Association of postoperative covert stroke and cognitive dysfunction among elderly patients undergoing non-cardiac surgery: protocol for a prospective cohort study (PRECISION study)

Qianyu Cui, Dexiang Wang, Min Zeng, Jia Dong, Hailong Jin, Zhengfang Hu, Yuan Zhang, Yuming Peng, Ruquan Han, Qianyu Cui, Dexiang Wang, Min Zeng, Jia Dong, Hailong Jin, Zhengfang Hu, Yuan Zhang, Yuming Peng, Ruquan Han

Abstract

Introduction: The incidence of covert stroke and cognitive dysfunction has gradually increased due to an ageing population. Recently, a prospective cohort study reported perioperative covert stroke was associated with an increased risk of postoperative cognitive dysfunction (POCD) 1 year after non-cardiac surgery. However, the mechanism remains unclear.

Methods and analysis: This is a prospective observational trial aiming to investigate the cumulative incidence of perioperative covert stroke and test the hypothesis that perioperative covert stroke associates with POCD in elderly patients undergoing non-cardiac and non-neurological surgery. Data on risk factors, brain MRI, cognitive function evaluation and serum immune-inflammatory cytokines will be collected and analysed.

Ethics and dissemination: Ethical approval has been granted by the Medical Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-027-02). The results of this study will be disseminated through presentations at scientific conferences and publication in scientific journals.

Trial registration number: NCT03081429.

Keywords: anaesthesia; cognitive dysfunction; covert stroke; prospective cohort study.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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