Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 data

Mai A Elobeid, Miguel A Padilla, David W Brock, Douglas M Ruden, David B Allison, Mai A Elobeid, Miguel A Padilla, David W Brock, Douglas M Ruden, David B Allison

Abstract

Recent evidence suggests that endocrine disrupting chemicals (EDCs) may cause perturbations in endogenous hormonal regulation that predispose to weight gain. Using data from NHANES (1999-2002), we investigated the association between body mass index (BMI), waist circumference (WC) and selected persistent organic pollutants (POPs) via multiple linear regressions. Consistent interaction was found between gender, ln oxychlordane and ln p,p' DDT. Also, we found an association between WC and ln oxychlordane and ln hpcdd in subjects with detectable levels of POPs, whereas an association between WC and ln p,p' DDT was observed in all subjects. Furthermore, ln Ocdd showed an increase with higher WC and BMI, whereas, ln trans-nonachlor decreased with higher BMI. Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic.

Keywords: Obesity; endocrine disruptors; persistent organic pollutants; public health; waist circumference.

References

    1. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999–2000. JAMA. 2002;288:1728–1732.
    1. Folsom AR, Kaye SA, Sellers TA, Hong CP, Cerhan JR, Potter JD, Prineas RJ. Body fat distribution and 5-year risk of death in older women. JAMA. 1993;269:483–487.
    1. Janssen I, Katzmarzyk PT, Ross R. Body mass index, waist circumference, and health risk: evidence in support of current National Institutes of Health guidelines. Arch. Intern. Med. 2002;162:2074–2079.
    1. Rimm EB, Stampfer MJ, Giovannucci E, Ascherio A, Spiegelman D, Colditz GA, Willett WC. Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. Am. J. Epidemiol. 1995;141:1117–1127.
    1. Seidell JC, Bjorntorp P, Sjostrom L, Sannerstedt R, Krotkiewski M, Kvist H. Regional distribution of muscle and fat mass in men—new insight into the risk of abdominal obesity using computed tomography. Int. J. Obes. 1989;13:289–303.
    1. Willett WC, Manson JE, Stampfer MJ, Colditz GA, Rosner B, Speizer FE, Hennekens CH. Weight, weight change, and coronary heart disease in women. Risk within the ‘normal’ weight range. JAMA. 1995;273:461–465.
    1. Despres JP. Abdominal obesity as important component of insulin-resistance syndrome. Nutrition. 1993;9:452–459.
    1. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X) Diabetes. 1992;41:715–722.
    1. Ivandic A, Prpic-Krizevac I, Bozic D, Barbir A, Peljhan V, Balog Z, Glasnovic M. Insulin resistance and androgens in healthy women with different body fat distributions. Wien. Klin. Wochenschr. 2002;114:321–326.
    1. Ross R, Freeman J, Hudson R, Janssen I. Abdominal obesity, muscle composition, and insulin resistance in premenopausal women. J .Clin. Endocrinol. Metab. 2002;87:5044–5051.
    1. Le Marchand L, Wilkens LR, Mi MP. Obesity in youth and middle age and risk of colorectal cancer in men. Cancer Cause. Control. 1992;3:349–354.
    1. Moyad MA. Obesity, interrelated mechanisms, and exposures and kidney cancer. Semin. Urol. Oncol. 2001;19:270–279.
    1. Stoll BA. Upper abdominal obesity, insulin resistance and breast cancer risk. Int. J. Obes. Relat. Metab. Disord. 2002;26:747–753.
    1. Elobeid MA, Desmond RA, Thomas O, Keith SW, Allison DB. Waist circumference values are increasing beyond those expected from BMI increases. Obesity (Silver Spring) 2007;15:2380–2383.
    1. Heindel JJ. Endocrine disruptors and the obesity epidemic. Toxicol. Sci. 2003;76:247–249.
    1. Newbold RR, Padilla-Banks E, Jefferson WN, Heindel JJ. Effects of endocrine disruptors on obesity. Int. J. Androl. 2008;31:201–208.
    1. Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR., Jr Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999–2002. Diabetologia. 2007;50:1841–1851.
    1. Lee DH, Lee IK, Jin SH, Steffes M, Jacobs DR., Jr Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: results from the National Health and Nutrition Examination Survey 1999–2002. Diabetes Care. 2007;30:622–628.
    1. Lee DH, Lee IK, Song K, Steffes M, Toscano W, Baker BA, Jacobs DR., Jr A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999–2002. Diabetes Care. 2006;29:1638–1644.
    1. Dioxins. Available online: (accessed on 16 July 2010).
    1. Takahama K, Ishii Y, Kanda M. Toxicological studies on organochlorine pesticides. 1. Effects of long term administration of organochlorine pesticides on rabbit body weight and organ weight. Nihon Hoigaku Zasshi. 1972;26:5–10.
    1. Deichmann WB, MacDonald WE, Cubit DA, Beasley AG. Effects of starvation in rats with elevated DDT and dieldrin tissue levels. Int. Arch. Arbeitsmed. 1972;29:233–252.
    1. Chadwick RW, Cooper RL, Chang J, Rehnberg GL, McElroy WK. Possible antiestrogenic activity of lindane in female rats. J .Biochem. Toxicol. 1988;3:147–158.
    1. Villeneuve DC, van Logten MJ, den Tonkelaar EM, Greve PA, Vos JG, Speijers GJ, van Esch GJ. Effect of food deprivation on low level hexachlorobenzene exposure in rats. Sci. Total Environ. 1977;8:179–186.
    1. Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J. Biol. Chem. 2001;276:25096–25100.
    1. Mariussen E, Fonnum F. Neurochemical targets and behavioral effects of organohalogen compounds: an update. Crit. Rev. Toxicol. 2006;36:253–289.
    1. Humblet O, Birnbaum L, Rimm E, Mittleman MA, Hauser R. Dioxins and cardiovascular disease mortality. Environ. Health Perspect. 2008;116:1443–1448.
    1. Gupta BN, McConnell EE, Goldstein JA, Harris MW, Moore JA. Effects of a polybrominated biphenyl mixture in the rat and mouse. I. Six-month exposure. Toxicol. Appl. Pharmacol. 1983;68:1–18.
    1. Trankina ML, Beitz DC, Trenkle AH. Effects of in vitro ronnel on metabolic activity in subcutaneous adipose tissue and skeletal muscle from steers. J. Anim. Sci. 1985;60:652–658.
    1. Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR, Wang C, Aronne LJ, Wright SM, Baskin M, Dhurandhar NV, Lijoi MC, Grilo CM, DeLuca M, Westfall AO, Allison DB. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int. J. Obes. (Lond) 2006;30:1585–1594.
    1. Needham LL, Barr DB, Caudill SP, Pirkle JL, Turner WE, Osterloh J, Jones RL, Sampson EJ. Concentrations of environmental chemicals associated with neurodevelopmental effects in U.S. population. Neurotoxicology. 2005;26:531–545.
    1. Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int. J. Epidemiol. 2002;31:1235–1239.
    1. Newbold RR, Padilla-Banks E, Snyder RJ, Phillips TM, Jefferson WN. Developmental exposure to endocrine disruptors and the obesity epidemic. Reprod. Toxicol. 2007;23:290–296.
    1. Newbold RR, Padilla-Banks E, Jefferson WN. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology. 2006;147:S11–S17.
    1. Ruden DM, Xiao L, Garfinkel MD, Lu X. Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer. Hum. Mol. Genet. 2005;14:R149–R155.
    1. Porta M. Persistent organic pollutants and the burden of diabetes. Lancet. 2006;368:558–559.

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