Weekly Infusions of Paclitaxel in Treating Women With Stage III or Stage IV Ovarian Cancer Refractory to Paclitaxel and Platinum
A Phase II Trial of Paclitaxel (Taxol) Administered as a Weekly One Hour Infusion in Patients With Taxol/Platinum-Refractory Stage III and IV Ovarian Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different ways may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating women with stage III or stage IV ovarian cancer that is refractory to paclitaxel and platinum-based regimens.
Studienübersicht
Status
Intervention / Behandlung
Detaillierte Beschreibung
OBJECTIVES: I. Determine the objective response rate of paclitaxel given as a weekly one hour infusion in patients with paclitaxel/platinum refractory stage III and IV ovarian cancer. II. Evaluate the safety of paclitaxel in this patient population. III. Assess the overall survival in these patients. IV. Assess quality of life in these patients.
OUTLINE: This is a multicenter, open label, nonrandomized study. Patients are administered paclitaxel as a one hour IV infusion every 7 days. Each cycle consists of four weeks. Treatment may be delayed for up to 2 weeks and there is no limit to the number of interruptions a patient may experience. Patients receive paclitaxel weekly until disease progression or unacceptable toxicity. Treatment is assessed every 3 cycles for one year and then every 6 months thereafter during study. Quality of life is assessed every cycle for the first 6 cycles, then every 3 cycles thereafter. Patients are followed every 3 months for survival.
PROJECTED ACCRUAL: There will be 100 patients accrued into this study.
Studientyp
Einschreibung (Voraussichtlich)
Phase
- Phase 2
Kontakte und Standorte
Studienorte
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Alabama
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Mobile, Alabama, Vereinigte Staaten, 36608
- Oncology Center at Providence Park
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Arizona
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Phoenix, Arizona, Vereinigte Staaten, 85013
- Hematology Associates, Ltd.
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Arkansas
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Fayetteville, Arkansas, Vereinigte Staaten, 72703
- Highlands Oncology Group, P.A.
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California
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Santa Barbara, California, Vereinigte Staaten, 93105
- Cancer Center of Santa Barbara
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Florida
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West Palm Beach, Florida, Vereinigte Staaten, 33401
- Good Samaritan Medical Center
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Illinois
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Decatur, Illinois, Vereinigte Staaten, 62526
- Decatur Memorial Hospital Cancer Care Institute
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Nebraska
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Omaha, Nebraska, Vereinigte Staaten, 68131-2197
- Creighton University Cancer Center
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New Jersey
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Neptune, New Jersey, Vereinigte Staaten, 07753
- Jersey Shore Cancer Center
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New York
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Albany, New York, Vereinigte Staaten, 12209
- Women's Health Center at Albany Medical Center
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North Carolina
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Charlotte, North Carolina, Vereinigte Staaten, 28232-2861
- Carolinas Medical Center
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Ohio
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Akron, Ohio, Vereinigte Staaten, 44302
- Akron General Medical Center
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Cincinnati, Ohio, Vereinigte Staaten, 45219
- Oncology/Hematology Care, Inc.
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Cleveland, Ohio, Vereinigte Staaten, 44195
- Cleveland Clinic Cancer Center
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Pennsylvania
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Harrisburg, Pennsylvania, Vereinigte Staaten, 17105-8700
- Women's Cancer Center of Central PA, P.C.
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Rhode Island
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Providence, Rhode Island, Vereinigte Staaten, 02905
- Women and Infants Hospital of Rhode Island
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Tennessee
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Nashville, Tennessee, Vereinigte Staaten, 37203
- Brookview Research, Inc.
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Texas
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Amarillo, Texas, Vereinigte Staaten, 79106
- Harrington Cancer Center
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Washington
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Spokane, Washington, Vereinigte Staaten, 99202
- Rockwood Clinic P.S.
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
Akzeptiert gesunde Freiwillige
Studienberechtigte Geschlechter
Beschreibung
DISEASE CHARACTERISTICS: Histologically confirmed stage III or IV ovarian cancer that is refractory to an initial chemotherapy regimen that included a platinum agent plus paclitaxel - Epithelial ovarian cancer - Primary carcinoma of the peritoneum - Fallopian tube cancer Initial response to platinum and paclitaxel must have been one of the following: Progression or stable disease Response that lasted less than 3 months Response that lasted at least 3 months, but when retreated with both agents (in combination or as single agents) disease was refractory Measurable or evaluable disease Evaluable disease is defined by: CA-125 at least 100 units/mL AND CA-125 level must have at least doubled from baseline determination
PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: At least 3 months Hematopoietic: Absolute granulocyte count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 2 times upper limit of normal (ULN) AST or ALT no greater than 2.5 times ULN Renal: Creatinine no greater than 2.0 mg/dL Cardiovascular: No New York Heart Association Class III or IV heart disease No myocardial infarction within last 6 months No congestive heart failure No unstable angina No clinically significant pericardial effusion or arrhythmia Neurology: No current peripheral neuropathy of any etiology that is greater than grade 1 Other: No active serious infection or other serious underlying medical condition No prior significant allergic reactions to drugs containing Cremophor, such as teniposide, cyclosporin, or vitamin K Not pregnant or nursing Adequate contraception required of all fertile patients
PRIOR CONCURRENT THERAPY: Biologic therapy: At least 3 weeks since immunotherapy No concurrent immunotherapy Chemotherapy: Prior paclitaxel treatment must have been administered on a 3 week or greater schedule No other prior chemotherapy besides platinum and paclitaxel At least 3 weeks since acceptable chemotherapy Endocrine therapy: At least 3 weeks since hormonal therapy No concurrent hormonal therapy Radiotherapy: At least 3 weeks since radiotherapy No prior radiation to greater than 30% of bone marrow Surgery: At least 3 weeks since major surgery
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Behandlung
Mitarbeiter und Ermittler
Sponsor
Ermittler
- Studienstuhl: Maurie Markman, MD, The Cleveland Clinic
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Schätzen)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Schätzen)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
Zusätzliche relevante MeSH-Bedingungen
- Neubildungen nach histologischem Typ
- Neubildungen
- Urogenitale Neoplasmen
- Neubildungen nach Standort
- Karzinom
- Neubildungen, Drüsen und Epithelien
- Genitale Neubildungen, weiblich
- Erkrankungen des endokrinen Systems
- Eierstockerkrankungen
- Adnexerkrankungen
- Gonadenstörungen
- Neoplasmen der endokrinen Drüse
- Eileitererkrankungen
- Eierstocktumoren
- Eileiterneoplasmen
- Karzinom, Eierstockepithel
- Molekulare Mechanismen der pharmakologischen Wirkung
- Antineoplastische Mittel
- Tubulin-Modulatoren
- Antimitotische Mittel
- Mitose-Modulatoren
- Antineoplastische Mittel, Phytogen
- Paclitaxel
Andere Studien-ID-Nummern
- CDR0000065955
- THERADEX-B97-3250
- BMS-TAX/MEN.03
- NCI-V97-1366
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