Un essai de phase II/III sur le nivolumab, l'ipilimumab et le GM-CSF chez des patients atteints de mélanome avancé
11 novembre 2026 mis à jour par: National Cancer Institute (NCI)
Étude randomisée de phase II/III comparant Nivolumab plus ipilimumab plus sargramostim versus nivolumab plus ipilimumab chez des patients atteints d'un mélanome de stade III ou IV non résécable
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma.
Aperçu de l'étude
Statut
Actif, ne recrute pas
Description détaillée
PRIMARY OBJECTIVE:
I. To compare the overall survival (OS) of nivolumab/ipilimumab/sargramostim (GM-CSF) versus nivolumab/ipilimumab.
SECONDARY OBJECTIVES:
I. To evaluate progression free survival (PFS) of patients treated with nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab.
II. To assess for differences in tolerability, specifically the rate of grade III or higher adverse events, between nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab.
III. To evaluate immune-related response rate (based on immune-related response criteria) and response rate (based on Response Evaluation Criteria in Solid Tumors [RECIST] criteria) and to compare them.
EXPLORATORY TOBACCO USE OBJECTIVES:
I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications).
II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.
III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.
IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM A: INDUCTION THERAPY: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1 of each cycle, ipilimumab IV over 30 minutes on day 1 of each age, and sargramostim subcutaneously (SC) on days 1-14 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.
MAINTENANCE THERAPY: Patients receive nivolumab and sargramostim as in induction therapy. Patients with partial response (PR), stable disease (SD), or complete response (CR) at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo magnetic resonance imaging (MRI), computed tomography (CT) scan, and blood sample collection throughout the study. Patients may also undergo a multigated acquisition (MUGA) during screening, as well as an echocardiography (ECHO) throughout the trial as clinically indicated.
ARM B: INDUCTION THERAPY: Patients receive nivolumab and ipilimumab as in Arm I. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.
MAINTENANCE THERAPY: Patients receive nivolumab as in induction therapy. Patients with PR, SD, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo MRI, CT scan, and blood sample collection throughout the study. Patients may also undergo a MUGA during screening, as well as an ECHO throughout the trial as clinically indicated.
After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Type d'étude
Interventionnel
Inscription (Estimé)
600
Phase
- Phase 2
- Phase 3
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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Alabama
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Birmingham, Alabama, États-Unis, 35233
- University of Alabama at Birmingham Cancer Center
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Arizona
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Kingman, Arizona, États-Unis, 86401
- Kingman Regional Medical Center
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Arkansas
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Little Rock, Arkansas, États-Unis, 72205
- CARTI Cancer Center
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Little Rock, Arkansas, États-Unis, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Anaheim, California, États-Unis, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, États-Unis, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, États-Unis, 93420
- PCR Oncology
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Auburn, California, États-Unis, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, États-Unis, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, États-Unis, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, États-Unis, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, États-Unis, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, États-Unis, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, États-Unis, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, États-Unis, 94546
- Eden Hospital Medical Center
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Davis, California, États-Unis, 95616
- Sutter Davis Hospital
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Duarte, California, États-Unis, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, États-Unis, 94568
- Kaiser Permanente Dublin
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Fontana, California, États-Unis, 92335
- Kaiser Permanente-Fontana
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Fremont, California, États-Unis, 94538
- Kaiser Permanente-Fremont
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Fremont, California, États-Unis, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, États-Unis, 93720
- Kaiser Permanente-Fresno
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Fresno, California, États-Unis, 93720
- Kaiser Permanente Fresno Orchard Plaza
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Harbor City, California, États-Unis, 90710
- Kaiser Permanente South Bay
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Irvine, California, États-Unis, 92618
- Kaiser Permanente-Irvine
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Irvine, California, États-Unis, 92612
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
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Los Angeles, California, États-Unis, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, États-Unis, 90034
- Kaiser Permanente West Los Angeles
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Modesto, California, États-Unis, 95355
- Memorial Medical Center
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Modesto, California, États-Unis, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, États-Unis, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, États-Unis, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, États-Unis, 94945
- Sutter Cancer Research Consortium
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Oakland, California, États-Unis, 94611
- Kaiser Permanente-Oakland
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Ontario, California, États-Unis, 91761
- Kaiser Permanente-Ontario
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Orange, California, États-Unis, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, États-Unis, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, États-Unis, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, États-Unis, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, États-Unis, 91402
- Kaiser Permanente - Panorama City
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Redwood City, California, États-Unis, 94063
- Kaiser Permanente-Redwood City
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Redwood City, California, États-Unis, 94063
- Kaiser Permanente- Marshall Medical Offices
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Richmond, California, États-Unis, 94801
- Kaiser Permanente-Richmond
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Riverside, California, États-Unis, 92505
- Kaiser Permanente-Riverside
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Roseville, California, États-Unis, 95661
- Kaiser Permanente-Roseville
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Roseville, California, États-Unis, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, États-Unis, 95661
- Sutter Roseville Medical Center
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Sacramento, California, États-Unis, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, États-Unis, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, États-Unis, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, États-Unis, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, États-Unis, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, États-Unis, 92134
- Naval Medical Center -San Diego
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San Diego, California, États-Unis, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, États-Unis, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, États-Unis, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, États-Unis, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, États-Unis, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, États-Unis, 92078
- Kaiser Permanente-San Marcos
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San Mateo, California, États-Unis, 94401
- Mills Health Center
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San Rafael, California, États-Unis, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, États-Unis, 94903
- Kaiser Permanente-San Rafael
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Santa Barbara, California, États-Unis, 93105
- Ridley-Tree Cancer Center
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Santa Clara, California, États-Unis, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, États-Unis, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Cruz, California, États-Unis, 95065
- Santa Cruz Radiation Oncology Medical Group
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Santa Rosa, California, États-Unis, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, États-Unis, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, États-Unis, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, États-Unis, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, États-Unis, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Upland, California, États-Unis, 91786
