Review of Randomized Controlled Trials of Massage in Preterm Infants

Anna-Kaisa Niemi, Anna-Kaisa Niemi

Abstract

Preterm birth affects about 10% of infants born in the United States. Massage therapy is being used in some neonatal intensive care units for its potential beneficial effects on preterm infants. This article reviews published randomized controlled trials on the effects of massage in preterm infants. Most studies evaluating the effect of massage in weight gain in premature infants suggest a positive effect on weight gain. Increase in vagal tone has been reported in infants who receive massage and has been suggested as a possible mechanism for improved weight gain. More studies are needed on the underlying mechanisms of the effects of massage therapy on weight gain in preterm infants. While some trials suggest improvements in developmental scores, decreased stress behavior, positive effects on immune system, improved pain tolerance and earlier discharge from the hospital, the number of such studies is small and further evidence is needed. Further studies, including randomized controlled trials, are needed on the effects of massage in preterm infants.

Keywords: hyperbilirubinemia; infant massage; mind–body; neonate; newborn; premature; preterm; randomized controlled trial; tactile‐kinesthetic stimulation; weight gain.

Conflict of interest statement

The author declares no conflict of interest.

References

    1. Hamilton B.E., Martin J.A., Osterman M.J., Curtin S.C., Matthews T.J. Births: Final data for 2014. Natl. Vital Stat. Rep. 2015;64:1–64.
    1. Saeadi R., Ghorbani Z., Shapouri Moghaddam A. The effect of massage with medium-chain triglyceride oil on weight gain in premature neonates. Acta Med. Iran. 2015;53:134–138.
    1. Basiri-Moghadam M., Basiri-Moghadam K., Kianmehr M., Jani S. The effect of massage on neonatal jaundice in stable preterm newborn infants: A randomized controlled trial. J. Pak. Med. Assoc. 2015;65:602–606.
    1. Yates C.C., Mitchell A.J., Booth M.Y., Williams D.K., Lowe L.M., Whit Hall R. The effects of massage therapy to induce sleep in infants born preterm. Pediatr. Phys. Ther. 2014;26:405–410. doi: 10.1097/PEP.0000000000000081.
    1. Diego M.A., Field T., Hernandez-Reif M. Preterm infant weight gain is increased by massage therapy and exercise via different underlying mechanisms. Early Hum. Dev. 2014;90:137–140. doi: 10.1016/j.earlhumdev.2014.01.009.
    1. Smith S.L., Lux R., Haley S., Slater H., Beachy J., Moyer-Mileur L.J. The effect of massage on heart rate variability in preterm infants. J. Perinatol. 2013;33:59–64. doi: 10.1038/jp.2012.47.
    1. Smith S.L., Haley S., Slater H., Moyer-Mileur L.J. Heart rate variability during caregiving and sleep after massage therapy in preterm infants. Early Hum. Dev. 2013;89:525–529. doi: 10.1016/j.earlhumdev.2013.01.004.
    1. Moyer-Mileur L.J., Haley S., Slater H., Beachy J., Smith S.L. Massage improves growth quality by decreasing body fat deposition in male preterm infants. J. Pediatr. 2013;162:490–495. doi: 10.1016/j.jpeds.2012.08.033.
    1. Kumar J., Upadhyay A., Dwivedi A.K., Gothwal S., Jaiswal V., Aggarwal S. Effect of oil massage on growth in preterm neonates less than 1800 g: A randomized control trial. Indian J. Pediatr. 2013;80:465–469. doi: 10.1007/s12098-012-0869-7.
    1. Fallah R., Akhavan Karbasi S., Golestan M., Fromandi M. Sunflower oil versus no oil moderate pressure massage leads to greater increases in weight in preterm neonates who are low birth weight. Early Hum. Dev. 2013;89:769–772. doi: 10.1016/j.earlhumdev.2013.06.002.
