The Effects of Immersive Virtual Reality-Based Exergaming Combined With Transcranial Direct Current Stimulation on Executive Functions in Healthy Older Adults
9 mei 2026 bijgewerkt door: Beijing Sport University
The goal of this clinical trial is to investigate the acute effects of immersive virtual reality (VR)-based exergaming combined with transcranial direct current stimulation (tDCS) on executive functions in healthy older adults. The main questions it aims to answer are:
- Does VR-based exergaming combined with tDCS improve executive function performance in healthy older adults compared with a control condition?
- Do single interventions (tDCS alone or VR-based exergaming alone) improve executive function performance compared with the control condition?
- Does the combined intervention produce greater improvements in executive function performance than either intervention alone? Researchers will compare four intervention conditions to evaluate differences in executive function performance following each session.
Participants will:
- Complete four intervention sessions in a randomized crossover sequence, with a washout period of at least 7 days between sessions
- Receive the following intervention conditions:
- sham-tDCS + VR-video
- tDCS + VR-video
- sham-tDCS + VR-exergaming
- tDCS + VR-exergaming
- Complete executive function assessments immediately after each session, including:
- the Flanker task for inhibitory control
- the more-odd shifting task for cognitive flexibility
- the Corsi block-tapping task for working memory
Studie Overzicht
Toestand
Nog niet aan het werven
Conditie
Studietype
Ingrijpend
Inschrijving (Geschat)
24
Fase
- Niet toepasbaar
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studiecontact
- Naam: Mengdie Hu
- Telefoonnummer: 86+13011852188
- E-mail: mengdie.hu0818@hotmail.com
Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
- Volwassen
- Oudere volwassene
Accepteert gezonde vrijwilligers
Ja
Beschrijving
Inclusion Criteria:
(1) Age between 60 to 70 years old; (2) Right-handed (Edinburgh Handedness Inventory (Chinese version) > 40); (3) Normal overall cognitive function (Montreal Cognitive Assessment (Beijing version) ≥ 26).
Exclusion Criteria:
(1) Musculoskeletal injury; (2) neurological/neurodegenerative disorders (e.g., Alzheimer's disease); (3) history of brain infections or cerebrovascular diseases; (4) psychiatric disorders (e.g., major depressive disorder, schizophrenia); (5) unstable or chronic medical conditions (e.g., cardiac disease, seizures (personal/family history)); (6) hearing and visual impairments (e.g., color blindness and conditions severely affecting the ability to see the screen or distinguish colors); (7) metal implants (e.g., pacemakers); (8) brain stimulation or exercise training intervention within the past 6 months; (9) failure to meet safety criteria for brain stimulation (e.g., pregnancy)
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Ander
- Toewijzing: Gerandomiseerd
- Interventioneel model: Crossover-opdracht
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
|---|---|
|
Sham-vergelijker: Sham tDCS + VR-video
Participants receive sham transcranial direct current stimulation and then watch a virtual reality video.
|
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area.
Sham stimulation is applied in the same locations for 20 min with only 15s ramp-up and 15s ramp-down stimulation to mimic the sensory experience of real stimulation.
For the VR-video condition, participants view a mild plant documentary called Journey of Chinese Plants through the same VR headset.
VR-video intervention consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min
|
|
Experimenteel: tDCS + VR-video
Participants receive active transcranial direct current stimulation and then watch a virtual reality video.
|
For the VR-video condition, participants view a mild plant documentary called Journey of Chinese Plants through the same VR headset.
VR-video intervention consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area.
The transcranial direct current stimulation is applied for 20 min at an intensity of 2 mA, with 15 s ramp-up and 15 s ramp-down.
|
|
Experimenteel: Sham tDCS + VR-exergaming
Participants receive sham transcranial direct current stimulation combined with immersive virtual reality-based exergaming.
|
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area.
Sham stimulation is applied in the same locations for 20 min with only 15s ramp-up and 15s ramp-down stimulation to mimic the sensory experience of real stimulation.
For the VR-exergaming condition, participants engage in an interactive rhythm-based fitness game called PowerBeatsVR.
It immerses participants in a virtual exercise environment accompanied by dynamic musical beats, with punching and tracking movements.
The VR-exergaming consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min
|
|
Experimenteel: tDCS + VR-exergaming
Participants receive active transcranial direct current stimulation combined with immersive virtual reality-based exergaming.
|
The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area.
The transcranial direct current stimulation is applied for 20 min at an intensity of 2 mA, with 15 s ramp-up and 15 s ramp-down.
For the VR-exergaming condition, participants engage in an interactive rhythm-based fitness game called PowerBeatsVR.
It immerses participants in a virtual exercise environment accompanied by dynamic musical beats, with punching and tracking movements.
The VR-exergaming consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min
|
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Tijdsspanne |
|---|---|
|
Reaction time and accuracy of inhibitory control are assessed by the Flanker task.
Tijdsspanne: Immediately after the intervention.
|
Immediately after the intervention.
|
Secundaire uitkomstmaten
Uitkomstmaat |
Tijdsspanne |
|---|---|
|
Reaction time and accuracy of cognitive flexibility are assessed by more odds shifting task.
Tijdsspanne: Immediately after the intervention.
|
Immediately after the intervention.
|
|
Scores of working memory are assessed by the Corsi Block-Tapping Task
Tijdsspanne: Immediately after the intervention.
|
Immediately after the intervention.
|
Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Sponsor
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Geschat)
20 mei 2026
Primaire voltooiing (Geschat)
25 juni 2026
Studie voltooiing (Geschat)
25 juni 2026
Studieregistratiedata
Eerst ingediend
9 mei 2026
Eerst ingediend dat voldeed aan de QC-criteria
9 mei 2026
Eerst geplaatst (Werkelijk)
15 mei 2026
Updates van studierecords
Laatste update geplaatst (Werkelijk)
15 mei 2026
Laatste update ingediend die voldeed aan QC-criteria
9 mei 2026
Laatst geverifieerd
1 mei 2026
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- 2024458H
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Nee
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
Nee
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