Cohort Construction for Preterm Infants With Growth Retardation and Its Influencing Factors
Обзор исследования
Статус
Условия
Вмешательство/лечение
Подробное описание
Preterm infants are at high risk of stunting due to premature birth, insufficient intrauterine nutrient reserves, burden of various diseases after birth, and persistent nutrient liabilities. The growth retardation of premature infants at different developmental stages has an important impact on both short-term survival and long-term health. The growth and development data of premature infants during hospitalization and after discharge are very limited in foreign countries. Domestic researches on growth retardation of preterm infants only involve retrospective cross-sectional studies during hospitalization, and lack of prospective follow-up study data on growth and development data of premature infants during hospitalization and after discharge.
In this cohort, prospective clinical cohort study was used to establish a follow-up cohort of preterm infants with different gestational ages. The regular monitoring indexes of physical development and neuropsychological development of preterm infants from birth to 3 years after birth were collected. The influencing factors of preterm infants' development at different stages were recorded, and the high-risk factors leading to different stages of preterm infants' growth retardation were analyzed. In order to provide a strong scientific basis for the development evaluation and intervention of premature infants in China, a systematic and scientific clinical cohort study method was explored to improve the overall medical quality and medical level of the Department and further promote the development of the discipline.
Тип исследования
Регистрация (Ожидаемый)
Контакты и местонахождение
Контакты исследования
- Имя: chunling huang, Ph.D.
- Номер телефона: +86 13811485908
- Электронная почта: huangchunling_19@163.com
Места учебы
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Beijing
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Peking, Beijing, Китай, 100191
- Рекрутинг
- Peking University Third Hospital
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Контакт:
- chunling huang, Ph.D.
- Номер телефона: +86 13811485908
- Электронная почта: huangchunling_19@163.con
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Критерии участия
Критерии приемлемости
Возраст, подходящий для обучения
Принимает здоровых добровольцев
Полы, имеющие право на обучение
Метод выборки
Исследуемая популяция
Описание
Inclusion Criteria:
- All preterm infants born less than 37 weeks during the study period
Exclusion Criteria:
- Congenital malformations or genetic diseases Various surgical treatments during the newborn period Interrupted treatment or discharged automatically
Учебный план
Как устроено исследование?
Детали дизайна
Когорты и вмешательства
Группа / когорта |
Вмешательство/лечение |
|---|---|
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Late preterm infant group
Gestational age 33 weeks-36 weeks
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Physical development assessment (head circumference, length, weight), Neurodevelopment assessment at 36 to 40 weeks of correction (GMS assessment, NBNA assessment), neurodevelopment assessment at 18 months, 24 months, and 36 months (ASQ scale, Language assessment, Wei-style scale), audiovisual screening, etc.
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Very premature infant group
Gestational age 28 weeks-32 weeks
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Physical development assessment (head circumference, length, weight), Neurodevelopment assessment at 36 to 40 weeks of correction (GMS assessment, NBNA assessment), neurodevelopment assessment at 18 months, 24 months, and 36 months (ASQ scale, Language assessment, Wei-style scale), audiovisual screening, etc.
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Super preterm infant group
Gestational age less than 28 weeks
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Physical development assessment (head circumference, length, weight), Neurodevelopment assessment at 36 to 40 weeks of correction (GMS assessment, NBNA assessment), neurodevelopment assessment at 18 months, 24 months, and 36 months (ASQ scale, Language assessment, Wei-style scale), audiovisual screening, etc.
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Что измеряет исследование?
Первичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
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Assessment of extrauterine growth retardation of preterm infants at 36-40 weeks of gestational age correction
Временное ограничение: correct gestational age 36~40 weeks
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According to Fenton 2003 growth curve of premature infants, the weight, length, and head circumference of preterm infants with corrected gestational age of 36-40 weeks were evaluated, If the weight, length and head circumference are lower than the 10th percentile of the corresponding gestational age, the child is diagnosed as EUGR（extrauterine growth retardation）
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correct gestational age 36~40 weeks
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Assessment of neurodevelopmental retardation of preterm infants at 36-40 weeks of gestational age correction
Временное ограничение: correct gestational age 36~40 weeks
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IF the NBNA score of preterm infants at 36-40 weeks of correction is lower than 36, and the abnormal GMs is evaluated, the child is diagnosed as neurodevelopmental retardation.
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correct gestational age 36~40 weeks
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Assessment of low weight of preterm infants at 2 to 3 years of age
Временное ограничение: 2~3 years old
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Compared with the same age and gender reference population standard, children's weight below the median minus 2 standard deviations (i.e. less than the 3rd percentile) is diagnosed as low weight
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2~3 years old
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Assessment of growth retardation of preterm infants at 2 to 3 years of age
Временное ограничение: 2~3 years old
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Compared with the same age and gender reference population standard, children's height below the median minus 2 standard deviations (i.e. less than the 3rd percentile) is diagnosed as growth retardation
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2~3 years old
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Assessment of small head circumference of preterm infants at 2 to 3 years of age
Временное ограничение: 2~3 years old
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Compared with the same age and gender reference population standard, the children's occipitofrontal circumference (OFC) less than 2 standard deviations (SD) of the mean OFC (i.e. less than the 3rd percentile) is diagnosed as small head circumference
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2~3 years old
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Assessment of neurodevelopmental retardation of preterm infants at 2 to 3 years of age
Временное ограничение: 2~3 years old
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IF the Wechsler intelligence scales score is lower than 70, the child is diagnosed as neurodevelopmental retardation.
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2~3 years old
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Соавторы и исследователи
Спонсор
Следователи
- Главный следователь: xiaomei tong, Ph.D., Peking University Third Hospital
- Директор по исследованиям: yanmei chang, Ph.D., Peking University Third Hospital
Даты записи исследования
Изучение основных дат
Начало исследования (Действительный)
Первичное завершение (Ожидаемый)
Завершение исследования (Ожидаемый)
Даты регистрации исследования
Первый отправленный
Впервые представлено, что соответствует критериям контроля качества
Первый опубликованный (Действительный)
Обновления учебных записей
Последнее опубликованное обновление (Действительный)
Последнее отправленное обновление, отвечающее критериям контроля качества
Последняя проверка
Дополнительная информация
Термины, связанные с этим исследованием
Другие идентификационные номера исследования
- bysy2020-423-01
Информация о лекарствах и устройствах, исследовательские документы
Изучает лекарственный продукт, регулируемый FDA США.
Изучает продукт устройства, регулируемый Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов США.
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