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The Effect of Low or High Dietary Fiber Diet on Volatile Organic Compounds in Exhaled Breath of Healthy Individuals (FIBRE-MATCH)

1 juni 2026 bijgewerkt door: Örebro University, Sweden

Characterization of Fiber-degrading Microbiota in Individuals Without Gastrointestinal Diseases

The aim of this crossover intervention study is to evaluate the volatile organic compounds (VOCs) present in participants at baseline and how these levels change after consuming either a low- or high-dietary fiber diet for three days. This study will involve adults, 18-65 years old, without any gastrointestinal diseases.

The primary objectives are to characterize baseline VOC profiles, assess changes in these profiles after a short-term dietary fiber intervention, determine if specific VOC patterns correlate with dietary fiber intake, and identify the time points at which VOC levels peak. This information will help establish the optimal timing for breath sampling and potentially provide insight into how VOC patterns relate to dietary fiber consumption and degradation.

The expected outcome is that a high-dietary fiber diet will produce a VOC profile enriched in metabolites associated with fiber fermentation compared to a low-dietary fiber diet, and that these VOCs will be consistent with those identified in vitro during fecal fermentation. Each participant will serve as an internal control, enabling within-subject comparisons of VOC levels at baseline and following the dietary fiber intervention.

Participants will receive a whole-food product that is rich in dietary fiber and will consume either a low-fiber diet (10 g/day) or a high-fiber diet (40 g/day) for three days. On the first day of each intervention, participants will also ingest a pH capsule to monitor gastrointestinal pH continuously throughout the three days. After a three-week washout period, participants will cross over to the other intervention arm and undergo another round of gastrointestinal pH monitoring.

In addition to the dietary intervention, participants will complete food and health questionnaires to assess habitual fiber intake and dietary habits. Fecal samples will be collected for in vitro fermentation to functionally profile the gut microbiota by assessing fecal VOCs, short-chain fatty acids (SCFA), and the microbial enzymatic activity and its pH-dependent modulation.

Studie Overzicht

Toestand

Werving

Conditie

Interventie / Behandeling

Studietype

Ingrijpend

Inschrijving (Geschat)

20

Fase

  • Niet toepasbaar

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studiecontact

Studie Contact Back-up

Studie Locaties

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Volwassen
  • Oudere volwassene

Accepteert gezonde vrijwilligers

Ja

Beschrijving

Inclusion Criteria:

  1. Signed informed consent obtained prior to any study-related procedures.
  2. Willingness to refrain from regular consumption of prebiotic or probiotic products, as well as medications known to affect gastrointestinal function, for at least four weeks prior to the study visits.

Exclusion Criteria:

  1. History of complicated gastrointestinal surgery.
  2. Presence of a gastrointestinal diagnosis or any condition that, in the opinion of the principal investigator, may influence the study outcomes.
  3. Current diagnosis of a psychiatric disorder.
  4. Systemic use of antibiotics or steroid medications within the past 3 months.
  5. Frequent use of NSAIDs (non-steroidal anti-inflammatory drugs) within the 2 months preceding the study visit.
  6. Regular consumption of prebiotic or probiotic products within the past 4 weeks.
  7. Alcohol or substance abuse.
  8. Current smoking or use of nicotine pouches.
  9. Frequent use of laxatives, antidiarrheal agents, or anticholinergic medications within the 12 weeks preceding the study visit.
  10. Pregnancy or breastfeeding.
  11. Respiratory disease or infection.

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Fundamentele wetenschap
  • Toewijzing: Gerandomiseerd
  • Interventioneel model: Crossover-opdracht
  • Masker: Dubbele

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Experimenteel: Low Fiber Diet, Then High Fiber Diet
Participants will receive a whole food dietary fiber product to consume 10g of dietary fiber per day over a total of 3 days, equal to a high fiber diet. After a washout period of 3 weeks, they then receive the same whole food dietary fiber product, to consume 40g of dietary fiber per day in a total of 3 days, equal to a high fiber diet.
Ander: Low, High Fiber Diet

Dietary Intervention: Low Fiber Diet

Whole food dietary fiber product, 10g of dietary fiber consumed per day for 3 days

Dietary Intervention: High Fiber Diet

Whole food dietary fiber product, 40g of dietary fiber consumed per day for 3 days
Experimenteel: High Fiber Diet, Then Low Fiber Diet
Participants will receive a whole food dietary fiber product to consume 40g of dietary fiber per day over a total of 3 days, equal to a high fiber diet. After a washout period of 3 weeks, they then receive the same whole food dietary fiber product, to consume 10g of dietary fiber per day in a total of 3 days, equal to a high fiber diet.
Ander: High, Low Fiber Diet

Dietary Intervention: High Fiber Diet

Whole food dietary fiber product, 40g of dietary fiber consumed per day for 3 days

Dietary Intervention: Low Fiber Diet

Whole food dietary fiber product, 10g of dietary fiber consumed per day for 3 days

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Effect of a 3-day low fiber diet compared to a 3-day high fiber diet on the Volatile Organic Compound profiles in exhaled breath
Tijdsspanne: 5 weeks
Volatile Organic Compound profiles in produced by the 3-day low fiber diet intervention compared to the profiles produced by the 3-day high fiber diet, with a 3-week washout inbetween
5 weeks

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Effect of a low fiber diet on Volatile Organic Compound profiles after 4 hours
Tijdsspanne: 4 hours
Volatile organic compound profiles 4 hours after the start of the low fiber diet intervention compared with baseline (0 hours)
4 hours
Effect of a low fiber diet on Volatile Organic Compound profiles after 6 hours
Tijdsspanne: 6 hours
Volatile organic compound profiles 6 hours after the start of the low fiber diet intervention compared with baseline (0 hours)
6 hours
Effect of a low fiber diet on Volatile Organic Compound profiles after 8 hours
Tijdsspanne: 8 hours
Volatile organic compound profiles 8 hours after the start of the low fiber diet intervention compared with baseline (0 hours)
8 hours
Effect of a high fiber diet on Volatile Organic Compound profiles after 4 hours
Tijdsspanne: 4 hours
Volatile organic compound profiles 4 hours after the start of the high fiber diet intervention compared with baseline (0 hours)
4 hours
Effect of a high fiber diet on Volatile Organic Compound profiles after 6 hours
Tijdsspanne: 6 hours
Volatile organic compound profiles 6 hours after the start of the high fiber diet intervention compared with baseline (0 hours)
6 hours
Effect of a high fiber diet on Volatile Organic Compound profiles after 8 hours
Tijdsspanne: 8 hours
Volatile organic compound profiles 8 hours after the start of the high fiber diet intervention compared with baseline (0 hours)
8 hours
Gastrointestinal pH after a 3-day low fiber diet
Tijdsspanne: 5 weeks
Assessment of Gastrointestinal pH measured by the alpHaONE JSPC-1 pH capsule, after a 3-day low fiber diet
5 weeks
Gastrointestinal pH after a 3-day high fiber diet
Tijdsspanne: 5 weeks
Assessment of Gastrointestinal pH measured by the alpHaONE JSPC-1 pH capsule, after a 3-day high fiber diet
5 weeks

Andere uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Fecal Volatile Organic Compound profiles
Tijdsspanne: 1 week
Changes in fecal Volatile Organic Compound profiles produced during fecal fermentation, comparison of baseline (0 hours) profiles with profiles at 24 hours
1 week
SCFA
Tijdsspanne: 1 Week
Changes in SCFA levels produced during fecal fermentation, comparison of baseline (0 hours) levels with levels at 24 hours
1 Week
Microbial enzymatic activity
Tijdsspanne: 1 week
Changes in microbial enzymatic activity during fecal fermentation, comparison of baseline (0 hours) activity with activity at 24 hours
1 week
Microbiota composition
Tijdsspanne: 1 week
Microbiota composition at baseline (0 hours) compared with composition at 24 hours
1 week

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Örebro University, Sweden

Medewerkers

University of Helsinki
European Innovation Council

Onderzoekers

  • Studie directeur: Robert Brummer, Professor, Örebro University, Sweden

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Geschat)

25 mei 2026

Primaire voltooiing (Geschat)

1 november 2026

Studie voltooiing (Geschat)

1 maart 2027

Studieregistratiedata

Eerst ingediend

13 mei 2026

Eerst ingediend dat voldeed aan de QC-criteria

13 mei 2026

Eerst geplaatst (Werkelijk)

19 mei 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)

4 juni 2026

Laatste update ingediend die voldeed aan QC-criteria

1 juni 2026

Laatst geverifieerd

1 juni 2026

Meer informatie

Termen gerelateerd aan deze studie

Trefwoorden

Andere studie-ID-nummers

  • 2026-00408-01
  • 101161484 (Ander subsidie-/financieringsnummer: European Innovation Council (EIC))

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

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