- City of Hope Upland
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Vacaville, California, États-Unis, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, États-Unis, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, États-Unis, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, États-Unis, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, États-Unis, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, États-Unis, 80012
- The Medical Center of Aurora
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Boulder, Colorado, États-Unis, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, États-Unis, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, États-Unis, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, États-Unis, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, États-Unis, 80923
- Saint Francis Cancer Center
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Denver, Colorado, États-Unis, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, États-Unis, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, États-Unis, 80220
- Rose Medical Center
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Denver, Colorado, États-Unis, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, États-Unis, 80210
- AdventHealth Porter
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Durango, Colorado, États-Unis, 81301
- Mercy Medical Center
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Durango, Colorado, États-Unis, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, États-Unis, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, États-Unis, 80113
- Swedish Medical Center
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Englewood, Colorado, États-Unis, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, États-Unis, 80113
- The Melanoma and Skin Cancer Institute
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Greeley, Colorado, États-Unis, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, États-Unis, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, États-Unis, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Lone Tree, Colorado, États-Unis, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, États-Unis, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, États-Unis, 80501
- Longmont United Hospital
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Loveland, Colorado, États-Unis, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, États-Unis, 80138
- AdventHealth Parker
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Pueblo, Colorado, États-Unis, 81004
- Saint Mary Corwin Medical Center
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Wheat Ridge, Colorado, États-Unis, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Glastonbury, Connecticut, États-Unis, 06033
- Smilow Cancer Hospital Care Center at Glastonbury
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Guilford, Connecticut, États-Unis, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, États-Unis, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Haven, Connecticut, États-Unis, 06520
- Yale University
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New Haven, Connecticut, États-Unis, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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Trumbull, Connecticut, États-Unis, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, États-Unis, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, États-Unis, 06385
- Smilow Cancer Hospital Care Center - Waterford
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District of Columbia
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Washington D.C., District of Columbia, États-Unis, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, États-Unis, 20007
- MedStar Georgetown University Hospital
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Florida
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Aventura, Florida, États-Unis, 33180
- UM Sylvester Comprehensive Cancer Center at Aventura
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Coral Gables, Florida, États-Unis, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, États-Unis, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, États-Unis, 33308
- Holy Cross Hospital
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Miami, Florida, États-Unis, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, États-Unis, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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North Miami, Florida, États-Unis, 33181
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
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Plantation, Florida, États-Unis, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Tampa, Florida, États-Unis, 33612
- Moffitt Cancer Center
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Tampa, Florida, États-Unis, 33607
- Moffitt Cancer Center-International Plaza
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Tampa, Florida, États-Unis, 33612
- Moffitt Cancer Center - McKinley Campus
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Georgia
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Athens, Georgia, États-Unis, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, États-Unis, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, États-Unis, 30342
- Northside Hospital
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Augusta, Georgia, États-Unis, 30912
- Augusta University Medical Center
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Cumming, Georgia, États-Unis, 30041
- Northside Hospital-Forsyth
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Decatur, Georgia, États-Unis, 30033
- Emory Decatur Hospital
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Duluth, Georgia, États-Unis, 30096
- Northside Hospital - Duluth
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Lawrenceville, Georgia, États-Unis, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, États-Unis, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, États-Unis, 31405
- Summit Cancer Care-Candler
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Hawaii
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Honolulu, Hawaii, États-Unis, 96813
- Queen's Medical Center
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Honolulu, Hawaii, États-Unis, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, États-Unis, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, États-Unis, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, États-Unis, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, États-Unis, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, États-Unis, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, États-Unis, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, États-Unis, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, États-Unis, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, États-Unis, 96813
- Island Urology
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Honolulu, Hawaii, États-Unis, 96819
- Kaiser Permanente Moanalua Medical Center
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Honolulu, Hawaii, États-Unis, 96817
- Hawaii Diagnostic Radiology Services LLC
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Kahului, Hawaii, États-Unis, 96732
- Straub Medical Center - Kahului Clinic
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Kailua, Hawaii, États-Unis, 96734
- Castle Medical Center
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Lihue, Hawaii, États-Unis, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, États-Unis, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, États-Unis, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, États-Unis, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, États-Unis, 96701
- The Cancer Center of Hawaii-Pali Momi
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‘Aiea, Hawaii, États-Unis, 96701
- Straub Pearlridge Clinic
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‘Ewa Beach, Hawaii, États-Unis, 96706
- The Queen's Medical Center - West Oahu
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Idaho
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Boise, Idaho, États-Unis, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Caldwell, Idaho, États-Unis, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, États-Unis, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, États-Unis, 83617
- Walter Knox Memorial Hospital
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Meridian, Idaho, États-Unis, 83642
- Idaho Urologic Institute-Meridian
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Nampa, Idaho, États-Unis, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Post Falls, Idaho, États-Unis, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, États-Unis, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Illinois
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Aurora, Illinois, États-Unis, 60504
- Rush-Copley Medical Center
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Aurora, Illinois, États-Unis, 60506
- Advocate Outpatient Center - Aurora
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Barrington, Illinois, États-Unis, 60010
- Advocate Good Shepherd Hospital
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Bloomington, Illinois, États-Unis, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, États-Unis, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, États-Unis, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, États-Unis, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, États-Unis, 62918
- SIH Cancer Institute
