Badanie fazy II/III niwolumabu, ipilimumabu i GM-CSF u pacjentów z zaawansowanym czerniakiem
11 listopada 2026 zaktualizowane przez: National Cancer Institute (NCI)
Randomizowane badanie fazy II/III porównujące niwolumab plus ipilimumab plus sargramostim z niwolumabem plus ipilimumabem u pacjentów z nieoperacyjnym czerniakiem w stadium III lub IV
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma.
Przegląd badań
Status
Aktywny, nie rekrutujący
Szczegółowy opis
PRIMARY OBJECTIVE:
I. To compare the overall survival (OS) of nivolumab/ipilimumab/sargramostim (GM-CSF) versus nivolumab/ipilimumab.
SECONDARY OBJECTIVES:
I. To evaluate progression free survival (PFS) of patients treated with nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab.
II. To assess for differences in tolerability, specifically the rate of grade III or higher adverse events, between nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab.
III. To evaluate immune-related response rate (based on immune-related response criteria) and response rate (based on Response Evaluation Criteria in Solid Tumors [RECIST] criteria) and to compare them.
EXPLORATORY TOBACCO USE OBJECTIVES:
I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications).
II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.
III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.
IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM A: INDUCTION THERAPY: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1 of each cycle, ipilimumab IV over 30 minutes on day 1 of each age, and sargramostim subcutaneously (SC) on days 1-14 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.
MAINTENANCE THERAPY: Patients receive nivolumab and sargramostim as in induction therapy. Patients with partial response (PR), stable disease (SD), or complete response (CR) at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo magnetic resonance imaging (MRI), computed tomography (CT) scan, and blood sample collection throughout the study. Patients may also undergo a multigated acquisition (MUGA) during screening, as well as an echocardiography (ECHO) throughout the trial as clinically indicated.
ARM B: INDUCTION THERAPY: Patients receive nivolumab and ipilimumab as in Arm I. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.
MAINTENANCE THERAPY: Patients receive nivolumab as in induction therapy. Patients with PR, SD, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo MRI, CT scan, and blood sample collection throughout the study. Patients may also undergo a MUGA during screening, as well as an ECHO throughout the trial as clinically indicated.
After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Typ studiów
Interwencyjne
Zapisy (Szacowany)
600
Faza
- Faza 2
- Faza 3
Kontakty i lokalizacje
Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.
Lokalizacje studiów
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Alabama
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Birmingham, Alabama, Stany Zjednoczone, 35233
- University of Alabama at Birmingham Cancer Center
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Arizona
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Kingman, Arizona, Stany Zjednoczone, 86401
- Kingman Regional Medical Center
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Arkansas
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Little Rock, Arkansas, Stany Zjednoczone, 72205
- CARTI Cancer Center
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Little Rock, Arkansas, Stany Zjednoczone, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Anaheim, California, Stany Zjednoczone, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Stany Zjednoczone, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Stany Zjednoczone, 93420
- PCR Oncology
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Auburn, California, Stany Zjednoczone, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Stany Zjednoczone, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, Stany Zjednoczone, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Stany Zjednoczone, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Stany Zjednoczone, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Stany Zjednoczone, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Stany Zjednoczone, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Stany Zjednoczone, 94546
- Eden Hospital Medical Center
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Davis, California, Stany Zjednoczone, 95616
- Sutter Davis Hospital
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Duarte, California, Stany Zjednoczone, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Stany Zjednoczone, 94568
- Kaiser Permanente Dublin
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Fontana, California, Stany Zjednoczone, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Stany Zjednoczone, 94538
- Kaiser Permanente-Fremont
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Fremont, California, Stany Zjednoczone, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, Stany Zjednoczone, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Stany Zjednoczone, 93720
- Kaiser Permanente Fresno Orchard Plaza
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Harbor City, California, Stany Zjednoczone, 90710
- Kaiser Permanente South Bay
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Irvine, California, Stany Zjednoczone, 92618
- Kaiser Permanente-Irvine
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Irvine, California, Stany Zjednoczone, 92612
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
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Los Angeles, California, Stany Zjednoczone, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Stany Zjednoczone, 90034
- Kaiser Permanente West Los Angeles
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Modesto, California, Stany Zjednoczone, 95355
- Memorial Medical Center
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Modesto, California, Stany Zjednoczone, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, Stany Zjednoczone, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Stany Zjednoczone, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, Stany Zjednoczone, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Stany Zjednoczone, 94611
- Kaiser Permanente-Oakland
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Ontario, California, Stany Zjednoczone, 91761
- Kaiser Permanente-Ontario
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Orange, California, Stany Zjednoczone, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, Stany Zjednoczone, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, Stany Zjednoczone, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Stany Zjednoczone, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Stany Zjednoczone, 91402
- Kaiser Permanente - Panorama City
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Redwood City, California, Stany Zjednoczone, 94063
- Kaiser Permanente-Redwood City
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Redwood City, California, Stany Zjednoczone, 94063
- Kaiser Permanente- Marshall Medical Offices
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Richmond, California, Stany Zjednoczone, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Stany Zjednoczone, 92505
- Kaiser Permanente-Riverside
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Roseville, California, Stany Zjednoczone, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Stany Zjednoczone, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Stany Zjednoczone, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Stany Zjednoczone, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Stany Zjednoczone, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Stany Zjednoczone, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Stany Zjednoczone, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Stany Zjednoczone, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Stany Zjednoczone, 92134
- Naval Medical Center -San Diego
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San Diego, California, Stany Zjednoczone, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, Stany Zjednoczone, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Stany Zjednoczone, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Stany Zjednoczone, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Stany Zjednoczone, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, Stany Zjednoczone, 92078
- Kaiser Permanente-San Marcos
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San Mateo, California, Stany Zjednoczone, 94401
- Mills Health Center
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San Rafael, California, Stany Zjednoczone, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, Stany Zjednoczone, 94903
- Kaiser Permanente-San Rafael
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Santa Barbara, California, Stany Zjednoczone, 93105
- Ridley-Tree Cancer Center
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Santa Clara, California, Stany Zjednoczone, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Stany Zjednoczone, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Cruz, California, Stany Zjednoczone, 95065
- Santa Cruz Radiation Oncology Medical Group
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Santa Rosa, California, Stany Zjednoczone, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Stany Zjednoczone, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Stany Zjednoczone, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Stany Zjednoczone, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, Stany Zjednoczone, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Upland, California, Stany Zjednoczone, 91786
- City of Hope Upland
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Vacaville, California, Stany Zjednoczone, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Stany Zjednoczone, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Stany Zjednoczone, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Stany Zjednoczone, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Stany Zjednoczone, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Stany Zjednoczone, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Stany Zjednoczone, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Stany Zjednoczone, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Stany Zjednoczone, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Stany Zjednoczone, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Stany Zjednoczone, 80923
