Cohort Construction for Preterm Infants With Growth Retardation and Its Influencing Factors
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Descripción detallada
Preterm infants are at high risk of stunting due to premature birth, insufficient intrauterine nutrient reserves, burden of various diseases after birth, and persistent nutrient liabilities. The growth retardation of premature infants at different developmental stages has an important impact on both short-term survival and long-term health. The growth and development data of premature infants during hospitalization and after discharge are very limited in foreign countries. Domestic researches on growth retardation of preterm infants only involve retrospective cross-sectional studies during hospitalization, and lack of prospective follow-up study data on growth and development data of premature infants during hospitalization and after discharge.
In this cohort, prospective clinical cohort study was used to establish a follow-up cohort of preterm infants with different gestational ages. The regular monitoring indexes of physical development and neuropsychological development of preterm infants from birth to 3 years after birth were collected. The influencing factors of preterm infants' development at different stages were recorded, and the high-risk factors leading to different stages of preterm infants' growth retardation were analyzed. In order to provide a strong scientific basis for the development evaluation and intervention of premature infants in China, a systematic and scientific clinical cohort study method was explored to improve the overall medical quality and medical level of the Department and further promote the development of the discipline.
Tipo de estudio
Inscripción (Anticipado)
Contactos y Ubicaciones
Estudio Contacto
- Nombre: chunling huang, Ph.D.
- Número de teléfono: +86 13811485908
- Correo electrónico: huangchunling_19@163.com
Ubicaciones de estudio
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Beijing
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Peking, Beijing, Porcelana, 100191
- Reclutamiento
- Peking University Third Hospital
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Contacto:
- chunling huang, Ph.D.
- Número de teléfono: +86 13811485908
- Correo electrónico: huangchunling_19@163.con
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- All preterm infants born less than 37 weeks during the study period
Exclusion Criteria:
- Congenital malformations or genetic diseases Various surgical treatments during the newborn period Interrupted treatment or discharged automatically
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
Intervención / Tratamiento |
|---|---|
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Late preterm infant group
Gestational age 33 weeks-36 weeks
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Physical development assessment (head circumference, length, weight), Neurodevelopment assessment at 36 to 40 weeks of correction (GMS assessment, NBNA assessment), neurodevelopment assessment at 18 months, 24 months, and 36 months (ASQ scale, Language assessment, Wei-style scale), audiovisual screening, etc.
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Very premature infant group
Gestational age 28 weeks-32 weeks
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Physical development assessment (head circumference, length, weight), Neurodevelopment assessment at 36 to 40 weeks of correction (GMS assessment, NBNA assessment), neurodevelopment assessment at 18 months, 24 months, and 36 months (ASQ scale, Language assessment, Wei-style scale), audiovisual screening, etc.
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Super preterm infant group
Gestational age less than 28 weeks
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Physical development assessment (head circumference, length, weight), Neurodevelopment assessment at 36 to 40 weeks of correction (GMS assessment, NBNA assessment), neurodevelopment assessment at 18 months, 24 months, and 36 months (ASQ scale, Language assessment, Wei-style scale), audiovisual screening, etc.
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Assessment of extrauterine growth retardation of preterm infants at 36-40 weeks of gestational age correction
Periodo de tiempo: correct gestational age 36~40 weeks
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According to Fenton 2003 growth curve of premature infants, the weight, length, and head circumference of preterm infants with corrected gestational age of 36-40 weeks were evaluated, If the weight, length and head circumference are lower than the 10th percentile of the corresponding gestational age, the child is diagnosed as EUGR（extrauterine growth retardation）
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correct gestational age 36~40 weeks
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Assessment of neurodevelopmental retardation of preterm infants at 36-40 weeks of gestational age correction
Periodo de tiempo: correct gestational age 36~40 weeks
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IF the NBNA score of preterm infants at 36-40 weeks of correction is lower than 36, and the abnormal GMs is evaluated, the child is diagnosed as neurodevelopmental retardation.
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correct gestational age 36~40 weeks
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Assessment of low weight of preterm infants at 2 to 3 years of age
Periodo de tiempo: 2~3 years old
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Compared with the same age and gender reference population standard, children's weight below the median minus 2 standard deviations (i.e. less than the 3rd percentile) is diagnosed as low weight
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2~3 years old
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Assessment of growth retardation of preterm infants at 2 to 3 years of age
Periodo de tiempo: 2~3 years old
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Compared with the same age and gender reference population standard, children's height below the median minus 2 standard deviations (i.e. less than the 3rd percentile) is diagnosed as growth retardation
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2~3 years old
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Assessment of small head circumference of preterm infants at 2 to 3 years of age
Periodo de tiempo: 2~3 years old
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Compared with the same age and gender reference population standard, the children's occipitofrontal circumference (OFC) less than 2 standard deviations (SD) of the mean OFC (i.e. less than the 3rd percentile) is diagnosed as small head circumference
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2~3 years old
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Assessment of neurodevelopmental retardation of preterm infants at 2 to 3 years of age
Periodo de tiempo: 2~3 years old
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IF the Wechsler intelligence scales score is lower than 70, the child is diagnosed as neurodevelopmental retardation.
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2~3 years old
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Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: xiaomei tong, Ph.D., Peking University Third Hospital
- Director de estudio: yanmei chang, Ph.D., Peking University Third Hospital
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Anticipado)
Finalización del estudio (Anticipado)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Otros números de identificación del estudio
- bysy2020-423-01
Información sobre medicamentos y dispositivos, documentos del estudio
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