- ICH GCP
- Rejestr badań klinicznych w USA
- Badanie kliniczne NCT00830999
Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance (DEV)
VLDL-triglyceride Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
Przegląd badań
Status
Warunki
Szczegółowy opis
Excess body fat and a sedentary lifestyle are associated with increased plasma triglyceride (TG) and apolipoprotein B-100 (apoB-100) concentrations, which are important risk factors for the development of cardiovascular disease.
Weight loss and endurance exercise improve plasma lipid and lipoprotein concentrations. However, the mechanisms responsible for this effect are largely unknown, and much uncertainty remains regarding the independent roles of dietary energy intake, exercise energy expenditure, and net energy balance in controlling plasma TG concentrations.
The main goal of this project, therefore, is to investigate the mechanisms by which acute alterations in energy balance, induced by diet and/or physical activity (endurance exercise), regulate very-low density lipoprotein (VLDL) metabolism.
Subjects will be asked to perform 3 separate trials. One of these will always be an "energy balance" trial that will act as the control trial for the other 2 trials they perform. Subjects will therefore be randomized to 2 different study arms.
Typ studiów
Zapisy (Rzeczywisty)
Faza
- Nie dotyczy
Kontakty i lokalizacje
Lokalizacje studiów
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Missouri
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Saint Louis, Missouri, Stany Zjednoczone, 63110
- Washington University in Saint Louis
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Kryteria uczestnictwa
Kryteria kwalifikacji
Wiek uprawniający do nauki
Akceptuje zdrowych ochotników
Płeć kwalifikująca się do nauki
Opis
Inclusion Criteria:
- overweight and obese men
- normal to mild hypertriglyceridemia
Exclusion Criteria:
- Smoking
- Any medical condition other than increased body weight (e.g. diabetes, heart disease, etc.).
- Use of drugs known to affect lipid metabolism (e.g. statins, etc.).
- Regular exercise training.
Plan studiów
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Zapobieganie
- Przydział: Randomizowane
- Model interwencyjny: Zadanie dla jednej grupy
- Maskowanie: Brak (otwarta etykieta)
Broń i interwencje
Grupa uczestników / Arm |
Interwencja / Leczenie |
---|---|
Eksperymentalny: Positive energy balance
Comparison between isocaloric and hypercaloric diets with no exercise performed in any trials
|
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands.
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
|
Eksperymentalny: Energy balance with exercise
Comparison between an isocaloric diet without exercise and a hypercaloric diet with a sufficient amount of exercise performed to match the excess calories consumed resulting in both trials being in net energy balance.
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Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands but will perform 2 hours of exercise that will be sufficient to burn off the excess calories consumed resulting in subjects being in net energy balance.
|
Eksperymentalny: Negative energy balance
Comparison between isocaloric and hypocaloric diets with no exercise performed in any trials
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Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Subjects will consume over a 24 h period only 66% of the calories required to meet their energy demands such that they will be in a net negative calorie balance in this trial.
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Eksperymentalny: Negative energy balance with exercise
Comparison between consuming an isocaloric diet without exercise and consuming the same amount of calories as in the isocaloric trial but with exercise performed resulting in net negative energy balance in the exercise trial.
|
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Subjects will consume over a 24 hour period the same amount of calories as ingested in the isocaloric trial but will also perform 2 hours of exercise that will be sufficient to burn off a third of the calories they consumed during this day resulting in subjects being in net negative energy balance in this trial
|
Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Ramy czasowe |
---|---|
Very Low Density Lipoprotein-Triglyceride and apoB-100 concentrations
Ramy czasowe: After acute (24 hour) changes in energy intake and/or energy expenditure
|
After acute (24 hour) changes in energy intake and/or energy expenditure
|
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
---|---|---|
Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 secretion rates
Ramy czasowe: After acute (24 hour) changes in energy intake and/or energy expenditure
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After acute (24 hour) changes in energy intake and/or energy expenditure
|
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Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 clearance rates from plasma
Ramy czasowe: After acute (24 hour) changes in energy intake and/or energy expenditure
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After acute (24 hour) changes in energy intake and/or energy expenditure
|
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Plasma glucose concentration and turnover rate
Ramy czasowe: After acute (24 hour) changes in energy intake and/or energy expenditure
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After acute (24 hour) changes in energy intake and/or energy expenditure
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Plasma insulin concentration
Ramy czasowe: After acute (24 hour) changes in energy intake and/or energy expenditure
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After acute (24 hour) changes in energy intake and/or energy expenditure
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Plasma free fatty acid concentration and turnover rate
Ramy czasowe: After acute (24 hour) changes in energy intake and/or energy expenditure
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After acute (24 hour) changes in energy intake and/or energy expenditure
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Plasma glucose concentration
Ramy czasowe: During acute (24 hour) changes in energy intake and/or energy expenditure
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Measured hourly over the 24 h period.
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During acute (24 hour) changes in energy intake and/or energy expenditure
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Plasma insulin concentration
Ramy czasowe: During acute (24 hour) changes in energy intake and/or energy expenditure
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Measured hourly over the 24 h period.
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During acute (24 hour) changes in energy intake and/or energy expenditure
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Plasma free fatty acid concentration
Ramy czasowe: During acute (24 hour) changes in energy intake and/or energy expenditure
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Measured hourly over the 24 h period.
|
During acute (24 hour) changes in energy intake and/or energy expenditure
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Współpracownicy i badacze
Publikacje i pomocne linki
Daty zapisu na studia
Główne daty studiów
Rozpoczęcie studiów
Zakończenie podstawowe (Rzeczywisty)
Ukończenie studiów (Rzeczywisty)
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy wysłany (Oszacować)
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Oszacować)
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia weryfikacja
Więcej informacji
Terminy związane z tym badaniem
Słowa kluczowe
Dodatkowe istotne warunki MeSH
Inne numery identyfikacyjne badania
- 05-0195
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