Upper Versus Lower Limb Responses to Higher Versus Lower Load Resistance Training in Young Men
Variability in Resistance Training-induced Hypertrophy and Strength Are Independent of Load and Limb Location in Healthy Young Men
Studienübersicht
Status
Bedingungen
Intervention / Behandlung
Detaillierte Beschreibung
Each participant will come to the Exercise Metabolism Research Laboratory gym three times per week for 10 weeks to perform lower- and upper-body resistance exercise training with both relatively heavy- (~80% one repetition maximum [1RM]) and light- (~40 %1RM) loads. One arm and one leg will be randomized to lift with relatively heavy loads such that the other arm and leg will be randomized to lift with relatively light loads. Each workout will be supervised by a study investigator.
The time commitment of this study is 12 weeks (including pre- and post-study testing). Each workout to take 30 minutes and, with testing days included, the investigators foresee a total time commitment of 41 hours, or just under three and half hours per week.
The pre- and post-study measurements include muscle biopsies, dual x-ray absorptiometry scans, ultrasonography scans, 1RM assessment, and maximum voluntary contraction assessment. The muscle biopsies will be taken from each of the participant's vastus lateralis to assess muscle fibre cross sectional area in both legs during the beginning (four biopsies) and end (four biopsies) of the intervention. The dual x-ray absorptiometry scans are used to assess body composition and will be done pre- and post-intervention. The ultrasonography scans will be used to assess biceps brachii and vastus laterals thickness and cross sectional area. The ultrasound scans will be assessed during the beginning (four scans) and end (four scans) of the intervention. The 1RM assessment will include 1RM testing on a knee extension machine and biceps curl machine and will be done at the beginning and end of the intervention. The maximum voluntary contraction assessment will be performed on a System 3 Biodex Dynamometer (Shirley, NY, USA), which is an immovable machine that the participants contract against to measure their peak force. The maximum voluntary contractions will be recorded three times: twice at the beginning of the intervention and once at the end of the intervention.
Studientyp
Einschreibung (Tatsächlich)
Phase
- Unzutreffend
Kontakte und Standorte
Studienorte
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Ontario
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Hamilton, Ontario, Kanada, L8S 4K1
- Exercise Metabolism Research Laboratory, McMaster Univeristy
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
Akzeptiert gesunde Freiwillige
Studienberechtigte Geschlechter
Beschreibung
Inclusion Criteria:
- Be between the ages of 18-30 years (inclusive)
- Be able to maintain a habitual diet and perform resistance exercise three times per week throughout the trial
- Be in general good health (assessed by Get Active Questionnaire)
- Understand the study procedures and sign this form providing informed consent to participate in the study.
Exclusion Criteria:
- Use of tobacco or related products
- A history of neuromuscular problems or muscle and/or bone wasting diseases
- Any acute or chronic illness; cardiac, pulmonary, liver, or kidney abnormalities; insulin- or non-insulin-dependent diabetes or other metabolic disorders (all ascertained through medical questionnaires)
- Use of medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatory drugs (prescription use or daily use of over the counter medication), or prescription strength acne medications)
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Grundlegende Wissenschaft
- Zuteilung: Zufällig
- Interventionsmodell: Parallele Zuordnung
- Maskierung: Single
Waffen und Interventionen
Teilnehmergruppe / Arm |
Intervention / Behandlung |
|---|---|
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Experimental: Higher Load
One arm and one leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
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The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.
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Experimental: Lower Load
The other arm and leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
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The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.
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Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
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Change in fat-free mass
Zeitfenster: up to 12 weeks
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Measured by dual x-ray absorptiometry pre- and post-training
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up to 12 weeks
|
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Change in vastus lateralis thickness
Zeitfenster: up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
|
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Change in vastus lateralis cross sectional area
Zeitfenster: up to 12 weeks
|
Measured by ultrasonography pre- and post-training
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up to 12 weeks
|
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Change in biceps brachii thickness
Zeitfenster: up to 12 weeks
|
Measured by ultrasonography pre- and post-training
|
up to 12 weeks
|
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Change in biceps brachii cross sectional area
Zeitfenster: up to 12 weeks
|
Measured by ultrasonography pre- and post-training
|
up to 12 weeks
|
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Change in muscle fibre cross sectional area
Zeitfenster: up to 12 weeks
|
Measured by muscle biopsies from the vastus lateralis pre- and post-training
|
up to 12 weeks
|
Mitarbeiter und Ermittler
Sponsor
Ermittler
- Hauptermittler: Stuart Phillips, PhD, McMaster University
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn (Tatsächlich)
Primärer Abschluss (Tatsächlich)
Studienabschluss (Tatsächlich)
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Tatsächlich)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Zusätzliche relevante MeSH-Bedingungen
Andere Studien-ID-Nummern
- HIREB 4774
Plan für individuelle Teilnehmerdaten (IPD)
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Beschreibung des IPD-Plans
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Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt
Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt
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