- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT00005266
Cardiovascular Disease Mortality in The NAS-NRC Twin Registry
Aperçu de l'étude
Statut
Description détaillée
BACKGROUND:
Methodologically, statistical methods in genetics and epidemiology have developed largely independently; and as a result, there seemed to be little communication between the two fields. Some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields. The method of analysis used in this study dealt simultaneously with survival time nature of the outcome variable, multiple and continuous environmental risk factors, and correlation in outcomes between related individuals.
The study was supported by the Small Grants Program established by the National Heart, Lung, and Blood Institute in January 1990 to extend analyses of research data generated by clinical trials, population research, and demonstration and education studies.
DESIGN NARRATIVE:
Data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking, diet, weight changes, physical activity, and socioeconomic variables. The contributions of genetic and environmental factors to twin similarities in health behavior were also examined.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Type d'étude
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Plan d'étude
Comment l'étude est-elle conçue ?
Collaborateurs et enquêteurs
Publications et liens utiles
Publications générales
- Carmelli D, Swan GE, Robinette D, Fabsitz R. Genetic influence on smoking--a study of male twins. N Engl J Med. 1992 Sep 17;327(12):829-33. doi: 10.1056/NEJM199209173271201.
- Carmelli D, Swan GE, Cardon LR. Genetic mediation in the relationship of education to cognitive function in older people. Psychol Aging. 1995 Mar;10(1):48-53. doi: 10.1037//0882-7974.10.1.48.
- Swan GE, Carmelli D. Characteristics associated with excessive weight gain after smoking cessation in men. Am J Public Health. 1995 Jan;85(1):73-7. doi: 10.2105/ajph.85.1.73.
- Carmelli D, Cardon LR, Fabsitz R. Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet. 1994 Sep;55(3):566-73.
- Carmelli D, Selby JV, Quiroga J, Reed T, Fabsitz RR, Christian JC. 16-year incidence of ischemic heart disease in the NHLBI twin study. A classification of subjects into high- and low-risk groups. Ann Epidemiol. 1994 May;4(3):198-204. doi: 10.1016/1047-2797(94)90097-3.
- Carmelli D, Robinette D, Fabsitz R. Concordance, discordance and prevalence of hypertension in World War II male veteran twins. J Hypertens. 1994 Mar;12(3):323-8.
- Carmelli D, Swan GE, Robinette D. The relationship between quitting smoking and changes in drinking in World War II veteran twins. J Subst Abuse. 1993;5(2):103-16. doi: 10.1016/0899-3289(93)90055-g.
- Carmelli D, Heath AC, Robinette D. Genetic analysis of drinking behavior in World War II veteran twins. Genet Epidemiol. 1993;10(3):201-13. doi: 10.1002/gepi.1370100306.
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 1150
- R03HL046115 (Subvention/contrat des NIH des États-Unis)
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