- Saint Francis Cancer Center
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Denver, Colorado, Stany Zjednoczone, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Stany Zjednoczone, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Stany Zjednoczone, 80220
- Rose Medical Center
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Denver, Colorado, Stany Zjednoczone, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Stany Zjednoczone, 80210
- AdventHealth Porter
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Durango, Colorado, Stany Zjednoczone, 81301
- Mercy Medical Center
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Durango, Colorado, Stany Zjednoczone, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Stany Zjednoczone, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Stany Zjednoczone, 80113
- Swedish Medical Center
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Englewood, Colorado, Stany Zjednoczone, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Stany Zjednoczone, 80113
- The Melanoma and Skin Cancer Institute
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Greeley, Colorado, Stany Zjednoczone, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Stany Zjednoczone, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Stany Zjednoczone, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Lone Tree, Colorado, Stany Zjednoczone, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Stany Zjednoczone, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, Stany Zjednoczone, 80501
- Longmont United Hospital
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Loveland, Colorado, Stany Zjednoczone, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Stany Zjednoczone, 80138
- AdventHealth Parker
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Pueblo, Colorado, Stany Zjednoczone, 81004
- Saint Mary Corwin Medical Center
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Wheat Ridge, Colorado, Stany Zjednoczone, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Glastonbury, Connecticut, Stany Zjednoczone, 06033
- Smilow Cancer Hospital Care Center at Glastonbury
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Guilford, Connecticut, Stany Zjednoczone, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, Stany Zjednoczone, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Haven, Connecticut, Stany Zjednoczone, 06520
- Yale University
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New Haven, Connecticut, Stany Zjednoczone, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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Trumbull, Connecticut, Stany Zjednoczone, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, Stany Zjednoczone, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, Stany Zjednoczone, 06385
- Smilow Cancer Hospital Care Center - Waterford
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District of Columbia
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Washington D.C., District of Columbia, Stany Zjednoczone, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, Stany Zjednoczone, 20007
- MedStar Georgetown University Hospital
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Florida
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Aventura, Florida, Stany Zjednoczone, 33180
- UM Sylvester Comprehensive Cancer Center at Aventura
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Coral Gables, Florida, Stany Zjednoczone, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, Stany Zjednoczone, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, Stany Zjednoczone, 33308
- Holy Cross Hospital
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Miami, Florida, Stany Zjednoczone, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Stany Zjednoczone, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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North Miami, Florida, Stany Zjednoczone, 33181
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
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Plantation, Florida, Stany Zjednoczone, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Tampa, Florida, Stany Zjednoczone, 33612
- Moffitt Cancer Center
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Tampa, Florida, Stany Zjednoczone, 33607
- Moffitt Cancer Center-International Plaza
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Tampa, Florida, Stany Zjednoczone, 33612
- Moffitt Cancer Center - McKinley Campus
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Georgia
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Athens, Georgia, Stany Zjednoczone, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Stany Zjednoczone, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Stany Zjednoczone, 30342
- Northside Hospital
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Augusta, Georgia, Stany Zjednoczone, 30912
- Augusta University Medical Center
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Cumming, Georgia, Stany Zjednoczone, 30041
- Northside Hospital-Forsyth
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Decatur, Georgia, Stany Zjednoczone, 30033
- Emory Decatur Hospital
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Duluth, Georgia, Stany Zjednoczone, 30096
- Northside Hospital - Duluth
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Lawrenceville, Georgia, Stany Zjednoczone, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, Stany Zjednoczone, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Stany Zjednoczone, 31405
- Summit Cancer Care-Candler
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Hawaii
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Honolulu, Hawaii, Stany Zjednoczone, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Stany Zjednoczone, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Stany Zjednoczone, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Stany Zjednoczone, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Stany Zjednoczone, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Stany Zjednoczone, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Stany Zjednoczone, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Stany Zjednoczone, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Stany Zjednoczone, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Stany Zjednoczone, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Stany Zjednoczone, 96813
- Island Urology
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Honolulu, Hawaii, Stany Zjednoczone, 96819
- Kaiser Permanente Moanalua Medical Center
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Honolulu, Hawaii, Stany Zjednoczone, 96817
- Hawaii Diagnostic Radiology Services LLC
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Kahului, Hawaii, Stany Zjednoczone, 96732
- Straub Medical Center - Kahului Clinic
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Kailua, Hawaii, Stany Zjednoczone, 96734
- Castle Medical Center
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Lihue, Hawaii, Stany Zjednoczone, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Stany Zjednoczone, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Stany Zjednoczone, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Stany Zjednoczone, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Stany Zjednoczone, 96701
- The Cancer Center of Hawaii-Pali Momi
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‘Aiea, Hawaii, Stany Zjednoczone, 96701
- Straub Pearlridge Clinic
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‘Ewa Beach, Hawaii, Stany Zjednoczone, 96706
- The Queen's Medical Center - West Oahu
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Idaho
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Boise, Idaho, Stany Zjednoczone, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Caldwell, Idaho, Stany Zjednoczone, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Stany Zjednoczone, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Stany Zjednoczone, 83617
- Walter Knox Memorial Hospital
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Meridian, Idaho, Stany Zjednoczone, 83642
- Idaho Urologic Institute-Meridian
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Nampa, Idaho, Stany Zjednoczone, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Post Falls, Idaho, Stany Zjednoczone, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Stany Zjednoczone, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Illinois
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Aurora, Illinois, Stany Zjednoczone, 60504
- Rush-Copley Medical Center
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Aurora, Illinois, Stany Zjednoczone, 60506
- Advocate Outpatient Center - Aurora
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Barrington, Illinois, Stany Zjednoczone, 60010
- Advocate Good Shepherd Hospital
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Bloomington, Illinois, Stany Zjednoczone, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Stany Zjednoczone, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, Stany Zjednoczone, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Stany Zjednoczone, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Stany Zjednoczone, 62918
- SIH Cancer Institute
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Carthage, Illinois, Stany Zjednoczone, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Stany Zjednoczone, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Stany Zjednoczone, 60611
- Northwestern University
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Chicago, Illinois, Stany Zjednoczone, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, Stany Zjednoczone, 60657
- Advocate Illinois Masonic Medical Center
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Crystal Lake, Illinois, Stany Zjednoczone, 60014
- AMG Crystal Lake - Oncology
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Danville, Illinois, Stany Zjednoczone, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Stany Zjednoczone, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Stany Zjednoczone, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Stany Zjednoczone, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Stany Zjednoczone, 61021
- Illinois CancerCare-Dixon
