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Effect of Menstrual Cycle Phase on Pain Perception and Anxiety During Non-Surgical Periodontal Treatment (MAPP)

20. juli 2026 opdateret af: Seda Nur Kabasakal, Karadeniz Technical University

Comparison of Pain Perception and Anxiety Levels During Non-Surgical Periodontal Treatment in Female Patients With Stage II and III Periodontitis at Different Phases of the Menstrual Cycle

This study evaluates the effect of menstrual cycle phases on pain perception and dental anxiety during non-surgical periodontal therapy in premenopausal women with Stage II and III periodontitis. Pain and anxiety levels were assessed using VAS and DAS scales in perimenstrual and postmenstrual phases. Periodontal treatment outcomes were also recorded before and after therapy.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

This study investigated the influence of menstrual cycle phases on pain perception and anxiety levels during non-surgical periodontal therapy (NSPT) in systemically healthy premenopausal women diagnosed with Stage II and III periodontitis. A total of 36 participants were included. Clinical periodontal parameters, including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and bleeding on probing (BoP), were recorded before and after NSPT. Pain perception was assessed using the Visual Analog Scale (VAS), and dental anxiety was evaluated using the Corah Dental Anxiety Scale (DAS). NSPT was performed without local anesthesia using a split-mouth design. Outcomes were compared between perimenstrual and postmenstrual phases.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

36

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Tyrkiet (Türkiye)
    • Trabzon
      • Trabzon, Trabzon, Tyrkiet (Türkiye), 61080
        • Karadeniz Technical University Faculty of Dentistry, Department of Periodontology

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Systemically healthy premenopausal female patients diagnosed with Stage II and III periodontitis attending the Department of Periodontology were included in the study.

Beskrivelse

Inclusion Criteria:

  • Female patients aged 18 years and older diagnosed with Stage II and III periodontitis, systemically healthy, and not using medications affecting pain perception or hormonal status. Participants with regular menstrual cycles were included.

Exclusion Criteria:

  • Patients with systemic diseases, pregnancy or lactation, use of analgesic, anti-inflammatory or hormonal medications, smokers (if excluded), and those with irregular menstrual cycles were excluded.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Perimenstrual Phase Group
Female patients with Stage II and III periodontitis who underwent non-surgical periodontal therapy during the perimenstrual phase.
Procedure: Non Surgical Periodontal Treatment
Standard non-surgical periodontal therapy including scaling and root planing performed without local anesthesia.
Postmenstrual Phase Group
Female patients with Stage II and III periodontitis who underwent non-surgical periodontal therapy during the postmenstrual phase.
Procedure: Non Surgical Periodontal Treatment
Standard non-surgical periodontal therapy including scaling and root planing performed without local anesthesia.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Pain perception
Tidsramme: Immediately after completion of each treatment session (session duration was not fixed and varied according to the extent of treatment required)
Pain perception during non-surgical periodontal therapy assessed using the Visual Analog Scale (VAS; score range: 0-10), where higher scores indicate greater pain intensity, across menstrual cycle phases.
Immediately after completion of each treatment session (session duration was not fixed and varied according to the extent of treatment required)
Dental Anxiety
Tidsramme: Immediately after completion of each treatment session (session duration was not fixed and varied according to the extent of treatment required)
Dental anxiety during non-surgical periodontal therapy was assessed using the Corah Dental Anxiety Scale (DAS; score range: 4-20). The scale consists of four questions related to different dental treatment situations, each with five response options of increasing intensity. Participants were asked to select the response that best reflected their level of anxiety. Higher scores indicate greater anxiety levels, across menstrual cycle phases.
Immediately after completion of each treatment session (session duration was not fixed and varied according to the extent of treatment required)

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Probing Pocket Depth (PPD)
Tidsramme: Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
PPD was measured in millimeters at six sites per tooth using a periodontal probe, and mean values were calculated per participant.
Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
Clinical Attachment Level (CAL)
Tidsramme: Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
CAL was measured in millimeters at six sites per tooth using a periodontal probe, and mean values were calculated per participant.
Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
Gingival Index (GI)
Tidsramme: Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
GI was assessed at four sites per tooth to evaluate gingival inflammation, and mean scores were calculated per participant.
Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
Plaque Index (PI)
Tidsramme: Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
PI was assessed at four sites per tooth to evaluate plaque accumulation, and mean scores were calculated per participant.
Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
Bleeding on Probing (BoP)
Tidsramme: Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy
BoP was recorded as the percentage of sites showing bleeding within 10 seconds after probing.
Baseline (pre-treatment) and 6 weeks after completion of non-surgical periodontal therapy

Samarbejdspartnere og efterforskere

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Sponsor

Karadeniz Technical University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. juni 2024

Primær færdiggørelse (Faktiske)

1. maj 2025

Studieafslutning (Faktiske)

1. maj 2025

Datoer for studieregistrering

Først indsendt

2. juli 2026

Først indsendt, der opfyldte QC-kriterier

20. juli 2026

Først opslået (Faktiske)

22. juli 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

22. juli 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

20. juli 2026

Sidst verificeret

1. juli 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • KTU-DENT-SK-01

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

Individual participant data will not be shared due to patient confidentiality and privacy considerations. Data may contain sensitive clinical and personal health information. Therefore, access to the dataset will be restricted to the study investigators only.

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Kliniske forsøg med Paradentose

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