602
    - Oncology Care Medical Associates
  - Woodland Hills, California, United States, 91367
    - Southern Permanente Medical Group
- Connecticut
  - Farmington, Connecticut, United States, 06030
    - University of Connecticut Health Center/John Dempsey Hospital
- Florida
  - Boca Raton, Florida, United States, 33486
    - The Center for Hematology-Oncology
  - Crystal River, Florida, United States, 34428
    - Citrus Diagnostic Center
  - Crystal River, Florida, United States, 34428
    - Citrus Hematology and Oncology Center
  - Crystal River, Florida, United States, 34429
    - Citrus Hematology and Oncology Center
  - Delray Beach, Florida, United States, 33484
    - The Center for Hematology-Oncology
  - Hollywood, Florida, United States, 33021
    - GYN Oncology Associates, Inc.
  - Inverness, Florida, United States, 34452
    - Citrus Hematology and Oncology Center
  - Inverness, Florida, United States, 34452
    - Florida Wellcare Alliance, LC
  - Inverness, Florida, United States, 34452
    - Citrus Memorial Hospital Radiology Dept.
  - Jacksonville, Florida, United States, 32209
    - Shands Jacksonville Medical Center
  - Jupiter, Florida, United States, 33458
    - Palm Beach Cancer Institute
  - Lecanto, Florida, United States, 34461
    - Cancer and Blood Disease Center
  - Orlando, Florida, United States, 32803
    - Florida Hospital
  - Orlando, Florida, United States, 32804
    - Gynecology Oncology
  - Ormond Beach, Florida, United States, 32174
    - Florida Hospital Memorial System
  - Ormond Beach, Florida, United States, 32174
    - Florida Hospital Memorial Division - Cancer Care Center
  - Palm Beach Gardens, Florida, United States, 33410
    - Palm Beach Cancer Institute
  - Pembroke Pines, Florida, United States, 33028
    - GYN Oncology Associates, Inc.
  - Wellington, Florida, United States, 33414
    - Palm Beach Cancer Institute
  - West Palm Beach, Florida, United States, 33401
    - Palm Beach Cancer Institute
- Georgia
  - Atlanta, Georgia, United States, 30342
    - Southeastern Gynecologic Oncology
  - Lawrenceville, Georgia, United States, 30045
    - Southeastern Gynecologic Oncology
  - Marietta, Georgia, United States, 30060
    - Southeastern Gynecologic Oncology
  - Riverdale, Georgia, United States, 30274
    - Southeastern Gynecologic Oncology
  - Savannah, Georgia, United States, 31404
    - Memorial Health University Medical Center
  - Tucker, Georgia, United States, 30084
    - Southeastern Gynecologic Oncology
- Hawaii
  - Honolulu, Hawaii, United States, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, United States, 96819
    - Kaiser Permanente Hawaii
- Illinois
  - Flossmoor, Illinois, United States, 60422
    - Joliet Oncology-Hematology Associates, Inc.
  - Joliet, Illinois, United States, 60432
    - Joliet Oncology-Hematology Associates, Inc.
  - Joliet, Illinois, United States, 60435
    - Joliet Oncology-Hematology Associates, Inc.
  - Kankakee, Illinois, United States, 60901
    - Joliet Oncology-Hematology Associates, Inc.
  - Morris, Illinois, United States, 60450
    - Joliet Oncology-Hematology Associates, Inc.
- Indiana
  - Elkhart, Indiana, United States, 46514
    - Elkhart General Hospital
  - Indianapolis, Indiana, United States, 46260
    - St. Vincent Hospital
  - LaPorte, Indiana, United States, 46350
    - LaPorte Hospital
  - South Bend, Indiana, United States, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, United States, 46617
    - Saint Joseph's Regional Medical Center
- Kentucky
  - Louisville, Kentucky, United States, 40202
    - James Graham Brown Cancer Center
  - Louisville, Kentucky, United States, 40202
    - University Medical Center, Inc. DBA: U of L Hospital
- Louisiana