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Downers Grove, Illinois, Stany Zjednoczone, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, Stany Zjednoczone, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Stany Zjednoczone, 62401
- Carle Physician Group-Effingham
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Elgin, Illinois, Stany Zjednoczone, 60123
- Advocate Sherman Hospital
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Eureka, Illinois, Stany Zjednoczone, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Stany Zjednoczone, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Stany Zjednoczone, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Stany Zjednoczone, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Stany Zjednoczone, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Stany Zjednoczone, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Glenview, Illinois, Stany Zjednoczone, 60026
- Northwestern Medicine Glenview Outpatient Center
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Grayslake, Illinois, Stany Zjednoczone, 60030
- Northwestern Medicine Grayslake Outpatient Center
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Hazel Crest, Illinois, Stany Zjednoczone, 60429
- Advocate South Suburban Hospital
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Highland Park, Illinois, Stany Zjednoczone, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Kewanee, Illinois, Stany Zjednoczone, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Stany Zjednoczone, 60045
- Northwestern Medicine Lake Forest Hospital
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Libertyville, Illinois, Stany Zjednoczone, 60048
- Condell Memorial Hospital
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Libertyville, Illinois, Stany Zjednoczone, 60048
- AMG Libertyville - Oncology
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Macomb, Illinois, Stany Zjednoczone, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Stany Zjednoczone, 61938
- Carle Physician Group-Mattoon/Charleston
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O'Fallon, Illinois, Stany Zjednoczone, 62269
- Cancer Care Center of O'Fallon
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O'Fallon, Illinois, Stany Zjednoczone, 62269
- HSHS Saint Elizabeth's Hospital
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Oak Lawn, Illinois, Stany Zjednoczone, 60453-2699
- Advocate Christ Medical Center
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Oak Lawn, Illinois, Stany Zjednoczone, 60453
- Advocate Outpatient Center - Oak Lawn
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Orland Park, Illinois, Stany Zjednoczone, 60462
- Northwestern Medicine Orland Park
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Ottawa, Illinois, Stany Zjednoczone, 61350
- Illinois CancerCare-Ottawa Clinic
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Palos Heights, Illinois, Stany Zjednoczone, 60463
- Advocate High Tech Medical Park
-
Park Ridge, Illinois, Stany Zjednoczone, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, Stany Zjednoczone, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Stany Zjednoczone, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Stany Zjednoczone, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Stany Zjednoczone, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Stany Zjednoczone, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Stany Zjednoczone, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Stany Zjednoczone, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Stany Zjednoczone, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Stany Zjednoczone, 61356
- Illinois CancerCare-Princeton
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Springfield Clinic
-
Springfield, Illinois, Stany Zjednoczone, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Stany Zjednoczone, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Stany Zjednoczone, 61801
- Carle Cancer Center
-
Urbana, Illinois, Stany Zjednoczone, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Stany Zjednoczone, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Washington, Illinois, Stany Zjednoczone, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Stany Zjednoczone, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Evansville, Indiana, Stany Zjednoczone, 47713
- Deaconess Clinic Downtown
-
Indianapolis, Indiana, Stany Zjednoczone, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Stany Zjednoczone, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Michigan City, Indiana, Stany Zjednoczone, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, Stany Zjednoczone, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Stany Zjednoczone, 46158
- Franciscan Health Mooresville
-
Newburgh, Indiana, Stany Zjednoczone, 47630
- Chancellor Center for Oncology
-
Richmond, Indiana, Stany Zjednoczone, 47374
- Reid Health
-
-
Iowa
-
Ames, Iowa, Stany Zjednoczone, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Stany Zjednoczone, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, Stany Zjednoczone, 50036
- McFarland Clinic - Boone
-
Council Bluffs, Iowa, Stany Zjednoczone, 51503
- Alegent Health Mercy Hospital
-
Council Bluffs, Iowa, Stany Zjednoczone, 51503
- Heartland Oncology and Hematology LLP
-
Council Bluffs, Iowa, Stany Zjednoczone, 51503
- Methodist Jennie Edmundson Hospital
-
Council Bluffs, Iowa, Stany Zjednoczone, 51503
- Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ
-
Fort Dodge, Iowa, Stany Zjednoczone, 50501
- McFarland Clinic - Trinity Cancer Center
-
Jefferson, Iowa, Stany Zjednoczone, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Stany Zjednoczone, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Stany Zjednoczone, 51101
- Siouxland Regional Cancer Center
-
-
Kansas
-
Chanute, Kansas, Stany Zjednoczone, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Stany Zjednoczone, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Stany Zjednoczone, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Stany Zjednoczone, 66701
- Cancer Center of Kansas - Fort Scott
-
Hays, Kansas, Stany Zjednoczone, 67601
- HaysMed
-
Independence, Kansas, Stany Zjednoczone, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Stany Zjednoczone, 66160
- University of Kansas Cancer Center
-
Kingman, Kansas, Stany Zjednoczone, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Stany Zjednoczone, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Stany Zjednoczone, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Stany Zjednoczone, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Stany Zjednoczone, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Stany Zjednoczone, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Stany Zjednoczone, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Stany Zjednoczone, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Stany Zjednoczone, 66211
- University of Kansas Hospital-Indian Creek Campus
-
Parsons, Kansas, Stany Zjednoczone, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Stany Zjednoczone, 66762
- Freeman Physician Group of Pittsburg
-
Pratt, Kansas, Stany Zjednoczone, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Stany Zjednoczone, 67401
- Salina Regional Health Center
-
Salina, Kansas, Stany Zjednoczone, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Stany Zjednoczone, 66606
- University of Kansas Health System Saint Francis Campus
-
Topeka, Kansas, Stany Zjednoczone, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Stany Zjednoczone, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Stany Zjednoczone, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Stany Zjednoczone, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Stany Zjednoczone, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Stany Zjednoczone, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Stany Zjednoczone, 67208
- Associates In Womens Health
-
Winfield, Kansas, Stany Zjednoczone, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Crestview Hills, Kentucky, Stany Zjednoczone, 41017
- Oncology Hematology Care Inc-Crestview
-
Louisville, Kentucky, Stany Zjednoczone, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Stany Zjednoczone, 40245
- UofL Health Medical Center Northeast
-
-
Louisiana
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70836
- Ochsner High Grove
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, Stany Zjednoczone, 70433
- Mary Bird Perkins Cancer Center - Covington
-
Covington, Louisiana, Stany Zjednoczone, 70433
- Northshore Oncology Associates-Covington
-
Houma, Louisiana, Stany Zjednoczone, 70360
- Mary Bird Perkins Cancer Center - Houma
-
Houma, Louisiana, Stany Zjednoczone, 70360
- Oncology Center of The South Incorporated
-
Kenner, Louisiana, Stany Zjednoczone, 70065
- Ochsner Medical Center Kenner
-
Monroe, Louisiana, Stany Zjednoczone, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Stany Zjednoczone, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Stany Zjednoczone, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Stany Zjednoczone, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, Stany Zjednoczone, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, Stany Zjednoczone, 71105
- CHRISTUS Highland Medical Center
-
-
Maine
-
Augusta, Maine, Stany Zjednoczone, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Stany Zjednoczone, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Stany Zjednoczone, 04412
- Lafayette Family Cancer Center-EMMC
-
Kennebunk, Maine, Stany Zjednoczone, 04043
- New England Cancer Specialists - Kennebunk
-
Westbrook, Maine, Stany Zjednoczone, 04092
- New England Cancer Specialists
-
-
Maryland
-
Baltimore, Maryland, Stany Zjednoczone, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Stany Zjednoczone, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Stany Zjednoczone, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Stany Zjednoczone, 21229
- Saint Agnes Hospital
-
Cumberland, Maryland, Stany Zjednoczone, 21502
- UPMC Western Maryland
-
Randallstown, Maryland, Stany Zjednoczone, 21133
- Northwest Hospital Center
-
-
Massachusetts
-
Boston, Massachusetts, Stany Zjednoczone, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Stany Zjednoczone, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Stany Zjednoczone, 02114
- Massachusetts General Hospital Cancer Center
-
Springfield, Massachusetts, Stany Zjednoczone, 01199
- Baystate Medical Center
-