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Carthage, Illinois, États-Unis, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, États-Unis, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, États-Unis, 60611
- Northwestern University
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Chicago, Illinois, États-Unis, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, États-Unis, 60657
- Advocate Illinois Masonic Medical Center
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Crystal Lake, Illinois, États-Unis, 60014
- AMG Crystal Lake - Oncology
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Danville, Illinois, États-Unis, 61832
- Carle at The Riverfront
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DeKalb, Illinois, États-Unis, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, États-Unis, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, États-Unis, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, États-Unis, 61021
- Illinois CancerCare-Dixon
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Downers Grove, Illinois, États-Unis, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, États-Unis, 62401
- Crossroads Cancer Center
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Effingham, Illinois, États-Unis, 62401
- Carle Physician Group-Effingham
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Elgin, Illinois, États-Unis, 60123
- Advocate Sherman Hospital
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Eureka, Illinois, États-Unis, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, États-Unis, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, États-Unis, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, États-Unis, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, États-Unis, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, États-Unis, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Glenview, Illinois, États-Unis, 60026
- Northwestern Medicine Glenview Outpatient Center
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Grayslake, Illinois, États-Unis, 60030
- Northwestern Medicine Grayslake Outpatient Center
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Hazel Crest, Illinois, États-Unis, 60429
- Advocate South Suburban Hospital
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Highland Park, Illinois, États-Unis, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Kewanee, Illinois, États-Unis, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, États-Unis, 60045
- Northwestern Medicine Lake Forest Hospital
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Libertyville, Illinois, États-Unis, 60048
- Condell Memorial Hospital
-
Libertyville, Illinois, États-Unis, 60048
- AMG Libertyville - Oncology
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Macomb, Illinois, États-Unis, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, États-Unis, 61938
- Carle Physician Group-Mattoon/Charleston
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O'Fallon, Illinois, États-Unis, 62269
- Cancer Care Center of O'Fallon
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O'Fallon, Illinois, États-Unis, 62269
- HSHS Saint Elizabeth's Hospital
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Oak Lawn, Illinois, États-Unis, 60453-2699
- Advocate Christ Medical Center
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Oak Lawn, Illinois, États-Unis, 60453
- Advocate Outpatient Center - Oak Lawn
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Orland Park, Illinois, États-Unis, 60462
- Northwestern Medicine Orland Park
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Ottawa, Illinois, États-Unis, 61350
- Illinois CancerCare-Ottawa Clinic
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Palos Heights, Illinois, États-Unis, 60463
- Advocate High Tech Medical Park
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Park Ridge, Illinois, États-Unis, 60068
- Advocate Lutheran General Hospital
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Pekin, Illinois, États-Unis, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, États-Unis, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, États-Unis, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, États-Unis, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, États-Unis, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, États-Unis, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, États-Unis, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, États-Unis, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, États-Unis, 61356
- Illinois CancerCare-Princeton
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Springfield, Illinois, États-Unis, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, États-Unis, 62702
- Springfield Clinic
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Springfield, Illinois, États-Unis, 62781
- Springfield Memorial Hospital
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Swansea, Illinois, États-Unis, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, États-Unis, 61801
- Carle Cancer Center
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Urbana, Illinois, États-Unis, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, États-Unis, 60555
- Northwestern Medicine Cancer Center Warrenville
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Washington, Illinois, États-Unis, 61571
- Illinois CancerCare - Washington
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Yorkville, Illinois, États-Unis, 60560
- Rush-Copley Healthcare Center
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Indiana
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Evansville, Indiana, États-Unis, 47713
- Deaconess Clinic Downtown
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Indianapolis, Indiana, États-Unis, 46237
- Franciscan Health Indianapolis
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Indianapolis, Indiana, États-Unis, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Michigan City, Indiana, États-Unis, 46360
- Franciscan Saint Anthony Health-Michigan City
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Michigan City, Indiana, États-Unis, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, États-Unis, 46158
- Franciscan Health Mooresville
-
Newburgh, Indiana, États-Unis, 47630
- Chancellor Center for Oncology
-
Richmond, Indiana, États-Unis, 47374
- Reid Health
-
-
Iowa
-
Ames, Iowa, États-Unis, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, États-Unis, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, États-Unis, 50036
- McFarland Clinic - Boone
-
Council Bluffs, Iowa, États-Unis, 51503
- Alegent Health Mercy Hospital
-
Council Bluffs, Iowa, États-Unis, 51503
- Heartland Oncology and Hematology LLP
-
Council Bluffs, Iowa, États-Unis, 51503
- Methodist Jennie Edmundson Hospital
-
Council Bluffs, Iowa, États-Unis, 51503
- Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ
-
Fort Dodge, Iowa, États-Unis, 50501
- McFarland Clinic - Trinity Cancer Center
-
Jefferson, Iowa, États-Unis, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, États-Unis, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, États-Unis, 51101
- Siouxland Regional Cancer Center
-
-
Kansas
-
Chanute, Kansas, États-Unis, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, États-Unis, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, États-Unis, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, États-Unis, 66701
- Cancer Center of Kansas - Fort Scott
-
Hays, Kansas, États-Unis, 67601
- HaysMed
-
Independence, Kansas, États-Unis, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, États-Unis, 66160
- University of Kansas Cancer Center
-
Kingman, Kansas, États-Unis, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, États-Unis, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, États-Unis, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, États-Unis, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, États-Unis, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, États-Unis, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, États-Unis, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, États-Unis, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, États-Unis, 66211
- University of Kansas Hospital-Indian Creek Campus
-
Parsons, Kansas, États-Unis, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, États-Unis, 66762
- Freeman Physician Group of Pittsburg
-
Pratt, Kansas, États-Unis, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, États-Unis, 67401
- Salina Regional Health Center
-
Salina, Kansas, États-Unis, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, États-Unis, 66606
- University of Kansas Health System Saint Francis Campus
-
Topeka, Kansas, États-Unis, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, États-Unis, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, États-Unis, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, États-Unis, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, États-Unis, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, États-Unis, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, États-Unis, 67208
- Associates In Womens Health
-
Winfield, Kansas, États-Unis, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Crestview Hills, Kentucky, États-Unis, 41017
- Oncology Hematology Care Inc-Crestview
-
Louisville, Kentucky, États-Unis, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, États-Unis, 40245
- UofL Health Medical Center Northeast
-
-
Louisiana
-
Baton Rouge, Louisiana, États-Unis, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, États-Unis, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, États-Unis, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, États-Unis, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, États-Unis, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, États-Unis, 70836
