Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance (DEV)
18. Januar 2013 aktualisiert von: Washington University School of Medicine
VLDL-triglyceride Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
This study is being conducted to learn more about the role of diet and exercise in regulating plasma triglyceride (fat) metabolism.
The investigators will examine the effect of acute (24 hour) changes in energy intake and expenditure on fat metabolism the following day.
Studienübersicht
Status
Abgeschlossen
Bedingungen
Detaillierte Beschreibung
Excess body fat and a sedentary lifestyle are associated with increased plasma triglyceride (TG) and apolipoprotein B-100 (apoB-100) concentrations, which are important risk factors for the development of cardiovascular disease.
Weight loss and endurance exercise improve plasma lipid and lipoprotein concentrations. However, the mechanisms responsible for this effect are largely unknown, and much uncertainty remains regarding the independent roles of dietary energy intake, exercise energy expenditure, and net energy balance in controlling plasma TG concentrations.
The main goal of this project, therefore, is to investigate the mechanisms by which acute alterations in energy balance, induced by diet and/or physical activity (endurance exercise), regulate very-low density lipoprotein (VLDL) metabolism.
Subjects will be asked to perform 3 separate trials. One of these will always be an "energy balance" trial that will act as the control trial for the other 2 trials they perform. Subjects will therefore be randomized to 2 different study arms.
Studientyp
Interventionell
Einschreibung (Tatsächlich)
12
Phase
- Unzutreffend
Kontakte und Standorte
Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.
Studienorte
-
-
Missouri
-
Saint Louis, Missouri, Vereinigte Staaten, 63110
- Washington University in Saint Louis
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-
Teilnahmekriterien
Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.
Zulassungskriterien
Studienberechtigtes Alter
21 Jahre bis 50 Jahre (Erwachsene)
Akzeptiert gesunde Freiwillige
Ja
Studienberechtigte Geschlechter
Männlich
Beschreibung
Inclusion Criteria:
- overweight and obese men
- normal to mild hypertriglyceridemia
Exclusion Criteria:
- Smoking
- Any medical condition other than increased body weight (e.g. diabetes, heart disease, etc.).
- Use of drugs known to affect lipid metabolism (e.g. statins, etc.).
- Regular exercise training.
Studienplan
Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Verhütung
- Zuteilung: Zufällig
- Interventionsmodell: Einzelgruppenzuweisung
- Maskierung: Keine (Offenes Etikett)
Waffen und Interventionen
Teilnehmergruppe / Arm |
Intervention / Behandlung |
|---|---|
|
Experimental: Positive energy balance
Comparison between isocaloric and hypercaloric diets with no exercise performed in any trials
|
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands.
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
|
|
Experimental: Energy balance with exercise
Comparison between an isocaloric diet without exercise and a hypercaloric diet with a sufficient amount of exercise performed to match the excess calories consumed resulting in both trials being in net energy balance.
|
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands but will perform 2 hours of exercise that will be sufficient to burn off the excess calories consumed resulting in subjects being in net energy balance.
|
|
Experimental: Negative energy balance
Comparison between isocaloric and hypocaloric diets with no exercise performed in any trials
|
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Subjects will consume over a 24 h period only 66% of the calories required to meet their energy demands such that they will be in a net negative calorie balance in this trial.
|
|
Experimental: Negative energy balance with exercise
Comparison between consuming an isocaloric diet without exercise and consuming the same amount of calories as in the isocaloric trial but with exercise performed resulting in net negative energy balance in the exercise trial.
|
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Subjects will consume over a 24 hour period the same amount of calories as ingested in the isocaloric trial but will also perform 2 hours of exercise that will be sufficient to burn off a third of the calories they consumed during this day resulting in subjects being in net negative energy balance in this trial
|
Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Zeitfenster |
|---|---|
|
Very Low Density Lipoprotein-Triglyceride and apoB-100 concentrations
Zeitfenster: After acute (24 hour) changes in energy intake and/or energy expenditure
|
After acute (24 hour) changes in energy intake and/or energy expenditure
|
Sekundäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
|
Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 secretion rates
Zeitfenster: After acute (24 hour) changes in energy intake and/or energy expenditure
|
After acute (24 hour) changes in energy intake and/or energy expenditure
|
|
|
Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 clearance rates from plasma
Zeitfenster: After acute (24 hour) changes in energy intake and/or energy expenditure
|
After acute (24 hour) changes in energy intake and/or energy expenditure
|
|
|
Plasma glucose concentration and turnover rate
Zeitfenster: After acute (24 hour) changes in energy intake and/or energy expenditure
|
After acute (24 hour) changes in energy intake and/or energy expenditure
|
|
|
Plasma insulin concentration
Zeitfenster: After acute (24 hour) changes in energy intake and/or energy expenditure
|
After acute (24 hour) changes in energy intake and/or energy expenditure
|
|
|
Plasma free fatty acid concentration and turnover rate
Zeitfenster: After acute (24 hour) changes in energy intake and/or energy expenditure
|
After acute (24 hour) changes in energy intake and/or energy expenditure
|
|
|
Plasma glucose concentration
Zeitfenster: During acute (24 hour) changes in energy intake and/or energy expenditure
|
Measured hourly over the 24 h period.
|
During acute (24 hour) changes in energy intake and/or energy expenditure
|
|
Plasma insulin concentration
Zeitfenster: During acute (24 hour) changes in energy intake and/or energy expenditure
|
Measured hourly over the 24 h period.
|
During acute (24 hour) changes in energy intake and/or energy expenditure
|
|
Plasma free fatty acid concentration
Zeitfenster: During acute (24 hour) changes in energy intake and/or energy expenditure
|
Measured hourly over the 24 h period.
|
During acute (24 hour) changes in energy intake and/or energy expenditure
|
Mitarbeiter und Ermittler
Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.
Publikationen und hilfreiche Links
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Studienaufzeichnungsdaten
Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.
Haupttermine studieren
Studienbeginn
1. April 2006
Primärer Abschluss (Tatsächlich)
1. Dezember 2012
Studienabschluss (Tatsächlich)
1. Dezember 2012
Studienanmeldedaten
Zuerst eingereicht
26. Januar 2009
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
26. Januar 2009
Zuerst gepostet (Schätzen)
28. Januar 2009
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Schätzen)
21. Januar 2013
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
18. Januar 2013
Zuletzt verifiziert
1. Januar 2013
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
Zusätzliche relevante MeSH-Bedingungen
Andere Studien-ID-Nummern
- 05-0195
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