Worcester, Massachusetts, Stany Zjednoczone, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Adrian, Michigan, Stany Zjednoczone, 49221
- Hickman Cancer Center
-
Alma, Michigan, Stany Zjednoczone, 48801
- MyMichigan Medical Center Gratiot
-
Alpena, Michigan, Stany Zjednoczone, 49707
- MyMichigan Medical Center Alpena
-
Ann Arbor, Michigan, Stany Zjednoczone, 48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor, Michigan, Stany Zjednoczone, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Stany Zjednoczone, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Stany Zjednoczone, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Stany Zjednoczone, 48116
- University of Michigan - Brighton Center for Specialty Care
-
Brighton, Michigan, Stany Zjednoczone, 48114
- Trinity Health Medical Center - Brighton
-
Canton, Michigan, Stany Zjednoczone, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Stany Zjednoczone, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Stany Zjednoczone, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Stany Zjednoczone, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Stany Zjednoczone, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Stany Zjednoczone, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Stany Zjednoczone, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, Stany Zjednoczone, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Stany Zjednoczone, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Stany Zjednoczone, 48054
- Henry Ford River District Hospital
-
Flint, Michigan, Stany Zjednoczone, 48503
- Hurley Medical Center
-
Flint, Michigan, Stany Zjednoczone, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Stany Zjednoczone, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Stany Zjednoczone, 48503
- Cancer Hematology Centers - Flint
-
Gladwin, Michigan, Stany Zjednoczone, 48624
- MyMichigan Medical Center Gladwin
-
Grand Rapids, Michigan, Stany Zjednoczone, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Stany Zjednoczone, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grosse Pointe Woods, Michigan, Stany Zjednoczone, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Stany Zjednoczone, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Stany Zjednoczone, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Stany Zjednoczone, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Stany Zjednoczone, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Stany Zjednoczone, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Stany Zjednoczone, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, Stany Zjednoczone, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Stany Zjednoczone, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Stany Zjednoczone, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Stany Zjednoczone, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Stany Zjednoczone, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Stany Zjednoczone, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Stany Zjednoczone, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Midland, Michigan, Stany Zjednoczone, 48670
- MyMichigan Medical Center Midland
-
Monroe, Michigan, Stany Zjednoczone, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Mount Pleasant, Michigan, Stany Zjednoczone, 48858
- MyMichigan Medical Center Mount Pleasant
-
Muskegon, Michigan, Stany Zjednoczone, 49444
- Trinity Health Muskegon Hospital
-
Norton Shores, Michigan, Stany Zjednoczone, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Pontiac, Michigan, Stany Zjednoczone, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Stany Zjednoczone, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Stany Zjednoczone, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Stany Zjednoczone, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Reed City, Michigan, Stany Zjednoczone, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Stany Zjednoczone, 48309
- Henry Ford Rochester Hospital
-
Royal Oak, Michigan, Stany Zjednoczone, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Stany Zjednoczone, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Stany Zjednoczone, 48601
- MyMichigan Medical Center Saginaw
-
Southfield, Michigan, Stany Zjednoczone, 48075
- Henry Ford Health Providence Southfield Hospital
-
Sterling Heights, Michigan, Stany Zjednoczone, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Stany Zjednoczone, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, Stany Zjednoczone, 49684
- Munson Medical Center
-
Troy, Michigan, Stany Zjednoczone, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Stany Zjednoczone, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Stany Zjednoczone, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Stany Zjednoczone, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Stany Zjednoczone, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Stany Zjednoczone, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Branch, Michigan, Stany Zjednoczone, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Stany Zjednoczone, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Stany Zjednoczone, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Stany Zjednoczone, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Stany Zjednoczone, 56431
- Riverwood Healthcare Center
-
Baxter, Minnesota, Stany Zjednoczone, 56425
- Essentia Health - Baxter Clinic
-
Bemidji, Minnesota, Stany Zjednoczone, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Stany Zjednoczone, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Stany Zjednoczone, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Stany Zjednoczone, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Stany Zjednoczone, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Stany Zjednoczone, 55433
- Mercy Hospital
-
Crosslake, Minnesota, Stany Zjednoczone, 56442
- Essentia Health - Saint Joseph's Crosslake Clinic
-
Deer River, Minnesota, Stany Zjednoczone, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Stany Zjednoczone, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Stany Zjednoczone, 55435
- Fairview Southdale Hospital
-
Ely, Minnesota, Stany Zjednoczone, 55731
- Essentia Health - Ely Clinic
-
Fergus Falls, Minnesota, Stany Zjednoczone, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Stany Zjednoczone, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Stany Zjednoczone, 55432
- Unity Hospital
-
Hibbing, Minnesota, Stany Zjednoczone, 55746
- Essentia Health Hibbing Clinic
-
International Falls, Minnesota, Stany Zjednoczone, 56649
- Essentia Health - International Falls Clinic
-
Maple Grove, Minnesota, Stany Zjednoczone, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Stany Zjednoczone, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Stany Zjednoczone, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Stany Zjednoczone, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Stany Zjednoczone, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Stany Zjednoczone, 55454
- Health Partners Inc
-
Monticello, Minnesota, Stany Zjednoczone, 55362
- Monticello Cancer Center
-
Moose Lake, Minnesota, Stany Zjednoczone, 55767
- Essentia Health - Moose Lake Clinic
-
New Ulm, Minnesota, Stany Zjednoczone, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Stany Zjednoczone, 56470
- Essentia Health - Park Rapids
-
Pequot Lakes, Minnesota, Stany Zjednoczone, 56472
- Essentia Health - Saint Joseph's Pequot Lakes Clinic
-
Pine River, Minnesota, Stany Zjednoczone, 56474
- Essentia Health - Saint Joseph's Pine River Clinic
-
Princeton, Minnesota, Stany Zjednoczone, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Stany Zjednoczone, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Stany Zjednoczone, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Stany Zjednoczone, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Stany Zjednoczone, 55102
- United Hospital
-
Sandstone, Minnesota, Stany Zjednoczone, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Stany Zjednoczone, 55379
- Saint Francis Regional Medical Center
-
Staples, Minnesota, Stany Zjednoczone, 56479
- Essentia Health - Saint Joseph's Staples Clinic
-
Stillwater, Minnesota, Stany Zjednoczone, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Stany Zjednoczone, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Stany Zjednoczone, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Stany Zjednoczone, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Stany Zjednoczone, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Stany Zjednoczone, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Stany Zjednoczone, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Stany Zjednoczone, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Jackson, Mississippi, Stany Zjednoczone, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bonne Terre, Missouri, Stany Zjednoczone, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, Stany Zjednoczone, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Stany Zjednoczone, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Stany Zjednoczone, 63017
- Saint Luke's Hospital
-
Farmington, Missouri, Stany Zjednoczone, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Stany Zjednoczone, 65109
- MU Health Care Goldschmidt Cancer Center
-
Kansas City, Missouri, Stany Zjednoczone, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Stany Zjednoczone, 64108
- University Health Truman Medical Center
-
Kansas City, Missouri, Stany Zjednoczone, 64116
- University of Kansas Cancer Center - Briarcliff
-
Lee's Summit, Missouri, Stany Zjednoczone, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, Stany Zjednoczone, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Saint Joseph, Missouri, Stany Zjednoczone, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Stany Zjednoczone, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Stany Zjednoczone, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Stany Zjednoczone, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Stany Zjednoczone, 63131
- Missouri Baptist Medical Center
-
Sullivan, Missouri, Stany Zjednoczone, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, Stany Zjednoczone, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Stany Zjednoczone, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, Stany Zjednoczone, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Stany Zjednoczone, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Stany Zjednoczone, 59405
- Benefis Sletten Cancer Institute
-