- Ochsner High Grove
-
Baton Rouge, Louisiana, États-Unis, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, États-Unis, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, États-Unis, 70433
- Mary Bird Perkins Cancer Center - Covington
-
Covington, Louisiana, États-Unis, 70433
- Northshore Oncology Associates-Covington
-
Houma, Louisiana, États-Unis, 70360
- Mary Bird Perkins Cancer Center - Houma
-
Houma, Louisiana, États-Unis, 70360
- Oncology Center of The South Incorporated
-
Kenner, Louisiana, États-Unis, 70065
- Ochsner Medical Center Kenner
-
Monroe, Louisiana, États-Unis, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, États-Unis, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, États-Unis, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, États-Unis, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, États-Unis, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, États-Unis, 71105
- CHRISTUS Highland Medical Center
-
-
Maine
-
Augusta, Maine, États-Unis, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, États-Unis, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, États-Unis, 04412
- Lafayette Family Cancer Center-EMMC
-
Kennebunk, Maine, États-Unis, 04043
- New England Cancer Specialists - Kennebunk
-
Westbrook, Maine, États-Unis, 04092
- New England Cancer Specialists
-
-
Maryland
-
Baltimore, Maryland, États-Unis, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, États-Unis, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, États-Unis, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, États-Unis, 21229
- Saint Agnes Hospital
-
Cumberland, Maryland, États-Unis, 21502
- UPMC Western Maryland
-
Randallstown, Maryland, États-Unis, 21133
- Northwest Hospital Center
-
-
Massachusetts
-
Boston, Massachusetts, États-Unis, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, États-Unis, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, États-Unis, 02114
- Massachusetts General Hospital Cancer Center
-
Springfield, Massachusetts, États-Unis, 01199
- Baystate Medical Center
-
Worcester, Massachusetts, États-Unis, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Adrian, Michigan, États-Unis, 49221
- Hickman Cancer Center
-
Alma, Michigan, États-Unis, 48801
- MyMichigan Medical Center Gratiot
-
Alpena, Michigan, États-Unis, 49707
- MyMichigan Medical Center Alpena
-
Ann Arbor, Michigan, États-Unis, 48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor, Michigan, États-Unis, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, États-Unis, 49017
- Bronson Battle Creek
-
Brighton, Michigan, États-Unis, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, États-Unis, 48116
- University of Michigan - Brighton Center for Specialty Care
-
Brighton, Michigan, États-Unis, 48114
- Trinity Health Medical Center - Brighton
-
Canton, Michigan, États-Unis, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, États-Unis, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, États-Unis, 48723
- Caro Cancer Center
-
Chelsea, Michigan, États-Unis, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, États-Unis, 48118
- Chelsea Hospital
-
Clarkston, Michigan, États-Unis, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, États-Unis, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, États-Unis, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, États-Unis, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, États-Unis, 48054
- Henry Ford River District Hospital
-
Flint, Michigan, États-Unis, 48503
- Hurley Medical Center
-
Flint, Michigan, États-Unis, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, États-Unis, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, États-Unis, 48503
- Cancer Hematology Centers - Flint
-
Gladwin, Michigan, États-Unis, 48624
- MyMichigan Medical Center Gladwin
-
Grand Rapids, Michigan, États-Unis, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, États-Unis, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, États-Unis, 49201
- Allegiance Health
-
Kalamazoo, Michigan, États-Unis, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, États-Unis, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, États-Unis, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, États-Unis, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, États-Unis, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, États-Unis, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, États-Unis, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, États-Unis, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, États-Unis, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, États-Unis, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Midland, Michigan, États-Unis, 48670
- MyMichigan Medical Center Midland
-
Monroe, Michigan, États-Unis, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Mount Pleasant, Michigan, États-Unis, 48858
- MyMichigan Medical Center Mount Pleasant
-
Muskegon, Michigan, États-Unis, 49444
- Trinity Health Muskegon Hospital
-
Norton Shores, Michigan, États-Unis, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Pontiac, Michigan, États-Unis, 48341
- Hope Cancer Center
-
Pontiac, Michigan, États-Unis, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, États-Unis, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, États-Unis, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Reed City, Michigan, États-Unis, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, États-Unis, 48309
- Henry Ford Rochester Hospital
-
Royal Oak, Michigan, États-Unis, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, États-Unis, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, États-Unis, 48601
- MyMichigan Medical Center Saginaw
-
Southfield, Michigan, États-Unis, 48075
- Henry Ford Health Providence Southfield Hospital
-
Sterling Heights, Michigan, États-Unis, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, États-Unis, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, États-Unis, 49684
- Munson Medical Center
-
Troy, Michigan, États-Unis, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, États-Unis, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, États-Unis, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, États-Unis, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, États-Unis, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, États-Unis, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Branch, Michigan, États-Unis, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, États-Unis, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, États-Unis, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, États-Unis, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, États-Unis, 56431
- Riverwood Healthcare Center
-
Baxter, Minnesota, États-Unis, 56425
- Essentia Health - Baxter Clinic
-
Bemidji, Minnesota, États-Unis, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, États-Unis, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, États-Unis, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, États-Unis, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, États-Unis, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, États-Unis, 55433
- Mercy Hospital
-
Crosslake, Minnesota, États-Unis, 56442
- Essentia Health - Saint Joseph's Crosslake Clinic
-
Deer River, Minnesota, États-Unis, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, États-Unis, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, États-Unis, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, États-Unis, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, États-Unis, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, États-Unis, 55435
- Fairview Southdale Hospital
-
Ely, Minnesota, États-Unis, 55731
- Essentia Health - Ely Clinic
-
Fergus Falls, Minnesota, États-Unis, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, États-Unis, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, États-Unis, 55432
- Unity Hospital
-
Hibbing, Minnesota, États-Unis, 55746
- Essentia Health Hibbing Clinic
-
International Falls, Minnesota, États-Unis, 56649
- Essentia Health - International Falls Clinic
-
Maple Grove, Minnesota, États-Unis, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, États-Unis, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, États-Unis, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, États-Unis, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, États-Unis, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, États-Unis, 55454
- Health Partners Inc
-
Monticello, Minnesota, États-Unis, 55362
- Monticello Cancer Center
-
Moose Lake, Minnesota, États-Unis, 55767
- Essentia Health - Moose Lake Clinic
-
New Ulm, Minnesota, États-Unis, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, États-Unis, 56470
- Essentia Health - Park Rapids
-
Pequot Lakes, Minnesota, États-Unis, 56472
- Essentia Health - Saint Joseph's Pequot Lakes Clinic
-
Pine River, Minnesota, États-Unis, 56474
- Essentia Health - Saint Joseph's Pine River Clinic
-
Princeton, Minnesota, États-Unis, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, États-Unis, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, États-Unis, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, États-Unis, 55101
- Regions Hospital
-
Saint Paul, Minnesota, États-Unis, 55102
- United Hospital
-
Sandstone, Minnesota, États-Unis, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, États-Unis, 55379
- Saint Francis Regional Medical Center
-
Staples, Minnesota, États-Unis, 56479
- Essentia Health - Saint Joseph's Staples Clinic
-
Stillwater, Minnesota, États-Unis, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, États-Unis, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, États-Unis, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, États-Unis, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, États-Unis, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, États-Unis, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, États-Unis, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, États-Unis, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Jackson, Mississippi, États-Unis, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bonne Terre, Missouri, États-Unis, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, États-Unis, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, États-Unis, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, États-Unis, 63017
- Saint Luke's Hospital
-
Farmington, Missouri, États-Unis, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, États-Unis, 65109
- MU Health Care Goldschmidt Cancer Center
-
Kansas City, Missouri, États-Unis, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, États-Unis, 64108
- University Health Truman Medical Center
-
Kansas City, Missouri, États-Unis, 64116
- University of Kansas Cancer Center - Briarcliff
-
Lee's Summit, Missouri, États-Unis, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, États-Unis, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Saint Joseph, Missouri, États-Unis, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, États-Unis, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, États-Unis, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, États-Unis, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, États-Unis, 63131
- Missouri Baptist Medical Center
-
Sullivan, Missouri, États-Unis, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, États-Unis, 59711
- Community Hospital of Anaconda
-
Billings, Montana, États-Unis, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, États-Unis, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, États-Unis, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, États-Unis, 59405
- Benefis Sletten Cancer Institute
-
Havre, Montana, États-Unis, 59501
- Hi-Line Sletten Cancer Center
-
Helena, Montana, États-Unis, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, États-Unis, 59901
- Logan Health Medical Center
-
-
Nebraska
-
Lincoln, Nebraska, États-Unis, 68510
- Saint Elizabeth Regional Medical Center
-
North Platte, Nebraska, États-Unis, 69101
- Great Plains Health Callahan Cancer Center
-
Omaha, Nebraska, États-Unis, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, États-Unis, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, États-Unis, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, États-Unis, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, États-Unis, 68114
- Oncology Associates PC
-
Omaha, Nebraska, États-Unis, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, États-Unis, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, États-Unis, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, États-Unis, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, États-Unis, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, États-Unis, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, États-Unis, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, États-Unis, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, États-Unis, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, États-Unis, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, États-Unis, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, États-Unis, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, États-Unis, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, États-Unis, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, États-Unis, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, États-Unis, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, États-Unis, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, États-Unis, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, États-Unis, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, États-Unis, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, États-Unis, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, États-Unis, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, États-Unis, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, États-Unis, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, États-Unis, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, États-Unis, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, États-Unis, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, États-Unis, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, États-Unis, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, États-Unis, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, États-Unis, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, États-Unis, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, États-Unis, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, États-Unis, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, États-Unis, 89102
- Desert West Surgery
-
Las Vegas, Nevada, États-Unis, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, États-Unis, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, États-Unis, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, États-Unis, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, États-Unis, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, États-Unis, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, États-Unis, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, États-Unis, 89169
- University Cancer Center
-
Las Vegas, Nevada, États-Unis, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, États-Unis, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, États-Unis, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, États-Unis, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, États-Unis, 89502
- Renown Regional Medical Center
-
Reno, Nevada, États-Unis, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, États-Unis, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, États-Unis, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Basking Ridge, New Jersey, États-Unis, 07920
- Memorial Sloan Kettering Basking Ridge
-
Hackensack, New Jersey, États-Unis, 07601
- Hackensack University Medical Center
-
Neptune City, New Jersey, États-Unis, 07753
- Jersey Shore Medical Center
-
Paramus, New Jersey, États-Unis, 07652
- John Theurer Cancer Center at From Road
-
Red Bank, New Jersey, États-Unis, 07701
- Riverview Medical Center/Booker Cancer Center
-
-
New Mexico
-
Albuquerque, New Mexico, États-Unis, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, États-Unis, 87109
- New Mexico Oncology Hematology Consultants
-
Albuquerque, New Mexico, États-Unis, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, États-Unis, 87110
- Presbyterian Kaseman Hospital
-
Rio Rancho, New Mexico, États-Unis, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
Santa Fe, New Mexico, États-Unis, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo, New York, États-Unis, 14263
- Roswell Park Cancer Institute
-
Commack, New York, États-Unis, 11725
- Memorial Sloan Kettering Commack
-
Cooperstown, New York, États-Unis, 13326
- Mary Imogene Bassett Hospital
-
Harrison, New York, États-Unis, 10604
- Memorial Sloan Kettering Westchester
-
New York, New York, États-Unis, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, États-Unis, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, États-Unis, 14642
- University of Rochester
-
-
North Carolina
-
Asheville, North Carolina, États-Unis, 28803
- AdventHealth Infusion Center Asheville
-
Clinton, North Carolina, États-Unis, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, États-Unis, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, États-Unis, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, États-Unis, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, États-Unis, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, États-Unis, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, États-Unis, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, États-Unis, 28501
- ECU Health Oncology Kinston
-
Richlands, North Carolina, États-Unis, 28574
- ECU Health Oncology Richlands
-
-
North Dakota
-
Bismarck, North Dakota, États-Unis, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, États-Unis, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, États-Unis, 58103
- Sanford South University Medical Center
-
Jamestown, North Dakota, États-Unis, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Avon, Ohio, États-Unis, 44011
- UH Seidman Cancer Center at UH Avon Health Center
-
Beachwood, Ohio, États-Unis, 44122
- UHHS-Chagrin Highlands Medical Center
-
Beavercreek, Ohio, États-Unis, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, États-Unis, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, États-Unis, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, États-Unis, 44708
- Cleveland Clinic Mercy Hospital
-
Centerville, Ohio, États-Unis, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, États-Unis, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, États-Unis, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, États-Unis, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, États-Unis, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, États-Unis, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, États-Unis, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, États-Unis, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, États-Unis, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cleveland, Ohio, États-Unis, 44106
