Kulturelle Anpassung und Umsetzung von DBT für Jugendliche mit emotionalen Störungen
Kulturelle Anpassung und Umsetzung der dialektischen Verhaltenstherapie-Trainingsgruppe für Jugendliche mit emotionalen Störungen: eine Machbarkeitsstudie und eine randomisierte kontrollierte Studie
Das Ziel dieser Studie ist es, dialektische Verhaltenstherapiefähigkeiten zu erlernen
Training for Adolescents (DBT-A-ST) befasst sich mit emotionalen Störungen bei Jugendlichen. Die wichtigsten Fragen, die beantwortet werden sollen, sind:
Führt DBT-A-ST im Vergleich zu ASG zu schnelleren Verbesserungen (d. h. steileren Anstiegen) bei den primären und sekundären Ergebnismessungen während der Behandlung und der 3-monatigen Nachbeobachtung?
Führt DBT-A-ST im Vergleich zu ASG zu größeren Verbesserungen bei primären und sekundären Ergebnismaßen?
Die Teilnehmer werden:
Zufällig zugewiesen an (a) eine kulturell angepasste DBT-A-ST oder (b) eine aktivitätsbasierte Selbsthilfegruppe (ASG).
Erhielt fünf Beurteilungen vor Beginn der Studie (T1), nach 4, 8 Sitzungen (T2, T3), nach der Intervention (T4) und nach drei Monaten Nachuntersuchung (T5).
Studienübersicht
Status
Bedingungen
Intervention / Behandlung
Detaillierte Beschreibung
Eine randomisierte kontrollierte Studie wird in der Abteilung für Kinder- und Jugendpsychiatrie eines medizinischen Zentrums durchgeführt. Teilnehmer im Alter von 12 bis 17 Jahren mit aktuellen depressiven oder Angststörungen, die mithilfe des K-SADS-E diagnostiziert wurden, werden rekrutiert und 1:1 zufällig einem von zwei Studienarmen zugeteilt: a) kulturell angepasste DBT-A-ST-Gruppe, b) Aktivitätsbasierte Selbsthilfegruppe. Beide Interventionen finden im Gruppenformat statt und umfassen 15 wöchentliche Sitzungen zu je 120 Minuten. Basierend auf der Leistungsberechnung wird eine Zielstichprobengröße von 160 Jugendlichen einbezogen. Die Beurteilungen erfolgen vor Beginn der Studie, bei der 4. und 8. Behandlungssitzung, am Ende und bei der Nachuntersuchung nach 3 Monaten.
Primäre Endpunkte sind der Schweregrad von Depressionen und Angstzuständen, der von blinden Gutachtern bewertet wird. Zu den sekundären Endpunkten gehören die allgemeine Psychopathologie, die Anzahl der DSM-5-Störungen, die Lebensqualität und selbstberichtete Messwerte. Auch die Behandlungsmechanismen und Umsetzungsprozesse werden untersucht.
Studientyp
Einschreibung (Geschätzt)
Phase
- Unzutreffend
Kontakte und Standorte
Studienkontakt
- Name: Hui-Chun Huang, Ph.D
- Telefonnummer: 3055 886-2-28094661
- E-Mail: aihch@mmh.org.tw
Studienorte
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Taipei, Taiwan
- Rekrutierung
- Mackay Memorial Hospital
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Kontakt:
- Dr.Hui-Chun Huang
- Telefonnummer: 3055 886 2 28094661
- E-Mail: aihch@mmh.org.tw
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Taipei, Taiwan
- Aktiv, nicht rekrutierend
- Mackay Memorial Hospital
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
- Kind
- Erwachsene
Akzeptiert gesunde Freiwillige
Beschreibung
Einschlusskriterien:
- 12-17 Jahre alt,
- Die Einverständniserklärung des Jugendlichen und eines Elternteils liegt vor.
- ausreichende Mandarin-Chinesischkenntnisse, um den Studienfragebogen auszufüllen,
- eine Gesamtpunktzahl von entweder PHQ-9≥ 10 oder GAD-7 ≥ 10,
- eine aktuelle Diagnose einer depressiven oder Angststörung aus einem K-SADS-E-Interview, einschließlich Depression (F32-33); anhaltende Stimmungsstörung (F34), phobische Angststörung (F40), andere Angststörung (F41) und Anpassungsstörungen (F43.2).
Eingeschrieben sind auch Personen mit komorbiden Diagnosen mehrerer emotionaler Störungen. Komorbiditäten werden nicht geschichtet, da dies die Komplexität des Designs erheblich erhöht (d. h. bei einigen Patienten können mehrere Komorbiditätsdiagnosen vorliegen).
