Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging) (VAMP-Aging)
29. april 2026 opdateret af: Eduardo Tibirica, MD, PhD, National Institute of Cardiology, Laranjeiras, Brazil
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging".
The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.
Studieoversigt
Status
Ikke rekrutterer endnu
Betingelser
Detaljeret beskrivelse
An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (>80).
Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls.
Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.
Undersøgelsestype
Observationel
Tilmelding (Anslået)
62
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Eduardo Tibirica, MD, PhD
- Telefonnummer: +55-21-99914-6075
- E-mail: etibi@uol.com.br
Studiesteder
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Rio de Janeiro, Brasilien, 22240006
- Eduardo Tibiriçá
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ja
Prøveudtagningsmetode
Sandsynlighedsprøve
Studiebefolkning
An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (>80).
Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls.
Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.
Beskrivelse
Inclusion Criteria:
- Absence of symptoms and history of cardiovascular and cerebrovascular diseases.
- Baseline blood pressure levels within the normal range (< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.
Exclusion Criteria:
- Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents.
- Smoking: Active or quit less than 5 years ago.
- Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.
- Surgery or trauma in the last 60 days.
- Renal Dysfunction: Chronic renal failure (estimated by eGFR < 60 mL/min/1.73m²).
- Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
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elderly (60-80 years)
Evaluation of systemic microcirculation
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Investigation of Systemic Endothelial Microvascular Function
Serving as a marker of systemic muscle strength and sarcopenia.
This test will assess the strength and power of the lower limbs.
Failure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls.
Overall cognitive function will be assessed using the Mini-Mental State Examination.
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very elderly (>80)
Evaluation of systemic microcirculation
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Investigation of Systemic Endothelial Microvascular Function
Serving as a marker of systemic muscle strength and sarcopenia.
This test will assess the strength and power of the lower limbs.
Failure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls.
Overall cognitive function will be assessed using the Mini-Mental State Examination.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Systemic (cutaneous) microcirculatory reactivity.
Tidsramme: up to 20 minutes
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To analyze structural and functional changes in the microcirculation in different ages groups, with emphasis on microvascular endothelial senescence.
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up to 20 minutes
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Muscle Strength
Tidsramme: up to 10 minutes
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Handgrip Dynamometry Maximum isometric strength will be assessed using a manual hydraulic dynamometer.
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up to 10 minutes
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Anslået)
1. juni 2026
Primær færdiggørelse (Anslået)
1. december 2029
Studieafslutning (Anslået)
1. december 2029
Datoer for studieregistrering
Først indsendt
22. april 2026
Først indsendt, der opfyldte QC-kriterier
29. april 2026
Først opslået (Faktiske)
4. maj 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
4. maj 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
29. april 2026
Sidst verificeret
1. april 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- VAMP-Aging
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
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