- Case Western Reserve University
-
Cleveland, Ohio, États-Unis, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, États-Unis, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, États-Unis, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, États-Unis, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, États-Unis, 43228
- Doctors Hospital
-
Columbus, Ohio, États-Unis, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, États-Unis, 43215
- Grant Medical Center
-
Columbus, Ohio, États-Unis, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, États-Unis, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, États-Unis, 45409
- Miami Valley Hospital
-
Dayton, Ohio, États-Unis, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, États-Unis, 45415
- Dayton Physician LLC - Englewood
-
Dayton, Ohio, États-Unis, 45409
- Premier Blood and Cancer Center
-
Delaware, Ohio, États-Unis, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, États-Unis, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, États-Unis, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, États-Unis, 43016
- Columbus Oncology and Hematology Associates
-
Fairfield, Ohio, États-Unis, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, États-Unis, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, États-Unis, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, États-Unis, 45840
- Orion Cancer Care
-
Franklin, Ohio, États-Unis, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, États-Unis, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, États-Unis, 45331
- Wayne Hospital
-
Greenville, Ohio, États-Unis, 45331
- Dayton Physicians LLC-Wayne
-
Greenville, Ohio, États-Unis, 45331
- Miami Valley Cancer Care and Infusion
-
Grove City, Ohio, États-Unis, 43123
- Mount Carmel Grove City Hospital
-
Grove City, Ohio, États-Unis, 43123
- Zangmeister Center Grove City
-
Kettering, Ohio, États-Unis, 45429
- Kettering Medical Center
-
Kettering, Ohio, États-Unis, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, États-Unis, 43130
- Fairfield Medical Center
-
Lima, Ohio, États-Unis, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, États-Unis, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, États-Unis, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, États-Unis, 43302
- OhioHealth Marion General Hospital
-
Marysville, Ohio, États-Unis, 43040
- Memorial Hospital
-
Maumee, Ohio, États-Unis, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, États-Unis, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mentor, Ohio, États-Unis, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middletown, Ohio, États-Unis, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, États-Unis, 43050
- Knox Community Hospital
-
New Albany, Ohio, États-Unis, 43054
- Mount Carmel New Albany Surgical Hospital
-
Newark, Ohio, États-Unis, 43055
- Licking Memorial Hospital
-
Newark, Ohio, États-Unis, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, États-Unis, 43616
- Saint Charles Hospital
-
Perrysburg, Ohio, États-Unis, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, États-Unis, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, États-Unis, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Sidney, Ohio, États-Unis, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, États-Unis, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, États-Unis, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, États-Unis, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, États-Unis, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, États-Unis, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, États-Unis, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, États-Unis, 43608
- Mercy Health - Saint Vincent Hospital
-
Toledo, Ohio, États-Unis, 43623
- Mercy Health Sylvania Radiation Oncology Center
-
Troy, Ohio, États-Unis, 45373
- Upper Valley Medical Center
-
Troy, Ohio, États-Unis, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, États-Unis, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, États-Unis, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, États-Unis, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, États-Unis, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Wilmington, Ohio, États-Unis, 45177
- Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
-
Youngstown, Ohio, États-Unis, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, États-Unis, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, États-Unis, 73104
- University of Oklahoma Health Sciences Center
-
-
Oregon
-
Baker City, Oregon, États-Unis, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Ontario, Oregon, États-Unis, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
-
Pennsylvania
-
Allentown, Pennsylvania, États-Unis, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Allentown, Pennsylvania, États-Unis, 18104
- Saint Luke's Cancer Center - Allentown
-
Allentown, Pennsylvania, États-Unis, 18104
- Saint Luke's Hospital-Allentown Campus
-
Beaver, Pennsylvania, États-Unis, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, États-Unis, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, États-Unis, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Coaldale, Pennsylvania, États-Unis, 18218
- Saint Luke's Hospital-Miners Campus
-
Danville, Pennsylvania, États-Unis, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, États-Unis, 18301
- Pocono Medical Center
-
Easton, Pennsylvania, États-Unis, 18045
- Saint Luke's Hospital-Anderson Campus
-
Erie, Pennsylvania, États-Unis, 16505
- UPMC Hillman Cancer Center Erie
-
Greensburg, Pennsylvania, États-Unis, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Hazleton, Pennsylvania, États-Unis, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, États-Unis, 18201
- Lehigh Valley Hospital-Hazleton
-
Indiana, Pennsylvania, États-Unis, 15701
- IRMC Cancer Center
-
Johnstown, Pennsylvania, États-Unis, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, États-Unis, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, États-Unis, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, États-Unis, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Mechanicsburg, Pennsylvania, États-Unis, 17050
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
-
Monroeville, Pennsylvania, États-Unis, 15146
- UPMC Hillman Cancer Center - Monroeville
-
Moon Township, Pennsylvania, États-Unis, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Pittsburgh, Pennsylvania, États-Unis, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, États-Unis, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, États-Unis, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, États-Unis, 17901
- Geisinger Cancer Services-Pottsville
-
Quakertown, Pennsylvania, États-Unis, 18951
- Saint Luke's Hospital - Upper Bucks Campus
-
Sayre, Pennsylvania, États-Unis, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, États-Unis, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, États-Unis, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Seneca, Pennsylvania, États-Unis, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, États-Unis, 16801
- Geisinger Medical Group
-
Stroudsburg, Pennsylvania, États-Unis, 18360
- Saint Luke's Hospital - Monroe Campus
-
Uniontown, Pennsylvania, États-Unis, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, États-Unis, 15301
- UPMC Washington Hospital Radiation Oncology
-
Washington, Pennsylvania, États-Unis, 15301
- UPMC Cancer Center-Washington
-
West Reading, Pennsylvania, États-Unis, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, États-Unis, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, États-Unis, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Westerly, Rhode Island, États-Unis, 02891
- Smilow Cancer Hospital Care Center - Westerly
-
-
South Carolina
-
Bluffton, South Carolina, États-Unis, 29910
- Saint Joseph's/Candler - Bluffton Campus
-
Greenville, South Carolina, États-Unis, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, États-Unis, 29601
- Saint Francis Hospital
-
Hilton Head Island, South Carolina, États-Unis, 29926-3827
- South Carolina Cancer Specialists PC
-
-
South Dakota
-
Sioux Falls, South Dakota, États-Unis, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, États-Unis, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Franklin, Tennessee, États-Unis, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Knoxville, Tennessee, États-Unis, 37916
- Covenant Health Cancer Centers
-
Knoxville, Tennessee, États-Unis, 37932
- Covenant Health Cancer Centers - West
-
Maryville, Tennessee, États-Unis, 37804
- Covenant Health Oncology Group - Maryville
-
Nashville, Tennessee, États-Unis, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, États-Unis, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Oak Ridge, Tennessee, États-Unis, 37830
- Covenant Health Oncology Group - Oak Ridge
-
-
Texas
-
Dallas, Texas, États-Unis, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, États-Unis, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
-
Utah
-
Farmington, Utah, États-Unis, 84025
- Farmington Health Center
-
Salt Lake City, Utah, États-Unis, 84112
- Huntsman Cancer Institute/University of Utah
-
South Jordan, Utah, États-Unis, 84009
- South Jordan Health Center
-
-
Vermont
-
Burlington, Vermont, États-Unis, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, États-Unis, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Charlottesville, Virginia, États-Unis, 22908
- University of Virginia Cancer Center
-
