- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT00612365
Association Between Abdominal Body Composition, Inflammation, and Risk for Cardiovascular Disease (The MESA ABD Study) (MESA ABD)
Abdominal Body Composition, Inflammation, and Cardiovascular Disease
Aperçu de l'étude
Statut
Les conditions
Description détaillée
Abdominal obesity is a serious condition and increases the risk for potentially life-threatening cardiovascular diseases (CVDs). Abdominal fat is made up of structurally and functionally different tissues, which include visceral fat, subcutaneous fat, and intramuscular fat. The distribution and levels of these fat tissues are highly variable among obese people, and the effects of ABC differences on cardiovascular health are not well known. Notably, the standard measure of body mass index cannot distinguish between different kinds or ratios of tissue types that make up body weight and, therefore, may not be the best measurement tool. Determining the specific measures of these tissue types by computed tomography (CT) may provide better insight into the varied CVD risk seen among different ethnicities, sexes, and ages. This study will evaluate the association between volumetric measures of ABC, CVD risk, and inflammation in terms of ethnicity-, sex-, and age-specific variables.
This substudy will use data and specimens, including blood samples and CT scans, from participants in the Multi-Ethnic Study of Atherosclerosis (MESA) for abdominal aortic calcium (AAC). Stored blood samples will be used to perform assays for several measures of inflammation and to generate new data on biomarkers and subclinical CVD measures. The existing CT scans will be used to calculate five discrete volumetric measures of ABC, which will include subcutaneous fat, visceral fat, intramuscular fat, the visceral fat to visceral cavity ratio, and the lean muscle to visceral fat ratio. There will be no study visits for this study.
The study completion date listed in this record was obtained from the "Completed Date" entered in the Query View Report System (QVR).
Type d'étude
Inscription (Réel)
Contacts et emplacements
Lieux d'étude
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California
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La Jolla, California, États-Unis, 92093
- University of California San Diego
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- Participant in the MESA study
Exclusion Criteria:
- History of cardiovascualar disease
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
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1
Participants from the Multi-Ethnic Study of Atherosclerosis (MESA) for abdominal aortic calcium (AAC) who have undergone computed tomography (CT) scans of the abdomen
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Délai |
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Relationship between abdominal tissue types, levels of inflammatory markers and adipokines, and CVD events
Délai: Measured at completion of sample analysis
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Measured at completion of sample analysis
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Mesures de résultats secondaires
Mesure des résultats |
Délai |
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How differences in age, sex, and ethnicity influence the association between ABC and CVD risk
Délai: Measured at completion of sample analysis
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Measured at completion of sample analysis
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Collaborateurs et enquêteurs
Les enquêteurs
- Chercheur principal: Matthew A. Allison, MD, MPH, University of California, San Diego
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 1419
- R01HL088451 (Subvention/contrat des NIH des États-Unis)
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