Upper Versus Lower Limb Responses to Higher Versus Lower Load Resistance Training in Young Men
Variability in Resistance Training-induced Hypertrophy and Strength Are Independent of Load and Limb Location in Healthy Young Men
研究概览
详细说明
Each participant will come to the Exercise Metabolism Research Laboratory gym three times per week for 10 weeks to perform lower- and upper-body resistance exercise training with both relatively heavy- (~80% one repetition maximum [1RM]) and light- (~40 %1RM) loads. One arm and one leg will be randomized to lift with relatively heavy loads such that the other arm and leg will be randomized to lift with relatively light loads. Each workout will be supervised by a study investigator.
The time commitment of this study is 12 weeks (including pre- and post-study testing). Each workout to take 30 minutes and, with testing days included, the investigators foresee a total time commitment of 41 hours, or just under three and half hours per week.
The pre- and post-study measurements include muscle biopsies, dual x-ray absorptiometry scans, ultrasonography scans, 1RM assessment, and maximum voluntary contraction assessment. The muscle biopsies will be taken from each of the participant's vastus lateralis to assess muscle fibre cross sectional area in both legs during the beginning (four biopsies) and end (four biopsies) of the intervention. The dual x-ray absorptiometry scans are used to assess body composition and will be done pre- and post-intervention. The ultrasonography scans will be used to assess biceps brachii and vastus laterals thickness and cross sectional area. The ultrasound scans will be assessed during the beginning (four scans) and end (four scans) of the intervention. The 1RM assessment will include 1RM testing on a knee extension machine and biceps curl machine and will be done at the beginning and end of the intervention. The maximum voluntary contraction assessment will be performed on a System 3 Biodex Dynamometer (Shirley, NY, USA), which is an immovable machine that the participants contract against to measure their peak force. The maximum voluntary contractions will be recorded three times: twice at the beginning of the intervention and once at the end of the intervention.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Ontario
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Hamilton、Ontario、加拿大、L8S 4K1
- Exercise Metabolism Research Laboratory, McMaster Univeristy
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Be between the ages of 18-30 years (inclusive)
- Be able to maintain a habitual diet and perform resistance exercise three times per week throughout the trial
- Be in general good health (assessed by Get Active Questionnaire)
- Understand the study procedures and sign this form providing informed consent to participate in the study.
Exclusion Criteria:
- Use of tobacco or related products
- A history of neuromuscular problems or muscle and/or bone wasting diseases
- Any acute or chronic illness; cardiac, pulmonary, liver, or kidney abnormalities; insulin- or non-insulin-dependent diabetes or other metabolic disorders (all ascertained through medical questionnaires)
- Use of medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatory drugs (prescription use or daily use of over the counter medication), or prescription strength acne medications)
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的：Higher Load
One arm and one leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
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The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.
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实验性的：Lower Load
The other arm and leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
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The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Change in fat-free mass
大体时间：up to 12 weeks
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Measured by dual x-ray absorptiometry pre- and post-training
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up to 12 weeks
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Change in vastus lateralis thickness
大体时间：up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
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Change in vastus lateralis cross sectional area
大体时间：up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
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Change in biceps brachii thickness
大体时间：up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
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Change in biceps brachii cross sectional area
大体时间：up to 12 weeks
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Measured by ultrasonography pre- and post-training
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up to 12 weeks
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Change in muscle fibre cross sectional area
大体时间：up to 12 weeks
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Measured by muscle biopsies from the vastus lateralis pre- and post-training
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up to 12 weeks
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合作者和调查者
调查人员
- 首席研究员：Stuart Phillips, PhD、McMaster University
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Unilateral resistance exercise的临床试验
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University of Maryland, BaltimoreNational Institute on Aging (NIA)完全的