VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma

DISEASE CHARACTERISTICS:

• Histologically confirmed incurable primary or metastatic solid tumor or non-Hodgkin's lymphoma

  • Relapsed after or is refractory (e.g., unresectable) to at least 2 standard chemotherapy regimens and rituximab
  • No standard curative surgery, chemotherapy, immunotherapy, other antitumor therapy, or radiotherapy options exist
• No known or suspected squamous cell carcinoma of the lung
• No prior or concurrent CNS (brain or leptomeningeal) metastases
• No prior or concurrent primary intracranial tumor by MRI or CT scan

PATIENT CHARACTERISTICS:

Age:

• 25 and over

Performance status:

• ECOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• WBC at least 3,500/mm^3
• Absolute neutrophil count at least 1,500/mm^3
• Platelet count at least 100,000/mm^3
• Hemoglobin at least 9.0 g/dL
• No other severe or uncontrolled hematologic condition

Hepatic:

• Bilirubin no greater than 1.5 times upper limit of normal (ULN)
• AST and ALT no greater than 2 times ULN
• Alkaline phosphatase no greater than 2 times ULN
• PT, PTT, and INR normal

Renal:

• Creatinine no greater than ULN
• No 1+ or greater proteinuria
• No other severe or uncontrolled renal condition

Cardiovascular:

• Electrocardiogram normal
• LVEF normal by echocardiogram or MUGA scan within the past 12 months or since completion of prior anthracycline
• No severe or uncontrolled cardiovascular condition
• No New York Heart Association class III or IV heart disease
• No active coronary artery disease, angina, congestive heart failure, or arrhythmia
• No myocardial infarction within the past 6 months

• No prior or concurrent peripheral vascular disease, including:

  • Angiographically or ultrasonographically documented arterial or venous occlusive event
  • Symptomatic claudication
• No untreated or uncontrolled hypertension
• No treated blood pressure more than 160/100 mm Hg on at least 3 repeated determinations on separate days within the past 6 weeks
• No symptomatic orthostatic hypotension

Pulmonary:

• No severe or uncontrolled pulmonary condition
• No pulmonary embolism

Other:

• No prior hypersensitivity reactions to any recombinant proteins (e.g., VEGF Trap)
• No severe or uncontrolled gastrointestinal, immunological, or musculoskeletal condition
• No severe or uncontrolled psychiatric or adverse social circumstance that would preclude study
• No active infection requiring antibiotics
• HIV negative
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective double-barrier contraception during and for at least 3 months after study

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• See Disease Characteristics
• At least 3 weeks since prior immunotherapy
• No concurrent epoetin alfa, filgrastim (G-CSF), or sargramostim (GM-CSF)

Chemotherapy:

• See Disease Characteristics
• At least 3 weeks since prior chemotherapy

Endocrine therapy:

• No concurrent adrenal corticosteroids, except low doses as replacement therapy in patients who have previously received suppressive doses or for adrenal insufficiency
• No concurrent systemic hormonal contraceptive agents

Radiotherapy:

• See Disease Characteristics
• At least 3 weeks since prior radiotherapy

Surgery:

• See Disease Characteristics
• At least 3 weeks since prior surgery (except fine needle biopsy/aspiration or removal/biopsy of a skin lesion)
• No prior surgical procedure for correction or prophylaxis of peripheral vascular insufficiency or cerebral ischemic events

Other:

• Recovered from prior therapy
• At least 6 months since prior treatment for acute congestive heart failure
• At least 30 days since prior investigational drugs
• No concurrent standard or other investigational anticancer agents
• No concurrent herbal supplements ("nutraceuticals")
• No concurrent anticoagulant or antiplatelet drugs, (e.g., warfarin, heparin, aspirin, or other non-steroidal anti-inflammatory drugs) except selective cyclo-oxygenase-2 (COX-2) inhibitors for analgesia
• No concurrent COX-2 inhibitors for tumor treatment or prophylaxis