Central Venous vs Arterial Blood Gas and CO2 Gap in Critically Ill Patients With and Without Diabetes
Correlation Between Central Venous and Arterial Blood Gas Parameters Including CO2 Gap in Diabetic and Non-Diabetic Critically Ill Patients
Frequent monitoring of acid-base status, ventilation, and tissue oxygenation is essential for managing critically ill patients in the intensive care unit (ICU). While arterial blood gas (ABG) analysis is considered the standard method for these evaluations, maintaining arterial catheters carries risks of complications, such as thrombosis, hematoma, and infection. Central venous blood gas (CVBG) analysis offers a safer alternative because central venous catheters are already routinely placed for patient care. Additionally, the venous-to-arterial carbon dioxide difference (CO2 gap) serves as an indicator of systemic blood flow and tissue perfusion.
However, patients with diabetes mellitus often present with underlying microvascular alterations, endothelial changes, and metabolic variations that might alter tissue perfusion and peripheral gas exchange. This study aims to assess the correlation and agreement between central venous and arterial blood gas parameters, as well as evaluate the diagnostic accuracy of the CO2 gap, in diabetic versus non-diabetic critically ill patients.
A total of 100 adult ICU patients (50 diabetic and 50 non-diabetic) with pre-existing central venous and arterial lines will be enrolled. Paired blood samples will be drawn simultaneously to compare blood gas values and calculate the CO2 gap without altering standard clinical treatment.
Descripción general del estudio
Estado
Tipo de estudio
Inscripción (Estimado)
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- Adult patients aged 18 years and older
- Critically ill patients admitted to the intensive care unit (ICU)
- Patients with indwelling central venous catheter and arterial line placed for routine clinical management
- Written informed consent obtained from the patient or legal next of kin
Exclusion Criteria:
- Known severe peripheral vascular occlusive disease affecting line placement
- Use of a pulmonary artery catheter (mixed venous blood line) instead of a standard central venous catheter positioned at the superior/inferior vena cava junction
- Refusal of the patient or legal representative to participate in the study
- Patients younger than 18 years of age
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
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Diabetic Critically Ill Patients
Critically ill adult patients admitted to the intensive care unit who have a confirmed diagnosis of Diabetes Mellitus.
All participants undergo simultaneous paired arterial and central venous blood gas sampling to evaluate agreement and CO2 gap dynamics.
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Non-Diabetic Critically Ill Patients
Critically ill adult patients admitted to the intensive care unit without a history or diagnosis of Diabetes Mellitus.
All participants undergo simultaneous paired arterial and central venous blood gas sampling to evaluate agreement and CO2 gap dynamics.
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
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Venous-to-Arterial Carbon Dioxide Tension Difference (Delta PCO2)
Periodo de tiempo: Baseline
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Delta PCO2 (CO2 gap) is calculated as central venous PCO2 minus arterial PCO2 (PvCO2 - PaCO2) measured in mmHg.
Paired arterial and central venous blood gas samples are collected simultaneously and analyzed within 10 minutes.
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Baseline
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Colaboradores e Investigadores
Patrocinador
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Finalización primaria (Estimado)
Finalización del estudio (Estimado)
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Publicado por primera vez (Actual)
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Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
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Otros números de identificación del estudio
- CVBG vs ABG in ICU Diabetics
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