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Intensity Training and Cardiovascular Health in Colombian Adults (HIIT-Heart)

24 octobre 2016 mis à jour par: Robinson Ramírez-Vélez, Universidad Santo Tomas

High Intensity Interval- vs Moderate Training on Biomarkers of Endothelial and Cardiovascular Health in Adults: Effect of Postprandial Period

Several studies have shown relationship between exercise intensity and improvement cardiometabolic health. It has been suggested that high intensity interval training and also moderate training generate positive effects on metabolic risk factors. For these reasons, it is necessary to clarify which type of training, is more effective to improve cardiometabolic health in latinamerican population.

Aperçu de l'étude

Statut

Complété

Les conditions

Intervention / Traitement

Type d'étude

Interventionnel

Inscription (Réel)

30

Phase

  • N'est pas applicable

Contacts et emplacements

Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.

Lieux d'étude

  • Colombie
      • Bogotá, Colombie
        • Robinson Ramírez Vélez Ph.D

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

20 ans à 45 ans (Adulte)

Accepte les volontaires sains

Oui

Sexes éligibles pour l'étude

Tout

La description

Inclusion Criteria:

  • Written informed consent.
  • Interested in improving health and fitness.

Exclusion Criteria:

  • Systemic infections.
  • Weight loss or gain of >10% of body weight in the past 6 months for any reason.
  • Currently taking medication that suppresses or stimulates appetite.
  • Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
  • Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
  • Asthma.
  • Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
  • Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
  • Any active use of illegal or illicit drugs.
  • Current exerciser (>30 min organized exercise per week).
  • Indication of unsuitability of current health for exercise protocol (PARQ).
  • Any other conditions which, in opinion of the investigators, would adversely affect the conduct of the trial.

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

  • Objectif principal: La prévention
  • Répartition: Randomisé
  • Modèle interventionnel: Affectation parallèle
  • Masquage: Seul

Armes et Interventions

Groupe de participants / Bras
Intervention / Traitement
Expérimental: High Intensity Interval Training
Walking on a treadmill 4min at 80-90% peak heart rate and recovery 4 min at 65% peak heart rate until expenditure of 300 kcal until the end of training.
Comportemental: High Intensity Interval Training
Exercise will be performed at three sessions per week. All sessions will be supervised by a trained health or exercise professional.
Comparateur actif: Moderate Intensity Interval Training
Walking on a treadmill at 60-80% peak heart rate until expenditure of 300 kcal until the end of training.
Comportemental: Moderate Intensity Interval Training
Exercise will be performed at three sessions per week. All sessions will be supervised by a trained health or exercise professional.

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats
Description de la mesure
Délai
Change from Baseline in endothelial function as measured by flow-mediated vasodilation (FMD)
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
FMD will be measured using the guidelines reported by Corretti et al. The diameter of the brachial artery will be assessed using a high-resolution ultrasound device (Siemens SG-60, USA), equipped with a 7.5 MHz linear array transducer
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.

Mesures de résultats secondaires

Mesure des résultats
Description de la mesure
Délai
Change from Baseline in LDL Cholesterol
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in HDL Cholesterol
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Triglycerides
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Glucose
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Heart rate variability
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
HRV will be performed according to current recommendations by European Society of Cardiology using an evaluated share-ware
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Aortic pulse wave velocity (PWVao)
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
PWVao (m s-1) will be performed within 3 to 4 minutes with the oscillometric, occlusive device, the Arteriograph. The measurement will be taken in a supine position and were accepted if the quality indicator of the recordings was within the acceptable range (i.e., if the standard deviation [SD] of the beat-to-beat measured PWVao values was less than 1.1 m/sec).
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in muscular fitness
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Muscular fitness (MF) will be assessed using handgrip test (maximum handgrip strength assessment) using a standard adjustable handle analogue handgrip dynamometer T-18 TKK SMEDLY III®
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Flexibility using the sit and reach test
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
It will be determined using a maximum treadmill exercise test (Precor TRM 885, Italy) following the modified Balke protocol
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in peak uptake of volume of oxygen
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Blood Pressure
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Body Mass Index
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
BMI will be calculated as the body weight in kilograms divided by the square of the height in meters.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Body Mass
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Change from Baseline in Quality & satisfaction with life by SF Community - short-form survey (SF-12™) Colombian version
Délai: Baseline and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Baseline and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
Augmentation index (AIx)
Délai: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
AIx (%) will be performed within 3 to 4 minutes with the oscillometric, occlusive device, the Arteriograph. The measurement will be taken in a supine position and were accepted if the quality indicator of the recordings was within the acceptable range (i.e., if the standard deviation [SD] of the beat-to-beat measured AIx values was less than 1.1 m/sec).
Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Parrainer

Universidad Santo Tomas

Les enquêteurs

  • Directeur d'études: Robinson Ramírez Vélez, Ph.D, Universidad del Rosario

Publications et liens utiles

La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.

Publications générales

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude

1 juin 2015

Achèvement primaire (Réel)

1 octobre 2016

Achèvement de l'étude (Réel)

1 octobre 2016

Dates d'inscription aux études

Première soumission

23 mars 2016

Première soumission répondant aux critères de contrôle qualité

8 avril 2016

Première publication (Estimation)

14 avril 2016

Mises à jour des dossiers d'étude

Dernière mise à jour publiée (Estimation)

25 octobre 2016

Dernière mise à jour soumise répondant aux critères de contrôle qualité

24 octobre 2016

Dernière vérification

1 octobre 2016

Plus d'information

Termes liés à cette étude

Termes MeSH pertinents supplémentaires

Autres numéros d'identification d'étude

  • 01-1802-2013

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