Havre, Montana, Stany Zjednoczone, 59501
- Hi-Line Sletten Cancer Center
-
Helena, Montana, Stany Zjednoczone, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Stany Zjednoczone, 59901
- Logan Health Medical Center
-
-
Nebraska
-
Lincoln, Nebraska, Stany Zjednoczone, 68510
- Saint Elizabeth Regional Medical Center
-
North Platte, Nebraska, Stany Zjednoczone, 69101
- Great Plains Health Callahan Cancer Center
-
Omaha, Nebraska, Stany Zjednoczone, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Stany Zjednoczone, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Stany Zjednoczone, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Stany Zjednoczone, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Stany Zjednoczone, 68114
- Oncology Associates PC
-
Omaha, Nebraska, Stany Zjednoczone, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, Stany Zjednoczone, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Stany Zjednoczone, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Stany Zjednoczone, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Stany Zjednoczone, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Stany Zjednoczone, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Stany Zjednoczone, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Stany Zjednoczone, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Stany Zjednoczone, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stany Zjednoczone, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Stany Zjednoczone, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Stany Zjednoczone, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Stany Zjednoczone, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Stany Zjednoczone, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Stany Zjednoczone, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Stany Zjednoczone, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Stany Zjednoczone, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Stany Zjednoczone, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Stany Zjednoczone, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Stany Zjednoczone, 89169
- University Cancer Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Stany Zjednoczone, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Stany Zjednoczone, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Stany Zjednoczone, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Stany Zjednoczone, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, Stany Zjednoczone, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Basking Ridge, New Jersey, Stany Zjednoczone, 07920
- Memorial Sloan Kettering Basking Ridge
-
Hackensack, New Jersey, Stany Zjednoczone, 07601
- Hackensack University Medical Center
-
Neptune City, New Jersey, Stany Zjednoczone, 07753
- Jersey Shore Medical Center
-
Paramus, New Jersey, Stany Zjednoczone, 07652
- John Theurer Cancer Center at From Road
-
Red Bank, New Jersey, Stany Zjednoczone, 07701
- Riverview Medical Center/Booker Cancer Center
-
-
New Mexico
-
Albuquerque, New Mexico, Stany Zjednoczone, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, Stany Zjednoczone, 87109
- New Mexico Oncology Hematology Consultants
-
Albuquerque, New Mexico, Stany Zjednoczone, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Stany Zjednoczone, 87110
- Presbyterian Kaseman Hospital
-
Rio Rancho, New Mexico, Stany Zjednoczone, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
Santa Fe, New Mexico, Stany Zjednoczone, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo, New York, Stany Zjednoczone, 14263
- Roswell Park Cancer Institute
-
Commack, New York, Stany Zjednoczone, 11725
- Memorial Sloan Kettering Commack
-
Cooperstown, New York, Stany Zjednoczone, 13326
- Mary Imogene Bassett Hospital
-
Harrison, New York, Stany Zjednoczone, 10604
- Memorial Sloan Kettering Westchester
-
New York, New York, Stany Zjednoczone, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Stany Zjednoczone, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, Stany Zjednoczone, 14642
- University of Rochester
-
-
North Carolina
-
Asheville, North Carolina, Stany Zjednoczone, 28803
- AdventHealth Infusion Center Asheville
-
Clinton, North Carolina, Stany Zjednoczone, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Stany Zjednoczone, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Stany Zjednoczone, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Stany Zjednoczone, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Stany Zjednoczone, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Stany Zjednoczone, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, Stany Zjednoczone, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, Stany Zjednoczone, 28501
- ECU Health Oncology Kinston
-
Richlands, North Carolina, Stany Zjednoczone, 28574
- ECU Health Oncology Richlands
-
-
North Dakota
-
Bismarck, North Dakota, Stany Zjednoczone, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Stany Zjednoczone, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Stany Zjednoczone, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Stany Zjednoczone, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Stany Zjednoczone, 58103
- Sanford South University Medical Center
-
Jamestown, North Dakota, Stany Zjednoczone, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Avon, Ohio, Stany Zjednoczone, 44011
- UH Seidman Cancer Center at UH Avon Health Center
-
Beachwood, Ohio, Stany Zjednoczone, 44122
- UHHS-Chagrin Highlands Medical Center
-
Beavercreek, Ohio, Stany Zjednoczone, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Stany Zjednoczone, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Stany Zjednoczone, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Stany Zjednoczone, 44708
- Cleveland Clinic Mercy Hospital
-
Centerville, Ohio, Stany Zjednoczone, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Stany Zjednoczone, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Stany Zjednoczone, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Stany Zjednoczone, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Stany Zjednoczone, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Stany Zjednoczone, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Stany Zjednoczone, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Stany Zjednoczone, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, Stany Zjednoczone, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cleveland, Ohio, Stany Zjednoczone, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Stany Zjednoczone, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Stany Zjednoczone, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Stany Zjednoczone, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Stany Zjednoczone, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Stany Zjednoczone, 43228
- Doctors Hospital
-
Columbus, Ohio, Stany Zjednoczone, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Stany Zjednoczone, 43215
- Grant Medical Center
-
Columbus, Ohio, Stany Zjednoczone, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Stany Zjednoczone, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Stany Zjednoczone, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Stany Zjednoczone, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Stany Zjednoczone, 45415
- Dayton Physician LLC - Englewood
-
Dayton, Ohio, Stany Zjednoczone, 45409
- Premier Blood and Cancer Center
-
Delaware, Ohio, Stany Zjednoczone, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Stany Zjednoczone, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Stany Zjednoczone, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, Stany Zjednoczone, 43016
- Columbus Oncology and Hematology Associates
-
Fairfield, Ohio, Stany Zjednoczone, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Stany Zjednoczone, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Stany Zjednoczone, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Stany Zjednoczone, 45840
- Orion Cancer Care
-
Franklin, Ohio, Stany Zjednoczone, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Stany Zjednoczone, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Stany Zjednoczone, 45331
- Wayne Hospital
-
Greenville, Ohio, Stany Zjednoczone, 45331
- Dayton Physicians LLC-Wayne
-
Greenville, Ohio, Stany Zjednoczone, 45331
- Miami Valley Cancer Care and Infusion
-
Grove City, Ohio, Stany Zjednoczone, 43123
- Mount Carmel Grove City Hospital
-
Grove City, Ohio, Stany Zjednoczone, 43123
- Zangmeister Center Grove City
-
Kettering, Ohio, Stany Zjednoczone, 45429
- Kettering Medical Center
-
Kettering, Ohio, Stany Zjednoczone, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, Stany Zjednoczone, 43130
- Fairfield Medical Center
-
Lima, Ohio, Stany Zjednoczone, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Stany Zjednoczone, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Stany Zjednoczone, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Stany Zjednoczone, 43302
- OhioHealth Marion General Hospital
-
Marysville, Ohio, Stany Zjednoczone, 43040
- Memorial Hospital
-
Maumee, Ohio, Stany Zjednoczone, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Stany Zjednoczone, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mentor, Ohio, Stany Zjednoczone, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middletown, Ohio, Stany Zjednoczone, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, Stany Zjednoczone, 43050
- Knox Community Hospital
-
New Albany, Ohio, Stany Zjednoczone, 43054
- Mount Carmel New Albany Surgical Hospital
-
Newark, Ohio, Stany Zjednoczone, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Stany Zjednoczone, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Stany Zjednoczone, 43616
- Saint Charles Hospital
-
Perrysburg, Ohio, Stany Zjednoczone, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Stany Zjednoczone, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Stany Zjednoczone, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Sidney, Ohio, Stany Zjednoczone, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Stany Zjednoczone, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Stany Zjednoczone, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Stany Zjednoczone, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Stany Zjednoczone, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Stany Zjednoczone, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Stany Zjednoczone, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Stany Zjednoczone, 43608
