Whole-body Vibration Versus Gravity Force Stimulation on Postural Stability in Children With Duchene Muscular Dystrophy
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
Duchenne Muscular Dystrophy (DMD) is a progressive X-linked neuromuscular disorder characterized by muscle fiber degeneration due to mutations in the dystrophin gene (Birnkrant et al., 2018). As muscle weakness advances, children with DMD experience impaired postural control, reduced balance function, and increased risk of falls, all of which significantly contribute to limitations in daily activities and loss of independence (Ricotti et al., 2016). Early therapeutic interventions are essential to slow functional decline and promote motor stability for as long as possible.
Whole-body vibration (WBV) has emerged as a potential modality to enhance neuromuscular activation, proprioception, and balance in individuals with muscle weakness or neurological impairments. Studies suggest that low-frequency WBV can improve muscle spindle sensitivity, postural reactions, and balance performance in pediatric and neuromuscular populations (Brunetti et al., 2015; Saquetto et al., 2015). Although research involving children with DMD is limited, preliminary evidence indicates that WBV may transiently enhance motor function without excessive muscle strain.
Gravity-force stimulation (GFS)-often delivered through tilt platforms, vertical acceleration devices, or graded gravitational loading-has been proposed as another means to stimulate proprioceptive pathways and increase postural control. GFS can enhance sensory input from weight-bearing structures and may promote improved equilibrium response strategies in children with neuromotor impairments (Bates & Hanson, 2019). However, its application specifically in DMD remains under-studied, and direct comparisons with WBV have not been adequately explored.
Type d'étude
Inscription (Réel)
Phase
- N'est pas applicable
Contacts et emplacements
Lieux d'étude
-
-
Giza Governorate
-
Giza, Giza Governorate, Egypte, 11432
- Cairo University
-
-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
- Enfant
Accepte les volontaires sains
La description
Inclusion Criteria:
- Children diagnosed with Duchenne Muscular Dystrophy (DMD).
- Age between 6 and 10 years.
- Lower extremity and trunk muscle strength graded at least 3+, based on the manual muscle testing criteria.
- Ability to move the upper and lower limbs within functional limits without severe joint restriction.
- Ability to walk independently without assistive devices, corresponding to Levels I and II of the Ambulation Function Classification System for DMD (AFCSD).
Exclusion Criteria:
- Presence of cardiopulmonary dysfunction or congenital or acquired skeletal abnormalities that may interfere with participation.
- History of lower-limb surgical procedures.
- Neurological conditions affecting balance or gait, or evidence of poor motor development not attributable to DMD.
- Behavioral disorders that would prevent cooperation during assessment or intervention sessions.
- Overweight status, defined as a body mass index (BMI) greater than 25 kg/m²
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: whole body vibration group
whole body vibration intervention
|
we use vibrating platform •
|
|
Expérimental: force gravity stimulation group
force gravity stimulation intervention
|
Thirty children received: • Gravity-Force Stimulation (GFS), which included:
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
abdominal muscle thickness
Délai: 3 months
|
measure the abdominal muscle thickness
|
3 months
|
|
postural stability
Délai: 3 months
|
• BIODEX MEDICAL SYSTEM used for assessment of postural stability and balance
|
3 months
|
Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: Mostafa S. Ali, Cairo University
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Autres numéros d'identification d'étude
- P.T.REC/012/006366
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Étudie un produit d'appareil réglementé par la FDA américaine
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .