Central Venous vs Arterial Blood Gas and CO2 Gap in Critically Ill Patients With and Without Diabetes
Correlation Between Central Venous and Arterial Blood Gas Parameters Including CO2 Gap in Diabetic and Non-Diabetic Critically Ill Patients
Frequent monitoring of acid-base status, ventilation, and tissue oxygenation is essential for managing critically ill patients in the intensive care unit (ICU). While arterial blood gas (ABG) analysis is considered the standard method for these evaluations, maintaining arterial catheters carries risks of complications, such as thrombosis, hematoma, and infection. Central venous blood gas (CVBG) analysis offers a safer alternative because central venous catheters are already routinely placed for patient care. Additionally, the venous-to-arterial carbon dioxide difference (CO2 gap) serves as an indicator of systemic blood flow and tissue perfusion.
However, patients with diabetes mellitus often present with underlying microvascular alterations, endothelial changes, and metabolic variations that might alter tissue perfusion and peripheral gas exchange. This study aims to assess the correlation and agreement between central venous and arterial blood gas parameters, as well as evaluate the diagnostic accuracy of the CO2 gap, in diabetic versus non-diabetic critically ill patients.
A total of 100 adult ICU patients (50 diabetic and 50 non-diabetic) with pre-existing central venous and arterial lines will be enrolled. Paired blood samples will be drawn simultaneously to compare blood gas values and calculate the CO2 gap without altering standard clinical treatment.
Aperçu de l'étude
Statut
Type d'étude
Inscription (Estimé)
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
- Adulte
- Adulte plus âgé
Accepte les volontaires sains
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- Adult patients aged 18 years and older
- Critically ill patients admitted to the intensive care unit (ICU)
- Patients with indwelling central venous catheter and arterial line placed for routine clinical management
- Written informed consent obtained from the patient or legal next of kin
Exclusion Criteria:
- Known severe peripheral vascular occlusive disease affecting line placement
- Use of a pulmonary artery catheter (mixed venous blood line) instead of a standard central venous catheter positioned at the superior/inferior vena cava junction
- Refusal of the patient or legal representative to participate in the study
- Patients younger than 18 years of age
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
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Diabetic Critically Ill Patients
Critically ill adult patients admitted to the intensive care unit who have a confirmed diagnosis of Diabetes Mellitus.
All participants undergo simultaneous paired arterial and central venous blood gas sampling to evaluate agreement and CO2 gap dynamics.
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Non-Diabetic Critically Ill Patients
Critically ill adult patients admitted to the intensive care unit without a history or diagnosis of Diabetes Mellitus.
All participants undergo simultaneous paired arterial and central venous blood gas sampling to evaluate agreement and CO2 gap dynamics.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Venous-to-Arterial Carbon Dioxide Tension Difference (Delta PCO2)
Délai: Baseline
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Delta PCO2 (CO2 gap) is calculated as central venous PCO2 minus arterial PCO2 (PvCO2 - PaCO2) measured in mmHg.
Paired arterial and central venous blood gas samples are collected simultaneously and analyzed within 10 minutes.
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Baseline
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Collaborateurs et enquêteurs
Parrainer
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Estimé)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- CVBG vs ABG in ICU Diabetics
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