Ausschlusskriterien:
- Diagnosen von geistiger Behinderung, Schizophrenie, tiefgreifender Entwicklungsstörung, Anorexia nervosa und Substanzgebrauchsstörung in den letzten 3 Monaten,
- aktive Suizidgedanken mit einem Plan oder einer Vorgeschichte häufiger oder kürzlicher Suizidrisiken in den letzten 3 Monaten,
- ADHS ohne Erhöhungen in den Bereichen Angstzustände, Depressionen oder Stressprobleme im CBCL,
- kürzliche (vergangene 4 Wochen) Änderung der psychiatrischen Medikation oder Unwilligkeit, während der Studienteilnahme eine stabile Dosierung der Medikamente aufrechtzuerhalten,
- in der Vergangenheit fünf oder mehr CBT-Sitzungen erhalten haben oder nicht bereit sind, die gleichzeitige Psychotherapie abzubrechen,
- jede geistige oder körperliche Erkrankung, die eine Krankenhauseinweisung erfordert,
- schwerer medizinischer Zustand.
Da wir auch ein naturalistisches Setting anstreben, schließen wir Patienten nicht aus, die sich während der Studie einer Medikamentenumstellung unterziehen, wenn der behandelnde Arzt dies für notwendig oder klinisch wichtig hält.
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Behandlung
- Zuteilung: Zufällig
- Interventionsmodell: Parallele Zuordnung
- Maskierung: Single
Waffen und Interventionen
Teilnehmergruppe / Arm |
Intervention / Behandlung |
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Experimental: Kulturell angepasste DBT-A-ST-Gruppe
Der kulturell angepasste DBT-A-ST besteht aus 15 wöchentlichen Gruppensitzungen mit einer Dauer von jeweils 120 Minuten, inklusive einer 10-minütigen Pause. Es behält die Kernelemente des Standard-DBT-A bei, einschließlich seiner philosophischen Grundlagen und Behandlungsstrategien. Therapeuten konzentrieren sich auf die Vermittlung von DBT-Fähigkeiten durch verschiedene Methoden wie Modellierung, strukturierte Verhaltensproben und Feedback. Jede Sitzung beginnt mit einer 40-minütigen Achtsamkeitsübung in der Gruppe und der Überprüfung der Hausaufgaben, gefolgt von 60 Minuten, die kompetenzspezifischen Didaktik- und Erfahrungsaktivitäten gewidmet sind, und endet mit einer 10-minütigen Hausaufgabe. Zwei Gruppenleiter moderieren die Sitzungen und die Teilnehmer verfolgen täglich ihre Fähigkeiten anhand von Tagebuchkarten, die wöchentlich überprüft werden. |
Der kulturell angepasste DBT-A-ST besteht aus 15 wöchentlichen Gruppensitzungen mit einer Dauer von jeweils 120 Minuten, inklusive einer 10-minütigen Pause. Es behält die Kernelemente des Standard-DBT-A bei, einschließlich seiner philosophischen Grundlagen und Behandlungsstrategien. Therapeuten konzentrieren sich auf die Vermittlung von DBT-Fähigkeiten durch verschiedene Methoden wie Modellierung, strukturierte Verhaltensproben und Feedback. Jede Sitzung beginnt mit einer 40-minütigen Achtsamkeitsübung in der Gruppe und der Überprüfung der Hausaufgaben, gefolgt von 60 Minuten, die kompetenzspezifischen Didaktik- und Erfahrungsaktivitäten gewidmet sind, und endet mit einer 10-minütigen Hausaufgabe. Zwei Gruppenleiter moderieren die Sitzungen und die Teilnehmer verfolgen täglich ihre Fähigkeiten anhand von Tagebuchkarten, die wöchentlich überprüft werden. |
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Placebo-Komparator: Satir-based group (SBG)
SBG, grounded in Satir's Iceberg Theory, aims to enhance self-awareness and communication by exploring participants' deeper emotions and beliefs.
Sessions include emotional sharing, communication skills training, and role-play exercises.
The program spans 15 weekly sessions (2 hours each): 12 for adolescents and 3 involving both adolescents and their parents.
Activities focus on practicing communication stances, reflection, and group discussion to foster personal growth and improved relationships.
The inclusion of parents is designed to help teens build supportive, resilient connections.
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SBG, grounded in Satir's Iceberg Theory, aims to enhance self-awareness and communication by exploring participants' deeper emotions and beliefs.
Sessions include emotional sharing, communication skills training, and role-play exercises.
The program spans 15 weekly sessions (2 hours each): 12 for adolescents and 3 involving both adolescents and their parents.
