Timing of Subcutaneous Tranexamic Acid Injection in Mohs Micrographic Surgery

Inclusion Criteria:

1. Age 18 years or older.
2. Undergoing MMS at a participating site with a planned same-day linear closure, flap reconstruction, or graft reconstruction.
3. Willing and able to provide written informed consent.
4. Able to participate in standard postoperative follow-up and to be reached if follow-up clarification is required.

Exclusion Criteria:

1. Known allergy or hypersensitivity to TXA.
2. Active deep-vein thrombosis, pulmonary embolism, stroke, myocardial infarction, or other active thromboembolic event at the time of surgery.
3. Thromboembolic event within the previous 3 months.
4. Systolic blood pressure greater than 200 mmHg at the time of surgery.
5. Pregnancy or breastfeeding.
6. Planned second-intention healing without reconstruction.
7. History of seizures or current medication judged by the investigator to materially lower seizure threshold.
8. Reported serum creatinine of 5 mg/dL or greater.
9. Unable to complete the 48-hour outcome assessment or standard postoperative follow-up.
10. Prior enrollment in this study.