Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus
Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus .
Parkinson'disease is a neurodegenerative disorder characterised by bradykinesia, rigidity, rest tremor and postural instability. Dopaminergic therapy such as L-Dopa and dopamine agonists usually leads to a dramatic improvement of symptoms, but disease progression nevertheless remains inevitable. Bilateral Deep brain stimulation in subthalamic nucleus is now considered the gold standard surgical treatment.
Parkinson'disease mainly affects the nigrostriatal dopaminergic system which is linked to the limbic system and could be responsible of a specific trouble in the recognition in some facial expression.
We hypothesise that patients with Parkinson'disease present a dysfunction of voluntary and automatic treatment of emotional information.
The main purpose of this study is to show if patients with Parkinson'disease present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).
We also examine the role of L-Dopa and the deep brain stimulation on emotion perception
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
40 patients with an Idiopathic Parkinson's disease divided in two groups :
- 20 patients evaluated before surgery and 6 month after surgery
20 patients only evaluated after surgery.
40 paired healthy volunteers
1) Study progress (patients):
Inclusion visit :
Neurological evaluations .
Neuropsychological evaluations : MMS, MADRS, MATTIS, BREF, Wisconsin test, Apathy test, Benton….
Ophthalmic visit : VISTECH
Protocol :
- for patients evaluated before surgery Facial expression recognition test Lexical decision test Made in two conditions : without the treatment (Med OFF) and one hour after the L-Dopa administration (MED ON)
for patients evaluated after surgery Facial expression recognition test Lexical decision test Made in four conditions
- Without stimulation (STIM OFF) and medication (MED OFF)
- MED OFF and STIM ON
- MED ON and STIM OFF
MED ON and STIM ON
2) Study progress (healthy volunteers): Ophthalmic visit MMS Facial expression recognition test Lexical decision test
Undersøgelsestype
Tilmelding (Forventet)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
-
-
-
Clermont-Ferrand, Frankrig, 63003
- CHU
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Age : 30-75 years
- Patient with an idiopathic Parkinson's disease according to the criteria of the "Parkinson's Disease Society Brain Bank" (Hughes et al., 1992)
- Patient treated with a deep brain stimulation according to the French consensus conference of treatment of Parkinson's disease (Consensus Conference Proceeding, 2000)
- Effect of the stimulation 50%
- Affiliation to social security
- Agreement of patients
Exclusion Criteria:
- Patients suffering of an atypical Parkinson syndrome
- Patients with severe tremor before surgery
- Patients with a vision contrast altered.
- Patients who do not understand the words associated with an emotion
- Pregnant women
- Person who participate to an other study
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Diagnostisk
- Tildeling: Ikke-randomiseret
- Interventionel model: Crossover opgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Andet: 2
40 patients with an idiopathic Parkinson's disease and 40 healthy paired volunteers (control group)
|
Ansigtsgenkendelsestest Leksikalsk beslutningstest
Facial expression recognition test Lexical decisiontest
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Ansigtsgenkendelsestest
Tidsramme: % af nøjagtige svar
|
% af nøjagtige svar
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Leksisk beslutningstest
Tidsramme: Tid til at svare
|
Tid til at svare
|
Samarbejdspartnere og efterforskere
Efterforskere
- Ledende efterforsker: Franck Durif, PUPH, University Hospital, Clermont-Ferrand
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- CHU-0033
- RBHP 2007 Durif
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