Activities focus on practicing communication stances, reflection, and group discussion to foster personal growth and improved relationships.
The inclusion of parents is designed to help teens build supportive, resilient connections.
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Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
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Youth Self Report (YSR)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Youth Self Report (YSR) is a self-reported measure assessing emotional and behavioral problems in adolescents. Each item is rated on a 3-point scale (0 = not true, 1 = sometimes true, 2 = mostly or completely true). The scale includes internalizing problems (withdrawal, anxiety/depression, and somatic complaints) and externalizing problems (rule-breaking and aggressive behaviors). Raw scores are converted to standardized T-scores based on normative data, with higher scores indicating more severe emotional and behavioral problems. T scores range approximately from 50 to 100, with scores above 70 indicating the clinical range. |
at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Child Behavior Checklist about their adolescents (CBCL)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Child Behavior Checklist (CBCL) is used to assess behavioral and emotional problems in children and adolescents. Each item is rated on a 3-point Likert scale (0-2). Raw scores are converted to standardized T-scores based on age- and gender-specific norms, with higher scores indicating more severe behavioral and emotional problems. T scores of ≤59 indicate nonclinical symptoms, scores of 60-64 suggest a risk for problem behaviors, and scores ≥65 indicate clinically significant symptoms. |
at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Sekundäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
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Hamilton Depression Scale-17 item (HAMD-17)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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HDRS-17 is a clinician-rated measure of depressive symptoms that consists of 17 items rated using a semi-structured interview.
Eight of the 17 HDRS-17 items are rated on a 5-point scale (0=absent; 1=doubtful or mild; 2=mild to moderate; 3=moderate to severe; 4=very severe), while the remaining 9 items are rated on a 3-point scale (0=absent; 1=doubtful or mild; 2=clearly present), yielding a minimum total score of 0 (least severe) and a maximum score of 52 (most severe).
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Hamilton Anxiety Scale (HAM-A)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Hamilton Anxiety Scale (HAM-A) comprises 14 items.
Each item is scored on a scale of 0 (not present) to 4 (severe), with a total score range of 0-56, where <17 indicates mild severity, 18-24 indicates mild to moderate severity, and 25-30 indicates moderate to severe severity.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Clinical Global Impressions-Severity (CGI-S)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Clinical Global Impressions-Severity (CGI-S) is a standardized assessment tool used by clinicians to rate illness severity, monitor changes over time, and evaluate medication efficacy.
It is rated on a seven-point scale: 1=normal, not at all ill; 2=borderline mentally ill; 3=mildly ill; 4=moderately ill; 5=markedly ill; 6=severely ill; 7=among the most extremely ill patients.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Clinical Global Impressions-Improvement (CGI-I)
Zeitfenster: at 15 weeks, and at 3 months after completion of the intervention
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The Clinical Global Impression-Improvement (CGI-I) is a 7-point scale that measures the extent to which the patient's illness has improved or worsened relative to baseline at the start of treatment.
It is rated on a scale from 1 to 7: 1 = very much improved since the beginning of treatment; 2 = much improved; 3 = minimally improved; 4 = no change from baseline (the start of treatment); 5 = minimally worse; 6 = much worse; 7 = very much worse since the start of treatment.
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at 15 weeks, and at 3 months after completion of the intervention
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Andere Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
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Patient Health Questionnaire-9 item (PHQ-9)
Zeitfenster: at baseline, at 4, 8, and 15 weeks, and at 3 months after completion of the intervention
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It consists of nine items evaluating the presence of the nine DSM-5 criteria of major depression in the past 2 weeks.
Each item is scored 0-3.
Total scores indicate: 0-4 (None/Minimal), 5-9 (Mild), 10-14 (Moderate), 15-19 (Moderately Severe), and 20-27 (Severe).
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at baseline, at 4, 8, and 15 weeks, and at 3 months after completion of the intervention
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Generalized Anxiety Disorder Scale-7 item (GAD-7)
Zeitfenster: at baseline, at 4, 8, and 15 weeks, and at 3 months after completion of the intervention
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It is a self-report 7-item scale to measure the severity of anxiety and has been validated in Chinese adolescent populations.
The total scores of the GAD-7 range from 0 to 21, with the higher scores indicating higher severity of anxiety disorders.
For the cutoff points of the GAD-7 scores, in general, the scores of 5, 10, and 15 match categorization of none/normal (0-4), mild anxiety (5-9), moderate anxiety (10-14), and severe anxiety (15-21), respectively.
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at baseline, at 4, 8, and 15 weeks, and at 3 months after completion of the intervention
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The number of the DSM-5 diagnoses
Zeitfenster: at baseline, at 15weeks, and at 3 months after completion of the intervention
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The number of DSM-5 diagnoses is assessed using the Mandarin version of the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Epidemiologic version (K-SADS-E), modified to align with DSM-5 criteria.
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at baseline, at 15weeks, and at 3 months after completion of the intervention
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The Strengths and Difficulties Questionnaire (SDQ)
Zeitfenster: Baseline
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It aims to evaluate emotional and behavioral challenges in children and adolescents, covering four problem areas: emotional symptoms, conduct issues, hyperactivity/inattention, and peer relationship difficulties.
All items are rated on a three-point scale (0=not true, 1=somewhat true, and 2=certainly true).
Five positively worded items from different SDQ difficulty scales are reverse-coded.
High scores on the difficulties scales indicate a high degree of difficulty; a high score on the prosocial scale indicates a high degree of prosocial behavior.
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Baseline
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10-item Positive and Negative Affect Schedule- Child/Parent (PANAS-C/P)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The 10-item Positive and Negative Affect Schedule for Children/Parents (PANAS-C/P) is used to assess positive and negative emotional states in youth, based on self-report or parent-report of recent emotional experiences.
The measure yields two subscale scores: Positive Affect (range 10-50; higher scores indicate greater positive affect) and Negative Affect (range 10-50; lower scores indicate less negative affect).
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Perceived Stress Scale (PSS-10)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Perceived Stress Scale (PSS) is a self-reported measure used to assess the degree to which individuals appraise situations in their lives as stressful.
Each item is rated on a 5-point Likert scale (0 = never to 4 = very often).
Total scores range from 0 to 40, with higher scores indicating greater perceived stress.
Scores of 0-13 indicate low stress, 14-26 indicate moderate stress, and 27-40 indicate high perceived stress.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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World Health Organization Quality of Life Scale, Brief Version (WHOQOL-BREF)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The WHOQOL-BREF assesses quality of life across physical, psychological, social, and environmental domains.
Each item is rated on a 1-5 scale.
Domain scores are transformed to a 0-100 scale, with higher scores indicating better quality of life.
Interpretation is based on comparisons across domains, changes over time, and reference to population norms; lower scores (e.g., below the 30th percentile) may indicate areas requiring clinical attention.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Adult Self-Report (ASR)
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Adult Self-Report is a self-report instrument assessing behavioral, emotional, and social functioning over the past 6 months.
Items are rated on a 3-point scale (0 = not true, 1 = somewhat true, 2 = very true).
A Total Problems score is calculated by summing all problem items, with higher scores indicating greater overall difficulties.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Academic Pressure subscale of Inventory of Influencing Factors of Trait Anxiety
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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It includes 10 items that describe daily events related to students' academic pressure.
Each item is rated on a 5-point Likert scale ranging from 1 = never to 5 = always.
The items are averaged to calculate scale scores; the higher the average score, the higher the level of self-reported academic pressure.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Chinese Adolescent Life Event Scale checklist
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Stressful Life Events Scale assesses the occurrence of stressful life events.
In this study, only eight items related to controllable negative events are included.
Each item is rated as 0 = no, 1 = yes, and a Total Score is calculated by summing all items, ranging from 0 to 8, with higher scores indicating a greater number of stressful life events.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Treatment History Interview (THI)
Zeitfenster: Baseline
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The Treatment History Questionnaire assesses the types and amounts of previous medical and psychological treatments received.
Items include self-reported hospital admissions, days in hospital, emergency department visits, medications, and outpatient psychosocial treatments.
Each item is rated 0 = no, 1 = yes, and a Total Score is calculated by summing all items, with higher scores indicating greater use of treatment resources.
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Baseline
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Emotion Regulation Questionnaire, Child and Adolescent Form (ERQ-C/A)
Zeitfenster: at baseline, at 8 and 15 weeks, and at 3 months after completion of the intervention
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The Emotion Regulation Questionnaire for Children and Adolescents is a 10-item self-report measure assessing emotion regulation strategies, including cognitive reappraisal and emotion suppression.
Items are rated on a 5-point Likert scale (1 = strongly disagree to 5 = strongly agree).
Subscale scores range from 6-30 for cognitive reappraisal and 4-20 for emotion suppression.
Higher scores indicate greater emotion dysregulation.
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at baseline, at 8 and 15 weeks, and at 3 months after completion of the intervention
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The Distress tolerance Scale-Short Form (DTS-SF)
Zeitfenster: at baseline, at 4, 8, and 15 weeks, and at 3 months after completion of the intervention
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The DTS-SF is a modification of the DTS and contains the highest-loading item from each subscale, forming a single DT factor.
