Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Healthy Individuals H
31. august 2026 opdateret af: Silvia Ulrich Somaini
Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in healthy individuals, who live permanently >2600m.
Studieoversigt
Status
Ikke rekrutterer endnu
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
The aim of this research is to investigate the heart rate variability and other hemodynamic outcomes during the descent from 2850m to sea level and during re-ascent from sea level to 2850m in healthy individuals, who permanently live at high altitude over 2600m
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
14
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Silvia Ulrich, Prof. Dr. med.
- Telefonnummer: +41442552220
- E-mail: silvia.ulrich@usz.ch
Undersøgelse Kontakt Backup
- Navn: Michael Furian, Prof. Dr. sc. ETH
- Telefonnummer: +41442552220
Studiesteder
-
-
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Zurich, Schweiz, 8091
- University Hospital of Zurich
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Adults aged 18-80 years and of all genders
- Permanent residence > 2600 m
- healthy: no self perceived cardiopulmonary disease limiting daily activities
- written informed consent to participate in the study.
Exclusion Criteria:
- Age <18 years or >80 years
- Participants who cannot follow the study investigations
- Participants permanently living < 2600m
- Participants who traveled and stayed overnight at altitudes <2000 m in the past 4 weeks.
- any self-perceived cardiopulmonary disease limiting daily activities
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Støttende pleje
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Eksperimentel: Heart rate variability HRV during descent and re-ascent
Assessment of heart rate variability and other hemodynamic outcomes in healthy individuals during descent from 2850m to sea level and during re-ascent from sea level (after one week stay) back to their living altitude at 2850m
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Descent from 2850m to sea level (in one day by bus) and re-ascent after 7 days from sea level to 2850m (in one day by bus)
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Heart rate variability HRV during descent and re-ascent
Tidsramme: From day of descent (day 1) and day of re-ascent (day 8)
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Difference/change in heart rate variability at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals
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From day of descent (day 1) and day of re-ascent (day 8)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
SpO2 during descent and re-ascent
Tidsramme: From day of descent (day 1) and day of re-ascent (day 8)
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Difference/change in SpO2 at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals
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From day of descent (day 1) and day of re-ascent (day 8)
|
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ECG-Repolarization during descent and re-ascent
Tidsramme: From day of descent (day 1) and day of re-ascent (day 8)
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Occurrence/changes in cardial arrhythmias at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals
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From day of descent (day 1) and day of re-ascent (day 8)
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Cardial arrhythmias during descent and re-ascent
Tidsramme: From day of descent (day 1) and day of re-ascent (day 8)
|
Occurrence/changes in cardial arrhythmias at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals
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From day of descent (day 1) and day of re-ascent (day 8)
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Pulse transit time during descent and re-ascent
Tidsramme: From day of descent (day 1) and day of re-ascent (day 8)
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Occurrence and difference/change in pulse transit time (drops) at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals
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From day of descent (day 1) and day of re-ascent (day 8)
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Silvia Ulrich, University Hospital Zurich, Departement of Pulmonology
- Ledende efterforsker: Rodrigo Hoyos, Hospital Carlos Andrade Marin of Quito, Ecuador
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Anslået)
25. september 2026
Primær færdiggørelse (Anslået)
4. oktober 2026
Studieafslutning (Anslået)
31. december 2026
Datoer for studieregistrering
Først indsendt
17. august 2026
Først indsendt, der opfyldte QC-kriterier
31. august 2026
Først opslået (Faktiske)
3. september 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
3. september 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
31. august 2026
Sidst verificeret
1. august 2026
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- Ec_DEvsA_HRV_H
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
JA
IPD-planbeskrivelse
Data will be provided upon request and based on a clear intention reviewed by an ethical review board.
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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Ingen
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
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