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Upper Versus Lower Limb Responses to Higher Versus Lower Load Resistance Training in Young Men

19. juni 2019 opdateret af: Stuart Phillips, McMaster University

Variability in Resistance Training-induced Hypertrophy and Strength Are Independent of Load and Limb Location in Healthy Young Men

Recent research suggests that performing resistance exercise training with relatively light loads is equally as effective at increasing muscle mass and muscle strength as performing resistance exercise training with relatively heavy loads. Whether or not performing resistance exercise with relatively heavy loads or light loads is equally as effective between the upper- and lower-body within the same individual has never been investigated. Given the substantial individual variance in resistance exercise training-induced changes in muscle mass and strength, this study is designed to quantify the relative influence that extrinsic training variables (e.g., load), as opposed to intrinsic muscle-based predisposition, has on resistance training-induced changes in muscle mass and muscle strength.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Each participant will come to the Exercise Metabolism Research Laboratory gym three times per week for 10 weeks to perform lower- and upper-body resistance exercise training with both relatively heavy- (~80% one repetition maximum [1RM]) and light- (~40 %1RM) loads. One arm and one leg will be randomized to lift with relatively heavy loads such that the other arm and leg will be randomized to lift with relatively light loads. Each workout will be supervised by a study investigator.

The time commitment of this study is 12 weeks (including pre- and post-study testing). Each workout to take 30 minutes and, with testing days included, the investigators foresee a total time commitment of 41 hours, or just under three and half hours per week.

The pre- and post-study measurements include muscle biopsies, dual x-ray absorptiometry scans, ultrasonography scans, 1RM assessment, and maximum voluntary contraction assessment. The muscle biopsies will be taken from each of the participant's vastus lateralis to assess muscle fibre cross sectional area in both legs during the beginning (four biopsies) and end (four biopsies) of the intervention. The dual x-ray absorptiometry scans are used to assess body composition and will be done pre- and post-intervention. The ultrasonography scans will be used to assess biceps brachii and vastus laterals thickness and cross sectional area. The ultrasound scans will be assessed during the beginning (four scans) and end (four scans) of the intervention. The 1RM assessment will include 1RM testing on a knee extension machine and biceps curl machine and will be done at the beginning and end of the intervention. The maximum voluntary contraction assessment will be performed on a System 3 Biodex Dynamometer (Shirley, NY, USA), which is an immovable machine that the participants contract against to measure their peak force. The maximum voluntary contractions will be recorded three times: twice at the beginning of the intervention and once at the end of the intervention.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

20

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
    • Ontario
      • Hamilton, Ontario, Canada, L8S 4K1
        • Exercise Metabolism Research Laboratory, McMaster Univeristy

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 30 år (Voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Han

Beskrivelse

Inclusion Criteria:

  • Be between the ages of 18-30 years (inclusive)
  • Be able to maintain a habitual diet and perform resistance exercise three times per week throughout the trial
  • Be in general good health (assessed by Get Active Questionnaire)
  • Understand the study procedures and sign this form providing informed consent to participate in the study.

Exclusion Criteria:

  • Use of tobacco or related products
  • A history of neuromuscular problems or muscle and/or bone wasting diseases
  • Any acute or chronic illness; cardiac, pulmonary, liver, or kidney abnormalities; insulin- or non-insulin-dependent diabetes or other metabolic disorders (all ascertained through medical questionnaires)
  • Use of medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatory drugs (prescription use or daily use of over the counter medication), or prescription strength acne medications)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Higher Load
One arm and one leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
Adfærdsmæssigt: Unilateral resistance exercise
The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.
Eksperimentel: Lower Load
The other arm and leg were randomized (based on limb dominance) to perform unilateral biceps curls (arm) and knee extensions (leg) with relatively higher loads (80 % of their one-repetition maximum).
Adfærdsmæssigt: Unilateral resistance exercise
The participants performed three sets of their unilateral resistance exercise (biceps curls and knee extensions) three times per week for 10 weeks.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change in fat-free mass
Tidsramme: up to 12 weeks
Measured by dual x-ray absorptiometry pre- and post-training
up to 12 weeks
Change in vastus lateralis thickness
Tidsramme: up to 12 weeks
Measured by ultrasonography pre- and post-training
up to 12 weeks
Change in vastus lateralis cross sectional area
Tidsramme: up to 12 weeks
Measured by ultrasonography pre- and post-training
up to 12 weeks
Change in biceps brachii thickness
Tidsramme: up to 12 weeks
Measured by ultrasonography pre- and post-training
up to 12 weeks
Change in biceps brachii cross sectional area
Tidsramme: up to 12 weeks
Measured by ultrasonography pre- and post-training
up to 12 weeks
Change in muscle fibre cross sectional area
Tidsramme: up to 12 weeks
Measured by muscle biopsies from the vastus lateralis pre- and post-training
up to 12 weeks

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

McMaster University

Efterforskere

  • Ledende efterforsker: Stuart Phillips, PhD, McMaster University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. juni 2018

Primær færdiggørelse (Faktiske)

5. oktober 2018

Studieafslutning (Faktiske)

5. oktober 2018

Datoer for studieregistrering

Først indsendt

17. juni 2019

Først indsendt, der opfyldte QC-kriterier

19. juni 2019

Først opslået (Faktiske)

20. juni 2019

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

20. juni 2019

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

19. juni 2019

Sidst verificeret

1. juni 2019

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • HIREB 4774

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

No individual participant data will be made available to other researchers

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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Kliniske forsøg med Muskelstyrke

Kliniske forsøg med Unilateral resistance exercise

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