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The Effects of Immersive Virtual Reality-Based Exergaming Combined With Transcranial Direct Current Stimulation on Executive Functions in Healthy Older Adults

9. maj 2026 opdateret af: Beijing Sport University

The goal of this clinical trial is to investigate the acute effects of immersive virtual reality (VR)-based exergaming combined with transcranial direct current stimulation (tDCS) on executive functions in healthy older adults. The main questions it aims to answer are:

  • Does VR-based exergaming combined with tDCS improve executive function performance in healthy older adults compared with a control condition?
  • Do single interventions (tDCS alone or VR-based exergaming alone) improve executive function performance compared with the control condition?
  • Does the combined intervention produce greater improvements in executive function performance than either intervention alone? Researchers will compare four intervention conditions to evaluate differences in executive function performance following each session.

Participants will:

  • Complete four intervention sessions in a randomized crossover sequence, with a washout period of at least 7 days between sessions
  • Receive the following intervention conditions:
  • sham-tDCS + VR-video
  • tDCS + VR-video
  • sham-tDCS + VR-exergaming
  • tDCS + VR-exergaming
  • Complete executive function assessments immediately after each session, including:
  • the Flanker task for inhibitory control
  • the more-odd shifting task for cognitive flexibility
  • the Corsi block-tapping task for working memory

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

24

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

(1) Age between 60 to 70 years old; (2) Right-handed (Edinburgh Handedness Inventory (Chinese version) > 40); (3) Normal overall cognitive function (Montreal Cognitive Assessment (Beijing version) ≥ 26).

Exclusion Criteria:

(1) Musculoskeletal injury; (2) neurological/neurodegenerative disorders (e.g., Alzheimer's disease); (3) history of brain infections or cerebrovascular diseases; (4) psychiatric disorders (e.g., major depressive disorder, schizophrenia); (5) unstable or chronic medical conditions (e.g., cardiac disease, seizures (personal/family history)); (6) hearing and visual impairments (e.g., color blindness and conditions severely affecting the ability to see the screen or distinguish colors); (7) metal implants (e.g., pacemakers); (8) brain stimulation or exercise training intervention within the past 6 months; (9) failure to meet safety criteria for brain stimulation (e.g., pregnancy)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Andet
  • Tildeling: Randomiseret
  • Interventionel model: Crossover opgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Sham-komparator: Sham tDCS + VR-video
Participants receive sham transcranial direct current stimulation and then watch a virtual reality video.
Enhed: sham transcranial direct current stimulation
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area. Sham stimulation is applied in the same locations for 20 min with only 15s ramp-up and 15s ramp-down stimulation to mimic the sensory experience of real stimulation.
Adfærdsmæssigt: VR-video
For the VR-video condition, participants view a mild plant documentary called Journey of Chinese Plants through the same VR headset. VR-video intervention consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min
Eksperimentel: tDCS + VR-video
Participants receive active transcranial direct current stimulation and then watch a virtual reality video.
Adfærdsmæssigt: VR-video
For the VR-video condition, participants view a mild plant documentary called Journey of Chinese Plants through the same VR headset. VR-video intervention consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min
Enhed: transcranial direct current stimulation
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area. The transcranial direct current stimulation is applied for 20 min at an intensity of 2 mA, with 15 s ramp-up and 15 s ramp-down.
Eksperimentel: Sham tDCS + VR-exergaming
Participants receive sham transcranial direct current stimulation combined with immersive virtual reality-based exergaming.
Enhed: sham transcranial direct current stimulation
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area. Sham stimulation is applied in the same locations for 20 min with only 15s ramp-up and 15s ramp-down stimulation to mimic the sensory experience of real stimulation.
Adfærdsmæssigt: VR-exergaming
For the VR-exergaming condition, participants engage in an interactive rhythm-based fitness game called PowerBeatsVR. It immerses participants in a virtual exercise environment accompanied by dynamic musical beats, with punching and tracking movements. The VR-exergaming consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min
Eksperimentel: tDCS + VR-exergaming
Participants receive active transcranial direct current stimulation combined with immersive virtual reality-based exergaming.
Enhed: transcranial direct current stimulation
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area. The transcranial direct current stimulation is applied for 20 min at an intensity of 2 mA, with 15 s ramp-up and 15 s ramp-down.
Adfærdsmæssigt: VR-exergaming
For the VR-exergaming condition, participants engage in an interactive rhythm-based fitness game called PowerBeatsVR. It immerses participants in a virtual exercise environment accompanied by dynamic musical beats, with punching and tracking movements. The VR-exergaming consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
Reaction time and accuracy of inhibitory control are assessed by the Flanker task.
Tidsramme: Immediately after the intervention.
Immediately after the intervention.

Sekundære resultatmål

Resultatmål
Tidsramme
Reaction time and accuracy of cognitive flexibility are assessed by more odds shifting task.
Tidsramme: Immediately after the intervention.
Immediately after the intervention.
Scores of working memory are assessed by the Corsi Block-Tapping Task
Tidsramme: Immediately after the intervention.
Immediately after the intervention.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Beijing Sport University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

20. maj 2026

Primær færdiggørelse (Anslået)

25. juni 2026

Studieafslutning (Anslået)

25. juni 2026

Datoer for studieregistrering

Først indsendt

9. maj 2026

Først indsendt, der opfyldte QC-kriterier

9. maj 2026

Først opslået (Faktiske)

15. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

15. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

9. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 2024458H

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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Kliniske forsøg med Sunde ældre voksne

Kliniske forsøg med sham transcranial direct current stimulation

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