Fredericksburg, Virginia, États-Unis, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Lynchburg, Virginia, États-Unis, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Richmond, Virginia, États-Unis, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, États-Unis, 23298
- VCU Massey Comprehensive Cancer Center
-
Winchester, Virginia, États-Unis, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Bellevue, Washington, États-Unis, 98004
- Overlake Medical Center
-
Port Townsend, Washington, États-Unis, 98368
- Jefferson Healthcare
-
Renton, Washington, États-Unis, 98055
- Valley Medical Center
-
Yakima, Washington, États-Unis, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Charleston, West Virginia, États-Unis, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Huntington, West Virginia, États-Unis, 25701
- Edwards Comprehensive Cancer Center
-
-
Wisconsin
-
Antigo, Wisconsin, États-Unis, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Ashland, Wisconsin, États-Unis, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, États-Unis, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, États-Unis, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, États-Unis, 54729
- Marshfield Clinic-Chippewa Center
-
Cudahy, Wisconsin, États-Unis, 53110
- Aurora Saint Luke's South Shore
-
Eau Claire, Wisconsin, États-Unis, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, États-Unis, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, États-Unis, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, États-Unis, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, États-Unis, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, États-Unis, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, États-Unis, 54301
- Bellin Memorial Hospital
-
Hayward, Wisconsin, États-Unis, 54843
- Tamarack Health Hayward Medical Center
-
Johnson Creek, Wisconsin, États-Unis, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, États-Unis, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, États-Unis, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, États-Unis, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, États-Unis, 53718
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
-
Marinette, Wisconsin, États-Unis, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, États-Unis, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, États-Unis, 54451
- Aspirus Medford Hospital
-
Milwaukee, Wisconsin, États-Unis, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, États-Unis, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, États-Unis, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, États-Unis, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, États-Unis, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, États-Unis, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, États-Unis, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, États-Unis, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, États-Unis, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, États-Unis, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, États-Unis, 54868
- Marshfield Medical Center-Rice Lake
-
Rice Lake, Wisconsin, États-Unis, 54868
- Lakeview Medical Center-Marshfield Clinic
-
Sheboygan, Wisconsin, États-Unis, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, États-Unis, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, États-Unis, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, États-Unis, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, États-Unis, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, États-Unis, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, États-Unis, 53188
- ProHealth Waukesha Memorial Hospital
-
Waukesha, Wisconsin, États-Unis, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, États-Unis, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, États-Unis, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, États-Unis, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, États-Unis, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, États-Unis, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, États-Unis, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, États-Unis, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans et plus (Adulte, Adulte plus âgé)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria:
- All patients must be >= 18 years of age
- Eastern Cooperative Oncology Group (ECOG) performance status: 0 or 1
- Patients must have known BRAF mutational status of tumor; wild-type (WT) or mutated, prior to randomization
- Patients must not be pregnant or breast-feeding due to use of cytotoxic immunotherapy and risk of teratogenic side effects; all patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a patient of childbearing potential is anyone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patients must not conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse from the time of study registration and continuing (for patients of child bearing potential) for at least 5 months after the last dose of protocol treatment; patients of childbearing potential must also not donate eggs during this same time period
- Patients must have unresectable stage III or stage IV melanoma according to American Joint Committee on Cancer (AJCC) version (v)7; patients must have histological or cytological confirmation of melanoma that is metastatic or unresectable and clearly progressive
- Patients must have measurable disease per RECIST 1.1 criteria; all sites of disease must be evaluated within 4 weeks prior to randomization
- Patients may have had prior systemic therapy in the adjuvant setting (e.g. interferon, BRAF, or MEK agents). Patients may have had prior anti-CTLA-4 in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment. Patients may have had any prior anti-PD-1 or anti-PD-L1 agent in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment
- Patients may not have had any prior ipilimumab and/or anti-PD-1/PD-L1 agent in the metastatic setting
- Patients must have discontinued chemotherapy, immunotherapy or other investigational agents used in the adjuvant setting >= 4 weeks prior to randomization and recovered from adverse events due to those agents; mitomycin and nitrosoureas must have been discontinued at least 6 weeks prior to entering the study; patients must have discontinued radiation therapy >= 2 weeks prior to entering the study and recovered from any adverse events associated with treatment; prior surgery must be >= 4 weeks from randomization and patients must be fully recovered from post-surgical complications
- Patients must not receive any other investigational agents while on study or within four weeks prior to randomization
- Patient must not have received any live vaccine within 30 days prior to randomization, while participating in the study, and for 4 weeks (28 days) after the last dose of protocol treatment; live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 19 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist (registered trademark) are live attenuated vaccines and are not allowed); if possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events)
- Patients are ineligible if they have any currently active central nervous system (CNS) metastases; patients who have treated brain metastases (with either surgical resection or stereotactic radiosurgery) that have been stable on head magnetic resonance imaging (MRI) or contrast computed tomography (CT) scan for at least 4 weeks following treatment and within 4 weeks prior to randomization are eligible; patients must not have taken any steroids =< 14 days prior to randomization for the purpose of managing their brain metastases; patients with only whole brain irradiation for treatment of CNS metastases will be ineligible
- Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for > 3 years prior to the time of randomization
- White blood count >= 3,000/uL (obtained within 4 weeks prior to randomization)
- Absolute neutrophil count (ANC) >= 1,500/uL (obtained within 4 weeks prior to randomization)
- Platelet count >= 100,000/uL (obtained within 4 weeks prior to randomization)
- Hemoglobin >= 9 g/dL (obtained within 4 weeks prior to randomization)
- Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min (obtained within 4 weeks prior to randomization)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) (obtained within 4 weeks prior to randomization)
- Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) (obtained within 4 weeks prior to randomization)
- Total bilirubin =< 1.5 x ULN except patients with normal direct bilirubin; those patients with known Gilbert's syndrome must have total bilirubin < 3 x ULN (obtained within 4 weeks prior to randomization)
- Serum lactate dehydrogenase (LDH) =< 10 X ULN (obtained within 4 weeks prior to randomization)
- Patients must not have any serious or unstable pre-existing medical conditions (aside from malignancy exceptions specified above), including but not limited to, ongoing or active infection requiring parenteral antibiotics on day 1, history of bleeding diathesis or need for concurrent anticoagulation (international normalized ratio [INR] =< 1.5 and partial thromboplastin time [PTT] within 1.1 x ULN), or psychiatric illness/social situations that would limit compliance with study requirements, interfere with patient's safety, or obtaining informed consent
- Patients with human immunodeficiency virus (HIV) infection are ineligible; due to the mechanism of action of ipilimumab and GM-CSF, activity and side effects in an immune compromised patient are unknown
