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The Effect of Low or High Dietary Fiber Diet on Volatile Organic Compounds in Exhaled Breath of Healthy Individuals (FIBRE-MATCH)

1. juni 2026 opdateret af: Örebro University, Sweden

Characterization of Fiber-degrading Microbiota in Individuals Without Gastrointestinal Diseases

The aim of this crossover intervention study is to evaluate the volatile organic compounds (VOCs) present in participants at baseline and how these levels change after consuming either a low- or high-dietary fiber diet for three days. This study will involve adults, 18-65 years old, without any gastrointestinal diseases.

The primary objectives are to characterize baseline VOC profiles, assess changes in these profiles after a short-term dietary fiber intervention, determine if specific VOC patterns correlate with dietary fiber intake, and identify the time points at which VOC levels peak. This information will help establish the optimal timing for breath sampling and potentially provide insight into how VOC patterns relate to dietary fiber consumption and degradation.

The expected outcome is that a high-dietary fiber diet will produce a VOC profile enriched in metabolites associated with fiber fermentation compared to a low-dietary fiber diet, and that these VOCs will be consistent with those identified in vitro during fecal fermentation. Each participant will serve as an internal control, enabling within-subject comparisons of VOC levels at baseline and following the dietary fiber intervention.

Participants will receive a whole-food product that is rich in dietary fiber and will consume either a low-fiber diet (10 g/day) or a high-fiber diet (40 g/day) for three days. On the first day of each intervention, participants will also ingest a pH capsule to monitor gastrointestinal pH continuously throughout the three days. After a three-week washout period, participants will cross over to the other intervention arm and undergo another round of gastrointestinal pH monitoring.

In addition to the dietary intervention, participants will complete food and health questionnaires to assess habitual fiber intake and dietary habits. Fecal samples will be collected for in vitro fermentation to functionally profile the gut microbiota by assessing fecal VOCs, short-chain fatty acids (SCFA), and the microbial enzymatic activity and its pH-dependent modulation.

Studieoversigt

Status

Rekruttering

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

20

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Undersøgelse Kontakt Backup

Studiesteder

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  1. Signed informed consent obtained prior to any study-related procedures.
  2. Willingness to refrain from regular consumption of prebiotic or probiotic products, as well as medications known to affect gastrointestinal function, for at least four weeks prior to the study visits.

Exclusion Criteria:

  1. History of complicated gastrointestinal surgery.
  2. Presence of a gastrointestinal diagnosis or any condition that, in the opinion of the principal investigator, may influence the study outcomes.
  3. Current diagnosis of a psychiatric disorder.
  4. Systemic use of antibiotics or steroid medications within the past 3 months.
  5. Frequent use of NSAIDs (non-steroidal anti-inflammatory drugs) within the 2 months preceding the study visit.
  6. Regular consumption of prebiotic or probiotic products within the past 4 weeks.
  7. Alcohol or substance abuse.
  8. Current smoking or use of nicotine pouches.
  9. Frequent use of laxatives, antidiarrheal agents, or anticholinergic medications within the 12 weeks preceding the study visit.
  10. Pregnancy or breastfeeding.
  11. Respiratory disease or infection.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Randomiseret
  • Interventionel model: Crossover opgave
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Low Fiber Diet, Then High Fiber Diet
Participants will receive a whole food dietary fiber product to consume 10g of dietary fiber per day over a total of 3 days, equal to a high fiber diet. After a washout period of 3 weeks, they then receive the same whole food dietary fiber product, to consume 40g of dietary fiber per day in a total of 3 days, equal to a high fiber diet.
Andet: Low, High Fiber Diet

Dietary Intervention: Low Fiber Diet

Whole food dietary fiber product, 10g of dietary fiber consumed per day for 3 days

Dietary Intervention: High Fiber Diet

Whole food dietary fiber product, 40g of dietary fiber consumed per day for 3 days
Eksperimentel: High Fiber Diet, Then Low Fiber Diet
Participants will receive a whole food dietary fiber product to consume 40g of dietary fiber per day over a total of 3 days, equal to a high fiber diet. After a washout period of 3 weeks, they then receive the same whole food dietary fiber product, to consume 10g of dietary fiber per day in a total of 3 days, equal to a high fiber diet.
Andet: High, Low Fiber Diet

Dietary Intervention: High Fiber Diet

Whole food dietary fiber product, 40g of dietary fiber consumed per day for 3 days

Dietary Intervention: Low Fiber Diet

Whole food dietary fiber product, 10g of dietary fiber consumed per day for 3 days

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Effect of a 3-day low fiber diet compared to a 3-day high fiber diet on the Volatile Organic Compound profiles in exhaled breath
Tidsramme: 5 weeks
Volatile Organic Compound profiles in produced by the 3-day low fiber diet intervention compared to the profiles produced by the 3-day high fiber diet, with a 3-week washout inbetween
5 weeks

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Effect of a low fiber diet on Volatile Organic Compound profiles after 4 hours
Tidsramme: 4 hours
Volatile organic compound profiles 4 hours after the start of the low fiber diet intervention compared with baseline (0 hours)
4 hours
Effect of a low fiber diet on Volatile Organic Compound profiles after 6 hours
Tidsramme: 6 hours
Volatile organic compound profiles 6 hours after the start of the low fiber diet intervention compared with baseline (0 hours)
6 hours
Effect of a low fiber diet on Volatile Organic Compound profiles after 8 hours
Tidsramme: 8 hours
Volatile organic compound profiles 8 hours after the start of the low fiber diet intervention compared with baseline (0 hours)
8 hours
Effect of a high fiber diet on Volatile Organic Compound profiles after 4 hours
Tidsramme: 4 hours
Volatile organic compound profiles 4 hours after the start of the high fiber diet intervention compared with baseline (0 hours)
4 hours
Effect of a high fiber diet on Volatile Organic Compound profiles after 6 hours
Tidsramme: 6 hours
Volatile organic compound profiles 6 hours after the start of the high fiber diet intervention compared with baseline (0 hours)
6 hours
Effect of a high fiber diet on Volatile Organic Compound profiles after 8 hours
Tidsramme: 8 hours
Volatile organic compound profiles 8 hours after the start of the high fiber diet intervention compared with baseline (0 hours)
8 hours
Gastrointestinal pH after a 3-day low fiber diet
Tidsramme: 5 weeks
Assessment of Gastrointestinal pH measured by the alpHaONE JSPC-1 pH capsule, after a 3-day low fiber diet
5 weeks
Gastrointestinal pH after a 3-day high fiber diet
Tidsramme: 5 weeks
Assessment of Gastrointestinal pH measured by the alpHaONE JSPC-1 pH capsule, after a 3-day high fiber diet
5 weeks

Andre resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Fecal Volatile Organic Compound profiles
Tidsramme: 1 week
Changes in fecal Volatile Organic Compound profiles produced during fecal fermentation, comparison of baseline (0 hours) profiles with profiles at 24 hours
1 week
SCFA
Tidsramme: 1 Week
Changes in SCFA levels produced during fecal fermentation, comparison of baseline (0 hours) levels with levels at 24 hours
1 Week
Microbial enzymatic activity
Tidsramme: 1 week
Changes in microbial enzymatic activity during fecal fermentation, comparison of baseline (0 hours) activity with activity at 24 hours
1 week
Microbiota composition
Tidsramme: 1 week
Microbiota composition at baseline (0 hours) compared with composition at 24 hours
1 week

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Örebro University, Sweden

Samarbejdspartnere

University of Helsinki
European Innovation Council

Efterforskere

  • Studieleder: Robert Brummer, Professor, Örebro University, Sweden

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

25. maj 2026

Primær færdiggørelse (Anslået)

1. november 2026

Studieafslutning (Anslået)

1. marts 2027

Datoer for studieregistrering

Først indsendt

13. maj 2026

Først indsendt, der opfyldte QC-kriterier

13. maj 2026

Først opslået (Faktiske)

19. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

4. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • 2026-00408-01
  • 101161484 (Andet bevillings-/finansieringsnummer: European Innovation Council (EIC))

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