  - Covington, Louisiana, United States, 70433
    - Hematology And Oncology Specialists, Llc
  - Metairie, Louisiana, United States, 70002
    - OncRx (Pharmacy)
  - New Orleans, Louisiana, United States, 70006
    - Hematology and Oncology Specialist
  - Shreveport, Louisiana, United States, 71103
    - LSU Health Sciences Center
- Maine
  - Portland, Maine, United States, 04102
    - Maine Medical Center
  - Portland, Maine, United States, 04102
    - Maine Medical Center - Brighton Campus
  - Scarborough, Maine, United States, 04074
    - Maine Medical Center - Scarborough Campus
- Maryland
  - Baltimore, Maryland, United States, 21215
    - Sinai Hospital of Baltimore
  - Bethesda, Maryland, United States, 20817
    - Center for Cancer and Blood Disorders, P. C.
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, United States, 02114
    - Massachusetts General Hospital
  - Boston, Massachusetts, United States, 02118
    - Boston Medical Center
  - Boston, Massachusetts, United States, 02135
    - Caritas St. Elizabeth's Medical Center
  - Boston, Massachusetts, United States, 02115
    - Dana Farber/Partners Cancer Care, Inc.
  - Boston, Massachusetts, United States, 02118
    - Boston Medical Center - Center for Cancer and Blood Disorders
  - Waltham, Massachusetts, United States, 02451
    - Perceptive Informatics, Inc.
- Michigan
  - Lansing, Michigan, United States, 48912
    - Sparrow Health System
  - Niles, Michigan, United States, 49120
    - Lakeland Hospital
  - Southfield, Michigan, United States, 48075
    - Providence Cancer Institute and Hospital
  - St. Joseph, Michigan, United States, 49085
    - Lakeland Hospital
- Minnesota
  - Duluth, Minnesota, United States, 55805
    - Duluth Clinic
- Mississippi
  - Olive Branch, Mississippi, United States, 38654
    - The Family Cancer Center
- Missouri
  - Columbia, Missouri, United States, 65203
    - Ellis Fischel Cancer Center
  - St. Louis, Missouri, United States, 63141
    - St. John's Mercy Medical Center
  - St. Louis, Missouri, United States, 63117
    - Saint Louis University
  - St. Louis, Missouri, United States, 63141
    - St. John's Mercy-David C. Pratt Cancer Center
- Montana
  - Billings, Montana, United States, 59101
    - Deaconess Billings Clinic
- Nebraska
  - Omaha, Nebraska, United States, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, United States, 68122
    - Hematology & Oncology Consultants, PC
  - Scottsbluff, Nebraska, United States, 69361
    - Regional West Medical Center
  - Scottsbluff, Nebraska, United States, 69361
    - Odyssey Research
  - Scottsbluff, Nebraska, United States, 69361
    - Horizons West Medical Group
  - Scottsbluff, Nebraska, United States, 69361
    - The Women's Center of Western Nebraska
- New Hampshire
  - Lebanon, New Hampshire, United States, 03756
    - Mary Hitchcock Memorial Hospital/Dartmouth-Hitchcock Medical Center
- New Jersey
  - Edison, New Jersey, United States, 08818
    - JFK Medical Center
  - Edison, New Jersey, United States, 08818
    - A. Richard Miskoff, DO, PA
  - Neptune, New Jersey, United States, 07754
    - Jersey Shore University Medical Center
  - New Brunswick, New Jersey, United States, 08901
    - The Cancer Institute of New Jersey
  - New Brunswick, New Jersey, United States, 08901
    - Robert Wood Johnson University Hospital
  - West Long Branch, New Jersey, United States, 07764
    - Jsumc Ob/Gyn
- New York
  - Babylon, New York, United States, 11702
    - Gynecologic Oncology & Minimally Invasive Surgery
  - Cooperstown, New York, United States, 13326
    - The Mary Imogene Bassett Hospital
  - East Islip, New York, United States, 11730
    - Schwartz Gynecologic Oncology
  - Manhasset, New York, United States, 11030
    - North Shore University Hospital