- Patients with evidence of active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are not eligible; patients with cleared HBV and HCV (0 viral load) infection will be allowed
- Patients must not have autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (e.g., prednisone, dexamethasone) or continuous use of topical steroid creams or ointments or ophthalmologic steroids; a history of occasional (but not continuous) use of steroid inhalers is allowed; replacement doses of steroids for patients with adrenal insufficiency are allowed; patients who discontinue use of these classes of medication for at least 2 weeks prior to randomization are eligible if, in the judgment of the treating physician investigator, the patient is not likely to require resumption of treatment with these classes of drugs during the study
- Exclusion from this study also includes patients with a history of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, Sjogren's syndrome, autoimmune vasculitis [e.g., Wegener's granulomatosis]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis); other CNS autoimmune disease (e.g., multiple sclerosis)
- Patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible
- Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed)
- Patients must not have other significant medical, surgical, or psychiatric conditions or require any medication or treatment that in the opinion of the investigator may interfere with compliance, make the administration of the study drugs hazardous or obscure the interpretation of adverse events (AEs), such as a condition associated with frequent diarrhea; patients must not have an active infection requiring current treatment with parenteral antibiotics
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: Arm A (nivolumab, ipilimumab, sargramostim)
INDUCTION THERAPY: Patients receive nivolumab IV over 30 minutes on day 1 of each cycle, ipilimumab IV over 30 minutes on day 1 of each cycle, and sargramostim SC on days 1-14 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab and sargramostim as in Induction therapy. Patients with PR, SC, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo MRI, CT scan, and blood sample collection throughout the study. Patients may also undergo a MUGA during screening, as well as an ECHO throughout the trial as clinically indicated. |
Undergo blood sample collection
Autres noms:
Given IV
Autres noms:
Given SC
Autres noms:
Undergo ECHO
Autres noms:
Undergo MUGA
Autres noms:
Given IV
Autres noms:
Undergo CT scan
Autres noms:
Undergo MRI
Autres noms:
|
|
Expérimental: Arm B (nivolumab, ipilimumab)
INDUCTION THERAPY: Patients receive nivolumab and ipilimumab as in Arm I. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab as in Induction therapy. Patients with PR, SD, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo MRI, CT scan, and blood sample collection throughout the study. Patients may also undergo a MUGA during screening, as well as an ECHO throughout the trial as clinically indicated. |
Undergo blood sample collection
Autres noms:
Given IV
Autres noms:
Undergo ECHO
Autres noms:
Undergo MUGA
Autres noms:
Given IV
Autres noms:
Undergo CT scan
Autres noms:
Undergo MRI
Autres noms:
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Overall survival
Délai: Time from randomization to death from any cause, assessed up to 5 years
|
Overall survival between the two arms will be compared using the stratified log-rank test. One-sided type I error rate of 0.2 will be used. Kaplan-Meier plot will be generated and two-sided p-values will be reported. This analysis will be summarized using the forest plots with hazard ratios and 95% confidence intervals. Cox multivariate models will be developed for overall survival. |
Time from randomization to death from any cause, assessed up to 5 years
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Progression free survival
Délai: Time from randomization to disease progression or death (whichever occurs first), assessed up to 5 years
|
Evaluated based on international criteria proposed by the revised Response Evaluation Criteria in Solid Tumors guideline (version 1.1). This analysis will be summarized using the forest plots with hazard ratios and 95% confidence intervals. Cox multivariate models will be developed for progression free survival. |
Time from randomization to disease progression or death (whichever occurs first), assessed up to 5 years
|
|
Incidence of toxicities
Délai: Up to 90 days after the last study drug administration
|
Defined using the Common Terminology Criteria for Adverse Events version 4.0 criteria. Individual toxicity type adverse event and categorized adverse event data (by autoimmune disorders, endocrine, gastrointestinal, liver, nervous system, pancreas, psychiatric disorders, skin, thromboembolic disorders) will be summarized by grade and treatment arm. The percentages of patients experiencing the worst degree toxicities (highest grade event per adverse event type per patient) will be evaluated and the distribution of the worst degree toxicities will be compared among the treatment arms. The proportion of patients with worst degree toxicities with 3 or higher will be summarized and compared among the treatment arms. |
Up to 90 days after the last study drug administration
|
|
Immune response
Délai: Up to 5 years
|
Assessed using the utility of immune related response criteria. The immune related response criteria and the Response Evaluation Criteria in Solid Tumors-based clinical response data will be compared between the two treatment arms, using the Fisher's exact test. Two-sided p-values will be reported. Furthermore immune related response criteria data will be associated with the Response Evaluation Criteria in Solid Tumors-based clinical response. The Kappa statistics which measures the degree of agreement between the Response Evaluation Criteria in Solid Tumors-based response and immune related response criteria will be estimated. McNemar's test will be used to evaluate the agreement between immune related response criteria and Response Evaluation Criteria in Solid Tumors-based clinical response. |
Up to 5 years
|
|
Clinical response
Délai: Up to 5 years
|
Assessed using the utility of immune related response criteria. Standard response criteria (based on the Response Evaluation Criteria in Solid Tumors) will be applied to assess clinical response. The immune related response criteria and the Response Evaluation Criteria in Solid Tumors-based clinical response data will be compared between the two treatment arms, using the Fisher's exact test. Two-sided p-values will be reported. Furthermore immune related response criteria data will be associated with the Response Evaluation Criteria in Solid Tumors-based clinical response. The Kappa statistics which measures the degree of agreement between the Response Evaluation Criteria in Solid Tumors-based response and immune related response criteria will be estimated. McNemar's test will be used to evaluate the agreement between immune related response criteria and Response Evaluation Criteria in Solid Tumors-based clinical response. |
Up to 5 years
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Les enquêteurs
- Chercheur principal: Frank S Hodi, ECOG-ACRIN Cancer Research Group
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Réel)
23 novembre 2015
Achèvement primaire (Estimé)
30 juin 2033
Achèvement de l'étude (Estimé)
30 juin 2033
Dates d'inscription aux études
Première soumission
12 janvier 2015
Première soumission répondant aux critères de contrôle qualité
12 janvier 2015
Première publication (Estimé)
15 janvier 2015
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
12 novembre 2026
Dernière mise à jour soumise répondant aux critères de contrôle qualité
11 novembre 2026
Dernière vérification
1 juillet 2026
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
- Tumeurs par site
- Tumeurs
- Tumeurs par type histologique
- Maladies de la peau
- Tumeurs neuroectodermiques
- Tumeurs, cellules germinales et embryonnaires
- Tumeurs, tissu nerveux
- Tumeurs neuroendocrines
- Nevi et mélanomes
- Tumeurs cutanées
- Maladies de la peau et du tissu conjonctif
- Mélanome
- Peptides
- Acides aminés, peptides et protéines
- Protéines
- Techniques d'investigation
- Techniques de laboratoire clinique
- Techniques et procédures de diagnostic
- Diagnostic
- Facteurs biologiques
- Glucides
- Anticorps, monoclonal, humanisé
- Anticorps, monoclonal
- Anticorps
- Immunoglobulines
- Immunoprotéines
- Protéines sanguines
- Globulines sériques
- Globulines
- Récepteurs, surface cellulaire
- Protéines membranaires
- Peptides de signalisation intercellulaire et protéines
- Glycoprotéines
- Glycoconjuguis
- Facteurs de croissance des cellules hématopoïétiques
- Cytokines
- Antigènes
- Antigènes, surface
- Biomarqueurs
- Récepteurs, immunologique
- Antigènes, différenciation, lymphocyte T
- Antigènes, différenciation
- Protéines de point de contrôle immunitaire
- Récepteurs costimulants et inhibiteurs des cellules T
- Nivolumab
- Ipilimumab
- Manipulation des échantillons
- sargramostim
- Antigène CTLA-4
- Facteurs de stimulation des colonies
Autres numéros d'identification d'étude
- NCI-2014-02674
- NCI-2014-02674 (Identificateur de registre: CTRP (Clinical Trial Reporting Program))
- EA6141 (Autre identifiant: CTEP)
- U10CA180820 (Subvention/contrat des NIH des États-Unis)
- U24CA196172 (Subvention/contrat des NIH des États-Unis)
- EA6141
- EA6141 (Autre identifiant: ECOG-ACRIN Cancer Research Group)
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Oui
Étudie un produit d'appareil réglementé par la FDA américaine
Non
produit fabriqué et exporté des États-Unis.
Non
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .