A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Technology in the in Vivo Diagnosis of Barrett's Oesophagus and Colorectal Polyps: The ELITE Study (ELITE)
Barrett's oesophagus is a condition where the lining of the oesophagus (gullet) wall changes. People with Barrett's oesophagus are at risk of developing oesophageal cancer but can have regular checkups to detect changes before they progress to cancer. Every two years patients with Barrett's are offered examination by passing a fibreoptic tube into the oesophagus (gastroscopy) to remove small tissue samples (biopsies), which are examined in the laboratory to check for changes.
Bowel cancer is the third most common cancer in the UK, and the second leading cause of cancer deaths. Prevention and early detection are the most effective strategies of dealing with bowel cancer. Most cancers develop from benign polyps (growths) in the bowel. Polyps are common and have the potential of developing into cancer over the course of many years.
Patients with a prior diagnosis of Barrett's oesophagus and colonic polyps undergo regular endoscopic examinations known as surveillance endoscopies. This is done to detect changes in the cells of Barrett's oesophagus or further polyps. Current practice is to capture recorded videos of Barrett's surveillance examinations and still images of polyps prior to their removal.
Endoscope technology continues to advance. These newly developed technologies are marketed to have claims of superiority in performance over preceding generations often without the back up of scientific data but at a significant financial cost. The aim of this study is to use endoscopic images and videos recorded as part of routine clinical practice to compare the current version of Olympus endoscopes with the new version launched by the company.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
-
-
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Portsmouth, Det Forenede Kongerige, PO6 3LY
- Queen Alexandra Hospital
-
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Patients attending for Barrett's surveillance OR
- Patients attending for colonic polyp surveillance or screening
- Patients are willing and able to give informed consent.
Exclusion Criteria:
- Polyp syndromes (eg FAP or Lynch Syndrome)
- Known history of IBD
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Diagnostisk
- Tildeling: Ikke-randomiseret
- Interventionel model: Sekventiel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Barrett's surveillance Olympus Spectrum
Barrett's surveillance with Olympus Spectrum.
|
Current generation Olympus endoscope
|
|
Eksperimentel: Barrett's Surveillance Olympus Elite
Barrett's surveillance with Olympus ELITE.
|
New generation Olympus endoscope
|
|
Eksperimentel: Polyp Surveillance Olympus Spectrum
Colonic polyp surveillance/screening with Olympus Spectrum.
|
Current generation Olympus endoscope
|
|
Eksperimentel: Polyp Surveillancewith Olympus ELITE.
Colonic polyp surveillance/screening with Olympus ELITE.
|
New generation Olympus endoscope
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Sensitivity
Tidsramme: Baseline and 1 day
|
Difference in the sensitivity of in vivo lesion characterisation between Lucera Elite vs Lucera Spectrum as compared to final histology.
|
Baseline and 1 day
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Difference in clarity of images/videos between Lucera Elite and Lucera Spectrum technology.
Tidsramme: Baseline and 1 day
|
Difference in clarity of images/videos between Lucera Elite and Lucera Spectrum technology.
|
Baseline and 1 day
|
|
Sensitivity of Dual Focus technology
Tidsramme: Baseline and 1 day
|
Difference in sensitivity of lesion characterisation when using dual focus technology.
|
Baseline and 1 day
|
|
Endoscopists confidence
Tidsramme: Baseline and 1 day
|
Difference in endoscopists' confidence scores in lesion characterisation between new and current technologies.
|
Baseline and 1 day
|
Samarbejdspartnere og efterforskere
Sponsor
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- PHT/2015/105
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
IPD-planbeskrivelse
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
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