  - New City, New York, United States, 10956
    - Hematology-Oncology Associates of Rockland
  - New Hyde Park, New York, United States, 11040
    - Long Island Jewish Medical Center
  - Nyack, New York, United States, 10960
    - The Union State Bank Cancer Center
- North Carolina
  - Asheville, North Carolina, United States, 28816
    - Hope A Women's Cancer Center
  - Asheville, North Carolina, United States, 28801
    - Asheville Radiology
  - Chapel Hill, North Carolina, United States, 27599-7570
    - University of North Carolina at Chapel Hill
  - Charlotte, North Carolina, United States, 28203
    - Carolinas Medical Center
  - Charlotte, North Carolina, United States, 28204
    - Presbyterian Hospital
  - Charlotte, North Carolina, United States, 28204
    - Presbyterian Gynecologic Oncology
  - Charlotte, North Carolina, United States, 28204
    - Blumenthal Cancer Center
  - Charlotte, North Carolina, United States, 28203
    - Inpatient Pharmacy
  - Winston Salem, North Carolina, United States, 27103
    - Piedmont Hematology Oncology Associates
- North Dakota
  - Bismarck, North Dakota, United States, 58501
    - Odyssey Research
  - Bismarck, North Dakota, United States, 58501
    - Cancer Care Center - Medcenter One, Inc.
  - Bismarck, North Dakota, United States, 58501
    - Cancer Treatment & Research Center - Mid Dakota Clinic, P. C.
  - Fargo, North Dakota, United States, 58104
    - Odyssey Research
  - Fargo, North Dakota, United States, 58103
    - Dakota Cancer Institute
- Ohio
  - Cincinnati, Ohio, United States, 45219
    - University of Cincinnati Medical Center
  - Cincinnati, Ohio, United States, 45219-0501
    - Barrett Cancer Center
  - Cincinnati, Ohio, United States, 45219
    - UC Physician's Medical Arts Building
  - Cleveland, Ohio, United States, 44111
    - Fairview Hospital Moll Pavilion
  - Columbus, Ohio, United States, 43213
    - Mid Ohio Onc/Hem (East)
  - Columbus, Ohio, United States, 43222
    - GOPSA
  - Columbus, Ohio, United States, 43222
    - Mid Ohio Onc/Hem (West)
  - Dayton, Ohio, United States, 45409
    - Miami Valley Hospital
  - Mayfield Heights, Ohio, United States, 44124
    - Hillcrest Hospital/Cleveland Clinic Health System
  - Toledo, Ohio, United States, 43606
    - The Toledo Hospital
  - Toledo, Ohio, United States, 43606
    - ProMedica Health System
  - Toledo, Ohio, United States, 43606
    - Garth Phibbs, M.D., FACOG
  - Westerville, Ohio, United States, 43081
    - Mid Onio Onc/Hem (North)
- Oklahoma
  - Tulsa, Oklahoma, United States, 74136
    - Cancer Care Associates
  - Tulsa, Oklahoma, United States, 74104
    - Cancer Care Associates
- Oregon
  - Portland, Oregon, United States, 97239
    - Oregon Health & Science University
  - Portland, Oregon, United States, 97227
    - Kaiser Permanente Northwest Region
- Pennsylvania
  - Abington, Pennsylvania, United States, 19001
    - Abington Memorial Hospital
  - Dunmore, Pennsylvania, United States, 18512
    - Hematology & Oncology Associates of NEPA
  - Dunmore, Pennsylvania, United States, 18512
    - Advance Imaging
  - Pittsburgh, Pennsylvania, United States, 15213
    - Magee-Womens Hospital of UPMC
  - Scranton, Pennsylvania, United States, 18510
    - Community Medical Center
  - Scranton, Pennsylvania, United States, 18510
    - Moses Taylor Hospital
  - Scranton, Pennsylvania, United States, 18508
    - Viewmont Medical Services
  - Scranton, Pennsylvania, United States, 18510
    - Mercy Health Partners
  - Scranton, Pennsylvania, United States, 18508
    - Hematology & Oncology Associates of NEPA
  - Upland, Pennsylvania, United States, 19013
    - Associates in Hematology-Oncology, P.C.
- South Carolina
  - Charleston, South Carolina, United States, 29407
