Value of Optic Nerve Sheath Diameter in Differentiating Ischemic From Hemorrhagic Stroke
8. september 2026 opdateret af: Cagdas Yildirim, MD, Ankara City Hospital Bilkent
Diagnostic Value of Bedside Ultrasonographic Optic Nerve Sheath Diameter Measurement in Differentiating Ischemic From Hemorrhagic Stroke in the Emergency Department
We aimed to examine bedside ONSD values measured by ocular ultrasonography in patients presenting to the ED with stroke, and to determine a diagnostic cut-off value for differentiating ischemic from hemorrhagic stroke.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
This study was conducted prospectively and observationally in the adult emergency department of a tertiary training and research hospital.
Patients older than 18 years who presented to the ED with stroke on the investigator's shift days, who were not followed up or treated by the investigator, and who were diagnosed with cerebrovascular disease (CVD) by radiological imaging (CT/MRI) were included in the study.
Patients who were intubated, those who were unwilling to participate, and those in whom mass, aneurysm, metastasis, hydrocephalus, sarcoidosis, ventriculoperitoneal shunt, optic neuritis, or any cause that could lead to cerebral edema or affect the ONSD by raising ICP was identified in their history or on imaging were excluded.
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
64
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
-
Ankara, Tyrkiet (Türkiye)
- Ankara Bilkent City Hospital Emergency Medicine Department
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
The study population consists of adult patients (aged 18 years and older) who presented to the adult emergency department of a tertiary training and research hospital with symptoms of acute stroke.
To be included in this population, patients must have a confirmed diagnosis of cerebrovascular disease (either ischemic or hemorrhagic stroke) verified by radiological neuroimaging (CT or MRI).
The population strictly excludes intubated patients and individuals with a history or imaging evidence of pre-existing conditions that could independently raise intracranial pressure or cause cerebral edema, such as intracranial masses, aneurysms, metastases, hydrocephalus, or optic neuritis.
Beskrivelse
Inclusion Criteria:
- Patients older than 18 years presenting to the ED with stroke.
- Patients diagnosed with cerebrovascular disease (CVD) by radiological imaging (CT/MRI).
Exclusion Criteria:
- Patients who are intubated. Patients unwilling to participate.
- History or imaging findings of mass, aneurysm, metastasis, hydrocephalus, sarcoidosis, ventriculoperitoneal shunt, or optic neuritis.
- Any condition leading to cerebral edema or affecting ONSD by independently raising intracranial pressure.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
Group 1
Hemorrhagic Stroke Patients
|
Measurement of the optic nerve sheath diameter using a high-frequency (4-10 MHz) linear probe at 3 mm posterior to the papilla, immediately after the CT/MRI procedure.
|
|
Group 2
Ischemic Stroke Patients
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Measurement of the optic nerve sheath diameter using a high-frequency (4-10 MHz) linear probe at 3 mm posterior to the papilla, immediately after the CT/MRI procedure.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Cut-off Value of Optic Nerve Sheath Diameter (ONSD)
Tidsramme: Evaluated immediately following the initial imaging procedure (CT/MRI) in the emergency department.
|
Determination of the optimal ONSD cut-off value (in millimeters) to effectively differentiate between ischemic and hemorrhagic stroke subtypes.
|
Evaluated immediately following the initial imaging procedure (CT/MRI) in the emergency department.
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Liu D, Li Z, Zhang X, Zhao L, Jia J, Sun F, Wang Y, Ma D, Wei W. Assessment of intracranial pressure with ultrasonographic retrobulbar optic nerve sheath diameter measurement. BMC Neurol. 2017 Sep 29;17(1):188. doi: 10.1186/s12883-017-0964-5.
- Sekhon MS, Griesdale DE, Robba C, McGlashan N, Needham E, Walland K, Shook AC, Smielewski P, Czosnyka M, Gupta AK, Menon DK. Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury. Intensive Care Med. 2014 Sep;40(9):1267-74. doi: 10.1007/s00134-014-3392-7. Epub 2014 Jul 18.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. april 2021
Primær færdiggørelse (Faktiske)
30. september 2021
Studieafslutning (Faktiske)
31. december 2021
Datoer for studieregistrering
Først indsendt
8. september 2026
Først indsendt, der opfyldte QC-kriterier
8. september 2026
Først opslået (Faktiske)
14. september 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
14. september 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
8. september 2026
Sidst verificeret
1. september 2026
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- ASH3
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