As with the DTS, items are rated on a 5-point Likert scale (1 = strongly agree, 5 = strongly disagree), with lower scores indicating poorer ability to withstand and tolerate distress.
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at baseline, at 4, 8, and 15 weeks, and at 3 months after completion of the intervention
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DBT skills subscale (DSS) of the DBT Ways of Coping Checklist
Zeitfenster: at baseline, at 15 weeks, and at 3 months after completion of the intervention
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The Dialectical Behavior Therapy Skills Use Scale is a 38-item self-report measure assessing the frequency of DBT skills use over the past month.
Participants rate how often they used specific skills when facing stressors on a 4-point scale (0 = never to 3 = regularly).
A Total Score (range: 0-114) is calculated by summing item scores, with higher scores indicating more frequent use of DBT skills.
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at baseline, at 15 weeks, and at 3 months after completion of the intervention
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Mindful Attention Awareness Scale-Children
Zeitfenster: at baseline, at 8 and 15 weeks, and at 3 months after completion of the intervention
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The Mindful Attention Awareness Scale is a 15-item self-report measure assessing mindfulness across cognitive, emotional, physical, interpersonal, and general domains.
Items are rated on a 6-point scale (1 = almost always to 6 = almost never), reverse-scored, and averaged to yield a total score.
Higher scores indicate greater mindfulness.
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at baseline, at 8 and 15 weeks, and at 3 months after completion of the intervention
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Group Climate Questionnaire-Short Form (GCQ-S)
Zeitfenster: at 4, 8, and 15 weeks
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It is a 12-item self-report instrument used to measure youths' perceptions of the atmosphere in therapy groups.
It contains 12 items rated on a 7-point Likert scale, indicating the extent of agreement, ranging from "not at all" (0) to "extremely" (6).
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at 4, 8, and 15 weeks
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Therapy Alliance Scale for Adolescence
Zeitfenster: Completed by adolescents: at 4, 8, and 15 weeks Completed by therapists: at 8 and 15 weeks
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It is widely used to measure therapeutic alliance in research with adolescent populations.
The higher the score, the better the therapeutic alliance.
Items are rated on a 4-point Likert scale ranging from 1 (Strongly Disagree) to 4 (Strongly Agree) and summed to create a single Total score with a maximum of 48.
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Completed by adolescents: at 4, 8, and 15 weeks Completed by therapists: at 8 and 15 weeks
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Client Satisfaction Questionnaire (CSQ-8)
Zeitfenster: at 15 weeks
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It consists of eight questions (quality of service, kind of service, whether needs were met, likelihood to recommend to a friend, amount of help received, handling of problems, overall satisfaction, and likelihood to return), each rated on a 4-point Likert scale (1-4).
Total scores range from 8 to 32, with higher scores indicating greater satisfaction.
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at 15 weeks
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Satisfaction of each session
Zeitfenster: From the first group session to the final (15th) group session, satisfaction for each session was assessed immediately after each session.
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This 4-item, content-specific scale is completed by patients after each session using a 5-point Likert scale (1 = very unsatisfied to 5 = excellent).
Total scores range from 4 to 20, with higher scores indicating better session evaluation.
It is designed to facilitate collaborative adjustments to therapy, including the therapeutic alliance, session content, and relevance.
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From the first group session to the final (15th) group session, satisfaction for each session was assessed immediately after each session.
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The Adolescent Dialectical Behavior Therapy Group Skills Learning Experience Scale (ADBT-SLES)
Zeitfenster: at 15 weeks
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The ADBT-SLES is a 12-item questionnaire assessing adolescents' perceived helpfulness of DBT group skills, rated on a 5-point Likert scale (1 = not helpful at all, 5 = extremely helpful).
It also includes four open-ended questions exploring participants' learning experiences in the group.
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at 15 weeks
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A short drop-out questionnaire
Zeitfenster: at the time of participant withdrawal during the 15-session group treatment program (up to 15 sessions)
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It contains 6 questions (i.e., reason for drop-out, date of drop-out, number of sessions attended, person who initiated the stop of treatment) to gather information about drop-outs, which is filled in by adolescents.
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at the time of participant withdrawal during the 15-session group treatment program (up to 15 sessions)
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Mitarbeiter und Ermittler
Sponsor
Ermittler
- Hauptermittler: Shen-Ing Liu, Ph.D, Mackay Memorial Hospital
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn (Tatsächlich)
Primärer Abschluss (Geschätzt)
Studienabschluss (Geschätzt)
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Tatsächlich)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
Zusätzliche relevante MeSH-Bedingungen
Andere Studien-ID-Nummern
- NSTC 113-2314-B-195 -012 -MY3
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