    - Carolina Center of Gynecologic Oncology, PA
  - Charleston, South Carolina, United States, 29401
    - Roper Hospital-Department of Radiology
  - Columbia, South Carolina, United States, 29210
    - South Carolina Oncology
  - Greenville, South Carolina, United States, 29605
    - Greenville Hospital System
  - Spartanburg, South Carolina, United States, 29303
    - Spartanburg Regional Healthcare System
- South Dakota
  - Sioux Falls, South Dakota, United States, 57104
    - Sioux Valley Clinic Oncology
  - Sioux Falls, South Dakota, United States, 57104
    - Sioux Valley Hospital - North Center Radiology
  - Sioux Falls, South Dakota, United States, 57104
    - Sioux Valley Clinic - Clinical Research Center
  - Sioux Falls, South Dakota, United States, 57105
    - Sioux Valley Clinic OBGYN, Ltd.
- Tennessee
  - Bartlett, Tennessee, United States, 38133
    - The Family Cancer Center
  - Chattanooga, Tennessee, United States, 37403
    - Chattanooga GYN Oncology
  - Chattanooga, Tennessee, United States, 37404
    - Parkridge Medical Center
  - Chattanooga, Tennessee, United States, 37403
    - Baroness Erlander Hospital
  - Collierville, Tennessee, United States, 38017
    - The Family Cancer Center
  - Memphis, Tennessee, United States, 38119
    - The Family Cancer Center
- Texas
  - Arlington, Texas, United States, 76012
    - Arlington Cancer Center
  - Dallas, Texas, United States, 75231
    - Texas Cancer Associates
  - Dallas, Texas, United States, 75230
    - Center for Oncology Research and Treatment, PA
  - Plano, Texas, United States, 75093
    - Texas Cancer Associates
  - Richardson, Texas, United States, 75080
    - Center for Oncology Research and Treatment, PA
- Virginia
  - Danville, Virginia, United States, 24541
    - Danville Hematology and Oncology, Inc.
  - Richmond, Virginia, United States, 23235
    - VCU Health System at Stony Point
  - Richmond, Virginia, United States, 23298
    - VCU Health System-Dalton Oncology Clinic, North Hospital
  - Roanoke, Virginia, United States, 24014
    - Carilion GYN Oncology Associates
- Washington
  - Aberdeen, Washington, United States, 98520
    - Western Washington Oncology, Inc., P.S.
  - Centralia, Washington, United States, 98531
    - Western Washington Oncology, Inc., P. S.
  - Covington, Washington, United States, 98042-4951
    - Covington MultiCare - Oncology Clinic
  - Gig Harbor, Washington, United States, 98335
    - Gig Harbor Medical Oncology
  - Lacey, Washington, United States, 98503
    - Western Washington Oncology, Inc., P.S.
  - Shelton, Washington, United States, 98584
    - Western Washington Oncology, Inc., P.S.
  - Tacoma, Washington, United States, 98405
    - Allenmore Hospital - Hematology Oncology Clinic
  - Tacoma, Washington, United States, 98405
    - MultiCare Health System - Medical Oncology
- Wisconsin
  - Chippewa Falls, Wisconsin, United States, 54729
    - Marshfield Clinic - Chippewa Falls Center
  - Eau Claire, Wisconsin, United States, 54701
    - Marshfield Clinic Cancer Care - Regional Cancer Center - Sacred Heart Hospital
  - Marshfield, Wisconsin, United States, 54449
    - Marshfield Clinic
  - Minocqua, Wisconsin, United States, 54548
    - Marshfield Clinic - Lakeland Center
  - Rice Lake, Wisconsin, United States, 54868
    - Marshfield Clinic - Indianhead Center
  - Stevens Point, Wisconsin, United States, 54481
    - St. Michael's Hospital
  - Wausau, Wisconsin, United States, 54401
    - Marchfield Clinic - Wausau Center
  - Weston, Wisconsin, United States, 54476
    - Marshfield Clinic Weston Center
  - Wisconsin Rapids, Wisconsin, United States, 54494
    - Marshfield Clinic - Wisconsin Rapids Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

Female

Description

Inclusion Criteria:

Are a woman 18 years of age or older
Have histologically or cytologically confirmed epithelial cancer of the ovary or fallopian tube, or primary peritoneal cancer
Have platinum refractory or resistant cancer
Measurable disease according to radiographic RECIST criteria with documented tumor progression

Exclusion Criteria:

Had treatment with first-line chemotherapy other than platinum-based regimens (carboplatin or cisplatin)
Have clinically significant cardiac disease
Have any sign of intestinal obstruction interfering with nutrition at the time of study entry
Are pregnant or lactating
Had prior treatment with liposomal doxorubicin for ovarian cancer
Had prior treatment with TLK286

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: TLK286 in Combination with Carboplatin	Drug: TLK286 in Combination with Carboplatin Experimental Arm
Active Comparator: Doxorubisin HCl Liposome Injection	Drug: Doxorubicin HCl Liposome Injection Active Comparator

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Study Objectives Time Frame: Every 8 Weeks	To demonstrate superiority in the objective response rate (ORR) of TLK286 in combination with carboplatin as compared to active control therapy with liposomal doxorubicin	Every 8 Weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Telik

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2004

Primary Completion (Actual)

July 1, 2008

Study Completion (Actual)

July 1, 2008

Study Registration Dates

First Submitted

February 4, 2005

First Submitted That Met QC Criteria

February 4, 2005

First Posted (Estimate)

February 7, 2005

Study Record Updates

Last Update Posted (Estimate)

May 31, 2012

Last Update Submitted That Met QC Criteria

May 30, 2012

Last Verified

June 1, 2006

More Information

Terms related to this study

Keywords

Ovary

Additional Relevant MeSH Terms

Other Study ID Numbers

TLK286.3024

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Ovarian Neoplasms

Roswell Park Cancer Institute

Completed

Intravital Microscopy in Evaluating Patients With Primary Peritoneal, Fallopian Tube, or Stage IA-IV Ovarian Cancer

Fallopian Tube Carcinoma | Primary Peritoneal Carcinoma | Stage IIA Ovarian Cancer | Stage IIB Ovarian Cancer | Stage IIC Ovarian Cancer | Stage IIIA Ovarian Cancer | Stage IIIB Ovarian Cancer | Stage IIIC Ovarian Cancer | Stage IV Ovarian Cancer | Stage IA Ovarian Cancer | Stage IB Ovarian Cancer | Stage IC... and other conditions

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Completed

Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer

Recurrent Ovarian Carcinoma | Ovarian Neoplasm | Ovarian Clear Cell Tumor | Adnexal Mass | Ovarian Endometrioid Tumor | Ovarian Serous Tumor | Borderline Ovarian Epithelial Tumor

United States
Centre Leon Berard
Cancer Côte d'or registry; Cancer Calvados registry

Unknown

Optimisation of Disease Management in Patients With Epithelial Ovarian Cancer in France (Ovaire01)

Ovarian Epithelial Cancer

France
Maastricht University Medical Center
VieCuri Medical Centre; Orbis Medical Centre; St.Jans Gasthuis Weert; Laurentius...

Terminated

Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal Masses (SUBSONiC)

Ovarian Cancer | Ovarian Carcinoma | Ovarian Cyst | Ovarian Mass

Netherlands
Massachusetts General Hospital
Johns Hopkins University; M.D. Anderson Cancer Center; National Cancer Institute... and other collaborators

Recruiting

Developing a Test for the Detection of Ovarian Cancer

Ovarian Neoplasms | Fallopian Tube Neoplasms | Stage III Ovarian Cancer AJCC v8 | Stage IIIA Ovarian Cancer AJCC v8 | Stage IIIA1 Ovarian Cancer AJCC v8 | Stage IIIA2 Ovarian Cancer AJCC v8 | Stage IIIB Ovarian Cancer AJCC v8 | Stage IIIC Ovarian Cancer AJCC v8 | Stage IV Ovarian Cancer AJCC v8 | Stage... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Survivorship Care Planning in Improving Quality of Life in Survivors of Ovarian Cancer

Cancer Survivor | Stage IIIA Ovarian Epithelial Cancer | Stage IIIB Ovarian Epithelial Cancer | Stage IIIC Ovarian Epithelial Cancer | Stage IIA Ovarian Epithelial Cancer | Stage IIB Ovarian Epithelial Cancer | Stage IIC Ovarian Epithelial Cancer | Stage IA Ovarian Epithelial Cancer | Stage IB Ovarian... and other conditions