- Mercy Health - Saint Vincent Hospital
-
Toledo, Ohio, Stany Zjednoczone, 43623
- Mercy Health Sylvania Radiation Oncology Center
-
Troy, Ohio, Stany Zjednoczone, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Stany Zjednoczone, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Stany Zjednoczone, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, Stany Zjednoczone, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Stany Zjednoczone, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Stany Zjednoczone, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Wilmington, Ohio, Stany Zjednoczone, 45177
- Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
-
Youngstown, Ohio, Stany Zjednoczone, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Stany Zjednoczone, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Stany Zjednoczone, 73104
- University of Oklahoma Health Sciences Center
-
-
Oregon
-
Baker City, Oregon, Stany Zjednoczone, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Ontario, Oregon, Stany Zjednoczone, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
-
Pennsylvania
-
Allentown, Pennsylvania, Stany Zjednoczone, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Allentown, Pennsylvania, Stany Zjednoczone, 18104
- Saint Luke's Cancer Center - Allentown
-
Allentown, Pennsylvania, Stany Zjednoczone, 18104
- Saint Luke's Hospital-Allentown Campus
-
Beaver, Pennsylvania, Stany Zjednoczone, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, Stany Zjednoczone, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, Stany Zjednoczone, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Coaldale, Pennsylvania, Stany Zjednoczone, 18218
- Saint Luke's Hospital-Miners Campus
-
Danville, Pennsylvania, Stany Zjednoczone, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Stany Zjednoczone, 18301
- Pocono Medical Center
-
Easton, Pennsylvania, Stany Zjednoczone, 18045
- Saint Luke's Hospital-Anderson Campus
-
Erie, Pennsylvania, Stany Zjednoczone, 16505
- UPMC Hillman Cancer Center Erie
-
Greensburg, Pennsylvania, Stany Zjednoczone, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Hazleton, Pennsylvania, Stany Zjednoczone, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Stany Zjednoczone, 18201
- Lehigh Valley Hospital-Hazleton
-
Indiana, Pennsylvania, Stany Zjednoczone, 15701
- IRMC Cancer Center
-
Johnstown, Pennsylvania, Stany Zjednoczone, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Stany Zjednoczone, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Stany Zjednoczone, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Stany Zjednoczone, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Mechanicsburg, Pennsylvania, Stany Zjednoczone, 17050
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
-
Monroeville, Pennsylvania, Stany Zjednoczone, 15146
- UPMC Hillman Cancer Center - Monroeville
-
Moon Township, Pennsylvania, Stany Zjednoczone, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Stany Zjednoczone, 17901
- Geisinger Cancer Services-Pottsville
-
Quakertown, Pennsylvania, Stany Zjednoczone, 18951
- Saint Luke's Hospital - Upper Bucks Campus
-
Sayre, Pennsylvania, Stany Zjednoczone, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Stany Zjednoczone, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Stany Zjednoczone, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Seneca, Pennsylvania, Stany Zjednoczone, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Stany Zjednoczone, 16801
- Geisinger Medical Group
-
Stroudsburg, Pennsylvania, Stany Zjednoczone, 18360
- Saint Luke's Hospital - Monroe Campus
-
Uniontown, Pennsylvania, Stany Zjednoczone, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Stany Zjednoczone, 15301
- UPMC Washington Hospital Radiation Oncology
-
Washington, Pennsylvania, Stany Zjednoczone, 15301
- UPMC Cancer Center-Washington
-
West Reading, Pennsylvania, Stany Zjednoczone, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Stany Zjednoczone, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Stany Zjednoczone, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Westerly, Rhode Island, Stany Zjednoczone, 02891
- Smilow Cancer Hospital Care Center - Westerly
-
-
South Carolina
-
Bluffton, South Carolina, Stany Zjednoczone, 29910
- Saint Joseph's/Candler - Bluffton Campus
-
Greenville, South Carolina, Stany Zjednoczone, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Stany Zjednoczone, 29601
- Saint Francis Hospital
-
Hilton Head Island, South Carolina, Stany Zjednoczone, 29926-3827
- South Carolina Cancer Specialists PC
-
-
South Dakota
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Franklin, Tennessee, Stany Zjednoczone, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Knoxville, Tennessee, Stany Zjednoczone, 37916
- Covenant Health Cancer Centers
-
Knoxville, Tennessee, Stany Zjednoczone, 37932
- Covenant Health Cancer Centers - West
-
Maryville, Tennessee, Stany Zjednoczone, 37804
- Covenant Health Oncology Group - Maryville
-
Nashville, Tennessee, Stany Zjednoczone, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Stany Zjednoczone, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Oak Ridge, Tennessee, Stany Zjednoczone, 37830
- Covenant Health Oncology Group - Oak Ridge
-
-
Texas
-
Dallas, Texas, Stany Zjednoczone, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Stany Zjednoczone, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
-
Utah
-
Farmington, Utah, Stany Zjednoczone, 84025
- Farmington Health Center
-
Salt Lake City, Utah, Stany Zjednoczone, 84112
- Huntsman Cancer Institute/University of Utah
-
South Jordan, Utah, Stany Zjednoczone, 84009
- South Jordan Health Center
-
-
Vermont
-
Burlington, Vermont, Stany Zjednoczone, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Stany Zjednoczone, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Charlottesville, Virginia, Stany Zjednoczone, 22908
- University of Virginia Cancer Center
-
Fredericksburg, Virginia, Stany Zjednoczone, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Lynchburg, Virginia, Stany Zjednoczone, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Richmond, Virginia, Stany Zjednoczone, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Stany Zjednoczone, 23298
- VCU Massey Comprehensive Cancer Center
-
Winchester, Virginia, Stany Zjednoczone, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Bellevue, Washington, Stany Zjednoczone, 98004
- Overlake Medical Center
-
Port Townsend, Washington, Stany Zjednoczone, 98368
- Jefferson Healthcare
-
Renton, Washington, Stany Zjednoczone, 98055
- Valley Medical Center
-
Yakima, Washington, Stany Zjednoczone, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Charleston, West Virginia, Stany Zjednoczone, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Huntington, West Virginia, Stany Zjednoczone, 25701
- Edwards Comprehensive Cancer Center
-
-
Wisconsin
-
Antigo, Wisconsin, Stany Zjednoczone, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Ashland, Wisconsin, Stany Zjednoczone, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Stany Zjednoczone, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, Stany Zjednoczone, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Stany Zjednoczone, 54729
- Marshfield Clinic-Chippewa Center
-
Cudahy, Wisconsin, Stany Zjednoczone, 53110
- Aurora Saint Luke's South Shore
-
Eau Claire, Wisconsin, Stany Zjednoczone, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Stany Zjednoczone, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, Stany Zjednoczone, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Stany Zjednoczone, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Stany Zjednoczone, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Stany Zjednoczone, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Stany Zjednoczone, 54301
- Bellin Memorial Hospital
-
Hayward, Wisconsin, Stany Zjednoczone, 54843
- Tamarack Health Hayward Medical Center
-
Johnson Creek, Wisconsin, Stany Zjednoczone, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Stany Zjednoczone, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Stany Zjednoczone, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Stany Zjednoczone, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Stany Zjednoczone, 53718
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
-
Marinette, Wisconsin, Stany Zjednoczone, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Stany Zjednoczone, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Stany Zjednoczone, 54451
- Aspirus Medford Hospital
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Stany Zjednoczone, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Stany Zjednoczone, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Stany Zjednoczone, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Stany Zjednoczone, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, Stany Zjednoczone, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Stany Zjednoczone, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Stany Zjednoczone, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, Stany Zjednoczone, 54868
- Marshfield Medical Center-Rice Lake
-
Rice Lake, Wisconsin, Stany Zjednoczone, 54868
- Lakeview Medical Center-Marshfield Clinic
-
Sheboygan, Wisconsin, Stany Zjednoczone, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Stany Zjednoczone, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, Stany Zjednoczone, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Stany Zjednoczone, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Stany Zjednoczone, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Stany Zjednoczone, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Stany Zjednoczone, 53188
- ProHealth Waukesha Memorial Hospital
-
Waukesha, Wisconsin, Stany Zjednoczone, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, Stany Zjednoczone, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, Stany Zjednoczone, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, Stany Zjednoczone, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Stany Zjednoczone, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Stany Zjednoczone, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Stany Zjednoczone, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Stany Zjednoczone, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Kryteria uczestnictwa
Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.