    1. Haley S., Beachy J., Ivaska K.K., Slater H., Smith S., Moyer-Mileur L.J. Tactile/kinesthetic stimulation (TKS) increases tibial speed of sound and urinary osteocalcin (U-MidOC and unOC) in premature infants (29–32 weeks PMA) Bone. 2012;51:661–666. doi: 10.1016/j.bone.2012.07.016.
    1. Ang J.Y., Lua J.L., Mathur A., Thomas R., Asmar B.I., Savasan S., Buck S., Long M., Shankaran S. A randomized placebo-controlled trial of massage therapy on the immune system of preterm infants. Pediatrics. 2012;130:e1549–e1558. doi: 10.1542/peds.2012-0196.
    1. Guzzetta A., D’Acunto M.G., Carotenuto M., Berardi N., Bancale A., Biagioni E., Boldrini A., Ghirri P., Maffei L., Cioni G. The effects of preterm infant massage on brain electrical activity. Dev. Med. Child Neurol. 2011;53(Suppl. 4):46–51. doi: 10.1111/j.1469-8749.2011.04065.x.
    1. Procianoy R.S., Mendes E.W., Silveira R.C. Massage therapy improves neurodevelopment outcome at two years corrected age for very low birth weight infants. Early Hum. Dev. 2010;86:7–11. doi: 10.1016/j.earlhumdev.2009.12.001.
    1. Ho Y.B., Lee R.S., Chow C.B., Pang M.Y. Impact of massage therapy on motor outcomes in very low-birthweight infants: Randomized controlled pilot study. Pediatr. Int. 2010;52:378–385. doi: 10.1111/j.1442-200X.2009.02964.x.
    1. Massaro A.N., Hammad T.A., Jazzo B., Aly H. Massage with kinesthetic stimulation improves weight gain in preterm infants. J. Perinatol. 2009;29:352–357. doi: 10.1038/jp.2008.230.
    1. Gonzalez A.P., Vasquez-Mendoza G., Garcia-Vela A., Guzman-Ramirez A., Salazar-Torres M., Romero-Gutierrez G. Weight gain in preterm infants following parent-administered vimala massage: A randomized controlled trial. Am. J. Perinatol. 2009;26:247–252. doi: 10.1055/s-0028-1103151.
    1. Mendes E.W., Procianoy R.S. Massage therapy reduces hospital stay and occurrence of late-onset sepsis in very preterm neonates. J. Perinatol. 2008;28:815–820. doi: 10.1038/jp.2008.108.
    1. Field T., Diego M., Hernandez-Reif M., Dieter J.N., Kumar A.M., Schanberg S., Kuhn C. Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy. J. Dev. Behav. Pediatr. 2008;29:463–466. doi: 10.1097/DBP.0b013e3181856d3b.
    1. Diego M.A., Field T., Hernandez-Reif M. Temperature increases in preterm infants during massage therapy. Infant Behav. Dev. 2008;31:149–152. doi: 10.1016/j.infbeh.2007.07.002.
    1. Chen L.L., Su Y.C., Su C.H., Lin H.C., Kuo H.W. Acupressure and meridian massage: Combined effects on increasing body weight in premature infants. J. Clin. Nurs. 2008;17:1174–1181. doi: 10.1111/j.1365-2702.2007.02147.x.
    1. Lahat S., Mimouni F.B., Ashbel G., Dollberg S. Energy expenditure in growing preterm infants receiving massage therapy. J. Am. Coll. Nutr. 2007;26:356–359. doi: 10.1080/07315724.2007.10719623.
    1. Hernandez-Reif M., Diego M., Field T. Preterm infants show reduced stress behaviors and activity after 5 days of massage therapy. Infant Behav. Dev. 2007;30:557–561. doi: 10.1016/j.infbeh.2007.04.002.
    1. Diego M.A., Field T., Hernandez-Reif M., Deeds O., Ascencio A., Begert G. Preterm infant massage elicits consistent increases in vagal activity and gastric motility that are associated with greater weight gain. Acta Paediatr. 2007;96:1588–1591. doi: 10.1111/j.1651-2227.2007.00476.x.
    1. Jain S., Kumar P., McMillan D.D. Prior leg massage decreases pain responses to heel stick in preterm babies. J. Paediatr. Child Health. 2006;42:505–508. doi: 10.1111/j.1440-1754.2006.00912.x.
    1. Field T., Diego M.A., Hernandez-Reif M., Deeds O., Figuereido B. Moderate versus light pressure massage therapy leads to greater weight gain in preterm infants. Infant Behav. Dev. 2006;29:574–578. doi: 10.1016/j.infbeh.2006.07.011.
