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Community-acquired Pneumonia Due to Chlamydia Pneumoniae (CHLAMPAC)

30. juni 2026 opdateret af: Centre Hospitalier de Saint-Denis

Prevalence and Phenotyping of Chlamydia Pneumoniae Infections Among Pnuemonias Tested With Simplex and Multiplex PCR

This international retrospective Franco-Swiss study focuses on community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae.

The working hypothesis is that the prevalence of C. pneumoniae pneumonia is overestimated by the medical community.

The primary objective is to determine the true prevalence of C. pneumoniae infections among patients with pneumonia who underwent simplex or multiplex PCR testing.

Secondary objectives include;

  1. Outpatient management
  2. Hospitalization in a medical ward
  3. Admission to the intensive care unit
  4. In-hospital mortality
  5. Radiological presentation of patients with community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae
  6. Prevalence of viral or bacterial co-infections associated with C. pneumoniae CAP

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Detaljeret beskrivelse

This international retrospective Franco-Swiss study focuses on community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae. The working hypothesis is that the prevalence of C. pneumoniae pneumonia is overestimated by the medical community. The primary objective is to determine the true prevalence of C. pneumoniae infections among patients with pneumonia who underwent simplex or multiplex PCR testing. Secondary objectives include;1)Outpatient management2)Hospitalization in a medical ward3)Admission to the intensive care unit4) In-hospital mortality5) Radiological presentation of patients with community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae 6)Prevalence of viral or bacterial co-infections associated with C. pneumoniae CAP

Detailed Description We have all learned and continue to teach that community-acquired pneumonia (CAP) is essentially represented by three bacteria: Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydia pneumoniae. While the recent Mycoplasma outbreak in France and the prevalence of severe Legionella infections in intensive care units confirm the real impact of these pathogens in CAP, the low number of Chlamydia pneumoniae cases documented by PCR raises questions.Over the past twenty years, the development of highly sensitive molecular tests (specific PCR or multiplex PCR targeting intracellular respiratory pathogens) has made it possible to precisely detect Chlamydia pneumoniae and to confirm or rule out its presence in the respiratory tract of patients with pneumonia.We are therefore conducting a retrospective study between France and Switzerland to determine, on the one hand, the number of CAP cases due to Chlamydia pneumoniae confirmed by PCR, and on the other hand, to better characterize the phenotype of these patients.

Undersøgelsestype

Observationel

Tilmelding (Anslået)

200

Kontakter og lokationer

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Studiekontakt

Undersøgelse Kontakt Backup

Studiesteder

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The study population consists of pediatric and adult patients from participating French and Swiss centers who had a positive simplex or multiplex PCR result for Chlamydia pneumoniae on an upper or lower respiratory tract specimen between January 2015 and December 2025. Eligible patients must have a documented diagnosis of pneumonia and available clinical data allowing characterization of disease presentation, management, radiological findings, co-infections, and outcomes. Patients who objected to the use of their medical data for research purposes or who did not have pneumonia are excluded.

Beskrivelse

Inclusion Criteria:

  • Positive simplex or multiplex PCR for Chlamydia pneumoniae on an upper or lower respiratory tract specimen between January 2015 and December 2025.
  • Availability of clinical data allowing confirmation of pneumonia diagnosis.

Exclusion Criteria:

  • Patient opposition to the use of medical data for research purposes.
  • Absence of pneumonia diagnosis.
  • Insufficient clinical data for analysis.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Prevalence of Chlamydia pneumoniae Among Pneumonia Cases Tested by PCR
Tidsramme: January 2015 to December 2025
Proportion of pneumonia cases with a positive simplex or multiplex PCR for Chlamydia pneumoniae among all patients who underwent respiratory PCR testing during the study period.
January 2015 to December 2025

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Clinical Severity of Chlamydia pneumoniae Pneumonia
Tidsramme: From hospital admission through hospital discharge (up to 90 days)
Distribution of patients according to outpatient management, hospitalization in a medical ward, admission to intensive care, and in-hospital mortality.
From hospital admission through hospital discharge (up to 90 days)
Radiological Characteristics
Tidsramme: Baseline (at the time of pneumonia diagnosis)
Chest radiograph and chest computed tomography findings associated with PCR-confirmed Chlamydia pneumoniae pneumonia.
Baseline (at the time of pneumonia diagnosis)
Viral Co-Infection Rate
Tidsramme: Baseline (at the time of PCR testing)
Proportion of patients with concomitant viral infection identified by microbiological testing.
Baseline (at the time of PCR testing)
Bacterial Co-Infection Rate
Tidsramme: Baseline (at the time of PCR testing)
Proportion of patients with concomitant bacterial infection identified by microbiological testing.
Baseline (at the time of PCR testing)
Length of Hospital Stay
Tidsramme: From hospital admission through hospital discharge (up to 90 days)
Duration of hospitalization among admitted patients.
From hospital admission through hospital discharge (up to 90 days)

Samarbejdspartnere og efterforskere

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Sponsor

Centre Hospitalier de Saint-Denis

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

1. juni 2026

Primær færdiggørelse (Anslået)

1. september 2026

Studieafslutning (Anslået)

1. juni 2027

Datoer for studieregistrering

Først indsendt

24. juni 2026

Først indsendt, der opfyldte QC-kriterier

30. juni 2026

Først opslået (Faktiske)

1. juli 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

1. juli 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

30. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 0079_MIR_CHLAMPAC

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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