Kryteria kwalifikacji
Wiek uprawniający do nauki
18 lat i starsze (Dorosły, Starszy dorosły)
Akceptuje zdrowych ochotników
Nie
Płeć kwalifikująca się do nauki
Wszystko
Opis
Inclusion Criteria:
- All patients must be >= 18 years of age
- Eastern Cooperative Oncology Group (ECOG) performance status: 0 or 1
- Patients must have known BRAF mutational status of tumor; wild-type (WT) or mutated, prior to randomization
- Patients must not be pregnant or breast-feeding due to use of cytotoxic immunotherapy and risk of teratogenic side effects; all patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a patient of childbearing potential is anyone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patients must not conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse from the time of study registration and continuing (for patients of child bearing potential) for at least 5 months after the last dose of protocol treatment; patients of childbearing potential must also not donate eggs during this same time period
- Patients must have unresectable stage III or stage IV melanoma according to American Joint Committee on Cancer (AJCC) version (v)7; patients must have histological or cytological confirmation of melanoma that is metastatic or unresectable and clearly progressive
- Patients must have measurable disease per RECIST 1.1 criteria; all sites of disease must be evaluated within 4 weeks prior to randomization
- Patients may have had prior systemic therapy in the adjuvant setting (e.g. interferon, BRAF, or MEK agents). Patients may have had prior anti-CTLA-4 in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment. Patients may have had any prior anti-PD-1 or anti-PD-L1 agent in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment
- Patients may not have had any prior ipilimumab and/or anti-PD-1/PD-L1 agent in the metastatic setting
- Patients must have discontinued chemotherapy, immunotherapy or other investigational agents used in the adjuvant setting >= 4 weeks prior to randomization and recovered from adverse events due to those agents; mitomycin and nitrosoureas must have been discontinued at least 6 weeks prior to entering the study; patients must have discontinued radiation therapy >= 2 weeks prior to entering the study and recovered from any adverse events associated with treatment; prior surgery must be >= 4 weeks from randomization and patients must be fully recovered from post-surgical complications
- Patients must not receive any other investigational agents while on study or within four weeks prior to randomization
- Patient must not have received any live vaccine within 30 days prior to randomization, while participating in the study, and for 4 weeks (28 days) after the last dose of protocol treatment; live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 19 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist (registered trademark) are live attenuated vaccines and are not allowed); if possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events)
- Patients are ineligible if they have any currently active central nervous system (CNS) metastases; patients who have treated brain metastases (with either surgical resection or stereotactic radiosurgery) that have been stable on head magnetic resonance imaging (MRI) or contrast computed tomography (CT) scan for at least 4 weeks following treatment and within 4 weeks prior to randomization are eligible; patients must not have taken any steroids =< 14 days prior to randomization for the purpose of managing their brain metastases; patients with only whole brain irradiation for treatment of CNS metastases will be ineligible
- Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for > 3 years prior to the time of randomization
- White blood count >= 3,000/uL (obtained within 4 weeks prior to randomization)
- Absolute neutrophil count (ANC) >= 1,500/uL (obtained within 4 weeks prior to randomization)
- Platelet count >= 100,000/uL (obtained within 4 weeks prior to randomization)
- Hemoglobin >= 9 g/dL (obtained within 4 weeks prior to randomization)
- Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min (obtained within 4 weeks prior to randomization)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) (obtained within 4 weeks prior to randomization)
- Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) (obtained within 4 weeks prior to randomization)
- Total bilirubin =< 1.5 x ULN except patients with normal direct bilirubin; those patients with known Gilbert's syndrome must have total bilirubin < 3 x ULN (obtained within 4 weeks prior to randomization)
- Serum lactate dehydrogenase (LDH) =< 10 X ULN (obtained within 4 weeks prior to randomization)
- Patients must not have any serious or unstable pre-existing medical conditions (aside from malignancy exceptions specified above), including but not limited to, ongoing or active infection requiring parenteral antibiotics on day 1, history of bleeding diathesis or need for concurrent anticoagulation (international normalized ratio [INR] =< 1.5 and partial thromboplastin time [PTT] within 1.1 x ULN), or psychiatric illness/social situations that would limit compliance with study requirements, interfere with patient's safety, or obtaining informed consent
- Patients with human immunodeficiency virus (HIV) infection are ineligible; due to the mechanism of action of ipilimumab and GM-CSF, activity and side effects in an immune compromised patient are unknown
- Patients with evidence of active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are not eligible; patients with cleared HBV and HCV (0 viral load) infection will be allowed
- Patients must not have autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (e.g., prednisone, dexamethasone) or continuous use of topical steroid creams or ointments or ophthalmologic steroids; a history of occasional (but not continuous) use of steroid inhalers is allowed; replacement doses of steroids for patients with adrenal insufficiency are allowed; patients who discontinue use of these classes of medication for at least 2 weeks prior to randomization are eligible if, in the judgment of the treating physician investigator, the patient is not likely to require resumption of treatment with these classes of drugs during the study
- Exclusion from this study also includes patients with a history of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, Sjogren's syndrome, autoimmune vasculitis [e.g., Wegener's granulomatosis]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis); other CNS autoimmune disease (e.g., multiple sclerosis)
- Patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible
- Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed)
- Patients must not have other significant medical, surgical, or psychiatric conditions or require any medication or treatment that in the opinion of the investigator may interfere with compliance, make the administration of the study drugs hazardous or obscure the interpretation of adverse events (AEs), such as a condition associated with frequent diarrhea; patients must not have an active infection requiring current treatment with parenteral antibiotics
Plan studiów
Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Leczenie
- Przydział: Randomizowane
- Model interwencyjny: Przydział równoległy
- Maskowanie: Brak (otwarta etykieta)
Broń i interwencje
Grupa uczestników / Arm |
Interwencja / Leczenie |
|---|---|
|
Eksperymentalny: Arm A (nivolumab, ipilimumab, sargramostim)
