Exploring Ketamine's Effects on Depression and Anxiety in Adults With Low Vision
The purpose of this open-label study is to evaluate the effects of a single intravenous infusion of ketamine on depression and anxiety in adults with low vision.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Undersøgelsestype
Tilmelding (Anslået)
Fase
- Fase 2
Kontakter og lokationer
Studiekontakt
- Navn: Study Team
- Telefonnummer: 650-497-5942
- E-mail: glaucomatrials@stanford.edu
Undersøgelse Kontakt Backup
- Navn: Kalena Caravalho
- Telefonnummer: 650-723-4095
- E-mail: ocdresearch@stanford.edu
Studiesteder
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California
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Stanford, California, Forenede Stater, 94305
- Department of Psychiatry & Behavioral Sciences
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Kontakt:
- OCD Research
- Telefonnummer: 650-723-4095
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria for Participants with Low Vision:
- Ages 18 and older
- Qualifies as a low vision participant based on ophthalmology assessments
- Capacity to provide informed consent
Inclusion Criteria for Healthy Controls:
- Ages 18 and older
- Qualifies as a normal vision participant based on ophthalmology assessments
- Capacity to provide informed consent
- Likely able to tolerate clinical study procedures
- No current or lifetime psychiatric diagnosis
- No current or past use of psychotropic medication
Exclusion Criteria for Participants with Low Vision and Healthy Controls:
- allergy to ketamine
- Any current or past medical/psychiatric condition that makes participation unsafe in the opinion of the investigator or study physician
- Pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Ikke-randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Low Vision
Adults with low vision, as determined by ophthalmology assessments |
Single intravenous racemic ketamine hydrochloride, 0.5 mg/kg in 100 ml of normal saline, infused over 40 minutes with continuous monitoring of vital signs.
Andre navne:
|
|
Andet: Healthy Controls
Healthy adults with normal vision and no psychiatric diagnosis |
Single intravenous racemic ketamine hydrochloride, 0.5 mg/kg in 100 ml of normal saline, infused over 40 minutes with continuous monitoring of vital signs.
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in depression symptom severity as measured by the Hamilton Depression Rating Scale 17 (HDRS-17)
Tidsramme: Baseline (pre-infusion) to 1 week (post-infusion)
|
Change in depression severity is measured by the Hamilton Depression Rating Scale 17 (HDRS-17). For the HDRS-17 the minimum units are 0 and Maximum units on the total scale are 52. The higher the number on the HDRS-17, the more severe the symptoms, a reduction means improvement in depression symptoms. Response is defined as ≥ 50% reduction in score from baseline. |
Baseline (pre-infusion) to 1 week (post-infusion)
|
|
Change in anxiety symptom severity as measured by the Hamilton Anxiety Rating Scale (HAM-A)
Tidsramme: Baseline (pre-infusion) to 1 week (post-infusion)
|
Change in anxiety severity is measured by the Hamilton Anxiety Rating Scale (HAM-A). For the HAM-A the minimum units are 0 and Maximum units on the total scale are 56. The higher the number on the HAM-A, the more severe the symptoms, a reduction means improvement in anxiety symptoms. Response is defined as ≥ 50% reduction in score from baseline. |
Baseline (pre-infusion) to 1 week (post-infusion)
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: Carolyn I Rodriguez, MD, PhD, Stanford University
Datoer for undersøgelser
Studer store datoer
Studiestart (Anslået)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Neurologiske manifestationer
- Sygdomme i nervesystemet
- Psykiske lidelser
- Adfærdsmæssige symptomer
- Øjensygdomme
- Sensationsforstyrrelser
- Patologiske tilstande, tegn og symptomer
- Opførsel
- Tegn og symptomer
- Angstlidelser
- Depression
- Syn, lav
- Synsforstyrrelser
- Organiske kemikalier
- Kulbrinter
- Cyclohexanes
- Cycloparaffiner
- Kulbrinter, alicyklisk
- Kulbrinter, cyklisk
- Ketamin
Andre undersøgelses-id-numre
- 88727
Plan for individuelle deltagerdata (IPD)
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Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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