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Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients

17 juillet 2026 mis à jour par: Riphah International University

Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training on Glycemic Control, BMI, Vo₂ Max, Pulmonary Function, and Physical Activity Among Prediabetic Patients

Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups; group A and group B. Group A will be assigned high intensity interval training and group B will be assigned to continuous training.

Aperçu de l'étude

Statut

Recrutement

Les conditions

Intervention / Traitement

Description détaillée

Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups: group A and group B. Group A will be assigned high intensity interval training, and group B will be assigned to continuous training. Both interventions will be conducted over a 12-week period, with pre- and post-intervention assessments. Each exercise session constitutes a 5-minute warm up and finished with a 5-minute cool-down. Participants aged between 35 to 54 years with sedentary lifestyle, Stable medical condition, and stable body weight with changes less 3kg in the past 6 months will be included in this study. The study will exclude individuals with uncontrolled hypertension, history of heart disease, myocardial infarction and stroke and diagnosed type 2 diabetes, use of specific medications, severe obesity, high fasting blood glucose, previous history of respiratory problems, and smoking. Primary outcomes include changes in fasting blood glucose, HbA1c levels, and insulin sensitivity. Pre and post values of glucose level and FEV1, FVC and FEV1/FVC will be calculated. Secondary outcomes will assess BMI, VO₂ max through graded exercise testing, pulmonary function using spirometry, and physical activity levels measured by validated questionnaire of short form of IPAQ-SF. Data will be analysed using SPSS 24 and Shapiro wilks test will be applied to assess the normality of data. After assesing the normality of data paired sample/independent t test/ANOVA test will be applied to find which technique will be more beneficial for prediabetic patients.

Type d'étude

Interventionnel

Inscription (Estimé)

80

Phase

  • N'est pas applicable

Contacts et emplacements

Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.

Coordonnées de l'étude

Sauvegarde des contacts de l'étude

Lieux d'étude

  • Pakistan
    • Punjab Province
      • Lahore, Punjab Province, Pakistan, 40100
        • Recrutement
        • Rihpah international university Lahore campus
        • Contact:
        • Contact:

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

  • Adulte

Accepte les volontaires sains

Oui

La description

Inclusion Criteria:

  • Sedentary lifestyle (Individuals reporting minimal structured physical activity e.g., <30 minutes of exercise per week) .

    • Stable Medical Condition (No history of significant cardiovascular events, uncontrolled hypertension, or other major comorbidities).
    • Stable Body Weight (Stable body weight with changes less than 3 kg in the past 6 months).

Exclusion Criteria:

  • uncontrolled hypertension

    • history of heart disease
    • myocardial infarction
    • stroke
    • Use of Specific Medications (Current use of insulin or other medications affecting glucose metabolism or exercise response)
    • Severe Obesity (Individuals with a BMI ≥ 40 kg/m)
    • High fasting blood glucose (Fasting blood glucose of >100mg.dl-1)
    • Previous history of respiratory problems
    • Smoking

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

  • Objectif principal: Traitement
  • Répartition: Randomisé
  • Modèle interventionnel: Affectation parallèle
  • Masquage: Double

Armes et Interventions

Groupe de participants / Bras
Intervention / Traitement
Comparateur actif: High-Intensity Interval Training
High intensity interval training is a training method that involves repeated bouts of short duration, highintensity exercise typicallyb performed at ≥ 85 -95% of maximal heart rate or vo2 max interspersed with period of low intensity recovery or complete rest.
Comportemental: High-Intensity Interval Training

5 minutes warm up including walk

  • 30s fast stairs climbing
  • 60s slow walk down
  • Repeat 5 to 6 rounds
  • 5 minute stretching or slow walk (cool down)
Comparateur actif: Continuous Endurance Training
Continuous endurance training also called moderate intensity continuous training involves sustained exercise at a moderate and steady intensity typically 60to 75% of vo2 max or maximal heart rate performed for a continuous duration without rest intervals
Comportemental: Continuous Endurance Training

5 to 10 minute walking (warm up )

  • 25 to 30minutes at 60 to 70 %continuous training
  • Continuous walk for 15 to 20 minutes.
  • 5 to 10 minutes stretching (cool down)

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats
Description de la mesure
Délai
fasting blood glucose
Délai: 12 weeks
Participants were instructed to fast overnight for 8 to 12 hours. FBG was measured using an automated glucose analyzer
12 weeks
Forced Vital Capacity
Délai: 12 weeks
Spirometry using devices like a digital spirometry will be used. Forced Vital Capacity (FVC) will be measured in liters (L) using spirometry. FVC represents the maximum volume of air that can be forcefully exhaled after a maximal inspiration.
12 weeks
Forced Expiratory Volume in One Second
Délai: 12 weeks
Forced Expiratory Volume in One Second (FEV₁) will be measured in liters (L) using spirometry. FEV₁ represents the volume of air exhaled during the first second of a forced expiratory maneuver.
12 weeks
FEV₁/FVC ratio
Délai: 12 weeks
The FEV₁/FVC ratio will be expressed as a percentage (%) and calculated from spirometric measurements to assess the degree of airflow limitation.
12 weeks
HbA1c
Délai: 12 weeks
HbA1c was assesed through high performance liquid chromatography
12 weeks

Mesures de résultats secondaires

Mesure des résultats
Description de la mesure
Délai
Body mass index (BMI)
Délai: 12 weeks
Participants weight was measured using a calibrated digital scale with minimal clothing and no shoes height was measured using a wall mounted stadiometer with participants standing upright
12 weeks
IPAQ (short form) questionnaire
Délai: 12 weeks

International physical activity questionnaire is applicable for survey among 18 to 65 years to Assess the level of physical activity along different countries. It is developed in 2 Versions; first is long version (27 items), and the second is the short version (7 items). We will use IPAQ short version which consists of job, transport, domestic, and leisure time physical activity domains.

Moderate and high-intensity walking and sitting time activities are addressed in this questionnaire
12 weeks
Maximal Oxygen Uptake (VO₂max)
Délai: 12 weeks
In this research VO2 Max will be measured through a submaximal 6 mint walk test
12 weeks

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Parrainer

Riphah International University

Les enquêteurs

  • Chercheur principal: Arjumand Bano, MS, Riphah International University

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude (Réel)

1 mai 2026

Achèvement primaire (Estimé)

1 août 2026

Achèvement de l'étude (Estimé)

1 août 2026

Dates d'inscription aux études

Première soumission

8 juin 2026

Première soumission répondant aux critères de contrôle qualité

17 juillet 2026

Première publication (Réel)

20 juillet 2026

Mises à jour des dossiers d'étude

Dernière mise à jour publiée (Réel)

20 juillet 2026

Dernière mise à jour soumise répondant aux critères de contrôle qualité

17 juillet 2026

Dernière vérification

1 juillet 2026

Plus d'information

Termes liés à cette étude

Mots clés

Termes MeSH pertinents supplémentaires

Autres numéros d'identification d'étude

  • REC/RCR & AHS/25/0302

Plan pour les données individuelles des participants (IPD)

Prévoyez-vous de partager les données individuelles des participants (DPI) ?

NON

Informations sur les médicaments et les dispositifs, documents d'étude

Étudie un produit pharmaceutique réglementé par la FDA américaine

Non

Étudie un produit d'appareil réglementé par la FDA américaine

Non

Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .

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