    1. Solanki K., Matnani M., Kale M., Joshi K., Bavdekar A., Bhave S., Pandit A. Transcutaneous absorption of topically massaged oil in neonates. Indian Pediatr. 2005;42:998–1005.
    1. Sankaranarayanan K., Mondkar J.A., Chauhan M.M., Mascarenhas B.M., Mainkar A.R., Salvi R.Y. Oil massage in neonates: An open randomized controlled study of coconut versus mineral oil. Indian Pediatr. 2005;42:877–884.
    1. Lee H.K. The effect of infant massage on weight gain, physiological and behavioral responses in premature infants. Taehan Kanho Hakhoe Chi. 2005;35:1451–1460. doi: 10.4040/jkan.2005.35.8.1451.
    1. Diego M.A., Field T., Hernandez-Reif M. Vagal activity, gastric motility, and weight gain in massaged preterm neonates. J. Pediatr. 2005;147:50–55. doi: 10.1016/j.jpeds.2005.02.023.
    1. Arora J., Kumar A., Ramji S. Effect of oil massage on growth and neurobehavior in very low birth weight preterm neonates. Indian Pediatr. 2005;42:1092–1100.
    1. Aly H., Moustafa M.F., Hassanein S.M., Massaro A.N., Amer H.A., Patel K. Physical activity combined with massage improves bone mineralization in premature infants: A randomized trial. J. Perinatol. 2004;24:305–309. doi: 10.1038/sj.jp.7211083.
    1. Ferber S.G., Kuint J., Weller A., Feldman R., Dollberg S., Arbel E., Kohelet D. Massage therapy by mothers and trained professionals enhances weight gain in preterm infants. Early Hum. Dev. 2002;67:37–45. doi: 10.1016/S0378-3782(01)00249-3.
    1. Wheeden A., Scafidi F.A., Field T., Ironson G., Valdeon C., Bandstra E. Massage effects on cocaine-exposed preterm neonates. J. Dev. Behav. Pediatr. 1993;14:318–322. doi: 10.1097/00004703-199310000-00005.
    1. Scafidi F.A., Field T., Schanberg S.M. Factors that predict which preterm infants benefit most from massage therapy. J. Dev. Behav. Pediatr. 1993;14:176–180. doi: 10.1097/00004703-199306010-00008.
    1. Field T.M., Schanberg S.M., Scafidi F., Bauer C.R., Vega-Lahr N., Garcia R., Nystrom J., Kuhn C.M. Tactile/kinesthetic stimulation effects on preterm neonates. Pediatrics. 1986;77:654–658.
    1. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Circulation. 1996;93:1043–1065.
    1. American Academy of Pediatrics, Committee on Nutrition Nutritional needs of low-birth-weight infants. Pediatrics. 1985;75:976–986.
    1. Manuck T.A., Rice M.M., Bailit J.L., Grobman W.A., Reddy U.M., Wapner R.J., Thorp J.M., Caritis S.N., Prasad M., Tita A.T., et al. Preterm neonatal morbidity and mortality by gestational age: A contemporary cohort. Am. J. Obstet. Gynecol. 2016;215:103.e1–103.e14. doi: 10.1016/j.ajog.2016.01.004.
    1. Stoll B.J., Hansen N.I., Bell E.F., Walsh M.C., Carlo W.A., Shankaran S., Laptook A.R., Sanchez P.J., Van Meurs K.P., Wyckoff M., et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993–2012. JAMA. 2015;314:1039–1051. doi: 10.1001/jama.2015.10244.
    1. Wang L., He J.L., Zhang X.H. The efficacy of massage on preterm infants: A meta-analysis. Am. J. Perinatol. 2013;30:731–738.
    1. Vickers A., Ohlsson A., Lacy J.B., Horsley A. Massage for promoting growth and development of preterm and/or low birth-weight infants. Cochrane Database Syst. Rev. 2004;2014:CD000390.
    1. Field T., Diego M., Hernandez-Reif M. Preterm infant massage therapy research: A review. Infant Behav. Dev. 2010;33:115–124. doi: 10.1016/j.infbeh.2009.12.004.
    1. Field T., Diego M., Hernandez-Reif M. Potential underlying mechanisms for greater weight gain in massaged preterm infants. Infant Behav. Dev. 2011;34:383–389. doi: 10.1016/j.infbeh.2010.12.001.

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