Upper Versus Lower Limb Responses to Higher Versus Lower Load Resistance Training in Young Men
Variability in Resistance Training-induced Hypertrophy and Strength Are Independent of Load and Limb Location in Healthy Young Men
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
Each participant will come to the Exercise Metabolism Research Laboratory gym three times per week for 10 weeks to perform lower- and upper-body resistance exercise training with both relatively heavy- (~80% one repetition maximum [1RM]) and light- (~40 %1RM) loads. One arm and one leg will be randomized to lift with relatively heavy loads such that the other arm and leg will be randomized to lift with relatively light loads. Each workout will be supervised by a study investigator.
The time commitment of this study is 12 weeks (including pre- and post-study testing). Each workout to take 30 minutes and, with testing days included, the investigators foresee a total time commitment of 41 hours, or just under three and half hours per week.
The pre- and post-study measurements include muscle biopsies, dual x-ray absorptiometry scans, ultrasonography scans, 1RM assessment, and maximum voluntary contraction assessment. The muscle biopsies will be taken from each of the participant's vastus lateralis to assess muscle fibre cross sectional area in both legs during the beginning (four biopsies) and end (four biopsies) of the intervention. The dual x-ray absorptiometry scans are used to assess body composition and will be done pre- and post-intervention. The ultrasonography scans will be used to assess biceps brachii and vastus laterals thickness and cross sectional area. The ultrasound scans will be assessed during the beginning (four scans) and end (four scans) of the intervention. The 1RM assessment will include 1RM testing on a knee extension machine and biceps curl machine and will be done at the beginning and end of the intervention. The maximum voluntary contraction assessment will be performed on a System 3 Biodex Dynamometer (Shirley, NY, USA), which is an immovable machine that the participants contract against to measure their peak force. The maximum voluntary contractions will be recorded three times: twice at the beginning of the intervention and once at the end of the intervention.
Type d'étude
Inscription (Réel)
Phase
- N'est pas applicable
Contacts et emplacements
Lieux d'étude
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Ontario
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Hamilton, Ontario, Canada, L8S 4K1
- Exercise Metabolism Research Laboratory, McMaster Univeristy
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Be between the ages of 18-30 years (inclusive)
- Be able to maintain a habitual diet and perform resistance exercise three times per week throughout the trial
- Be in general good health (assessed by Get Active Questionnaire)
- Understand the study procedures and sign this form providing informed consent to participate in the study.
Exclusion Criteria:
- Use of tobacco or related products
- A history of neuromuscular problems or muscle and/or bone wasting diseases
- Any acute or chronic illness; cardiac, pulmonary, liver, or kidney abnormalities; insulin- or non-insulin-dependent diabetes or other metabolic disorders (all ascertained through medical questionnaires)
- Use of medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatory drugs (prescription use or daily use of over the counter medication), or prescription strength acne medications)
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Science basique
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Seul
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
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Expérimental: Higher Load
One arm and one leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
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The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.
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Expérimental: Lower Load
The other arm and leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
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The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Change in fat-free mass
Délai: up to 12 weeks
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Measured by dual x-ray absorptiometry pre- and post-training
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up to 12 weeks
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Change in vastus lateralis thickness
Délai: up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
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Change in vastus lateralis cross sectional area
Délai: up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
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Change in biceps brachii thickness
Délai: up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
|
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Change in biceps brachii cross sectional area
Délai: up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
|
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Change in muscle fibre cross sectional area
Délai: up to 12 weeks
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Measured by muscle biopsies from the vastus lateralis pre- and post-training
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up to 12 weeks
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Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: Stuart Phillips, PhD, McMaster University
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- HIREB 4774
Plan pour les données individuelles des participants (IPD)
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Description du régime IPD
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
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