Food allergy in children

V R Baral, J O'B Hourihane, V R Baral, J O'B Hourihane

Abstract

Food allergy is being increasingly recognised with the highest prevalence being in preschool children. Pathogenesis varies so diagnosis rests on careful history and clinical examination, appropriate use of skin prick and serum-specific IgE testing, food challenge, and supervised elimination diets. A double blind placebo controlled food challenge is the gold standard diagnostic test. Avoidance of the allergenic food is the key towards successful management. IgE mediated food allergy may present as a potentially fatal anaphylactic reaction, and management consists of the appropriate use of adrenaline (epinephrine) and supportive measures. Sensitisation remains a key target for intervention. Disease modifying agents are currently under trial for managing difficult allergies. Management requires a multidisciplinary approach and follow up.

References

    1. Arch Dis Child. 2000 Feb;82(2):93-5
    1. BMJ. 2003 Nov 15;327(7424):1142-3
    1. BMJ. 2000 Apr 1;320(7239):929-32
    1. BMJ. 2000 May 27;320(7247):1441
    1. Lancet. 2000 May 13;355(9216):1680-3
    1. BMJ. 2000 Aug 12;321(7258):424
    1. J Allergy Clin Immunol. 2001 Jan;107(1):191-3
    1. Lancet. 2001 Jan 13;357(9250):111-5
    1. Allergy. 2003 Dec;58(12):1217-23
    1. Clin Exp Allergy. 2003 Nov;33(11):1484-99
    1. Arch Dis Child. 2004 Feb;89(2):97-102
    1. Allergy. 2004 Feb;59(2):185-91
    1. Methods. 2004 Mar;32(3):292-9
    1. J Allergy Clin Immunol. 2004 May;113(5):805-19; quiz 820
    1. J Allergy Clin Immunol. 2004 May;113(5):832-6
    1. Clin Exp Allergy. 2004 May;34(5):761-9
    1. Allergy. 2004 Jul;59(7):690-7
    1. Acta Paediatr. 2004 Jun;93(6):759-64
    1. Eur J Immunol. 2004 Aug;34(8):2100-9
    1. Pediatr Allergy Immunol. 2004 Oct;15(5):435-41
    1. Clin Allergy. 1981 Nov;11(6):533-9
    1. J Allergy Clin Immunol. 1988 May;81(5 Pt 2):1059-65
    1. J Pediatr. 1988 Sep;113(3):447-51
    1. J Pediatr. 1989 Jul;115(1):23-7
    1. Allergy. 1990 Nov;45(8):587-96
    1. Lancet. 1994 May 7;343(8906):1127-30
    1. BMJ. 1994 Jul 23;309(6949):223-5
    1. N Engl J Med. 1995 May 11;332(19):1262-6
    1. BMJ. 1996 Aug 31;313(7056):514-7
    1. Ann Ist Super Sanita. 1995;31(4):481-8
    1. Clin Exp Allergy. 1996 Dec;26(12):1364-70
    1. Pediatr Allergy Immunol. 1996;7(9 Suppl):42-50
    1. J Allergy Clin Immunol. 1997 Oct;100(4):444-51
    1. JAMA. 1997 Dec 10;278(22):1888-94
    1. BMJ. 1998 Apr 25;316(7140):1271-5
    1. J Allergy Clin Immunol. 1999 May;103(5 Pt 1):717-28
    1. Ann Allergy Asthma Immunol. 1999 Aug;83(2):132-6
    1. Curr Allergy Asthma Rep. 2005 Jan;5(1):51-5
    1. J Allergy Clin Immunol. 2001 May;107(5):891-6
    1. Arch Dis Child. 2001 Oct;85(4):348
    1. J Allergy Clin Immunol. 2001 Dec;108(6):1040-4
    1. Arch Dis Child. 2002 Apr;86(4):236-9
    1. Arch Dis Child. 2002 Apr;86(4):240-4
    1. Allerg Immunol (Paris). 2002 Sep;34(7):241-4
    1. J Allergy Clin Immunol. 2002 Dec;110(6):834-40
    1. Arch Dis Child. 2003 Jan;88(1):79-81
    1. N Engl J Med. 2003 Mar 13;348(11):977-85
    1. J Clin Invest. 2003 Apr;111(7):1065-72
    1. Pediatrics. 2003 Jun;111(6 Pt 3):1672-80
    1. Curr Opin Allergy Clin Immunol. 2003 Jun;3(3):199-203
    1. J Allergy Clin Immunol. 2003 Jul;112(1):183-9
    1. J Paediatr Child Health. 2003 Jul;39(5):372-5
    1. Curr Opin Allergy Clin Immunol. 2003 Dec;3(6):501-10
    1. Allergy. 2000 Jan;55(1):2-10

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