United States
Health Science Center of Xi'an Jiaotong University

Recruiting

Efficacy and Safety of Involving Field Radiotherapy in the Oligo-lesions(Metastasis/Recurrent/Refractory) of Ovarian Cancer

Ovarian Cancer | Cancer of the Ovary | Ovarian Neoplasm | Ovary Cancer | Neoplasms, Ovarian | Ovary Neoplasms | Ovary Neoplasm | Cancer of Ovary | Cancer, Ovarian | Ovarian Cancers | Neoplasm, Ovarian | Neoplasm, Ovary | Neoplasms, Ovary | Cancer, Ovarian Stromal | Cancers, Ovary | Ovary Cancers | Cancers, Ovarian

China
Gynecologic Oncology Group
National Cancer Institute (NCI)

Recruiting

Study of Tumor Tissue Samples From Patients Who Have Undergone Surgery for Advanced Stage III or Stage IV Ovarian Epithelial Cancer

Stage IIIA Ovarian Cancer | Stage IIIB Ovarian Cancer | Stage IIIC Ovarian Cancer | Stage IV Ovarian Cancer

United States
University of Washington
National Cancer Institute (NCI)

Completed

Taking Care of Her Program in Patients With Stage III or IV Ovarian Cancer and Spouse Caregivers

Caregiver | Stage IIIA Ovarian Cancer | Stage IIIB Ovarian Cancer | Stage IIIC Ovarian Cancer | Stage IV Ovarian Cancer

United States
Medical University of Lublin

Completed

Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor

Ovarian Cancer | Unexplained Infertility | Borderline Ovarian Tumors | Benign Ovarian Tumor

Poland

Clinical Trials on TLK286 in Combination with Carboplatin

Telik

Completed

Phase 1-2a Dose-Ranging Study of TLK286 in Combination With Docetaxel in Platinum-Resistant Non-Small Cell Lung Cancer

Carcinoma, Non-small-cell Lung

United States
Pfizer

Terminated

Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies

Non-small Cell Lung Cancer | Urothelial Cancer

Spain, Czechia, United States, Australia, United Kingdom, Italy, Canada, Hungary
Charite University, Berlin, Germany
Novartis Pharmaceuticals; KKS Netzwerk

Unknown

Everolimus (RAD001) and Carboplatin in Pretreated Metastatic Breast Cancer

Breast Cancer

Germany
Shen Lin

Unknown

Anti-HER2 Therapy in Patients of HER2 Positive Metastatic Carcinoma of Digestive System

Colorectal Cancer | Esophageal Squamous Cell Carcinoma | Biliary Tract Cancer | Targeted Therapy | HER2

China
Peking Union Medical College

Not yet recruiting

Vedicitumomab Alone or in Combination for the Treatment of Locally Advanced or Metastatic SDC

Salivary Gland Cancer
Hunan Province Tumor Hospital

Not yet recruiting

Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR Mutant Advanced NSCLC-RW (WUKONG-32-RW)

Non-small Cell Lung Cancer

China
Hunan Province Tumor Hospital

Not yet recruiting

Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR-Sensitive Mutations Combined With Co-Mutations Advanced NSCLC (WUKONG-32)

Non-Small Cell Lung Cancer

China
Akeso

Not yet recruiting

A Phase Ib/II Clinical Study of AK127 in Combination With AK112 in Patients With Advanced Solid Tumors

Advanced Solid Tumors
Sun Yat-sen University

Recruiting

Linperlisib in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma

Peripheral T-cell Lymphoma

China
Aurora Health Care

Recruiting

BurstDR Stimulation for Painful Diabetic Neuropathy

Painful Diabetic Neuropathy

United States

TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Doxil in Platinum Refractory or Resistant Ovarian Cancer

Phase III Randomized Study of TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Liposomal Doxorubicin (Doxil) as Second-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-3]

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Study record dates

Study Major Dates

Study Start

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimate)

Study Record Updates

Last Update Posted (Estimate)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Clinical Trials on Ovarian Neoplasms

Clinical Trials on TLK286 in Combination with Carboplatin

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Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in New Zealand

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations