Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus

Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus .

Parkinson'disease is a neurodegenerative disorder characterised by bradykinesia, rigidity, rest tremor and postural instability. Dopaminergic therapy such as L-Dopa and dopamine agonists usually leads to a dramatic improvement of symptoms, but disease progression nevertheless remains inevitable. Bilateral Deep brain stimulation in subthalamic nucleus is now considered the gold standard surgical treatment.

Parkinson'disease mainly affects the nigrostriatal dopaminergic system which is linked to the limbic system and could be responsible of a specific trouble in the recognition in some facial expression.

We hypothesise that patients with Parkinson'disease present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Parkinson'disease present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

We also examine the role of L-Dopa and the deep brain stimulation on emotion perception

Study Overview

• Status: Completed
• Conditions: Idiopathic Parkinson's Disease
• Intervention / Treatment: Behavioral: Facial expression recognition of emotion; Behavioral: Facial expression recognition of emotion

Detailed Description

40 patients with an Idiopathic Parkinson's disease divided in two groups :

• 20 patients evaluated before surgery and 6 month after surgery

• 20 patients only evaluated after surgery.

  40 paired healthy volunteers

  1) Study progress (patients):

Inclusion visit :

Neurological evaluations .

Neuropsychological evaluations : MMS, MADRS, MATTIS, BREF, Wisconsin test, Apathy test, Benton….

Ophthalmic visit : VISTECH

Protocol :

1. for patients evaluated before surgery Facial expression recognition test Lexical decision test Made in two conditions : without the treatment (Med OFF) and one hour after the L-Dopa administration (MED ON)

2. for patients evaluated after surgery Facial expression recognition test Lexical decision test Made in four conditions

   • Without stimulation (STIM OFF) and medication (MED OFF)
   • MED OFF and STIM ON
   • MED ON and STIM OFF

   • MED ON and STIM ON

     2) Study progress (healthy volunteers): Ophthalmic visit MMS Facial expression recognition test Lexical decision test

• Study Type: Interventional
• Enrollment (Anticipated): 80
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Clermont-Ferrand, France, 63003
    • CHU

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 30 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Age : 30-75 years
• Patient with an idiopathic Parkinson's disease according to the criteria of the "Parkinson's Disease Society Brain Bank" (Hughes et al., 1992)
• Patient treated with a deep brain stimulation according to the French consensus conference of treatment of Parkinson's disease (Consensus Conference Proceeding, 2000)
• Effect of the stimulation 50%
• Affiliation to social security
• Agreement of patients

Exclusion Criteria:

• Patients suffering of an atypical Parkinson syndrome
• Patients with severe tremor before surgery
• Patients with a vision contrast altered.
• Patients who do not understand the words associated with an emotion
• Pregnant women
• Person who participate to an other study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: Non-Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: 2; 40 patients with an idiopathic Parkinson's disease and 40 healthy paired volunteers (control group)	Behavioral: Facial expression recognition of emotion; Facial expression recognition test Lexical decision test; Behavioral: Facial expression recognition of emotion; Facial expression recognition test Lexical decisiontest

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Facial expression recognition test	% of exact responses

Secondary Outcome Measures

Outcome Measure	Time Frame
Lexical decision test	The time to respond

Collaborators and Investigators

• Sponsor: University Hospital, Clermont-Ferrand
• Investigators: Principal Investigator: Franck Durif, PUPH, University Hospital, Clermont-Ferrand

Study record dates

Study Major Dates

• Study Start: September 1, 2007
• Primary Completion (Actual): October 1, 2008
• Study Completion (Actual): October 1, 2009

Study Registration Dates

• First Submitted: April 21, 2008
• First Submitted That Met QC Criteria: April 21, 2008
• First Posted (Estimate): April 22, 2008

Study Record Updates

• Last Update Posted (Estimate): January 19, 2011
• Last Update Submitted That Met QC Criteria: January 18, 2011
• Last Verified: January 1, 2011

More Information

Terms related to this study

• Keywords: Idiopathic Parkinson's disease; Facial expression recognition of emotion; Frequency levels; Automatic and voluntary information treatment; Patient with an Idiopathic Parkinson's disease; L-Dopa; Deep Brain stimulation
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Parkinson Disease
• Other Study ID Numbers: CHU-0033; RBHP 2007 Durif