INDUCTION THERAPY: Patients receive nivolumab IV over 30 minutes on day 1 of each cycle, ipilimumab IV over 30 minutes on day 1 of each cycle, and sargramostim SC on days 1-14 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab and sargramostim as in Induction therapy. Patients with PR, SC, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo MRI, CT scan, and blood sample collection throughout the study. Patients may also undergo a MUGA during screening, as well as an ECHO throughout the trial as clinically indicated. |
Undergo blood sample collection
Inne nazwy:
Given IV
Inne nazwy:
Given SC
Inne nazwy:
Undergo ECHO
Inne nazwy:
Undergo MUGA
Inne nazwy:
Given IV
Inne nazwy:
Undergo CT scan
Inne nazwy:
Undergo MRI
Inne nazwy:
|
|
Eksperymentalny: Arm B (nivolumab, ipilimumab)
INDUCTION THERAPY: Patients receive nivolumab and ipilimumab as in Arm I. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab as in Induction therapy. Patients with PR, SD, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo MRI, CT scan, and blood sample collection throughout the study. Patients may also undergo a MUGA during screening, as well as an ECHO throughout the trial as clinically indicated. |
Undergo blood sample collection
Inne nazwy:
Given IV
Inne nazwy:
Undergo ECHO
Inne nazwy:
Undergo MUGA
Inne nazwy:
Given IV
Inne nazwy:
Undergo CT scan
Inne nazwy:
Undergo MRI
Inne nazwy:
|
Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Overall survival
Ramy czasowe: Time from randomization to death from any cause, assessed up to 5 years
|
Overall survival between the two arms will be compared using the stratified log-rank test. One-sided type I error rate of 0.2 will be used. Kaplan-Meier plot will be generated and two-sided p-values will be reported. This analysis will be summarized using the forest plots with hazard ratios and 95% confidence intervals. Cox multivariate models will be developed for overall survival. |
Time from randomization to death from any cause, assessed up to 5 years
|
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Progression free survival
Ramy czasowe: Time from randomization to disease progression or death (whichever occurs first), assessed up to 5 years
|
Evaluated based on international criteria proposed by the revised Response Evaluation Criteria in Solid Tumors guideline (version 1.1). This analysis will be summarized using the forest plots with hazard ratios and 95% confidence intervals. Cox multivariate models will be developed for progression free survival. |
Time from randomization to disease progression or death (whichever occurs first), assessed up to 5 years
|
|
Incidence of toxicities
Ramy czasowe: Up to 90 days after the last study drug administration
|
Defined using the Common Terminology Criteria for Adverse Events version 4.0 criteria. Individual toxicity type adverse event and categorized adverse event data (by autoimmune disorders, endocrine, gastrointestinal, liver, nervous system, pancreas, psychiatric disorders, skin, thromboembolic disorders) will be summarized by grade and treatment arm. The percentages of patients experiencing the worst degree toxicities (highest grade event per adverse event type per patient) will be evaluated and the distribution of the worst degree toxicities will be compared among the treatment arms. The proportion of patients with worst degree toxicities with 3 or higher will be summarized and compared among the treatment arms. |
Up to 90 days after the last study drug administration
|
|
Immune response
Ramy czasowe: Up to 5 years
|
Assessed using the utility of immune related response criteria. The immune related response criteria and the Response Evaluation Criteria in Solid Tumors-based clinical response data will be compared between the two treatment arms, using the Fisher's exact test. Two-sided p-values will be reported. Furthermore immune related response criteria data will be associated with the Response Evaluation Criteria in Solid Tumors-based clinical response. The Kappa statistics which measures the degree of agreement between the Response Evaluation Criteria in Solid Tumors-based response and immune related response criteria will be estimated. McNemar's test will be used to evaluate the agreement between immune related response criteria and Response Evaluation Criteria in Solid Tumors-based clinical response. |
Up to 5 years
|
|
Clinical response
Ramy czasowe: Up to 5 years
|
Assessed using the utility of immune related response criteria. Standard response criteria (based on the Response Evaluation Criteria in Solid Tumors) will be applied to assess clinical response. The immune related response criteria and the Response Evaluation Criteria in Solid Tumors-based clinical response data will be compared between the two treatment arms, using the Fisher's exact test. Two-sided p-values will be reported. Furthermore immune related response criteria data will be associated with the Response Evaluation Criteria in Solid Tumors-based clinical response. The Kappa statistics which measures the degree of agreement between the Response Evaluation Criteria in Solid Tumors-based response and immune related response criteria will be estimated. McNemar's test will be used to evaluate the agreement between immune related response criteria and Response Evaluation Criteria in Solid Tumors-based clinical response. |
Up to 5 years
|
Współpracownicy i badacze
Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.
Sponsor
Śledczy
- Główny śledczy: Frank S Hodi, ECOG-ACRIN Cancer Research Group
Daty zapisu na studia
Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.
Główne daty studiów
Rozpoczęcie studiów (Rzeczywisty)
23 listopada 2015
Zakończenie podstawowe (Szacowany)
30 czerwca 2033
Ukończenie studiów (Szacowany)
30 czerwca 2033
Daty rejestracji na studia
Pierwszy przesłany
12 stycznia 2015
Pierwszy przesłany, który spełnia kryteria kontroli jakości
12 stycznia 2015
Pierwszy wysłany (Szacowany)
15 stycznia 2015
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
12 listopada 2026
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
11 listopada 2026
Ostatnia weryfikacja
1 lipca 2026
Więcej informacji
Terminy związane z tym badaniem
Dodatkowe istotne warunki MeSH
- Nowotwory według lokalizacji
- Nowotwory
- Nowotwory według typu histologicznego
- Choroby skórne
- Nowotwory neuroektodermalne
- Nowotwory, komórki rozrodcze i embrionalne
- Nowotwory, tkanka nerwowa
- Guzy neuroendokrynne
- Nevi i czerniaki
- Nowotwory skóry
- Choroby skóry i tkanki łącznej
- Czerniak
- Peptydy
- Aminokwasy, peptydy i białka
- Białka
- Techniki śledcze
- Techniki laboratoryjne kliniczne
- Techniki i procedury diagnostyczne
- Diagnoza
- Czynniki biologiczne
- Węglowodany
- Przeciwciała, monoklonalne, humanizowane
- Przeciwciała, monoklonalne
- Przeciwciała
- Immunoglobuliny
- Immunoproteiny
- Białka krwi
- Globuliny w surowicy
- Globuliny
- Receptory, powierzchnia komórkowa
- Białka błony
- Międzykomórkowe peptydy sygnalizacyjne i białka
- Glikoproteiny
- Glikokoniugaty
- Czynniki wzrostu komórek hematopoetycznych
- Cytokiny
- Antygeny
- Antygeny, powierzchnia
- Biomarkery
- Receptory, immunologiczne
- Antygeny, różnicowanie, limfocyt t
- Antygeny, różnicowanie
- Białka immunologiczne
- Kostymulujące i hamujące receptory komórek T
- Niwolumab
- Ipilimumab
- Prowadzenie okazów
- Sargramostim
- Antygen CTLA-4
- Czynniki stymulujące kolonię
Inne numery identyfikacyjne badania
- NCI-2014-02674
- NCI-2014-02674 (Identyfikator rejestru: CTRP (Clinical Trial Reporting Program))
- EA6141 (Inny identyfikator: CTEP)
- U10CA180820 (Grant/umowa NIH USA)
- U24CA196172 (Grant/umowa NIH USA)
- EA6141
- EA6141 (Inny identyfikator: ECOG-ACRIN Cancer Research Group)
Informacje o lekach i urządzeniach, dokumenty badawcze
Bada produkt leczniczy regulowany przez amerykańską FDA
Tak
Bada produkt urządzenia regulowany przez amerykańską FDA
Nie
produkt wyprodukowany i wyeksportowany z USA
Nie
Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .